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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10645
|
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Calcium/calmodulin dependent protein kinase kinase 2 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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CAMKK2 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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CAMKK, CAMKKB |
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Chromosome
Chromosome number
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12 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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12q24.31 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosph |
| UniProt ID |
Q96RR4
|
| Protein name |
Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) |
| Protein function |
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D |
| PDB |
2ZV2
,
5UY6
,
5UYJ
,
5VT1
,
5YV8
,
5YV9
,
5YVA
,
5YVB
,
5YVC
,
6BKU
,
6BLE
,
6BQL
,
6BQP
,
6BQQ
,
6BRC
,
6CMJ
,
6EF5
,
6EWW
,
6FEL
,
6Y3O
,
6Y4K
,
6Y6B
,
6Y8A
,
8TUC
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| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
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PF00069
|
Pkinase |
165 → 446 |
Protein kinase domain |
Domain |
|
| Tissue specificity |
TISSUE SPECIFICITY: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. {ECO:0000269|PubMed:9662074}. |
| Sequence |
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| Sequence length |
588 |
| Interactions |
View interactions
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