DERL2 (derlin 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 51009 |
| Gene name | Derlin 2 |
| Gene symbol | DERL2 |
| Synonyms (NCBI Gene) |
CGI-101DERtrin-2F-LAN-1F-LANaFLANaderlin-2
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| Chromosome | 17 |
| Chromosome location | 17p13.2 |
| Summary | Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[s |
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miRNA
miRNA information provided by mirtarbase database.
419
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9GZP9 | ||||||||||
| Protein name | Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa) | ||||||||||
| Protein function | Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoprotei | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Ubiquitous. Overexpressed in various hepatocarcinomas. {ECO:0000269|PubMed:11500051, ECO:0000269|PubMed:16449189}. | ||||||||||
| Sequence |
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| Sequence length | 239 | ||||||||||
| Interactions | View interactions | ||||||||||