Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1019
Gene name Gene Name - the full gene name approved by the HGNC.
Cyclin dependent kinase 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CDK4
Synonyms (NCBI Gene) Gene synonyms aliases
CMM3, PSK-J3
Disease Acronyms (UniProt) Disease acronyms from UniProt database
CMM3
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q14.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs11547328 G>A,T Likely-pathogenic, pathogenic Coding sequence variant, missense variant
rs104894340 C>A,T Risk-factor, likely-pathogenic, pathogenic Coding sequence variant, missense variant
rs144890720 T>C Conflicting-interpretations-of-pathogenicity, likely-benign, uncertain-significance Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000765 hsa-miR-34c-5p Review, Luciferase reporter assay 19461653
MIRT000764 hsa-miR-34b-5p Review, Luciferase reporter assay 19461653
MIRT000763 hsa-miR-34a-5p Review, Luciferase reporter assay 19461653
MIRT000763 hsa-miR-34a-5p Review, Luciferase reporter assay, Western blot, Microarray 17914404
MIRT003636 hsa-miR-302a-3p Luciferase reporter assay, qRT-PCR, Western blot 18710938
Transcription factors
Transcription factor Regulation Reference
ESR1 Unknown 22179484
IRF1 Repression 22200613
MYC Activation 22395148
MYC Unknown 10688915;21384303
NFKB1 Activation 18425349
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000079 Process Regulation of cyclin-dependent protein serine/threonine kinase activity IEA
GO:0000082 Process G1/S transition of mitotic cell cycle IMP 7603984
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IDA 17420273, 18827403
GO:0000785 Component Chromatin IDA 18827403
GO:0002088 Process Lens development in camera-type eye IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
123829 1773 ENSG00000135446
Protein
UniProt ID P11802
Protein name Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Protein function Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociat
PDB 2W96 , 2W99 , 2W9F , 2W9Z , 3G33 , 5FWK , 5FWL , 5FWM , 5FWP , 6P8E , 6P8F , 6P8G , 6P8H , 7SJ3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 6 295 Protein kinase domain Domain
Sequence
Sequence length 303
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Pancreatic Neoplasm malignant pancreatic neoplasm GenCC
Melanoma melanoma, cutaneous malignant, susceptibility to, 3 SMAD3 and SLC9A5 gain?of?function increases invasion capability of melanoma cells. GenCC, CBGDA
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abdomen Acute Associate 25121597
Adenocarcinoma Associate 17072968, 21593195, 30718927, 35395071
Adenocarcinoma of Lung Associate 23792647, 26418953, 27151654, 28381877, 32091408, 34642306, 36040373
Adenoma Associate 17072968, 35260162
Adenoma Pleomorphic Associate 16446704, 9723034
Adenosarcoma Associate 28267263
Adenosarcoma of the uterus Associate 26592504, 27255164
Adrenocortical Carcinoma Associate 25078331, 29283884, 29581542, 30413320, 32373071, 35462410
Albinism Oculocutaneous Associate 23103111
Alzheimer Disease Associate 9176387, 9525997