DDO (D-aspartate oxidase)

Gene

• Entrez ID: 8528
• Gene name: D-aspartate oxidase
• Gene symbol: DDO
• Synonyms (NCBI Gene): DASOX, DASPO, DDO-1, DDO-2
• Chromosome: 6
• Chromosome location: 6q21
• Summary: The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT663082	hsa-miR-6750-3p	HITS-CLIP	23824327
MIRT663081	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT663080	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT663079	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT663078	hsa-miR-5701	HITS-CLIP	23824327
MIRT663082	hsa-miR-6750-3p	HITS-CLIP	23824327
MIRT663081	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT663080	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT663079	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT663078	hsa-miR-5701	HITS-CLIP	23824327
MIRT929418	hsa-miR-3199	CLIP-seq
MIRT929419	hsa-miR-4715-3p	CLIP-seq
MIRT2210574	hsa-miR-4698	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003884	Function	D-amino-acid oxidase activity	IEA
GO:0005515	Function	Protein binding	IPI	9820813, 37805834
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005777	Component	Peroxisome	IDA	37805834
GO:0005777	Component	Peroxisome	IDA	1991137, 33650155
GO:0005777	Component	Peroxisome	IEA
GO:0005777	Component	Peroxisome	NAS	9820813
GO:0005782	Component	Peroxisomal matrix	IEA
GO:0005782	Component	Peroxisomal matrix	ISS
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	IDA	37805834
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006531	Process	Aspartate metabolic process	IEA
GO:0006533	Process	L-aspartate catabolic process	IDA	9163533
GO:0007320	Process	Insemination	IEA
GO:0007625	Process	Grooming behavior	IEA
GO:0008445	Function	D-aspartate oxidase activity	IBA
GO:0008445	Function	D-aspartate oxidase activity	IDA	9163533, 20603179, 25747990, 28393897, 28629864, 31914658, 33650155
GO:0008445	Function	D-aspartate oxidase activity	IEA
GO:0010646	Process	Regulation of cell communication	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0019478	Process	D-amino acid catabolic process	IBA
GO:0019478	Process	D-amino acid catabolic process	IDA	20603179, 25747990, 28629864, 33650155
GO:0019478	Process	D-amino acid catabolic process	IEA
GO:0042445	Process	Hormone metabolic process	IEA
GO:0046416	Process	D-amino acid metabolic process	IEA
GO:0047821	Function	D-glutamate oxidase activity	IEA
GO:0050877	Process	Nervous system process	IEA
GO:0050877	Process	Nervous system process	IMP	28560262
GO:0050877	Process	Nervous system process	ISS
GO:0071949	Function	FAD binding	IDA	20603179, 31914658
GO:0071949	Function	FAD binding	IEA
GO:0170035	Process	L-amino acid catabolic process	IEA
GO:0170040	Process	Proteinogenic amino acid catabolic process	IEA

Other IDs

• MIM: 124450
• HGNC: 2727
• e!Ensembl: ENSG00000203797

Protein

• UniProt ID: Q99489
• Protein name: D-aspartate oxidase (DASOX) (DASPO) (DDO) (EC 1.4.3.1)
• Protein function: Selectively catalyzes the oxidative deamination of acidic amino acids (PubMed:1991137, PubMed:20603179, PubMed:23391306, PubMed:25747990, PubMed:28393897, PubMed:28560262, PubMed:28629864, PubMed:29292239, PubMed:31914658, PubMed:32553892, PubMe
• PDB: 6RKF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01266	DAO	5 → 324	FAD dependent oxidoreductase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in epithelial cells of the proximal nephron tubules in the renal cortex (at protein level) (PubMed:12209855, PubMed:1991137). In the brain, expressed in the frontal, temporal, and occipital lobes of the cortex, hippocampus, s
• Sequence:

  MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTP
  IHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMT
  EAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVV
  NCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKG
  DWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPV
  VHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL

• Sequence length: 341