Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10458
Gene name Gene Name - the full gene name approved by the HGNC.	BAR/IMD domain containing adaptor protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	BAIAP2
Synonyms (NCBI Gene) Gene synonyms aliases	BAP2, FLAF3, IRSP53, WAML
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q25.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor ty

Show/Hide all(106)

miRTarBase ID	miRNA	Experiments	Reference
MIRT037874	hsa-miR-455-3p	CLASH	23622248
MIRT815462	hsa-miR-1237	CLIP-seq
MIRT815463	hsa-miR-15a	CLIP-seq
MIRT815464	hsa-miR-15b	CLIP-seq
MIRT815465	hsa-miR-16	CLIP-seq
MIRT815466	hsa-miR-195	CLIP-seq
MIRT815467	hsa-miR-214	CLIP-seq
MIRT815468	hsa-miR-2355-5p	CLIP-seq
MIRT815469	hsa-miR-3135b	CLIP-seq
MIRT815470	hsa-miR-3187-3p	CLIP-seq
MIRT815471	hsa-miR-3619-5p	CLIP-seq
MIRT815472	hsa-miR-424	CLIP-seq
MIRT815473	hsa-miR-4434	CLIP-seq
MIRT815474	hsa-miR-4436b-3p	CLIP-seq
MIRT815475	hsa-miR-4516	CLIP-seq
MIRT815476	hsa-miR-4529-5p	CLIP-seq
MIRT815477	hsa-miR-4722-5p	CLIP-seq
MIRT815478	hsa-miR-4755-3p	CLIP-seq
MIRT815479	hsa-miR-4768-3p	CLIP-seq
MIRT815480	hsa-miR-497	CLIP-seq
MIRT815481	hsa-miR-761	CLIP-seq
MIRT815482	hsa-miR-938	CLIP-seq
MIRT815483	hsa-miR-1268	CLIP-seq
MIRT815484	hsa-miR-1268b	CLIP-seq
MIRT815485	hsa-miR-361-3p	CLIP-seq
MIRT815486	hsa-miR-4447	CLIP-seq
MIRT815487	hsa-miR-4466	CLIP-seq
MIRT815488	hsa-miR-4472	CLIP-seq
MIRT815489	hsa-miR-4488	CLIP-seq
MIRT815490	hsa-miR-4697-5p	CLIP-seq
MIRT815491	hsa-miR-4726-3p	CLIP-seq
MIRT815492	hsa-miR-675	CLIP-seq
MIRT815493	hsa-miR-1193	CLIP-seq
MIRT815494	hsa-miR-1287	CLIP-seq
MIRT815495	hsa-miR-1827	CLIP-seq
MIRT815496	hsa-miR-219-1-3p	CLIP-seq
MIRT815468	hsa-miR-2355-5p	CLIP-seq
MIRT815497	hsa-miR-3126-5p	CLIP-seq
MIRT815469	hsa-miR-3135b	CLIP-seq
MIRT815498	hsa-miR-3150a-3p	CLIP-seq
MIRT815499	hsa-miR-3175	CLIP-seq
MIRT815500	hsa-miR-3190	CLIP-seq
MIRT815501	hsa-miR-3194-3p	CLIP-seq
MIRT815502	hsa-miR-3202	CLIP-seq
MIRT815503	hsa-miR-3612	CLIP-seq
MIRT815504	hsa-miR-3622b-5p	CLIP-seq
MIRT815505	hsa-miR-3663-3p	CLIP-seq
MIRT815506	hsa-miR-3670	CLIP-seq
MIRT815507	hsa-miR-4533	CLIP-seq
MIRT815508	hsa-miR-4694-5p	CLIP-seq
MIRT815477	hsa-miR-4722-5p	CLIP-seq
MIRT815509	hsa-miR-4728-5p	CLIP-seq
MIRT815510	hsa-miR-4758-3p	CLIP-seq
MIRT815479	hsa-miR-4768-3p	CLIP-seq
MIRT815511	hsa-miR-4783-3p	CLIP-seq
MIRT815512	hsa-miR-650	CLIP-seq
MIRT815513	hsa-miR-658	CLIP-seq
MIRT815514	hsa-miR-939	CLIP-seq
MIRT815515	hsa-miR-940	CLIP-seq
MIRT1941247	hsa-miR-3065-3p	CLIP-seq
MIRT1941248	hsa-miR-3689d	CLIP-seq
MIRT2180004	hsa-miR-1293	CLIP-seq
MIRT2180005	hsa-miR-146b-3p	CLIP-seq
MIRT2180006	hsa-miR-181a	CLIP-seq
MIRT2180007	hsa-miR-181b	CLIP-seq
MIRT2180008	hsa-miR-181c	CLIP-seq
MIRT2180009	hsa-miR-181d	CLIP-seq
MIRT2180010	hsa-miR-2113	CLIP-seq
MIRT2180011	hsa-miR-3173-5p	CLIP-seq
MIRT2180012	hsa-miR-323-5p	CLIP-seq
MIRT2180013	hsa-miR-342-5p	CLIP-seq
MIRT2180014	hsa-miR-3618	CLIP-seq
MIRT2180015	hsa-miR-4262	CLIP-seq
MIRT815486	hsa-miR-4447	CLIP-seq
MIRT815488	hsa-miR-4472	CLIP-seq
MIRT2180016	hsa-miR-4483	CLIP-seq
MIRT2180017	hsa-miR-4651	CLIP-seq
MIRT2180018	hsa-miR-4664-5p	CLIP-seq
MIRT2180019	hsa-miR-4675	CLIP-seq
MIRT2180020	hsa-miR-4711-3p	CLIP-seq
MIRT2180021	hsa-miR-4741	CLIP-seq
MIRT2180022	hsa-miR-4793-3p	CLIP-seq
MIRT2180023	hsa-miR-592	CLIP-seq
MIRT2180024	hsa-miR-593	CLIP-seq
MIRT2180025	hsa-miR-599	CLIP-seq
MIRT2180026	hsa-miR-608	CLIP-seq
MIRT2180027	hsa-miR-874	CLIP-seq
MIRT2180028	hsa-miR-934	CLIP-seq
MIRT815485	hsa-miR-361-3p	CLIP-seq
MIRT815495	hsa-miR-1827	CLIP-seq
MIRT815496	hsa-miR-219-1-3p	CLIP-seq
MIRT815503	hsa-miR-3612	CLIP-seq
MIRT815505	hsa-miR-3663-3p	CLIP-seq
MIRT815477	hsa-miR-4722-5p	CLIP-seq
MIRT815479	hsa-miR-4768-3p	CLIP-seq
MIRT815512	hsa-miR-650	CLIP-seq
MIRT815513	hsa-miR-658	CLIP-seq
MIRT815515	hsa-miR-940	CLIP-seq
MIRT2483421	hsa-miR-125a-3p	CLIP-seq
MIRT2483422	hsa-miR-3934	CLIP-seq
MIRT2483423	hsa-miR-4419a	CLIP-seq
MIRT815473	hsa-miR-4434	CLIP-seq
MIRT2483424	hsa-miR-4510	CLIP-seq
MIRT815475	hsa-miR-4516	CLIP-seq
MIRT2483425	hsa-miR-4687-5p	CLIP-seq
MIRT2483426	hsa-miR-764	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	IEA
GO:0005515	Function	Protein binding	IPI	11157984, 11696321, 12598619, 15289329, 16189514, 17003044, 18448434, 19171758, 19460367, 19564905, 19933840, 20936779, 21311754, 24189400, 24658140, 25416956, 25519916, 25814554, 28514442, 31980649
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	TAS	10343108
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	19366662
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005912	Component	Adherens junction	HDA	25468996
GO:0007009	Process	Plasma membrane organization	IEA
GO:0007409	Process	Axonogenesis	TAS	10343108
GO:0008022	Function	Protein C-terminus binding	TAS	10343108
GO:0008093	Function	Cytoskeletal anchor activity	IEA
GO:0008286	Process	Insulin receptor signaling pathway	TAS	10343108
GO:0008360	Process	Regulation of cell shape	ISS
GO:0009617	Process	Response to bacterium	IMP	19366662
GO:0015629	Component	Actin cytoskeleton	IDA	19366662
GO:0030175	Component	Filopodium	IEA
GO:0030838	Process	Positive regulation of actin filament polymerization	IBA	21873635
GO:0032956	Process	Regulation of actin cytoskeleton organization	IMP	19366662
GO:0038096	Process	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
GO:0042802	Function	Identical protein binding	IPI	11696321, 14752106, 25416956
GO:0048010	Process	Vascular endothelial growth factor receptor signaling pathway	TAS
GO:0051017	Process	Actin filament bundle assembly	IBA	21873635
GO:0051017	Process	Actin filament bundle assembly	ISS
GO:0051764	Process	Actin crosslink formation	IBA	21873635
GO:0051764	Process	Actin crosslink formation	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0070064	Function	Proline-rich region binding	IDA	19366662
GO:0098609	Process	Cell-cell adhesion	IEA
GO:0098641	Function	Cadherin binding involved in cell-cell adhesion	HDA	25468996
GO:2000251	Process	Positive regulation of actin cytoskeleton reorganization	IBA	21873635

MIM	HGNC	e!Ensembl
605475	947	ENSG00000175866

Protein

UniProt ID

Q9UQB8

Protein name

BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58)

Protein function

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin c

PDB

1WDZ , 1Y2O , 2YKT , 3RNJ , 4JS0 , 6BCR , 6BCY , 6BD1 , 6BD2 , 6BQT , 6ZEG , 6ZEI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08397	IMD	17 → 237	IRSp53/MIM homology domain	Family
PF07653	SH3_2	378 → 435	Variant SH3 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. {EC

Sequence

MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG
ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL
KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS
DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA
VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN
GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKT
LPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEK
TKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPA
QTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGRE
HGDGSARTLAGR

Sequence length

552

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	Source
Unknown
Neuroticism	Neuroticism		GWAS
Breast cancer	Breast cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Metabolic Syndrome	Metabolic Syndrome		GWAS

Show/Hide Text Mining Associations (21)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Inhibit	23537733
Attention Deficit Disorder with Hyperactivity	Associate	24377651, 28938222
Auditory Perceptual Disorders	Associate	24377651
Breast Neoplasms	Associate	29871690, 33216456
Carcinoma Hepatocellular	Stimulate	34616498
Cognition Disorders	Associate	37211381
Colorectal Neoplasms	Associate	35159257
Depressive Disorder	Associate	32681239
Esophageal Squamous Cell Carcinoma	Associate	32375686
Hemochromatosis	Associate	27285756
Infections	Associate	20585556
Keratitis Dendritic	Associate	28195572
Neoplasm Metastasis	Inhibit	34616498
Neoplasms	Associate	28489605, 40596964
Obesity	Associate	36839421
Pain	Associate	32681239
Pulmonary Disease Chronic Obstructive	Associate	34523824
Schizophrenia	Associate	28195572
Sezary Syndrome	Associate	28489605
Urinary Bladder Neoplasms	Associate	40596964
Weight Loss	Associate	34523824

BAIAP2 (BAR/IMD domain containing adaptor protein 2)