DERL3 (derlin 3)

Gene

• Entrez ID: 91319
• Gene name: Derlin 3
• Gene symbol: DERL3
• Synonyms (NCBI Gene): C22orf14, IZP6, LLN2, derlin-3
• Chromosome: 22
• Chromosome location: 22q11.23
• Summary: The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT933231	hsa-miR-1207-3p	CLIP-seq
MIRT933232	hsa-miR-1252	CLIP-seq
MIRT933233	hsa-miR-1257	CLIP-seq
MIRT933234	hsa-miR-1273f	CLIP-seq
MIRT933235	hsa-miR-143	CLIP-seq
MIRT933236	hsa-miR-1825	CLIP-seq
MIRT933237	hsa-miR-2110	CLIP-seq
MIRT933238	hsa-miR-3123	CLIP-seq
MIRT933239	hsa-miR-3202	CLIP-seq
MIRT933240	hsa-miR-3675-5p	CLIP-seq
MIRT933241	hsa-miR-3914	CLIP-seq
MIRT933242	hsa-miR-4271	CLIP-seq
MIRT933243	hsa-miR-4283	CLIP-seq
MIRT933244	hsa-miR-4447	CLIP-seq
MIRT933245	hsa-miR-4472	CLIP-seq
MIRT933246	hsa-miR-4489	CLIP-seq
MIRT933247	hsa-miR-4494	CLIP-seq
MIRT933248	hsa-miR-4525	CLIP-seq
MIRT933249	hsa-miR-4533	CLIP-seq
MIRT933250	hsa-miR-4676-5p	CLIP-seq
MIRT933251	hsa-miR-4708-5p	CLIP-seq
MIRT933252	hsa-miR-4709-3p	CLIP-seq
MIRT933253	hsa-miR-4715-3p	CLIP-seq
MIRT933254	hsa-miR-4724-5p	CLIP-seq
MIRT933255	hsa-miR-4725-3p	CLIP-seq
MIRT933256	hsa-miR-4770	CLIP-seq
MIRT933257	hsa-miR-4786-3p	CLIP-seq
MIRT933258	hsa-miR-4790-3p	CLIP-seq
MIRT933259	hsa-miR-512-3p	CLIP-seq
MIRT933260	hsa-miR-575	CLIP-seq
MIRT933261	hsa-miR-637	CLIP-seq
MIRT933262	hsa-miR-658	CLIP-seq
MIRT933263	hsa-miR-671-5p	CLIP-seq
MIRT933264	hsa-miR-2117	CLIP-seq
MIRT933265	hsa-miR-4273	CLIP-seq
MIRT2515479	hsa-miR-146b-3p	CLIP-seq
MIRT2515480	hsa-miR-1827	CLIP-seq
MIRT2515481	hsa-miR-4316	CLIP-seq
MIRT2515482	hsa-miR-4530	CLIP-seq
MIRT2515483	hsa-miR-4690-3p	CLIP-seq
MIRT2515484	hsa-miR-4699-5p	CLIP-seq
MIRT2515485	hsa-miR-4710	CLIP-seq
MIRT2515486	hsa-miR-488	CLIP-seq
MIRT2515482	hsa-miR-4530	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005047	Function	Signal recognition particle binding	IBA
GO:0005047	Function	Signal recognition particle binding	IDA	26565908
GO:0005047	Function	Signal recognition particle binding	IEA
GO:0005515	Function	Protein binding	IPI	16449189, 19135427, 32296183
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	16449189
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0018279	Process	Protein N-linked glycosylation via asparagine	IMP	22607976
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IBA
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IDA	16449189
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IEA
GO:0036503	Process	ERAD pathway	IBA
GO:0036503	Process	ERAD pathway	IEA
GO:0036503	Process	ERAD pathway	IMP	22607976
GO:0036503	Process	ERAD pathway	NAS	16449189
GO:0036503	Process	ERAD pathway	TAS	22013210
GO:0044877	Function	Protein-containing complex binding	IPI	26565908
GO:1904153	Process	Negative regulation of retrograde protein transport, ER to cytosol	IEA
GO:1904153	Process	Negative regulation of retrograde protein transport, ER to cytosol	IMP	25660456

Other IDs

• MIM: 610305
• HGNC: 14236
• e!Ensembl: ENSG00000099958

Protein

• UniProt ID: Q96Q80
• Protein name: Derlin-3 (Degradation in endoplasmic reticulum protein 3) (DERtrin-3) (Der1-like protein 3)
• Protein function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoprotei
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04511	DER1	13 → 203	Der1-like family	Family

• Tissue specificity: TISSUE SPECIFICITY: Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine. {ECO:0000269|PubMed:16449189}.
• Sequence:

  MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
  FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
  GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
  IYYFLEDVFPNQPGGKRLLQTPGFLKLLLDAPAEDPNYLPLPEEQPGPHLPPPQQ

• Sequence length: 235