Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1464
Gene name Gene Name - the full gene name approved by the HGNC.	Chondroitin sulfate proteoglycan 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CSPG4
Synonyms (NCBI Gene) Gene synonyms aliases	CSPG4A, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q24.2
Summary Summary of gene provided in NCBI Entrez Gene.	A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfa

Show/Hide all(41)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022345	hsa-miR-124-3p	Microarray	18668037
MIRT912897	hsa-miR-1237	CLIP-seq
MIRT912898	hsa-miR-1248	CLIP-seq
MIRT912899	hsa-miR-1285	CLIP-seq
MIRT912900	hsa-miR-1915	CLIP-seq
MIRT912901	hsa-miR-1972	CLIP-seq
MIRT912902	hsa-miR-296-5p	CLIP-seq
MIRT912903	hsa-miR-3157-3p	CLIP-seq
MIRT912904	hsa-miR-3187-5p	CLIP-seq
MIRT912905	hsa-miR-378g	CLIP-seq
MIRT912906	hsa-miR-4252	CLIP-seq
MIRT912907	hsa-miR-4279	CLIP-seq
MIRT912908	hsa-miR-4310	CLIP-seq
MIRT912909	hsa-miR-4486	CLIP-seq
MIRT912910	hsa-miR-490-3p	CLIP-seq
MIRT912911	hsa-miR-502-5p	CLIP-seq
MIRT912912	hsa-miR-612	CLIP-seq
MIRT912913	hsa-miR-642b	CLIP-seq
MIRT912914	hsa-miR-649	CLIP-seq
MIRT912915	hsa-miR-874	CLIP-seq
MIRT1970749	hsa-miR-1912	CLIP-seq
MIRT1970750	hsa-miR-331-3p	CLIP-seq
MIRT1970751	hsa-miR-4292	CLIP-seq
MIRT1970752	hsa-miR-4308	CLIP-seq
MIRT1970753	hsa-miR-4447	CLIP-seq
MIRT1970754	hsa-miR-4459	CLIP-seq
MIRT1970755	hsa-miR-4472	CLIP-seq
MIRT1970756	hsa-miR-4488	CLIP-seq
MIRT1970757	hsa-miR-4697-5p	CLIP-seq
MIRT1970758	hsa-miR-711	CLIP-seq
MIRT2206525	hsa-miR-1910	CLIP-seq
MIRT912900	hsa-miR-1915	CLIP-seq
MIRT2206526	hsa-miR-361-3p	CLIP-seq
MIRT2206527	hsa-miR-4283	CLIP-seq
MIRT1970751	hsa-miR-4292	CLIP-seq
MIRT1970752	hsa-miR-4308	CLIP-seq
MIRT2206528	hsa-miR-455-3p	CLIP-seq
MIRT2678719	hsa-miR-198	CLIP-seq
MIRT2678720	hsa-miR-3591-3p	CLIP-seq
MIRT2678721	hsa-miR-520a-5p	CLIP-seq
MIRT2678722	hsa-miR-525-5p	CLIP-seq

Show/Hide all(29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	IEA
GO:0001525	Process	Angiogenesis	IEA
GO:0001726	Component	Ruffle	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005887	Component	Integral component of plasma membrane	TAS	8790396
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006929	Process	Substrate-dependent cell migration	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008347	Process	Glial cell migration	IEA
GO:0009986	Component	Cell surface	HDA	19581412
GO:0009986	Component	Cell surface	TAS	10587647
GO:0015026	Function	Coreceptor activity	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0019901	Function	Protein kinase binding	IPI	10587647
GO:0030206	Process	Chondroitin sulfate biosynthetic process	TAS
GO:0030207	Process	Chondroitin sulfate catabolic process	TAS
GO:0030208	Process	Dermatan sulfate biosynthetic process	TAS
GO:0031258	Component	Lamellipodium membrane	IEA
GO:0035556	Process	Intracellular signal transduction	IDA	10587647
GO:0043202	Component	Lysosomal lumen	TAS
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	IEA
GO:0048771	Process	Tissue remodeling	IEA
GO:0050731	Process	Positive regulation of peptidyl-tyrosine phosphorylation	IDA	10587647
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	27068509, 28675934
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0097178	Process	Ruffle assembly	IEA

MIM	HGNC	e!Ensembl
601172	2466	ENSG00000173546

Protein

UniProt ID

Q6UVK1

Protein name

Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan)

Protein function

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface re

PDB

7ML7 , 7N8X , 7N9Y

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02210	Laminin_G_2	55 → 178	Laminin G domain	Domain
PF02210	Laminin_G_2	230 → 363	Laminin G domain	Domain
PF16184	Cadherin_3	423 → 524		Domain
PF16184	Cadherin_3	536 → 645		Domain
PF16184	Cadherin_3	652 → 766		Domain
PF16184	Cadherin_3	771 → 879		Domain
PF16184	Cadherin_3	884 → 990		Domain
PF16184	Cadherin_3	1001 → 1110		Domain
PF16184	Cadherin_3	1115 → 1218		Domain
PF16184	Cadherin_3	1221 → 1339		Domain
PF16184	Cadherin_3	1358 → 1450		Domain
PF16184	Cadherin_3	1456 → 1563		Domain
PF16184	Cadherin_3	1572 → 1679		Domain
PF16184	Cadherin_3	1690 → 1803		Domain
PF16184	Cadherin_3	1815 → 1924		Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in fibroblasts (at protein level) (PubMed:36213313). Detected in placenta (at protein level) (PubMed:32337544). Detected in malignant melanoma cells. {ECO:0000269|PubMed:32337544, ECO:0000269|PubMed:36213313, ECO:0000269|PubMe

Sequence

MQSGPRPPLPAPGLALALTLTMLARLASAASFFGENHLEVPVATALTDIDLQLQFSTSQP
EALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLLSDSIPHTVVLTVVEGW
ATLSVDGFLNASSAVPGAPLEVPYGLFVGGTGTLGLPYLRGTSRPLRGCLHAATLNGRSL
LRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLA
FQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISV
DQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSV
NGQRRGLREALLTRNMAAGCRLEEEEYEDDAYGHYEAFSTLAPEAWPAMELPEPCVPEPG
LPPVFANFTQLLTISPLVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGE
LELDIPGAQARKMFTLLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMPSCLRRGQTY
LLPIQVNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSG
LPVERRDQPGEPATEFSCRELEAGSLVYVHRGGPAQDLTFRVSDGLQASPPATLKVVAIR
PAIQIHRSTGLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQKQGAGGV
EGAEWWATQAFHQRDVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEILSNLSFPVTIQ
RATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNLQLQGTR
LSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIHIGGDPDAP
VLTNVLLVVPEGGEGVLSADHLFVKSLNSASYLYEVMERPRHGRLAWRGTQDKTTMVTSF
TNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPV
QTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYR
FTQEDLRKRRVLFVHSGADRGWIQLQVSDGQHQATALLEVQASEPYLRVANGSSLVVPQG
GQGTIDTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAGQPATAFSQQDLLDGAVLYS
HNGSLSPRDTMAFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRD
QLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLY
LHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLL
RVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETL
TDSFVLMANASEMDRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRST
DGDSGSEDLVYTIEQPSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRGTLDGGFRFRL
SDGEHTSPGHFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLY
RVVRGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSS
PPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSP
QRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHF
RAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVD
PDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFVANGSSVAGIFQLS
MSDGASPPLPMSLAVDILPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEAAYR
LIQGPQYGHLLVGGRPTSAFSQFQIDQGEVVFAFTNFSSSHDHFRVLALARGVNASAVVN
VTVRALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVPRFRLLEGPRHGRVVRVPRA
RTEPGGSQLVEQFTQQDLEDGRLGLEVGRPEGRAPGPAGDSLTLELWAQGVPPAVASLDF
ATEPYNAARPYSVALLSVPEAARTEAGKPESSTPTGEPGPMASSPEPAVAKGGFLSFLEA
NMFSVIIPMCLVLLLLALILPLLFYLRKRNKTGKHDVQVLTAKPRNGLAGDTETFRKVEP
GQAIPLTAVPGQGPPPGGQPDPELLQFCRTPNPALKNGQYWV

Sequence length

2322

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Schizophrenia	schizophrenia			GenCC

Show/Hide Text Mining Associations (63)

Disease Name	Relationship Type	References
Associations from Text Mining
Angiomyolipoma	Associate	17592550
Arteriovenous Malformations	Inhibit	36012380
Astrocytoma	Associate	10468613, 28945172, 32599896
Breast Neoplasms	Associate	22984505, 24177010, 34993493
Calcinosis Cutis	Associate	18634019
Calcinosis Cutis	Stimulate	26689475
Carcinoma Hepatocellular	Inhibit	22732936
Carcinoma Hepatocellular	Associate	26074703
Carcinoma Squamous Cell	Associate	34318902
Chondrosarcoma	Associate	18641983, 27292772
Chordoma	Associate	18641983, 26689475
Death	Stimulate	26689475
Delirium	Associate	30367354
Drug Related Side Effects and Adverse Reactions	Associate	33189883
Dysplastic Nevus Syndrome	Associate	25760270
Elejalde Disease	Associate	16309171
Fibrocartilaginous embolism	Associate	32973250
Glioblastoma	Associate	10468613, 21863242, 28643756, 28945172, 32599896, 37849763
Glioma	Associate	23804106, 28643756, 32599896, 34318902, 36292695
Gurrieri Sammito Bellussi syndrome	Associate	19110214
Head and Neck Neoplasms	Associate	25935541
HEM dysplasia	Associate	19110214
Hematoma Subdural Chronic	Associate	38030262
Hypoxia	Associate	24932730
Hypoxia	Inhibit	36012380
Idiopathic Pulmonary Fibrosis	Associate	37858084
Inflammation	Stimulate	26715280
Intracranial Arteriovenous Malformations	Inhibit	39682704
Legius syndrome	Associate	34344877
Leukemia	Associate	25706398, 31195686, 38037221
Leukemia B Cell	Associate	31195686
Leukemia Biphenotypic Acute	Associate	31195686
Leukemia Myeloid Acute	Associate	25706398
Lung Neoplasms	Associate	37849763
Lymphangioleiomyomatosis	Associate	19717640
Lymphatic Metastasis	Stimulate	20805128
Lymphatic Metastasis	Associate	26074703
Melanoma	Associate	10197164, 10400790, 18337643, 18519770, 19233913, 20395199, 20805128, 21595914, 21660451, 2203468, 22281663, 24177010, 25574741, 26815318, 27879288 View all (8 more)
Melanoma	Stimulate	20448346
Melanoma Cutaneous Malignant	Stimulate	20805128
Melanoma Cutaneous Malignant	Associate	31195686
Mevalonate Kinase Deficiency	Associate	29268706
Neoplasm Metastasis	Associate	18634019, 26689475, 34516824
Neoplasm Micrometastasis	Associate	18519770
Neoplasms	Associate	18469852, 21863242, 22467596, 22732936, 23472067, 24021875, 24278309, 24932730, 25706398, 26074703, 26689475, 28445515, 28981720, 32599896, 34318902, 36221119, 36422502, 37849763 View all (3 more)
Neuroblastoma	Associate	21660451
Neurofibromatosis 1	Associate	34344877
Nevus	Associate	20805128
Oligodendroglioma	Associate	10468613, 24278309, 32599896
Osteoarthritis	Associate	19546472
Pancreatic Neoplasms	Associate	24932730
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	38037221
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	10583275
Pyruvate Carboxylase Deficiency Disease	Stimulate	24367504
Sarcoma	Associate	18634019, 36221119
Spinal Cord Injuries	Associate	19604403, 25713464
Spondyloepimetaphyseal Dysplasia X Linked	Associate	19110214
Squamous Cell Carcinoma of Head and Neck	Associate	25935541, 38422829
Thyroid Neoplasms	Associate	37854594
Triple Negative Breast Neoplasms	Associate	34318902, 37432459
Urinary Bladder Neoplasms	Associate	35462469, 38015710, 40615671
Uveal melanoma	Associate	12714409
Wounds and Injuries	Associate	19604403

CSPG4 (chondroitin sulfate proteoglycan 4)