Gene Gene information from NCBI Gene database.
Entrez ID 51009
Gene name Derlin 2
Gene symbol DERL2
Synonyms (NCBI Gene)
CGI-101DERtrin-2F-LAN-1F-LANaFLANaderlin-2
Chromosome 17
Chromosome location 17p13.2
Summary Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[s
miRNA miRNA information provided by mirtarbase database.
419
miRTarBase ID miRNA Experiments Reference
MIRT042933 hsa-miR-324-3p CLASH 23622248
MIRT708338 hsa-miR-4793-5p HITS-CLIP 19536157
MIRT708337 hsa-miR-4722-3p HITS-CLIP 19536157
MIRT708336 hsa-miR-6727-3p HITS-CLIP 19536157
MIRT708335 hsa-miR-6747-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
GO ID Ontology Definition Evidence Reference
GO:0001967 Process Suckling behavior IEA
GO:0005047 Function Signal recognition particle binding IBA
GO:0005047 Function Signal recognition particle binding IDA 26565908
GO:0005047 Function Signal recognition particle binding IEA
GO:0005515 Function Protein binding IPI 16449189, 22119785, 25416956, 32296183, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610304 17943 ENSG00000072849
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9GZP9
Protein name Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa)
Protein function Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoprotei
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04511 DER1 13 203 Der1-like family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Overexpressed in various hepatocarcinomas. {ECO:0000269|PubMed:11500051, ECO:0000269|PubMed:16449189}.
Sequence
Sequence length 239
Interactions View interactions