Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
493
Gene name Gene Name - the full gene name approved by the HGNC.
ATPase plasma membrane Ca2+ transporting 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ATP2B4
Synonyms (NCBI Gene) Gene synonyms aliases
ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017163 hsa-miR-335-5p Microarray 18185580
MIRT023603 hsa-miR-1-3p Proteomics 18668040
MIRT030786 hsa-miR-21-5p Microarray 18591254
MIRT038088 hsa-miR-423-5p CLASH 23622248
MIRT712582 hsa-miR-6752-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003407 Process Neural retina development IEA
GO:0005388 Function Calcium transmembrane transporter activity, phosphorylative mechanism IBA 21873635
GO:0005388 Function Calcium transmembrane transporter activity, phosphorylative mechanism IMP 8530416
GO:0005515 Function Protein binding IPI 17242280, 17689535, 22084111, 25906147
GO:0005516 Function Calmodulin binding IDA 8530416
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
108732 817 ENSG00000058668
Protein
UniProt ID P23634
Protein name Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)
Protein function Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motil
PDB 1CFF , 2KNE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00690 Cation_ATPase_N 46 116 Cation transporter/ATPase, N-terminus Domain
PF00122 E1-E2_ATPase 185 301 Family
PF00122 E1-E2_ATPase 335 443 Family
PF13246 Cation_ATPase 508 604 Family
PF00702 Hydrolase 633 797 Domain
PF00689 Cation_ATPase_C 867 1049 Cation transporting ATPase, C-terminus Family
PF12424 ATP_Ca_trans_C 1089 1125 Plasma membrane calcium transporter ATPase C terminal Family
PF12424 ATP_Ca_trans_C 1126 1171 Plasma membrane calcium transporter ATPase C terminal Family
Tissue specificity TISSUE SPECIFICITY: Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex. {ECO:0000269
Sequence
MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGGVQNLCSRLKT
SPVEGLSGNPADLEKRRQVFGHNVIPPKKPKTFLELVWEALQDVTLIILEIAAIIS
LVLS
FYRPAGEENELCGQVATTPEDENEAQAGWIEGAAILFSVIIVVLVTAFNDWSKEKQFRGL
QCRIEQEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLT
GESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKK
G
KKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKSVLQGKLTRLA
VQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYIQYFVKFFIIGITVLVVA
VPEGLPLAVTISLAYSVKKMMKD
NNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQA
YIGGIHYRQIPSPDVFLPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALL
GFVTDLKQDYQAVRNEVPEEKLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRK
CNRI
LDRKGEAVPFKNKDRDDMVRTVIEPMACDGLRTICIAYRDFDDTEPSWDNENEILT
ELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFL
CLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVV
AVTGDGTNDGPALKKAD
VGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSI
SKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLL
KRRPYGRNKPLISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHY
TIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFS
CTSLSLSQWLWCLFIGIGELLWGQFISAI
PTRSLKFLKEAGHGTTKEEITKDAEGLDEID
HAEMELRRGQILWFRGLNRIQTQIDVINTFQTGASFKGVLRRQNMGQHLDVKLVPSSSYI
KVVKAFHSSLHESIQKPYNQKSIHSFMTHPE
FAIEEELPRTPLLDEEEEENPDKASKFGT
RVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQSLETSV
Sequence length 1241
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acute Kidney Injury Associate 25906147
Alzheimer Disease Associate 28800327
Arrhythmias Cardiac Associate 26448358
Breast Neoplasms Associate 22733819, 24439526
Breast Neoplasms Inhibit 30352569
Burkitt Lymphoma Associate 30849090
Carcinoma Pancreatic Ductal Stimulate 36876504
Cardiomegaly Associate 25906147
Developmental Dysplasia of the Hip Associate 28327142, 34174923
Diabetes Mellitus Stimulate 17957572