CXCL3 (C-X-C motif chemokine ligand 3)

Gene

• Entrez ID: 2921
• Gene name: C-X-C motif chemokine ligand 3
• Gene symbol: CXCL3
• Synonyms (NCBI Gene): CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3
• Chromosome: 4
• Chromosome location: 4q13.3
• Summary: This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattra

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005823	hsa-miR-204-5p	Microarray	21282569
MIRT018278	hsa-miR-335-5p	Microarray	18185580
MIRT023824	hsa-miR-1-3p	Microarray	18668037
MIRT711194	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT711193	hsa-miR-3161	HITS-CLIP	19536157
MIRT711194	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT711193	hsa-miR-3161	HITS-CLIP	19536157
MIRT711194	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT711193	hsa-miR-3161	HITS-CLIP	19536157
MIRT711194	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT711193	hsa-miR-3161	HITS-CLIP	19536157
MIRT711194	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT711193	hsa-miR-3161	HITS-CLIP	19536157
MIRT711194	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT711193	hsa-miR-3161	HITS-CLIP	19536157
MIRT711194	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT711193	hsa-miR-3161	HITS-CLIP	19536157
MIRT711194	hsa-miR-100-3p	HITS-CLIP	19536157
MIRT711193	hsa-miR-3161	HITS-CLIP	19536157
MIRT2511332	hsa-miR-1245	CLIP-seq
MIRT2511333	hsa-miR-1273d	CLIP-seq
MIRT2511334	hsa-miR-1279	CLIP-seq
MIRT2511335	hsa-miR-132	CLIP-seq
MIRT2511336	hsa-miR-145	CLIP-seq
MIRT2511337	hsa-miR-150	CLIP-seq
MIRT2511338	hsa-miR-181a	CLIP-seq
MIRT2511339	hsa-miR-181b	CLIP-seq
MIRT2511340	hsa-miR-181c	CLIP-seq
MIRT2511341	hsa-miR-181d	CLIP-seq
MIRT2511342	hsa-miR-204	CLIP-seq
MIRT2511343	hsa-miR-211	CLIP-seq
MIRT2511344	hsa-miR-212	CLIP-seq
MIRT2511345	hsa-miR-2355-5p	CLIP-seq
MIRT2511346	hsa-miR-300	CLIP-seq
MIRT2511347	hsa-miR-3121-3p	CLIP-seq
MIRT2511348	hsa-miR-3156-3p	CLIP-seq
MIRT2511349	hsa-miR-3163	CLIP-seq
MIRT2511350	hsa-miR-3169	CLIP-seq
MIRT2511351	hsa-miR-3177-5p	CLIP-seq
MIRT2511352	hsa-miR-3613-3p	CLIP-seq
MIRT2511353	hsa-miR-381	CLIP-seq
MIRT2511354	hsa-miR-3925-3p	CLIP-seq
MIRT2511355	hsa-miR-3938	CLIP-seq
MIRT2511356	hsa-miR-425	CLIP-seq
MIRT2511357	hsa-miR-4262	CLIP-seq
MIRT2511358	hsa-miR-4286	CLIP-seq
MIRT2511359	hsa-miR-4301	CLIP-seq
MIRT2511360	hsa-miR-4307	CLIP-seq
MIRT2511361	hsa-miR-4436a	CLIP-seq
MIRT2511362	hsa-miR-4495	CLIP-seq
MIRT2511363	hsa-miR-4655-3p	CLIP-seq
MIRT2511364	hsa-miR-4713-5p	CLIP-seq
MIRT2511365	hsa-miR-4740-5p	CLIP-seq
MIRT2511366	hsa-miR-4755-5p	CLIP-seq
MIRT2511367	hsa-miR-494	CLIP-seq
MIRT2511368	hsa-miR-532-3p	CLIP-seq
MIRT2511369	hsa-miR-548aa	CLIP-seq
MIRT2511370	hsa-miR-548l	CLIP-seq
MIRT2511371	hsa-miR-548n	CLIP-seq
MIRT2511372	hsa-miR-562	CLIP-seq
MIRT2511373	hsa-miR-576-3p	CLIP-seq
MIRT2511374	hsa-miR-584	CLIP-seq
MIRT2511375	hsa-miR-603	CLIP-seq
MIRT2511376	hsa-miR-607	CLIP-seq
MIRT2511377	hsa-miR-610	CLIP-seq
MIRT2511378	hsa-miR-623	CLIP-seq
MIRT2511379	hsa-miR-640	CLIP-seq
MIRT2511380	hsa-miR-642b	CLIP-seq
MIRT2511332	hsa-miR-1245	CLIP-seq
MIRT2511333	hsa-miR-1273d	CLIP-seq
MIRT2678860	hsa-miR-1273e	CLIP-seq
MIRT2511334	hsa-miR-1279	CLIP-seq
MIRT2511335	hsa-miR-132	CLIP-seq
MIRT2511337	hsa-miR-150	CLIP-seq
MIRT2511338	hsa-miR-181a	CLIP-seq
MIRT2511339	hsa-miR-181b	CLIP-seq
MIRT2511340	hsa-miR-181c	CLIP-seq
MIRT2511341	hsa-miR-181d	CLIP-seq
MIRT2511342	hsa-miR-204	CLIP-seq
MIRT2511343	hsa-miR-211	CLIP-seq
MIRT2511344	hsa-miR-212	CLIP-seq
MIRT2511346	hsa-miR-300	CLIP-seq
MIRT2678861	hsa-miR-302f	CLIP-seq
MIRT2511347	hsa-miR-3121-3p	CLIP-seq
MIRT2511348	hsa-miR-3156-3p	CLIP-seq
MIRT2511349	hsa-miR-3163	CLIP-seq
MIRT2511350	hsa-miR-3169	CLIP-seq
MIRT2511351	hsa-miR-3177-5p	CLIP-seq
MIRT2678862	hsa-miR-33a	CLIP-seq
MIRT2678863	hsa-miR-33b	CLIP-seq
MIRT2511353	hsa-miR-381	CLIP-seq
MIRT2511355	hsa-miR-3938	CLIP-seq
MIRT2511356	hsa-miR-425	CLIP-seq
MIRT2511357	hsa-miR-4262	CLIP-seq
MIRT2511359	hsa-miR-4301	CLIP-seq
MIRT2511360	hsa-miR-4307	CLIP-seq
MIRT2678864	hsa-miR-4327	CLIP-seq
MIRT2511361	hsa-miR-4436a	CLIP-seq
MIRT2511362	hsa-miR-4495	CLIP-seq
MIRT2511364	hsa-miR-4713-5p	CLIP-seq
MIRT2511365	hsa-miR-4740-5p	CLIP-seq
MIRT2511366	hsa-miR-4755-5p	CLIP-seq
MIRT2511367	hsa-miR-494	CLIP-seq
MIRT2511368	hsa-miR-532-3p	CLIP-seq
MIRT2511369	hsa-miR-548aa	CLIP-seq
MIRT2511370	hsa-miR-548l	CLIP-seq
MIRT2511371	hsa-miR-548n	CLIP-seq
MIRT2511373	hsa-miR-576-3p	CLIP-seq
MIRT2511374	hsa-miR-584	CLIP-seq
MIRT2511375	hsa-miR-603	CLIP-seq
MIRT2511377	hsa-miR-610	CLIP-seq
MIRT2511378	hsa-miR-623	CLIP-seq
MIRT2511379	hsa-miR-640	CLIP-seq
MIRT2511380	hsa-miR-642b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IDA	10095777
GO:0005615	Component	Extracellular space	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0006952	Process	Defense response	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0006955	Process	Immune response	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008009	Function	Chemokine activity	IEA
GO:0008009	Function	Chemokine activity	ISS
GO:0030593	Process	Neutrophil chemotaxis	ISS
GO:0031640	Process	Killing of cells of another organism	IDA	12949249
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	12949249

Other IDs

• MIM: 139111
• HGNC: 4604
• e!Ensembl: ENSG00000163734

Protein

• UniProt ID: P19876
• Protein name: C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)]
• Protein function: Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher
• PDB: 8XWF, 8XX3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00048	IL8	41 → 100	Small cytokines (intecrine/chemokine), interleukin-8 like	Domain

• Sequence:

  MAHATLSAAPSNPRLLRVALLLLLLVAASRRAAGASVVTELRCQCLQTLQGIHLKNIQSV
  NVRSPGPHCAQTEVIATLKNGKKACLNPASPMVQKIIEKILNKGSTN

• Sequence length: 107