CSNK2A3 (casein kinase 2 alpha 3)

Gene

• Entrez ID: 283106
• Gene name: Casein kinase 2 alpha 3
• Gene symbol: CSNK2A3
• Synonyms (NCBI Gene): CSNK2A1P
• Chromosome: 11
• Chromosome location: 11p15.4
• Summary: This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	20625391
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	20625391
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005956	Component	Protein kinase CK2 complex	IBA
GO:0006302	Process	Double-strand break repair	IBA
GO:0006468	Process	Protein phosphorylation	IDA	20625391
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	20625391
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030307	Process	Positive regulation of cell growth	IDA	20625391
GO:0042176	Process	Regulation of protein catabolic process	IEA
GO:0045732	Process	Positive regulation of protein catabolic process	IDA	20625391
GO:0051726	Process	Regulation of cell cycle	IBA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8NEV1
• Protein name: Casein kinase II subunit alpha 3 (CK II alpha 3) (EC 2.7.11.1) (Casein kinase II alpha 1 polypeptide pseudogene)
• Protein function: Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-depende
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	39 → 324	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in blood platelets and megakaryocyte cell lines. Poorly expressed in lung. Highly expressed in lung tumor tissues. {ECO:0000269|PubMed:12102635, ECO:0000269|PubMed:20625391}.
• Sequence:

  MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
  NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
  FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
  FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWRLGCMLASMIFRKEPFFHGRDNYD
  QLVRIAKFLGTEDLYGYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
  LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANVMSGISSVPT
  PSPLGPLAGSPVIAAANPLGMPVPAATGAQQ

• Sequence length: 391

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