CCNA2 (cyclin A2)

Gene
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
890
Gene name Gene Name - the full gene name approved by the HGNC.
Cyclin A2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCNA2
Synonyms (NCBI Gene) Gene synonyms aliases
CCN1, CCNA
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q27
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provide
miRNA miRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(578)
miRTarBase ID miRNA Experiments Reference
MIRT000119 hsa-miR-24-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 19748357
MIRT000119 hsa-miR-24-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 19748357
MIRT004017 hsa-miR-146a-5p Microarray, qRT-PCR, Western blot 19944095
MIRT003999 hsa-let-7b-5p Immunoblot, Immunofluorescence, Luciferase reporter assay, qRT-PCR 18379589
MIRT016556 hsa-miR-193b-3p Microarray 20304954
Transcription factors
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(14)
Transcription factor Regulation Reference
CREM Repression 9280058
E2F3 Unknown 16909110
E4F1 Repression 15805267
E4F1 Unknown 14645522
ESR1 Activation 17681750
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(53)
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle IBA
GO:0000082 Process G1/S transition of mitotic cell cycle NAS 1312467
GO:0000086 Process G2/M transition of mitotic cell cycle IDA 1312467
GO:0000086 Process G2/M transition of mitotic cell cycle NAS 1312467
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IDA 1312467
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
123835 1578 ENSG00000145386
Protein
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID P20248
Protein name Cyclin-A2 (Cyclin-A) (Cyclin A)
Protein function Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cy
PDB 1E9H , 1FIN , 1FVV , 1GY3 , 1H1P , 1H1Q , 1H1R , 1H1S , 1H24 , 1H25 , 1H26 , 1H27 , 1H28 , 1JST , 1JSU , 1OGU , 1OI9 , 1OIU , 1OIY , 1OKV , 1OKW , 1OL1 , 1OL2 , 1P5E , 1PKD , 1QMZ , 1URC , 1VYW , 2BKZ , 2BPM , 2C4G , 2C5N , 2C5O , 2C5V , 2C5X , 2C6T , 2CCH , 2CCI , 2CJM , 2I40 , 2IW6 , 2IW8 , 2IW9 , 2UUE , 2UZB , 2UZD , 2UZE , 2UZL , 2V22 , 2WEV , 2WFY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16500 Cyclin_N2 28 → 166 N-terminal region of cyclin_N Family
PF00134 Cyclin_N 181 → 307 Cyclin, N-terminal domain Domain
PF02984 Cyclin_C 309 → 427 Cyclin, C-terminal domain Domain
Sequence
Sequence length 432
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Hepatocellular Carcinoma Hepatocellular carcinoma Overlapping CRISPR screens and HCC expression microarray data, we found 13 clinically relevant targets that are essential for HCC tumor cell growth and were significantly up-regulated in HCC tumors 31022357 CBGDA
Neurodevelopmental Disorders neurodevelopmental disorder N/A N/A GenCC
Show/Hide Text Mining Associations (123)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 17255290, 27893678
Adenocarcinoma of Lung Associate 23874428, 32121037, 33187219, 33627711, 34039308, 34304612, 34880385, 35783192, 35929837, 37254219, 37537521
Adenocarcinoma of Lung Stimulate 33398330
Adrenocortical Carcinoma Associate 32147961, 37535572, 38053725
Anthropophobia Associate 39466061
Astrocytoma Associate 10656729
Ataxia Telangiectasia Associate 35782055
Barrett Esophagus Associate 17255290, 27893678
Behcet Syndrome Associate 37335738
Breast Neoplasms Associate 10934345, 11875707, 12429812, 12627500, 12719458, 15187102, 16670718, 16823179, 17201163, 19706846, 22918167, 23446853, 24207091, 24622579, 25220500
View all (9 more)