Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	818
Gene name Gene Name - the full gene name approved by the HGNC.	Calcium/calmodulin dependent protein kinase II gamma
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CAMK2G
Synonyms (NCBI Gene) Gene synonyms aliases	CAMK, CAMK-II, CAMKG, MRD59
Disease Acronyms (UniProt) Disease acronyms from UniProt database	MRD59
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q22.2
Summary Summary of gene provided in NCBI Entrez Gene.	The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs397514627	C>A,G	Likely-pathogenic, pathogenic	Coding sequence variant, non coding transcript variant, missense variant

Show/Hide all(222)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004446	hsa-miR-219a-5p	Luciferase reporter assay	19196972
MIRT024052	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT031976	hsa-miR-16-5p	Proteomics	18668040
MIRT043311	hsa-miR-331-3p	CLASH	23622248
MIRT053737	hsa-miR-1268a	Microarray	22942087
MIRT720329	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT720329	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT720328	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT720327	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT720326	hsa-miR-4301	HITS-CLIP	19536157
MIRT720325	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT720324	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT720323	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT720322	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT659906	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT659905	hsa-miR-4704-5p	HITS-CLIP	23824327
MIRT659904	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT659903	hsa-miR-623	HITS-CLIP	23824327
MIRT659902	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT659901	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT659900	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT659899	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT659898	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT659897	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT720329	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT720329	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT720328	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT720327	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT720326	hsa-miR-4301	HITS-CLIP	19536157
MIRT720325	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT720324	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT720323	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT720322	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT659906	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT659905	hsa-miR-4704-5p	HITS-CLIP	23824327
MIRT659904	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT659903	hsa-miR-623	HITS-CLIP	23824327
MIRT659902	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT659901	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT659900	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT659899	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT659898	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT659897	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT860256	hsa-miR-1202	CLIP-seq
MIRT860257	hsa-miR-1248	CLIP-seq
MIRT860258	hsa-miR-1976	CLIP-seq
MIRT860259	hsa-miR-2278	CLIP-seq
MIRT860260	hsa-miR-2392	CLIP-seq
MIRT860261	hsa-miR-3972	CLIP-seq
MIRT860262	hsa-miR-4274	CLIP-seq
MIRT860263	hsa-miR-4297	CLIP-seq
MIRT860264	hsa-miR-4446-3p	CLIP-seq
MIRT860265	hsa-miR-4535	CLIP-seq
MIRT860266	hsa-miR-4675	CLIP-seq
MIRT860267	hsa-miR-4722-3p	CLIP-seq
MIRT860268	hsa-miR-4741	CLIP-seq
MIRT860269	hsa-miR-4755-3p	CLIP-seq
MIRT860270	hsa-miR-4778-3p	CLIP-seq
MIRT860271	hsa-miR-485-3p	CLIP-seq
MIRT860272	hsa-miR-492	CLIP-seq
MIRT860273	hsa-miR-633	CLIP-seq
MIRT860274	hsa-miR-876-3p	CLIP-seq
MIRT860275	hsa-miR-1245b-3p	CLIP-seq
MIRT860276	hsa-miR-28-5p	CLIP-seq
MIRT860277	hsa-miR-3139	CLIP-seq
MIRT860278	hsa-miR-3664-3p	CLIP-seq
MIRT860279	hsa-miR-3943	CLIP-seq
MIRT860280	hsa-miR-4323	CLIP-seq
MIRT860281	hsa-miR-4433	CLIP-seq
MIRT860282	hsa-miR-4459	CLIP-seq
MIRT860283	hsa-miR-4686	CLIP-seq
MIRT860284	hsa-miR-4705	CLIP-seq
MIRT860285	hsa-miR-4728-3p	CLIP-seq
MIRT860286	hsa-miR-4768-3p	CLIP-seq
MIRT860287	hsa-miR-4796-5p	CLIP-seq
MIRT860288	hsa-miR-499-3p	CLIP-seq
MIRT860289	hsa-miR-499a-3p	CLIP-seq
MIRT860290	hsa-miR-558	CLIP-seq
MIRT860291	hsa-miR-628-5p	CLIP-seq
MIRT860292	hsa-miR-708	CLIP-seq
MIRT1955291	hsa-miR-1184	CLIP-seq
MIRT1955292	hsa-miR-1205	CLIP-seq
MIRT1955293	hsa-miR-1236	CLIP-seq
MIRT1955294	hsa-miR-150	CLIP-seq
MIRT1955295	hsa-miR-3065-3p	CLIP-seq
MIRT1955296	hsa-miR-3158-5p	CLIP-seq
MIRT860263	hsa-miR-4297	CLIP-seq
MIRT1955297	hsa-miR-4492	CLIP-seq
MIRT1955298	hsa-miR-4498	CLIP-seq
MIRT1955299	hsa-miR-4713-5p	CLIP-seq
MIRT1955300	hsa-miR-762	CLIP-seq
MIRT1955301	hsa-miR-1909	CLIP-seq
MIRT1955291	hsa-miR-1184	CLIP-seq
MIRT1955292	hsa-miR-1205	CLIP-seq
MIRT1955293	hsa-miR-1236	CLIP-seq
MIRT1955296	hsa-miR-3158-5p	CLIP-seq
MIRT860263	hsa-miR-4297	CLIP-seq
MIRT2193030	hsa-miR-495	CLIP-seq
MIRT1955292	hsa-miR-1205	CLIP-seq
MIRT2385501	hsa-miR-15a	CLIP-seq
MIRT2385502	hsa-miR-15b	CLIP-seq
MIRT2385503	hsa-miR-16	CLIP-seq
MIRT1955301	hsa-miR-1909	CLIP-seq
MIRT2385504	hsa-miR-195	CLIP-seq
MIRT2385505	hsa-miR-330-3p	CLIP-seq
MIRT2385506	hsa-miR-424	CLIP-seq
MIRT2385507	hsa-miR-4667-3p	CLIP-seq
MIRT2385508	hsa-miR-497	CLIP-seq
MIRT1955292	hsa-miR-1205	CLIP-seq
MIRT2446139	hsa-miR-1298	CLIP-seq
MIRT2446140	hsa-miR-3661	CLIP-seq
MIRT2446141	hsa-miR-3684	CLIP-seq
MIRT2446142	hsa-miR-384	CLIP-seq
MIRT2446143	hsa-miR-555	CLIP-seq
MIRT2446144	hsa-miR-631	CLIP-seq
MIRT2496108	hsa-miR-101	CLIP-seq
MIRT2496109	hsa-miR-103a	CLIP-seq
MIRT2496110	hsa-miR-107	CLIP-seq
MIRT1955291	hsa-miR-1184	CLIP-seq
MIRT1955292	hsa-miR-1205	CLIP-seq
MIRT1955293	hsa-miR-1236	CLIP-seq
MIRT2496111	hsa-miR-1296	CLIP-seq
MIRT2496112	hsa-miR-1302	CLIP-seq
MIRT2496113	hsa-miR-1908	CLIP-seq
MIRT1955301	hsa-miR-1909	CLIP-seq
MIRT2496114	hsa-miR-1915	CLIP-seq
MIRT2496115	hsa-miR-204	CLIP-seq
MIRT2496116	hsa-miR-211	CLIP-seq
MIRT2496117	hsa-miR-214	CLIP-seq
MIRT2496118	hsa-miR-22	CLIP-seq
MIRT2496119	hsa-miR-29a	CLIP-seq
MIRT2496120	hsa-miR-29b	CLIP-seq
MIRT2496121	hsa-miR-29c	CLIP-seq
MIRT1955295	hsa-miR-3065-3p	CLIP-seq
MIRT2496122	hsa-miR-3120-3p	CLIP-seq
MIRT2496123	hsa-miR-3135b	CLIP-seq
MIRT2496124	hsa-miR-3151	CLIP-seq
MIRT1955296	hsa-miR-3158-5p	CLIP-seq
MIRT2496125	hsa-miR-3166	CLIP-seq
MIRT2496126	hsa-miR-3192	CLIP-seq
MIRT2496127	hsa-miR-3619-5p	CLIP-seq
MIRT2496128	hsa-miR-3652	CLIP-seq
MIRT2496129	hsa-miR-3653	CLIP-seq
MIRT2496130	hsa-miR-3907	CLIP-seq
MIRT2496131	hsa-miR-423-3p	CLIP-seq
MIRT2496132	hsa-miR-4283	CLIP-seq
MIRT2496133	hsa-miR-4298	CLIP-seq
MIRT2496134	hsa-miR-4300	CLIP-seq
MIRT2496135	hsa-miR-4418	CLIP-seq
MIRT2496136	hsa-miR-4430	CLIP-seq
MIRT2496137	hsa-miR-4436b-3p	CLIP-seq
MIRT2496138	hsa-miR-4489	CLIP-seq
MIRT1955297	hsa-miR-4492	CLIP-seq
MIRT2496139	hsa-miR-4494	CLIP-seq
MIRT1955298	hsa-miR-4498	CLIP-seq
MIRT2496140	hsa-miR-4505	CLIP-seq
MIRT2496141	hsa-miR-4512	CLIP-seq
MIRT2496142	hsa-miR-4639-5p	CLIP-seq
MIRT2496143	hsa-miR-4645-3p	CLIP-seq
MIRT2496144	hsa-miR-4690-5p	CLIP-seq
MIRT2496145	hsa-miR-4771	CLIP-seq
MIRT2496146	hsa-miR-4795-5p	CLIP-seq
MIRT2496147	hsa-miR-509-3-5p	CLIP-seq
MIRT2496148	hsa-miR-509-5p	CLIP-seq
MIRT2496149	hsa-miR-544	CLIP-seq
MIRT2496150	hsa-miR-663	CLIP-seq
MIRT2496151	hsa-miR-761	CLIP-seq
MIRT1955300	hsa-miR-762	CLIP-seq
MIRT2496152	hsa-miR-765	CLIP-seq
MIRT2496153	hsa-miR-920	CLIP-seq
MIRT1955296	hsa-miR-3158-5p	CLIP-seq
MIRT1955297	hsa-miR-4492	CLIP-seq
MIRT1955298	hsa-miR-4498	CLIP-seq
MIRT1955300	hsa-miR-762	CLIP-seq
MIRT2496109	hsa-miR-103a	CLIP-seq
MIRT2496110	hsa-miR-107	CLIP-seq
MIRT1955291	hsa-miR-1184	CLIP-seq
MIRT1955292	hsa-miR-1205	CLIP-seq
MIRT2677322	hsa-miR-1226	CLIP-seq
MIRT1955293	hsa-miR-1236	CLIP-seq
MIRT2496111	hsa-miR-1296	CLIP-seq
MIRT2496112	hsa-miR-1302	CLIP-seq
MIRT2496113	hsa-miR-1908	CLIP-seq
MIRT1955301	hsa-miR-1909	CLIP-seq
MIRT2496114	hsa-miR-1915	CLIP-seq
MIRT2496117	hsa-miR-214	CLIP-seq
MIRT2496118	hsa-miR-22	CLIP-seq
MIRT2496119	hsa-miR-29a	CLIP-seq
MIRT2496120	hsa-miR-29b	CLIP-seq
MIRT2496121	hsa-miR-29c	CLIP-seq
MIRT1955295	hsa-miR-3065-3p	CLIP-seq
MIRT1955296	hsa-miR-3158-5p	CLIP-seq
MIRT2496125	hsa-miR-3166	CLIP-seq
MIRT2496126	hsa-miR-3192	CLIP-seq
MIRT2496127	hsa-miR-3619-5p	CLIP-seq
MIRT2496130	hsa-miR-3907	CLIP-seq
MIRT2496131	hsa-miR-423-3p	CLIP-seq
MIRT2496133	hsa-miR-4298	CLIP-seq
MIRT2496134	hsa-miR-4300	CLIP-seq
MIRT2496135	hsa-miR-4418	CLIP-seq
MIRT2496137	hsa-miR-4436b-3p	CLIP-seq
MIRT1955297	hsa-miR-4492	CLIP-seq
MIRT2496139	hsa-miR-4494	CLIP-seq
MIRT1955298	hsa-miR-4498	CLIP-seq
MIRT2496140	hsa-miR-4505	CLIP-seq
MIRT2496141	hsa-miR-4512	CLIP-seq
MIRT2677323	hsa-miR-4677-3p	CLIP-seq
MIRT2496144	hsa-miR-4690-5p	CLIP-seq
MIRT2496145	hsa-miR-4771	CLIP-seq
MIRT2677324	hsa-miR-4794	CLIP-seq
MIRT2496147	hsa-miR-509-3-5p	CLIP-seq
MIRT2496148	hsa-miR-509-5p	CLIP-seq
MIRT2496149	hsa-miR-544	CLIP-seq
MIRT2677325	hsa-miR-605	CLIP-seq
MIRT2677326	hsa-miR-627	CLIP-seq
MIRT2677327	hsa-miR-634	CLIP-seq
MIRT2496150	hsa-miR-663	CLIP-seq
MIRT2496151	hsa-miR-761	CLIP-seq
MIRT1955300	hsa-miR-762	CLIP-seq
MIRT2496152	hsa-miR-765	CLIP-seq
MIRT2496153	hsa-miR-920	CLIP-seq
MIRT2677328	hsa-miR-924	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004683	Function	Calmodulin-dependent protein kinase activity	IBA	21873635
GO:0004723	Function	Calcium-dependent protein serine/threonine phosphatase activity	NAS	9060999
GO:0005515	Function	Protein binding	IPI	22939624
GO:0005516	Function	Calmodulin binding	IBA	21873635
GO:0005516	Function	Calmodulin binding	NAS	9060999
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005954	Component	Calcium- and calmodulin-dependent protein kinase complex	IDA	20668654
GO:0006468	Process	Protein phosphorylation	IEA
GO:0006470	Process	Protein dephosphorylation	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0010975	Process	Regulation of neuron projection development	IMP	30184290
GO:0014733	Process	Regulation of skeletal muscle adaptation	TAS	15294044
GO:0016020	Component	Membrane	HDA	19946888
GO:0030073	Process	Insulin secretion	NAS	9240463
GO:0030154	Process	Cell differentiation	IEA
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0033017	Component	Sarcoplasmic reticulum membrane	IEA
GO:0042802	Function	Identical protein binding	IPI	20668654
GO:0042803	Function	Protein homodimerization activity	IPI	20668654
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0051924	Process	Regulation of calcium ion transport	TAS	15294044
GO:0060333	Process	Interferon-gamma-mediated signaling pathway	TAS
GO:1900034	Process	Regulation of cellular response to heat	TAS

MIM	HGNC	e!Ensembl
602123	1463	ENSG00000148660

Protein

UniProt ID

Q13555

Protein name

Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17)

Protein function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine an

PDB

2UX0 , 2V7O

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	14 → 272	Protein kinase domain	Domain
PF08332	CaMKII_AD	426 → 553	Calcium/calmodulin dependent protein kinase II association domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in skeletal muscle. {ECO:0000269|PubMed:16690701}.

Sequence

MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQI
LESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT
VTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKL
KGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPL
QTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKGRVPEGRSSRDRTAPSAGMQPQPSL
CSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFE
NLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDG
KWLNVHYHCSGAPAAPLQ

Sequence length

558

Interactions

View interactions

Show/Hide Unknown Diseases (11)

Disease term	Disease name	Source
Unknown
Developmental And Epileptic Encephalopathy	genetic developmental and epileptic encephalopathy	GenCC
Multiple Sclerosis	Multiple Sclerosis	GWAS
Diabetes	Diabetes	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	GWAS
Psoriasis	Psoriasis	GWAS
Inflammatory Bowel Disease	Inflammatory Bowel Disease	GWAS
Psoriasis vulgaris	Psoriasis vulgaris	GWAS
Restless Legs Syndrome	Restless Legs Syndrome	GWAS
Asthma	Asthma	GWAS
Crohn Disease	Crohn Disease	GWAS
Eosinophilia	Eosinophilia	GWAS

Show/Hide Text Mining Associations (64)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	28640357
Alzheimer Disease	Associate	24731980
Anemia Aplastic	Associate	25800665
Arrhythmias Cardiac	Associate	25815641, 25910598, 29410121, 36671453
Arthritis Psoriatic	Associate	20353560
Astrocytoma	Associate	12937144
Ataxia Telangiectasia	Associate	10403399
Atherosclerosis	Associate	28011257
Atrial Fibrillation	Associate	37523735
Atrial Remodeling	Associate	34196135, 37523735
Brain Diseases	Associate	37510258
Breast Neoplasms	Associate	27605043
Carcinoma Hepatocellular	Associate	28869833, 35724265
Carcinoma Non Small Cell Lung	Associate	35692887
Cardiomyopathies	Associate	37300940
Cardiomyopathy Dilated	Associate	37372357
Cardiomyopathy Hypertrophic	Associate	25910598, 27688314
Cardiotoxicity	Associate	35260914, 36111515
Cognition Disorders	Associate	34196135
Colonic Neoplasms	Associate	11274166, 28970726
Colorectal Neoplasms	Associate	19298255, 28692053, 28970726, 33761465
Craniocerebral Trauma	Inhibit	32483284
Cyclic neutropenia	Associate	25800665
Dementia Vascular	Associate	28011257
Developmental Disabilities	Associate	37372357
Diabetes Mellitus Type 2	Associate	35767566
Drug Resistant Epilepsy	Associate	28388656
Failed Back Surgery Syndrome	Associate	20443916
Fractures Spontaneous	Associate	36111515
GATA2 Deficiency	Associate	32641029
Glioblastoma	Associate	12937144, 21649900, 30816530
Glioma	Associate	12496285, 20139089, 22049206, 23261316, 30816530, 31593589
Glycogen Storage Disease Type IIb	Associate	36671453
Heart Diseases	Associate	25910598
Heart Failure	Associate	25201344, 25815641, 25910598, 29410121, 35805993
Hypertension	Stimulate	20392834
Hypertrophy	Associate	25910598
Hypertrophy	Stimulate	30205161
Hypoplastic Left Heart Syndrome	Associate	24793904
Intellectual Disability	Associate	37510258
Iron Overload	Associate	33039869
Ischemia	Associate	25910598
Leukemia	Associate	25446257
Leukemia Myeloid	Associate	11376870, 17431504, 18483256, 25446257
Leukemia Myeloid Acute	Associate	18483256
Long QT Syndrome	Associate	36496072
Lymphoma	Associate	35482553
Lymphoma Large B Cell Diffuse	Associate	34088288
Malformations of Cortical Development Group I	Associate	32787872
Mammary Neoplasms Animal	Associate	9060999
Mental Retardation X Linked 53	Associate	37510258
Microcephaly	Associate	36137748
Mitochondrial Diseases	Associate	29901626
Myotonic Dystrophy	Associate	34371182
Neoplasm Metastasis	Associate	28970726
Neoplasms	Associate	18305109, 19749792, 20454608, 26719529, 28869833, 28970726, 30816530, 9060999
Neoplasms	Stimulate	35482553
Neuroblastoma	Associate	9060999
Osteoarthritis	Stimulate	30205161
Osteogenesis imperfecta type 1A	Associate	37410216
Plaque Atherosclerotic	Associate	28011257
Polymorphic catecholergic ventricular tachycardia	Associate	34888671
Prostatic Neoplasms	Associate	17387273, 20454608
Reperfusion Injury	Associate	35805993

CAMK2G (calcium/calmodulin dependent protein kinase II gamma)