Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Transcription factors Other IDs
Entrez ID	2919
Gene name	C-X-C motif chemokine ligand 1
Gene symbol	CXCL1
Synonyms (NCBI Gene)	FSPGRO1GROaMGSAMGSA-aNAP-3SCYB1
Chromosome	4
Chromosome location	4q13.3
Summary	This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattra

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023084	hsa-miR-124-3p	Microarray	18668037
MIRT023999	hsa-miR-1-3p	Microarray	18668037
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT734007	hsa-miR-302e	Luciferase reporter assayqRT-PCRWestern blotting	34079750
MIRT613684	hsa-miR-27b-5p	Luciferase reporter assayqRT-PCR	32782028
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT613684	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT756129	hsa-miR-34c-5p	Luciferase reporter assayMicroarrayqRT-PCRImmunofluorescenceELISA	36829591
MIRT756130	hsa-miR-34b-5p	Luciferase reporter assayMicroarrayqRT-PCRImmunofluorescenceELISA	36829591
MIRT917939	hsa-miR-371-5p	CLIP-seq
MIRT1972088	hsa-miR-1184	CLIP-seq
MIRT1972089	hsa-miR-1205	CLIP-seq
MIRT1972090	hsa-miR-1301	CLIP-seq
MIRT1972091	hsa-miR-3158-5p	CLIP-seq
MIRT1972092	hsa-miR-3545-3p	CLIP-seq
MIRT1972093	hsa-miR-4517	CLIP-seq
MIRT1972094	hsa-miR-4660	CLIP-seq
MIRT1972095	hsa-miR-4757-5p	CLIP-seq
MIRT1972096	hsa-miR-5047	CLIP-seq
MIRT2207914	hsa-miR-181a	CLIP-seq
MIRT2207915	hsa-miR-181b	CLIP-seq
MIRT2207916	hsa-miR-181c	CLIP-seq
MIRT2207917	hsa-miR-181d	CLIP-seq
MIRT2207918	hsa-miR-4262	CLIP-seq
MIRT2436544	hsa-miR-1237	CLIP-seq
MIRT2436545	hsa-miR-3155	CLIP-seq
MIRT2436546	hsa-miR-3155b	CLIP-seq
MIRT2436547	hsa-miR-3622b-5p	CLIP-seq
MIRT2436548	hsa-miR-4268	CLIP-seq
MIRT2436549	hsa-miR-4287	CLIP-seq
MIRT2436550	hsa-miR-4684-3p	CLIP-seq
MIRT2436551	hsa-miR-4685-3p	CLIP-seq
MIRT2436552	hsa-miR-4691-5p	CLIP-seq
MIRT2436553	hsa-miR-484	CLIP-seq
MIRT2436554	hsa-miR-516a-3p	CLIP-seq
MIRT1972088	hsa-miR-1184	CLIP-seq
MIRT2511174	hsa-miR-1197	CLIP-seq
MIRT1972089	hsa-miR-1205	CLIP-seq
MIRT2511175	hsa-miR-1273e	CLIP-seq
MIRT2511176	hsa-miR-128	CLIP-seq
MIRT1972090	hsa-miR-1301	CLIP-seq
MIRT2511177	hsa-miR-1305	CLIP-seq
MIRT2511178	hsa-miR-141	CLIP-seq
MIRT2207914	hsa-miR-181a	CLIP-seq
MIRT2207915	hsa-miR-181b	CLIP-seq
MIRT2207916	hsa-miR-181c	CLIP-seq
MIRT2207917	hsa-miR-181d	CLIP-seq
MIRT2511179	hsa-miR-186	CLIP-seq
MIRT2511180	hsa-miR-200a	CLIP-seq
MIRT2511181	hsa-miR-2116	CLIP-seq
MIRT2511182	hsa-miR-2682	CLIP-seq
MIRT2511183	hsa-miR-27a	CLIP-seq
MIRT2511184	hsa-miR-27b	CLIP-seq
MIRT2511185	hsa-miR-3143	CLIP-seq
MIRT2511186	hsa-miR-3145-3p	CLIP-seq
MIRT2436545	hsa-miR-3155	CLIP-seq
MIRT2436546	hsa-miR-3155b	CLIP-seq
MIRT1972091	hsa-miR-3158-5p	CLIP-seq
MIRT2511187	hsa-miR-3163	CLIP-seq
MIRT2511188	hsa-miR-3168	CLIP-seq
MIRT2511189	hsa-miR-3170	CLIP-seq
MIRT2511190	hsa-miR-3187-3p	CLIP-seq
MIRT2511191	hsa-miR-3194-5p	CLIP-seq
MIRT2511192	hsa-miR-331-3p	CLIP-seq
MIRT1972092	hsa-miR-3545-3p	CLIP-seq
MIRT2511193	hsa-miR-3607-3p	CLIP-seq
MIRT2511194	hsa-miR-3613-3p	CLIP-seq
MIRT2511195	hsa-miR-3617	CLIP-seq
MIRT2511196	hsa-miR-3622a-5p	CLIP-seq
MIRT2436547	hsa-miR-3622b-5p	CLIP-seq
MIRT2511197	hsa-miR-3652	CLIP-seq
MIRT2511198	hsa-miR-3662	CLIP-seq
MIRT2511199	hsa-miR-3665	CLIP-seq
MIRT2511200	hsa-miR-3671	CLIP-seq
MIRT2511201	hsa-miR-369-3p	CLIP-seq
MIRT2511202	hsa-miR-3714	CLIP-seq
MIRT2511203	hsa-miR-374a	CLIP-seq
MIRT2511204	hsa-miR-374b	CLIP-seq
MIRT2511205	hsa-miR-3927	CLIP-seq
MIRT2511206	hsa-miR-3944-5p	CLIP-seq
MIRT2511207	hsa-miR-409-3p	CLIP-seq
MIRT2511208	hsa-miR-421	CLIP-seq
MIRT2207918	hsa-miR-4262	CLIP-seq
MIRT2436548	hsa-miR-4268	CLIP-seq
MIRT2436549	hsa-miR-4287	CLIP-seq
MIRT2511209	hsa-miR-4297	CLIP-seq
MIRT2511210	hsa-miR-4302	CLIP-seq
MIRT2511211	hsa-miR-4423-3p	CLIP-seq
MIRT2511212	hsa-miR-4424	CLIP-seq
MIRT2511213	hsa-miR-4430	CLIP-seq
MIRT2511214	hsa-miR-4434	CLIP-seq
MIRT2511215	hsa-miR-4435	CLIP-seq
MIRT2511216	hsa-miR-4451	CLIP-seq
MIRT2511217	hsa-miR-449c	CLIP-seq
MIRT2511218	hsa-miR-4505	CLIP-seq
MIRT2511219	hsa-miR-4516	CLIP-seq
MIRT1972093	hsa-miR-4517	CLIP-seq
MIRT2511220	hsa-miR-4529-5p	CLIP-seq
MIRT2511221	hsa-miR-4531	CLIP-seq
MIRT2511222	hsa-miR-4633-5p	CLIP-seq
MIRT2511223	hsa-miR-4637	CLIP-seq
MIRT1972094	hsa-miR-4660	CLIP-seq
MIRT2436550	hsa-miR-4684-3p	CLIP-seq
MIRT2436551	hsa-miR-4685-3p	CLIP-seq
MIRT2436552	hsa-miR-4691-5p	CLIP-seq
MIRT2511224	hsa-miR-4695-3p	CLIP-seq
MIRT2511225	hsa-miR-4701-5p	CLIP-seq
MIRT2511226	hsa-miR-4720-5p	CLIP-seq
MIRT2511227	hsa-miR-4724-3p	CLIP-seq
MIRT1972095	hsa-miR-4757-5p	CLIP-seq
MIRT2511228	hsa-miR-4773	CLIP-seq
MIRT2511229	hsa-miR-4799-3p	CLIP-seq
MIRT2511230	hsa-miR-4803	CLIP-seq
MIRT2436553	hsa-miR-484	CLIP-seq
MIRT2511231	hsa-miR-487a	CLIP-seq
MIRT2511232	hsa-miR-489	CLIP-seq
MIRT1972096	hsa-miR-5047	CLIP-seq
MIRT2511233	hsa-miR-513b	CLIP-seq
MIRT2436554	hsa-miR-516a-3p	CLIP-seq
MIRT2511234	hsa-miR-520d-5p	CLIP-seq
MIRT2511235	hsa-miR-524-5p	CLIP-seq
MIRT2511236	hsa-miR-532-5p	CLIP-seq
MIRT2511237	hsa-miR-539	CLIP-seq
MIRT2511238	hsa-miR-543	CLIP-seq
MIRT2511239	hsa-miR-548a-3p	CLIP-seq
MIRT2511240	hsa-miR-548e	CLIP-seq
MIRT2511241	hsa-miR-548f	CLIP-seq
MIRT2511242	hsa-miR-548s	CLIP-seq
MIRT2511243	hsa-miR-561	CLIP-seq
MIRT2511244	hsa-miR-563	CLIP-seq
MIRT2511245	hsa-miR-570	CLIP-seq
MIRT2511246	hsa-miR-576-3p	CLIP-seq
MIRT2511247	hsa-miR-588	CLIP-seq
MIRT2511248	hsa-miR-607	CLIP-seq
MIRT2511249	hsa-miR-641	CLIP-seq
MIRT2511250	hsa-miR-648	CLIP-seq
MIRT2511251	hsa-miR-657	CLIP-seq
MIRT2511252	hsa-miR-935	CLIP-seq
MIRT2511253	hsa-miR-944	CLIP-seq
MIRT1972088	hsa-miR-1184	CLIP-seq
MIRT2511174	hsa-miR-1197	CLIP-seq
MIRT1972089	hsa-miR-1205	CLIP-seq
MIRT2436544	hsa-miR-1237	CLIP-seq
MIRT2678849	hsa-miR-1238	CLIP-seq
MIRT2511175	hsa-miR-1273e	CLIP-seq
MIRT2511176	hsa-miR-128	CLIP-seq
MIRT1972090	hsa-miR-1301	CLIP-seq
MIRT2511177	hsa-miR-1305	CLIP-seq
MIRT2207914	hsa-miR-181a	CLIP-seq
MIRT2207915	hsa-miR-181b	CLIP-seq
MIRT2207916	hsa-miR-181c	CLIP-seq
MIRT2207917	hsa-miR-181d	CLIP-seq
MIRT2511179	hsa-miR-186	CLIP-seq
MIRT2678850	hsa-miR-205	CLIP-seq
MIRT2511181	hsa-miR-2116	CLIP-seq
MIRT2511183	hsa-miR-27a	CLIP-seq
MIRT2511184	hsa-miR-27b	CLIP-seq
MIRT2678851	hsa-miR-3124-3p	CLIP-seq
MIRT2511185	hsa-miR-3143	CLIP-seq
MIRT2511186	hsa-miR-3145-3p	CLIP-seq
MIRT2436545	hsa-miR-3155	CLIP-seq
MIRT2436546	hsa-miR-3155b	CLIP-seq
MIRT1972091	hsa-miR-3158-5p	CLIP-seq
MIRT2511187	hsa-miR-3163	CLIP-seq
MIRT2511188	hsa-miR-3168	CLIP-seq
MIRT2511189	hsa-miR-3170	CLIP-seq
MIRT2511190	hsa-miR-3187-3p	CLIP-seq
MIRT2511191	hsa-miR-3194-5p	CLIP-seq
MIRT2511192	hsa-miR-331-3p	CLIP-seq
MIRT1972092	hsa-miR-3545-3p	CLIP-seq
MIRT2511194	hsa-miR-3613-3p	CLIP-seq
MIRT2436547	hsa-miR-3622b-5p	CLIP-seq
MIRT2511197	hsa-miR-3652	CLIP-seq
MIRT2511198	hsa-miR-3662	CLIP-seq
MIRT2511199	hsa-miR-3665	CLIP-seq
MIRT2511200	hsa-miR-3671	CLIP-seq
MIRT2511201	hsa-miR-369-3p	CLIP-seq
MIRT2511203	hsa-miR-374a	CLIP-seq
MIRT2511204	hsa-miR-374b	CLIP-seq
MIRT2678852	hsa-miR-3918	CLIP-seq
MIRT2511205	hsa-miR-3927	CLIP-seq
MIRT2511206	hsa-miR-3944-5p	CLIP-seq
MIRT2511207	hsa-miR-409-3p	CLIP-seq
MIRT2511208	hsa-miR-421	CLIP-seq
MIRT2207918	hsa-miR-4262	CLIP-seq
MIRT2436548	hsa-miR-4268	CLIP-seq
MIRT2436549	hsa-miR-4287	CLIP-seq
MIRT2511209	hsa-miR-4297	CLIP-seq
MIRT2511210	hsa-miR-4302	CLIP-seq
MIRT2511212	hsa-miR-4424	CLIP-seq
MIRT2511213	hsa-miR-4430	CLIP-seq
MIRT2511214	hsa-miR-4434	CLIP-seq
MIRT2511215	hsa-miR-4435	CLIP-seq
MIRT2511216	hsa-miR-4451	CLIP-seq
MIRT2511218	hsa-miR-4505	CLIP-seq
MIRT2678853	hsa-miR-4512	CLIP-seq
MIRT2511219	hsa-miR-4516	CLIP-seq
MIRT1972093	hsa-miR-4517	CLIP-seq
MIRT2511220	hsa-miR-4529-5p	CLIP-seq
MIRT2511221	hsa-miR-4531	CLIP-seq
MIRT2511223	hsa-miR-4637	CLIP-seq
MIRT1972094	hsa-miR-4660	CLIP-seq
MIRT2436550	hsa-miR-4684-3p	CLIP-seq
MIRT2436551	hsa-miR-4685-3p	CLIP-seq
MIRT2678854	hsa-miR-4691-3p	CLIP-seq
MIRT2436552	hsa-miR-4691-5p	CLIP-seq
MIRT2511224	hsa-miR-4695-3p	CLIP-seq
MIRT2511225	hsa-miR-4701-5p	CLIP-seq
MIRT2678855	hsa-miR-4711-3p	CLIP-seq
MIRT2511226	hsa-miR-4720-5p	CLIP-seq
MIRT2511227	hsa-miR-4724-3p	CLIP-seq
MIRT2678856	hsa-miR-4753-3p	CLIP-seq
MIRT1972095	hsa-miR-4757-5p	CLIP-seq
MIRT2511228	hsa-miR-4773	CLIP-seq
MIRT2511229	hsa-miR-4799-3p	CLIP-seq
MIRT2511230	hsa-miR-4803	CLIP-seq
MIRT2436553	hsa-miR-484	CLIP-seq
MIRT2511231	hsa-miR-487a	CLIP-seq
MIRT2511232	hsa-miR-489	CLIP-seq
MIRT1972096	hsa-miR-5047	CLIP-seq
MIRT2511233	hsa-miR-513b	CLIP-seq
MIRT2436554	hsa-miR-516a-3p	CLIP-seq
MIRT2511234	hsa-miR-520d-5p	CLIP-seq
MIRT2511235	hsa-miR-524-5p	CLIP-seq
MIRT2511237	hsa-miR-539	CLIP-seq
MIRT2511238	hsa-miR-543	CLIP-seq
MIRT2511242	hsa-miR-548s	CLIP-seq
MIRT2511243	hsa-miR-561	CLIP-seq
MIRT2511244	hsa-miR-563	CLIP-seq
MIRT2511245	hsa-miR-570	CLIP-seq
MIRT2511246	hsa-miR-576-3p	CLIP-seq
MIRT2511247	hsa-miR-588	CLIP-seq
MIRT2678857	hsa-miR-593	CLIP-seq
MIRT2678858	hsa-miR-603	CLIP-seq
MIRT2511248	hsa-miR-607	CLIP-seq
MIRT2511250	hsa-miR-648	CLIP-seq
MIRT2511251	hsa-miR-657	CLIP-seq
MIRT2678859	hsa-miR-873	CLIP-seq
MIRT2511252	hsa-miR-935	CLIP-seq

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Transcription factor	Regulation	Reference
BRCA1	Repression	22120723
CEBPD	Activation	23028973
GATA3	Repression	22120723
HMGA1	Unknown	11112786;7479086
NFKB1	Activation	10530453;15958549
NFKB1	Unknown	11112786;16040075;7479086
PARP1	Unknown	11112786
RELA	Activation	10530453;15958549
RELA	Unknown	11112786;16040075
SP1	Unknown	11112786;7479086

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	TAS	9079638, 10820279
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	TAS	10881932
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	TAS	10820279
GO:0006952	Process	Defense response	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	TAS	9725262
GO:0006955	Process	Immune response	IEA
GO:0007165	Process	Signal transduction	TAS	9725262, 10820279
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	10820279
GO:0007399	Process	Nervous system development	TAS	9058825
GO:0008009	Function	Chemokine activity	IEA
GO:0008009	Function	Chemokine activity	TAS	10820279
GO:0008047	Function	Enzyme activator activity	TAS	9079638
GO:0008083	Function	Growth factor activity	IEA
GO:0008083	Function	Growth factor activity	TAS	8380167
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	9551928
GO:0030036	Process	Actin cytoskeleton organization	TAS	9725262
GO:0031640	Process	Killing of cells of another organism	IDA	12949249
GO:0035556	Process	Intracellular signal transduction	TAS	9551928
GO:0035580	Component	Specific granule lumen	TAS
GO:0060326	Process	Cell chemotaxis	IEA
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	12949249
GO:1904724	Component	Tertiary granule lumen	TAS

MIM	HGNC	e!Ensembl
155730	4602	ENSG00000163739

P09341

Protein name

Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)]

Protein function

Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold high

PDB

1MGS , 1MSG , 1MSH , 1ROD , 8K4O , 8XWA , 8XWV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00048	IL8	41 → 100	Small cytokines (intecrine/chemokine), interleukin-8 like	Domain

Sequence

MARAALSAAPSNPRLLRVALLLLLLVAAGRRAAGASVATELRCQCLQTLQGIHPKNIQSV
NVKSPGPHCAQTEVIATLKNGRKACLNPASPIVKKIIEKMLNSDKSN

Sequence length

107

Interactions

View interactions

CXCL1 (C-X-C motif chemokine ligand 1)