Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51009
Gene name Gene Name - the full gene name approved by the HGNC.
Derlin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DERL2
Synonyms (NCBI Gene) Gene synonyms aliases
CGI-101, DERtrin-2, F-LAN-1, F-LANa, FLANa, derlin-2
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[s
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT042933 hsa-miR-324-3p CLASH 23622248
MIRT708338 hsa-miR-4793-5p HITS-CLIP 19536157
MIRT708337 hsa-miR-4722-3p HITS-CLIP 19536157
MIRT708336 hsa-miR-6727-3p HITS-CLIP 19536157
MIRT708335 hsa-miR-6747-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000839 Component Hrd1p ubiquitin ligase ERAD-L complex IBA 21873635
GO:0001967 Process Suckling behavior IEA
GO:0005047 Function Signal recognition particle binding IDA 26565908
GO:0005515 Function Protein binding IPI 16449189, 25416956, 32296183
GO:0005769 Component Early endosome IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610304 17943 ENSG00000072849
Protein
UniProt ID Q9GZP9
Protein name Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa)
Protein function Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoprotei
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04511 DER1 13 203 Der1-like family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Overexpressed in various hepatocarcinomas. {ECO:0000269|PubMed:11500051, ECO:0000269|PubMed:16449189}.
Sequence
Sequence length 239
Interactions View interactions