B3GAT2 (beta-1,3-glucuronyltransferase 2)

Gene

• Entrez ID: 135152
• Gene name: Beta-1,3-glucuronyltransferase 2
• Gene symbol: B3GAT2
• Synonyms (NCBI Gene): GLCATS
• Chromosome: 6
• Chromosome location: 6q13
• Summary: The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4G

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT539000	hsa-miR-4310	PAR-CLIP	22012620
MIRT538999	hsa-miR-7157-5p	PAR-CLIP	22012620
MIRT538998	hsa-miR-4530	PAR-CLIP	22012620
MIRT538997	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT538996	hsa-miR-766-3p	PAR-CLIP	22012620
MIRT538994	hsa-miR-4326	PAR-CLIP	22012620
MIRT538995	hsa-miR-4691-5p	PAR-CLIP	22012620
MIRT538993	hsa-miR-6792-3p	PAR-CLIP	22012620
MIRT538992	hsa-miR-6749-3p	PAR-CLIP	22012620
MIRT539000	hsa-miR-4310	PAR-CLIP	22012620
MIRT538999	hsa-miR-7157-5p	PAR-CLIP	22012620
MIRT538998	hsa-miR-4530	PAR-CLIP	22012620
MIRT538997	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT538996	hsa-miR-766-3p	PAR-CLIP	22012620
MIRT538994	hsa-miR-4326	PAR-CLIP	22012620
MIRT538995	hsa-miR-4691-5p	PAR-CLIP	22012620
MIRT538993	hsa-miR-6792-3p	PAR-CLIP	22012620
MIRT538992	hsa-miR-6749-3p	PAR-CLIP	22012620
MIRT813139	hsa-miR-298	CLIP-seq
MIRT813140	hsa-miR-3123	CLIP-seq
MIRT813141	hsa-miR-3613-5p	CLIP-seq
MIRT813142	hsa-miR-3674	CLIP-seq
MIRT813143	hsa-miR-3925-5p	CLIP-seq
MIRT813144	hsa-miR-4732-5p	CLIP-seq
MIRT813145	hsa-miR-570	CLIP-seq
MIRT2444558	hsa-miR-1245b-3p	CLIP-seq
MIRT2444559	hsa-miR-136	CLIP-seq
MIRT2444560	hsa-miR-2964a-5p	CLIP-seq
MIRT2444561	hsa-miR-4718	CLIP-seq
MIRT2444558	hsa-miR-1245b-3p	CLIP-seq
MIRT2444559	hsa-miR-136	CLIP-seq
MIRT2444560	hsa-miR-2964a-5p	CLIP-seq
MIRT2482860	hsa-miR-3137	CLIP-seq
MIRT2482861	hsa-miR-3140-5p	CLIP-seq
MIRT2482862	hsa-miR-3194-3p	CLIP-seq
MIRT2444561	hsa-miR-4718	CLIP-seq
MIRT2482863	hsa-miR-4724-5p	CLIP-seq
MIRT2482864	hsa-miR-495	CLIP-seq
MIRT2444558	hsa-miR-1245b-3p	CLIP-seq
MIRT2444559	hsa-miR-136	CLIP-seq
MIRT2444560	hsa-miR-2964a-5p	CLIP-seq
MIRT2482860	hsa-miR-3137	CLIP-seq
MIRT2482861	hsa-miR-3140-5p	CLIP-seq
MIRT2482862	hsa-miR-3194-3p	CLIP-seq
MIRT2444561	hsa-miR-4718	CLIP-seq
MIRT2482863	hsa-miR-4724-5p	CLIP-seq
MIRT2482864	hsa-miR-495	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0005975	Process	Carbohydrate metabolic process	IBA
GO:0006486	Process	Protein glycosylation	IEA
GO:0015018	Function	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA
GO:0015018	Function	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IEA
GO:0015018	Function	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	ISS
GO:0016020	Component	Membrane	IEA
GO:0016051	Process	Carbohydrate biosynthetic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IBA

Other IDs

• MIM: 607497
• HGNC: 922
• e!Ensembl: ENSG00000112309

Protein

• UniProt ID: Q9NPZ5
• Protein name: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 2) (GlcAT-D) (UDP-glucuronosyltransferase S) (GlcAT-S) (Glucuronosyltransferase S)
• Protein function: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins.
• PDB: 2D0J
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03360	Glyco_transf_43	101 → 304	Glycosyltransferase family 43	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the trachea, retina, spinal cord, hippocampus and other brain regions, and, at lower levels, in testis and ovary.
• Sequence:

  MKSALFTRFFILLPWILIVIIMLDVDTRRPVPPLTPRPYFSPYAVGRGGARLPLRRGGPA
  HGTQKRNQSRPQPQPEPQLPTIYAITPTYSRPVQKAELTRLANTFRQVAQLHWILVEDAA
  ARSELVSRFLARAGLPSTHLHVPTPRRYKRPGLPRATEQRNAGLAWLRQRHQHQRAQPGV
  LFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRYERPLVENGKVVGWYTGWRADRPF
  AIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESDFLKQITTVEELEPKANNCTKVLVWH
  TRTEKVNLANEPKYHLDTVKIEV

• Sequence length: 323