CACNG6 (calcium voltage-gated channel auxiliary subunit gamma 6)

Gene

• Entrez ID: 59285
• Gene name: Calcium voltage-gated channel auxiliary subunit gamma 6
• Gene symbol: CACNG6
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19q13.42
• Summary: Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is an integral membrane protein that

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT650164	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT650163	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT650162	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT650161	hsa-miR-4733-5p	HITS-CLIP	23824327
MIRT650160	hsa-miR-1288-5p	HITS-CLIP	23824327
MIRT650159	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT650158	hsa-miR-5100	HITS-CLIP	23824327
MIRT650157	hsa-miR-2053	HITS-CLIP	23824327
MIRT650164	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT650163	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT650162	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT650161	hsa-miR-4733-5p	HITS-CLIP	23824327
MIRT650160	hsa-miR-1288-5p	HITS-CLIP	23824327
MIRT650159	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT650158	hsa-miR-5100	HITS-CLIP	23824327
MIRT650157	hsa-miR-2053	HITS-CLIP	23824327
MIRT858217	hsa-miR-296-5p	CLIP-seq
MIRT858218	hsa-miR-4270	CLIP-seq
MIRT858219	hsa-miR-4441	CLIP-seq
MIRT858220	hsa-miR-3919	CLIP-seq
MIRT858221	hsa-miR-4691-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005245	Function	Voltage-gated calcium channel activity	NAS	11170751
GO:0005246	Function	Calcium channel regulator activity	IBA
GO:0005246	Function	Calcium channel regulator activity	IDA	21127204
GO:0005262	Function	Calcium channel activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005891	Component	Voltage-gated calcium channel complex	NAS	11170751
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006816	Process	Calcium ion transport	NAS	11170751
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:1902514	Process	Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IBA
GO:1990454	Component	L-type voltage-gated calcium channel complex	IBA
GO:1990454	Component	L-type voltage-gated calcium channel complex	IDA	21127204

Other IDs

• MIM: 606898
• HGNC: 13625
• e!Ensembl: ENSG00000130433

Protein

• UniProt ID: Q9BXT2
• Protein name: Voltage-dependent calcium channel gamma-6 subunit (Neuronal voltage-gated calcium channel gamma-6 subunit)
• Protein function: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13903	Claudin_2	47 → 241	PMP-22/EMP/MP20/Claudin tight junction	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in heart left ventricle. {ECO:0000269|PubMed:21127204}.
• Sequence:

  MMWSNFFLQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTE
  FWVELNTYKANGSAVCEAAHLGLWKACTKRLWQADVPVDRDTCGPAELPGEANCTYFKFF
  TTGENARIFQRTTKKEVNLAAAVIAVLGLAVMALGCLCIIMVLSKGAEFLLRVGAVCFGL
  SGLLLLVSLEVFRHSVRALLQRVSPEPPPAPRLTYEYSWSLGCGVGAGLILLLGAGCFLL
  LTLPSWPWGSLCPKRGHRAT

• Sequence length: 260