Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	784
Gene name Gene Name - the full gene name approved by the HGNC.	Calcium voltage-gated channel auxiliary subunit beta 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CACNB3
Synonyms (NCBI Gene) Gene synonyms aliases	CAB3, CACNLB3
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q13.12
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regul

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016710	hsa-miR-335-5p	Microarray	18185580
MIRT042695	hsa-miR-196b-5p	CLASH	23622248
MIRT857899	hsa-miR-1	CLIP-seq
MIRT857900	hsa-miR-206	CLIP-seq
MIRT857901	hsa-miR-3064-3p	CLIP-seq
MIRT857902	hsa-miR-3673	CLIP-seq
MIRT857903	hsa-miR-4300	CLIP-seq
MIRT857904	hsa-miR-432	CLIP-seq
MIRT857905	hsa-miR-4474-3p	CLIP-seq
MIRT857906	hsa-miR-4764-5p	CLIP-seq
MIRT857907	hsa-miR-604	CLIP-seq
MIRT857908	hsa-miR-613	CLIP-seq
MIRT857909	hsa-miR-619	CLIP-seq
MIRT857910	hsa-miR-647	CLIP-seq
MIRT857911	hsa-miR-920	CLIP-seq
MIRT1954778	hsa-miR-1202	CLIP-seq
MIRT1954779	hsa-miR-1275	CLIP-seq
MIRT1954780	hsa-miR-1291	CLIP-seq
MIRT1954781	hsa-miR-1294	CLIP-seq
MIRT1954782	hsa-miR-134	CLIP-seq
MIRT1954783	hsa-miR-140-3p	CLIP-seq
MIRT1954784	hsa-miR-183	CLIP-seq
MIRT1954785	hsa-miR-219-5p	CLIP-seq
MIRT1954786	hsa-miR-3118	CLIP-seq
MIRT1954787	hsa-miR-3194-5p	CLIP-seq
MIRT1954788	hsa-miR-330-3p	CLIP-seq
MIRT1954789	hsa-miR-34a	CLIP-seq
MIRT1954790	hsa-miR-34c-5p	CLIP-seq
MIRT1954791	hsa-miR-3612	CLIP-seq
MIRT1954792	hsa-miR-3620	CLIP-seq
MIRT1954793	hsa-miR-3649	CLIP-seq
MIRT1954794	hsa-miR-371-3p	CLIP-seq
MIRT1954795	hsa-miR-371b-3p	CLIP-seq
MIRT1954796	hsa-miR-3972	CLIP-seq
MIRT1954797	hsa-miR-4260	CLIP-seq
MIRT1954798	hsa-miR-4274	CLIP-seq
MIRT1954799	hsa-miR-4292	CLIP-seq
MIRT1954800	hsa-miR-4308	CLIP-seq
MIRT857904	hsa-miR-432	CLIP-seq
MIRT1954801	hsa-miR-4443	CLIP-seq
MIRT1954802	hsa-miR-4445	CLIP-seq
MIRT1954803	hsa-miR-4488	CLIP-seq
MIRT1954804	hsa-miR-449a	CLIP-seq
MIRT1954805	hsa-miR-449b	CLIP-seq
MIRT1954806	hsa-miR-4514	CLIP-seq
MIRT1954807	hsa-miR-4656	CLIP-seq
MIRT1954808	hsa-miR-4659a-5p	CLIP-seq
MIRT1954809	hsa-miR-4659b-5p	CLIP-seq
MIRT1954810	hsa-miR-4663	CLIP-seq
MIRT1954811	hsa-miR-4665-5p	CLIP-seq
MIRT1954812	hsa-miR-4692	CLIP-seq
MIRT1954813	hsa-miR-4697-5p	CLIP-seq
MIRT1954814	hsa-miR-4782-3p	CLIP-seq
MIRT1954815	hsa-miR-508-3p	CLIP-seq
MIRT1954816	hsa-miR-515-3p	CLIP-seq
MIRT1954817	hsa-miR-519e	CLIP-seq
MIRT1954818	hsa-miR-637	CLIP-seq
MIRT1954819	hsa-miR-650	CLIP-seq
MIRT1954787	hsa-miR-3194-5p	CLIP-seq
MIRT2446042	hsa-miR-147	CLIP-seq
MIRT2446043	hsa-miR-1914	CLIP-seq
MIRT2446044	hsa-miR-3150b-3p	CLIP-seq
MIRT2446045	hsa-miR-3689a-3p	CLIP-seq
MIRT2446046	hsa-miR-3689c	CLIP-seq
MIRT2446047	hsa-miR-3911	CLIP-seq
MIRT2446048	hsa-miR-4648	CLIP-seq
MIRT2446049	hsa-miR-4654	CLIP-seq
MIRT2446050	hsa-miR-4728-5p	CLIP-seq
MIRT2446051	hsa-miR-4769-5p	CLIP-seq
MIRT2446052	hsa-miR-4784	CLIP-seq
MIRT2446053	hsa-miR-486-3p	CLIP-seq
MIRT2446054	hsa-miR-516a-3p	CLIP-seq
MIRT2446055	hsa-miR-644	CLIP-seq
MIRT2446056	hsa-miR-765	CLIP-seq
MIRT2446042	hsa-miR-147	CLIP-seq
MIRT2446043	hsa-miR-1914	CLIP-seq
MIRT2446044	hsa-miR-3150b-3p	CLIP-seq
MIRT2446045	hsa-miR-3689a-3p	CLIP-seq
MIRT2446046	hsa-miR-3689c	CLIP-seq
MIRT2446047	hsa-miR-3911	CLIP-seq
MIRT2446048	hsa-miR-4648	CLIP-seq
MIRT2446049	hsa-miR-4654	CLIP-seq
MIRT2446050	hsa-miR-4728-5p	CLIP-seq
MIRT2446051	hsa-miR-4769-5p	CLIP-seq
MIRT2446052	hsa-miR-4784	CLIP-seq
MIRT2446053	hsa-miR-486-3p	CLIP-seq
MIRT2446054	hsa-miR-516a-3p	CLIP-seq
MIRT2446055	hsa-miR-644	CLIP-seq
MIRT2446056	hsa-miR-765	CLIP-seq
MIRT2495744	hsa-miR-1227	CLIP-seq
MIRT857901	hsa-miR-3064-3p	CLIP-seq
MIRT1954792	hsa-miR-3620	CLIP-seq
MIRT1954799	hsa-miR-4292	CLIP-seq
MIRT2495745	hsa-miR-4455	CLIP-seq
MIRT2495746	hsa-miR-4715-3p	CLIP-seq
MIRT2495747	hsa-miR-545	CLIP-seq
MIRT2495748	hsa-miR-609	CLIP-seq
MIRT1954818	hsa-miR-637	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005245	Function	Voltage-gated calcium channel activity	IDA	11160515
GO:0005246	Function	Calcium channel regulator activity	ISS
GO:0005515	Function	Protein binding	IPI	18535142, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0005891	Component	Voltage-gated calcium channel complex	IBA	21873635
GO:0005891	Component	Voltage-gated calcium channel complex	IDA	11160515
GO:0006816	Process	Calcium ion transport	IDA	11160515
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0007528	Process	Neuromuscular junction development	IBA	21873635
GO:0008331	Function	High voltage-gated calcium channel activity	IBA	21873635
GO:0008331	Function	High voltage-gated calcium channel activity	ISS	25527503
GO:0016020	Component	Membrane	IDA	16525042
GO:0016324	Component	Apical plasma membrane	IEA
GO:0019901	Function	Protein kinase binding	IEA
GO:0045202	Component	Synapse	IEA
GO:0050852	Process	T cell receptor signaling pathway	IEA
GO:0050966	Process	Detection of mechanical stimulus involved in sensory perception of pain	IEA
GO:0051899	Process	Membrane depolarization	TAS
GO:0060402	Process	Calcium ion transport into cytosol	ISS	25527503
GO:0061337	Process	Cardiac conduction	TAS
GO:0061577	Process	Calcium ion transmembrane transport via high voltage-gated calcium channel	ISS	25527503
GO:0072659	Process	Protein localization to plasma membrane	ISS	25527503
GO:0090314	Process	Positive regulation of protein targeting to membrane	IEA
GO:0090650	Process	Cellular response to oxygen-glucose deprivation	IEA
GO:0098903	Process	Regulation of membrane repolarization during action potential	ISS	25527503
GO:1901385	Process	Regulation of voltage-gated calcium channel activity	IBA	21873635
GO:1901386	Process	Negative regulation of voltage-gated calcium channel activity	IEA
GO:1901843	Process	Positive regulation of high voltage-gated calcium channel activity	ISS
GO:1902630	Process	Regulation of membrane hyperpolarization	IEA
GO:1905788	Process	Negative regulation of detection of mechanical stimulus involved in sensory perception of touch	IEA
GO:1990454	Component	L-type voltage-gated calcium channel complex	ISS	25527503
GO:2000463	Process	Positive regulation of excitatory postsynaptic potential	IEA

MIM	HGNC	e!Ensembl
601958	1403	ENSG00000167535

Protein

UniProt ID

P54284

Protein name

Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3)

Protein function

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity

PDB

7MIX , 7MIY , 7UHF , 7UHG , 8E59 , 8E5A , 8E5B , 8EPL , 8FHS , 8WE6 , 8WE7 , 8WE8 , 8WE9 , 8X90 , 8X91 , 8X93

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12052	VGCC_beta4Aa_N	16 → 58	Voltage gated calcium channel subunit beta domain 4Aa N terminal	Domain
PF00625	Guanylate_kin	176 → 356	Guanylate kinase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed mostly in brain, colon and ovary. {ECO:0000269|PubMed:8119293}.

Sequence

MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPV
AFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPS
PQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPV
VLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIER
SSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVL
QRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRAT
HHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQR
SSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWP
KDSY

Sequence length

484

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Bipolar Disorder	Bipolar Disorder			GWAS

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining
Bipolar Disorder	Associate	25623948
Carcinoma Non Small Cell Lung	Associate	21242119
Epilepsy	Associate	37341859
Epilepsy Familial Mesial Temporal Lobe	Associate	37341859
Neoplasms	Associate	21242119
Polycystic Ovary Syndrome	Associate	39754246
Seizures	Associate	37341859
Uterine Cervical Neoplasms	Associate	35924232

CACNB3 (calcium voltage-gated channel auxiliary subunit beta 3)