Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Transcription factors Other IDs
Entrez ID	2920
Gene name	C-X-C motif chemokine ligand 2
Gene symbol	CXCL2
Synonyms (NCBI Gene)	CINC-2aGRO2GRObMGSA-bMIP-2aMIP2MIP2ASCYB2
Chromosome	4
Chromosome location	4q13.3
Summary	This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residue

167

Show/Hide all (167)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018317	hsa-miR-335-5p	Microarray	18185580
MIRT023893	hsa-miR-1-3p	Microarray	18668037
MIRT027726	hsa-miR-98-5p	Microarray	19088304
MIRT438285	hsa-miR-223-3p	Luciferase reporter assay	24084739
MIRT438285	hsa-miR-223-3p	Luciferase reporter assay	24084739
MIRT733913	hsa-miR-532-5p	Luciferase reporter assay	26807173
MIRT733913	hsa-miR-532-5p	Luciferase reporter assayqRT-PCR	34093945
MIRT733913	hsa-miR-532-5p	Luciferase reporter assayWestern blottingMicroarrayqRT-PCR	32308429
MIRT756209	hsa-miR-4512	Luciferase reporter assayWestern blottingqRT-PCR	34721432
MIRT756291	hsa-miR-27a-3p	Luciferase reporter assayWestern blottingqRT-PCR	37854860
MIRT918048	hsa-miR-4279	CLIP-seq
MIRT1972118	hsa-miR-1184	CLIP-seq
MIRT1972119	hsa-miR-1205	CLIP-seq
MIRT1972120	hsa-miR-1301	CLIP-seq
MIRT1972121	hsa-miR-3158-5p	CLIP-seq
MIRT1972122	hsa-miR-4660	CLIP-seq
MIRT1972123	hsa-miR-4757-5p	CLIP-seq
MIRT1972124	hsa-miR-5047	CLIP-seq
MIRT2511255	hsa-miR-128	CLIP-seq
MIRT2511256	hsa-miR-141	CLIP-seq
MIRT2511257	hsa-miR-181a	CLIP-seq
MIRT2511258	hsa-miR-181b	CLIP-seq
MIRT2511259	hsa-miR-181c	CLIP-seq
MIRT2511260	hsa-miR-181d	CLIP-seq
MIRT2511261	hsa-miR-190	CLIP-seq
MIRT2511262	hsa-miR-190b	CLIP-seq
MIRT2511263	hsa-miR-192	CLIP-seq
MIRT2511264	hsa-miR-193a-3p	CLIP-seq
MIRT2511265	hsa-miR-193b	CLIP-seq
MIRT2511266	hsa-miR-200a	CLIP-seq
MIRT2511267	hsa-miR-2116	CLIP-seq
MIRT2511268	hsa-miR-215	CLIP-seq
MIRT2511269	hsa-miR-217	CLIP-seq
MIRT2511270	hsa-miR-2276	CLIP-seq
MIRT2511271	hsa-miR-23a	CLIP-seq
MIRT2511272	hsa-miR-23b	CLIP-seq
MIRT2511273	hsa-miR-23c	CLIP-seq
MIRT2511274	hsa-miR-2682	CLIP-seq
MIRT2511275	hsa-miR-27a	CLIP-seq
MIRT2511276	hsa-miR-27b	CLIP-seq
MIRT2511277	hsa-miR-3121-3p	CLIP-seq
MIRT2511278	hsa-miR-3123	CLIP-seq
MIRT2511279	hsa-miR-3143	CLIP-seq
MIRT2511280	hsa-miR-3145-3p	CLIP-seq
MIRT2511281	hsa-miR-3163	CLIP-seq
MIRT2511282	hsa-miR-3168	CLIP-seq
MIRT2511283	hsa-miR-3187-3p	CLIP-seq
MIRT2511284	hsa-miR-320a	CLIP-seq
MIRT2511285	hsa-miR-320b	CLIP-seq
MIRT2511286	hsa-miR-320c	CLIP-seq
MIRT2511287	hsa-miR-320d	CLIP-seq
MIRT2511288	hsa-miR-3545-3p	CLIP-seq
MIRT2511289	hsa-miR-3607-5p	CLIP-seq
MIRT2511290	hsa-miR-3617	CLIP-seq
MIRT2511291	hsa-miR-3662	CLIP-seq
MIRT2511292	hsa-miR-3671	CLIP-seq
MIRT2511293	hsa-miR-3689a-5p	CLIP-seq
MIRT2511294	hsa-miR-3689b	CLIP-seq
MIRT2511295	hsa-miR-3689e	CLIP-seq
MIRT2511296	hsa-miR-3689f	CLIP-seq
MIRT2511297	hsa-miR-3714	CLIP-seq
MIRT2511298	hsa-miR-3925-5p	CLIP-seq
MIRT2511299	hsa-miR-3940-5p	CLIP-seq
MIRT2511300	hsa-miR-409-3p	CLIP-seq
MIRT2511301	hsa-miR-421	CLIP-seq
MIRT2511302	hsa-miR-4261	CLIP-seq
MIRT2511303	hsa-miR-4262	CLIP-seq
MIRT2511304	hsa-miR-432	CLIP-seq
MIRT2511305	hsa-miR-4320	CLIP-seq
MIRT2511306	hsa-miR-4429	CLIP-seq
MIRT2511307	hsa-miR-4446-5p	CLIP-seq
MIRT2511308	hsa-miR-449c	CLIP-seq
MIRT2511309	hsa-miR-4507	CLIP-seq
MIRT2511310	hsa-miR-4517	CLIP-seq
MIRT2511311	hsa-miR-4529-5p	CLIP-seq
MIRT2511312	hsa-miR-4633-5p	CLIP-seq
MIRT2511313	hsa-miR-4637	CLIP-seq
MIRT2511314	hsa-miR-4686	CLIP-seq
MIRT2511315	hsa-miR-4695-3p	CLIP-seq
MIRT2511316	hsa-miR-4755-5p	CLIP-seq
MIRT2511317	hsa-miR-4772-3p	CLIP-seq
MIRT2511318	hsa-miR-4773	CLIP-seq
MIRT2511319	hsa-miR-4789-3p	CLIP-seq
MIRT2511320	hsa-miR-495	CLIP-seq
MIRT2511321	hsa-miR-520d-5p	CLIP-seq
MIRT2511322	hsa-miR-524-5p	CLIP-seq
MIRT2511323	hsa-miR-539	CLIP-seq
MIRT2511324	hsa-miR-543	CLIP-seq
MIRT2511325	hsa-miR-578	CLIP-seq
MIRT2511326	hsa-miR-582-5p	CLIP-seq
MIRT2511327	hsa-miR-607	CLIP-seq
MIRT2511328	hsa-miR-629	CLIP-seq
MIRT2511329	hsa-miR-641	CLIP-seq
MIRT2511330	hsa-miR-670	CLIP-seq
MIRT2511331	hsa-miR-935	CLIP-seq
MIRT2511256	hsa-miR-141	CLIP-seq
MIRT2511257	hsa-miR-181a	CLIP-seq
MIRT2511258	hsa-miR-181b	CLIP-seq
MIRT2511259	hsa-miR-181c	CLIP-seq
MIRT2511260	hsa-miR-181d	CLIP-seq
MIRT2511261	hsa-miR-190	CLIP-seq
MIRT2511262	hsa-miR-190b	CLIP-seq
MIRT2511263	hsa-miR-192	CLIP-seq
MIRT2511264	hsa-miR-193a-3p	CLIP-seq
MIRT2511265	hsa-miR-193b	CLIP-seq
MIRT2511266	hsa-miR-200a	CLIP-seq
MIRT2511267	hsa-miR-2116	CLIP-seq
MIRT2511268	hsa-miR-215	CLIP-seq
MIRT2511269	hsa-miR-217	CLIP-seq
MIRT2511270	hsa-miR-2276	CLIP-seq
MIRT2511271	hsa-miR-23a	CLIP-seq
MIRT2511272	hsa-miR-23b	CLIP-seq
MIRT2511273	hsa-miR-23c	CLIP-seq
MIRT2511274	hsa-miR-2682	CLIP-seq
MIRT2511277	hsa-miR-3121-3p	CLIP-seq
MIRT2511278	hsa-miR-3123	CLIP-seq
MIRT2511279	hsa-miR-3143	CLIP-seq
MIRT2511280	hsa-miR-3145-3p	CLIP-seq
MIRT2511281	hsa-miR-3163	CLIP-seq
MIRT2511282	hsa-miR-3168	CLIP-seq
MIRT2511283	hsa-miR-3187-3p	CLIP-seq
MIRT2511284	hsa-miR-320a	CLIP-seq
MIRT2511285	hsa-miR-320b	CLIP-seq
MIRT2511286	hsa-miR-320c	CLIP-seq
MIRT2511287	hsa-miR-320d	CLIP-seq
MIRT2511288	hsa-miR-3545-3p	CLIP-seq
MIRT2511289	hsa-miR-3607-5p	CLIP-seq
MIRT2511290	hsa-miR-3617	CLIP-seq
MIRT2511291	hsa-miR-3662	CLIP-seq
MIRT2511292	hsa-miR-3671	CLIP-seq
MIRT2511293	hsa-miR-3689a-5p	CLIP-seq
MIRT2511294	hsa-miR-3689b	CLIP-seq
MIRT2511295	hsa-miR-3689e	CLIP-seq
MIRT2511296	hsa-miR-3689f	CLIP-seq
MIRT2511297	hsa-miR-3714	CLIP-seq
MIRT2511298	hsa-miR-3925-5p	CLIP-seq
MIRT2511299	hsa-miR-3940-5p	CLIP-seq
MIRT2511301	hsa-miR-421	CLIP-seq
MIRT2511302	hsa-miR-4261	CLIP-seq
MIRT2511303	hsa-miR-4262	CLIP-seq
MIRT2511304	hsa-miR-432	CLIP-seq
MIRT2511305	hsa-miR-4320	CLIP-seq
MIRT2511306	hsa-miR-4429	CLIP-seq
MIRT2511307	hsa-miR-4446-5p	CLIP-seq
MIRT2511308	hsa-miR-449c	CLIP-seq
MIRT2511309	hsa-miR-4507	CLIP-seq
MIRT2511310	hsa-miR-4517	CLIP-seq
MIRT2511311	hsa-miR-4529-5p	CLIP-seq
MIRT2511312	hsa-miR-4633-5p	CLIP-seq
MIRT2511313	hsa-miR-4637	CLIP-seq
MIRT2511314	hsa-miR-4686	CLIP-seq
MIRT2511315	hsa-miR-4695-3p	CLIP-seq
MIRT2511316	hsa-miR-4755-5p	CLIP-seq
MIRT2511317	hsa-miR-4772-3p	CLIP-seq
MIRT2511318	hsa-miR-4773	CLIP-seq
MIRT2511319	hsa-miR-4789-3p	CLIP-seq
MIRT2511320	hsa-miR-495	CLIP-seq
MIRT2511321	hsa-miR-520d-5p	CLIP-seq
MIRT2511322	hsa-miR-524-5p	CLIP-seq
MIRT2511324	hsa-miR-543	CLIP-seq
MIRT2511325	hsa-miR-578	CLIP-seq
MIRT2511326	hsa-miR-582-5p	CLIP-seq
MIRT2511327	hsa-miR-607	CLIP-seq
MIRT2511328	hsa-miR-629	CLIP-seq
MIRT2511329	hsa-miR-641	CLIP-seq
MIRT2511330	hsa-miR-670	CLIP-seq
MIRT2511331	hsa-miR-935	CLIP-seq

Show/Hide all (3)

Transcription factor	Regulation	Reference
NFKB1	Unknown	17363596
RELA	Unknown	17363596
SMAD1	Unknown	17363596

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002237	Process	Response to molecule of bacterial origin	IDA	19912257
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	18275857, 21314817, 28381538
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	TAS	9873037
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	TAS	2643119
GO:0006952	Process	Defense response	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	TAS	2643119
GO:0006955	Process	Immune response	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008009	Function	Chemokine activity	IEA
GO:0008009	Function	Chemokine activity	TAS	9873037
GO:0031640	Process	Killing of cells of another organism	IDA	12949249
GO:0060326	Process	Cell chemotaxis	IEA
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	12949249

MIM	HGNC	e!Ensembl
139110	4603	ENSG00000081041

P19875

Protein name

C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]

Protein function

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic act

PDB

1QNK , 5OB5 , 8XVU , 8XXH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00048	IL8	41 → 100	Small cytokines (intecrine/chemokine), interleukin-8 like	Domain

Sequence

MARATLSAAPSNPRLLRVALLLLLLVAASRRAAGAPLATELRCQCLQTLQGIHLKNIQSV
KVKSPGPHCAQTEVIATLKNGQKACLNPASPMVKKIIEKMLKNGKSN

Sequence length

107

Interactions

View interactions

CXCL2 (C-X-C motif chemokine ligand 2)