Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1050
Gene name Gene Name - the full gene name approved by the HGNC.
CCAAT enhancer binding protein alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CEBPA
Synonyms (NCBI Gene) Gene synonyms aliases
C/EBP-alpha, CEBP
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.11
Summary Summary of gene provided in NCBI Entrez Gene.
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-b
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002025 hsa-miR-124-3p Western blot, Reporter assay 18451139
MIRT002025 hsa-miR-124-3p Luciferase reporter assay 18451139
MIRT000390 hsa-miR-1-3p Luciferase reporter assay 18818206
MIRT002025 hsa-miR-124-3p Review 20029422
MIRT002025 hsa-miR-124-3p Review 20029422
Transcription factors
Transcription factor Regulation Reference
DDIT3 Repression 21983012
GATA1 Repression 19825991
LEF1 Unknown 19620402
MYB Unknown 10706719
MYC Repression 19259613
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000050 Process Urea cycle IEA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 12695546, 28186500
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
116897 1833 ENSG00000245848
Protein
UniProt ID P49715
Protein name CCAAT/enhancer-binding protein alpha (C/EBP alpha)
Protein function Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting
PDB 6DC0 , 8K8C
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07716 bZIP_2 281 334 Basic region leucine zipper Coiled-coil
Sequence
MESADFYEAEPRPPMSSHLQSPPHAPSSAAFGFPRGAGPAQPPAPPAAPEPLGGICEHET
SIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAVGPTGGGGGGDFDYPGAPAGPGGAVM
PGGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFP
YQPPPPPPPSHPHPHPPPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPA
LGAAGLPGPGSALKGLGAAHPDLRASGGSGAGKAKKSVDKNSNEYRVRRERNNIAVRKSR
DKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRE
LDTLRGIFRQLPESSLVKAMGNCA
Sequence length 358
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Myeloid Leukemia acute myeloid leukemia KAT2A inhibition demonstrated anti-AML activity by inducing myeloid differentiation and apoptosis. GenCC, CBGDA
Eczema Eczema GWAS
Asthma Asthma GWAS
Crohn Disease Crohn Disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abdominal Injuries Associate 38477908
Acute erythroleukemia Associate 19304957, 25987038, 35032366
Adenocarcinoma of Lung Associate 11912209, 30984536
Adenocarcinoma of Lung Inhibit 28746919
Alzheimer Disease Associate 37735671
Anemia Hemolytic Associate 30942098
Anodontia Inhibit 19414368
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis Associate 22403660
Aortic Aneurysm Abdominal Associate 28912007
Asthma Associate 37301411