Gene Gene information from NCBI Gene database.
Entrez ID 79139
Gene name Derlin 1
Gene symbol DERL1
Synonyms (NCBI Gene)
DER-1DER1derlin-1
Chromosome 8
Chromosome location 8q24.13
Summary The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradatio
miRNA miRNA information provided by mirtarbase database.
523
miRTarBase ID miRNA Experiments Reference
MIRT000172 hsa-miR-21-5p Luciferase reporter assayQuantitative proteomic approach 19253296
MIRT028468 hsa-miR-30a-5p Proteomics 18668040
MIRT000172 hsa-miR-21-5p Microarray 18591254
MIRT031154 hsa-miR-19b-3p Sequencing 20371350
MIRT050045 hsa-miR-26b-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
46
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IPI 25239945
GO:0005047 Function Signal recognition particle binding IBA
GO:0005047 Function Signal recognition particle binding IDA 26565908
GO:0005515 Function Protein binding IPI 15215856, 16901789, 17872946, 18555783, 18675248, 19135427, 19275885, 19818707, 24089527, 25239945, 25416956, 26618866, 29275994, 32296183, 36012204
GO:0005769 Component Early endosome IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608813 28454 ENSG00000136986
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BUN8
Protein name Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1)
Protein function Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins (PubMed:15215856, PubMed:33658201). Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane
PDB 5GLF , 7CZB , 7Y4W , 7Y53 , 7Y59
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04511 DER1 11 204 Der1-like family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}.
Sequence
Sequence length 251
Interactions View interactions