Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1457
Gene name Gene Name - the full gene name approved by the HGNC.
Casein kinase 2 alpha 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CSNK2A1
Synonyms (NCBI Gene) Gene synonyms aliases
CK2A1, CKII, Cka1, Cka2, OCNDS
Disease Acronyms (UniProt) Disease acronyms from UniProt database
OCNDS
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20p13
Summary Summary of gene provided in NCBI Entrez Gene.
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is c
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs869312840 T>C Pathogenic Missense variant, coding sequence variant
rs869312845 C>T Likely-pathogenic, pathogenic Missense variant, coding sequence variant, 5 prime UTR variant
rs869312846 A>G Pathogenic Splice donor variant
rs869312848 T>C Pathogenic Missense variant, coding sequence variant
rs869312849 T>C,G Pathogenic Missense variant, coding sequence variant, 5 prime UTR variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007207 hsa-miR-216b-5p Immunoblot, Luciferase reporter assay, qRT-PCR, Western blot 23137536
MIRT007208 hsa-miR-337-3p Immunoblot, Luciferase reporter assay, qRT-PCR, Western blot 23137536
MIRT007209 hsa-miR-760 Immunoblot, Luciferase reporter assay, qRT-PCR, Western blot 23137536
MIRT007210 hsa-miR-186-5p Immunoblot, Luciferase reporter assay, qRT-PCR, Western blot 23137536
MIRT030638 hsa-miR-22-3p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
ETS1 Unknown 19027835
NFKB1 Unknown 19027835
RELA Unknown 19027835
SP1 Unknown 19027835
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 12700239, 15723517, 16193064, 20625391, 20864032, 23123191, 30699359
GO:0004674 Function Protein serine/threonine kinase activity IGI 28031292
GO:0004674 Function Protein serine/threonine kinase activity IMP 11035045
GO:0004674 Function Protein serine/threonine kinase activity TAS 2174700
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
115440 2457 ENSG00000101266
Protein
UniProt ID P68400
Protein name Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
Protein function Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:117048
PDB 1JWH , 1NA7 , 1PJK , 2PVR , 2ZJW , 3AMY , 3AT2 , 3AT3 , 3AT4 , 3AXW , 3BQC , 3C13 , 3FWQ , 3H30 , 3JUH , 3MB6 , 3MB7 , 3NGA , 3NSZ , 3OWJ , 3OWK , 3OWL , 3PE1 , 3PE2 , 3PE4 , 3Q04 , 3Q9W , 3Q9X , 3Q9Y , 3Q9Z , 3QA0 , 3R0T , 3RPS , 3TAX , 3U4U , 3U87 , 3U9C , 3W8L , 3WAR , 3WIK , 3WIL , 3WOW , 4DGL , 4FBX , 4GRB , 4GUB , 4GYW , 4GYY , 4GZ3 , 4IB5 , 4KWP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 39 324 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level). {ECO:0000269|PubMed:24962073}.
Sequence
Sequence length 391
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Mental retardation syndromic intellectual disability GenCC
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 35266446, 40179422
Adenoma Oxyphilic Associate 28975890
Alzheimer Disease Associate 28558704
Arthritis Rheumatoid Associate 25880754
Atrial Fibrillation Stimulate 35607269
Breast Neoplasms Associate 27746184, 37348024
Calcinosis Cutis Associate 28975890
Carcinogenesis Associate 27746184
Carcinoma Non Small Cell Lung Associate 38155968
Carcinoma Ovarian Epithelial Associate 26637171