CXCL8 (C-X-C motif chemokine ligand 8)

Gene
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3576
Gene name Gene Name - the full gene name approved by the HGNC.
C-X-C motif chemokine ligand 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CXCL8
Synonyms (NCBI Gene) Gene synonyms aliases
GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, SCYB8
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q13.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, e
miRNA miRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(11)
miRTarBase ID miRNA Experiments Reference
MIRT438087 hsa-miR-93-5p Luciferase reporter assay, qRT-PCR 24433094
MIRT438087 hsa-miR-93-5p Luciferase reporter assay, qRT-PCR 24433094
MIRT731479 hsa-miR-203a-3p qRT-PCR 26304234
MIRT731479 hsa-miR-203a-3p qRT-PCR 26304234
MIRT731479 hsa-miR-203a-3p qRT-PCR 26304234
Transcription factors
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(39)
Transcription factor Regulation Reference
ATF4 Unknown 16931790
CEBPB Activation 15085176;15688424
CEBPB Unknown 11120852
DDIT3 Unknown 18772138
DEK Unknown 16829531
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(47)
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis TAS 11483765
GO:0002237 Process Response to molecule of bacterial origin IDA 19912257
GO:0005153 Function Interleukin-8 receptor binding IPI 1840701
GO:0005515 Function Protein binding IPI 10880251, 22904195, 23597562, 24501198, 26829648, 28381538
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
146930 6025 ENSG00000169429
Protein
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID P10145
Protein name Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Ne
Protein function Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:18692776, PubMed:7636208). Also plays an important role in neutrophil activat
PDB 1ICW , 1IKL , 1IKM , 1IL8 , 1ILP , 1ILQ , 1QE6 , 1ROD , 2IL8 , 3IL8 , 4XDX , 5D14 , 5WDZ , 6LFM , 6LFO , 6N2U , 6WZM , 6XMN , 8IC0 , 8XWN , 8XX6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 32 → 92 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Sequence
Sequence length 99
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide Unknown Diseases (5)
Unknown
Disease term Disease name Evidence References Source
Ischemic Stroke Ischemic Stroke GWAS
Coronary artery disease Coronary artery disease GWAS
Myocardial Infarction Myocardial Infarction GWAS
Kidney Disease Kidney Disease GWAS
Show/Hide Text Mining Associations (986)
Associations from Text Mining
Disease Name Relationship Type References
3 Hydroxyacyl CoA Dehydrogenase Deficiency Stimulate 18653246
Abortion Habitual Associate 22505054
Abortion Spontaneous Associate 35090453
Abscess Stimulate 34539639
Abscess Associate 8178948
Acanthamoeba Keratitis Associate 33755043
Achlorhydria Associate 26045613
Achondrogenesis type 2 Associate 31277141
Acne Vulgaris Associate 16528362, 26547713, 31281837, 31662521
Acquired Immunodeficiency Syndrome Associate 10775602, 17360650, 20507572, 22664113