Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	489
Gene name Gene Name - the full gene name approved by the HGNC.	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ATP2A3
Synonyms (NCBI Gene) Gene synonyms aliases	SERCA3
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to

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miRTarBase ID	miRNA	Experiments	Reference
MIRT489870	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT489869	hsa-miR-1321	PAR-CLIP	23592263
MIRT489868	hsa-miR-4739	PAR-CLIP	23592263
MIRT489867	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT489865	hsa-miR-4270	PAR-CLIP	23592263
MIRT489866	hsa-miR-4441	PAR-CLIP	23592263
MIRT489864	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT489863	hsa-miR-4419a	PAR-CLIP	23592263
MIRT489862	hsa-miR-4510	PAR-CLIP	23592263
MIRT489861	hsa-miR-6127	PAR-CLIP	23592263
MIRT489860	hsa-miR-6129	PAR-CLIP	23592263
MIRT489859	hsa-miR-6130	PAR-CLIP	23592263
MIRT489858	hsa-miR-6133	PAR-CLIP	23592263
MIRT489857	hsa-miR-938	PAR-CLIP	23592263
MIRT489856	hsa-miR-6886-3p	PAR-CLIP	23592263
MIRT489855	hsa-miR-3656	PAR-CLIP	23592263
MIRT489854	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT489853	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT489851	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT489852	hsa-miR-8085	PAR-CLIP	23592263
MIRT489850	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT489849	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT489848	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT489847	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT441153	hsa-miR-127-5p	HITS-CLIP	24374217
MIRT441153	hsa-miR-127-5p	HITS-CLIP	24374217
MIRT489870	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT489869	hsa-miR-1321	PAR-CLIP	23592263
MIRT489868	hsa-miR-4739	PAR-CLIP	23592263
MIRT489867	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT489865	hsa-miR-4270	PAR-CLIP	23592263
MIRT489866	hsa-miR-4441	PAR-CLIP	23592263
MIRT489864	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT489863	hsa-miR-4419a	PAR-CLIP	23592263
MIRT489862	hsa-miR-4510	PAR-CLIP	23592263
MIRT489861	hsa-miR-6127	PAR-CLIP	23592263
MIRT489860	hsa-miR-6129	PAR-CLIP	23592263
MIRT489859	hsa-miR-6130	PAR-CLIP	23592263
MIRT489858	hsa-miR-6133	PAR-CLIP	23592263
MIRT489857	hsa-miR-938	PAR-CLIP	23592263
MIRT489856	hsa-miR-6886-3p	PAR-CLIP	23592263
MIRT489855	hsa-miR-3656	PAR-CLIP	23592263
MIRT489854	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT489853	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT489851	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT489852	hsa-miR-8085	PAR-CLIP	23592263
MIRT489850	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT489849	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT489848	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT489847	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT807424	hsa-miR-1184	CLIP-seq
MIRT807425	hsa-miR-1205	CLIP-seq
MIRT807426	hsa-miR-1252	CLIP-seq
MIRT807427	hsa-miR-1915	CLIP-seq
MIRT807428	hsa-miR-1972	CLIP-seq
MIRT807429	hsa-miR-216b	CLIP-seq
MIRT807430	hsa-miR-3144-5p	CLIP-seq
MIRT807431	hsa-miR-3158-5p	CLIP-seq
MIRT807432	hsa-miR-3190	CLIP-seq
MIRT807433	hsa-miR-3191	CLIP-seq
MIRT807434	hsa-miR-3615	CLIP-seq
MIRT807435	hsa-miR-4267	CLIP-seq
MIRT807436	hsa-miR-4269	CLIP-seq
MIRT807437	hsa-miR-4537	CLIP-seq
MIRT807438	hsa-miR-4636	CLIP-seq
MIRT807439	hsa-miR-4652-5p	CLIP-seq
MIRT807440	hsa-miR-4716-3p	CLIP-seq
MIRT807441	hsa-miR-4723-5p	CLIP-seq
MIRT807442	hsa-miR-4726-3p	CLIP-seq
MIRT807443	hsa-miR-4752	CLIP-seq
MIRT807444	hsa-miR-4793-3p	CLIP-seq
MIRT807445	hsa-miR-4795-5p	CLIP-seq
MIRT807446	hsa-miR-491-5p	CLIP-seq
MIRT807447	hsa-miR-671-5p	CLIP-seq
MIRT807448	hsa-miR-759	CLIP-seq
MIRT807449	hsa-miR-766	CLIP-seq
MIRT807450	hsa-miR-939	CLIP-seq
MIRT807451	hsa-miR-129-5p	CLIP-seq
MIRT807452	hsa-miR-190	CLIP-seq
MIRT807453	hsa-miR-190b	CLIP-seq
MIRT807454	hsa-miR-214	CLIP-seq
MIRT807455	hsa-miR-3130-3p	CLIP-seq
MIRT807456	hsa-miR-3163	CLIP-seq
MIRT807457	hsa-miR-3183	CLIP-seq
MIRT807458	hsa-miR-320a	CLIP-seq
MIRT807459	hsa-miR-320b	CLIP-seq
MIRT807460	hsa-miR-320c	CLIP-seq
MIRT807461	hsa-miR-320d	CLIP-seq
MIRT807462	hsa-miR-338-3p	CLIP-seq
MIRT807463	hsa-miR-3619-5p	CLIP-seq
MIRT807464	hsa-miR-3665	CLIP-seq
MIRT807465	hsa-miR-3973	CLIP-seq
MIRT807466	hsa-miR-4326	CLIP-seq
MIRT807467	hsa-miR-4424	CLIP-seq
MIRT807468	hsa-miR-4429	CLIP-seq
MIRT807469	hsa-miR-4530	CLIP-seq
MIRT807470	hsa-miR-4668-3p	CLIP-seq
MIRT807471	hsa-miR-4682	CLIP-seq
MIRT807472	hsa-miR-4691-5p	CLIP-seq
MIRT807473	hsa-miR-4723-3p	CLIP-seq
MIRT807474	hsa-miR-4757-3p	CLIP-seq
MIRT807475	hsa-miR-4776-3p	CLIP-seq
MIRT807444	hsa-miR-4793-3p	CLIP-seq
MIRT807476	hsa-miR-544	CLIP-seq
MIRT807477	hsa-miR-548p	CLIP-seq
MIRT807478	hsa-miR-562	CLIP-seq
MIRT807479	hsa-miR-622	CLIP-seq
MIRT807480	hsa-miR-657	CLIP-seq
MIRT807481	hsa-miR-761	CLIP-seq
MIRT807449	hsa-miR-766	CLIP-seq
MIRT807424	hsa-miR-1184	CLIP-seq
MIRT807425	hsa-miR-1205	CLIP-seq
MIRT1938405	hsa-miR-1275	CLIP-seq
MIRT1938406	hsa-miR-1587	CLIP-seq
MIRT807452	hsa-miR-190	CLIP-seq
MIRT807453	hsa-miR-190b	CLIP-seq
MIRT1938407	hsa-miR-1976	CLIP-seq
MIRT807454	hsa-miR-214	CLIP-seq
MIRT1938408	hsa-miR-299-3p	CLIP-seq
MIRT1938409	hsa-miR-3132	CLIP-seq
MIRT1938410	hsa-miR-3151	CLIP-seq
MIRT1938411	hsa-miR-3153	CLIP-seq
MIRT1938412	hsa-miR-3154	CLIP-seq
MIRT1938413	hsa-miR-3157-5p	CLIP-seq
MIRT807431	hsa-miR-3158-5p	CLIP-seq
MIRT807456	hsa-miR-3163	CLIP-seq
MIRT807457	hsa-miR-3183	CLIP-seq
MIRT1938414	hsa-miR-3606	CLIP-seq
MIRT807463	hsa-miR-3619-5p	CLIP-seq
MIRT1938415	hsa-miR-3657	CLIP-seq
MIRT1938416	hsa-miR-378g	CLIP-seq
MIRT1938417	hsa-miR-3913-3p	CLIP-seq
MIRT1938418	hsa-miR-3929	CLIP-seq
MIRT1938419	hsa-miR-4257	CLIP-seq
MIRT1938420	hsa-miR-4290	CLIP-seq
MIRT807466	hsa-miR-4326	CLIP-seq
MIRT1938421	hsa-miR-4419b	CLIP-seq
MIRT1938422	hsa-miR-4440	CLIP-seq
MIRT1938423	hsa-miR-4447	CLIP-seq
MIRT1938424	hsa-miR-4448	CLIP-seq
MIRT1938425	hsa-miR-4472	CLIP-seq
MIRT1938426	hsa-miR-4478	CLIP-seq
MIRT1938427	hsa-miR-4492	CLIP-seq
MIRT1938428	hsa-miR-4496	CLIP-seq
MIRT1938429	hsa-miR-4498	CLIP-seq
MIRT1938430	hsa-miR-4505	CLIP-seq
MIRT1938431	hsa-miR-4525	CLIP-seq
MIRT1938432	hsa-miR-4529-5p	CLIP-seq
MIRT1938433	hsa-miR-4650-3p	CLIP-seq
MIRT807439	hsa-miR-4652-5p	CLIP-seq
MIRT1938434	hsa-miR-4656	CLIP-seq
MIRT1938435	hsa-miR-4665-5p	CLIP-seq
MIRT1938436	hsa-miR-4667-3p	CLIP-seq
MIRT807470	hsa-miR-4668-3p	CLIP-seq
MIRT1938437	hsa-miR-4669	CLIP-seq
MIRT1938438	hsa-miR-4675	CLIP-seq
MIRT1938439	hsa-miR-4691-3p	CLIP-seq
MIRT807472	hsa-miR-4691-5p	CLIP-seq
MIRT1938440	hsa-miR-4722-3p	CLIP-seq
MIRT807473	hsa-miR-4723-3p	CLIP-seq
MIRT807441	hsa-miR-4723-5p	CLIP-seq
MIRT1938441	hsa-miR-4741	CLIP-seq
MIRT1938442	hsa-miR-4755-3p	CLIP-seq
MIRT807474	hsa-miR-4757-3p	CLIP-seq
MIRT1938443	hsa-miR-4764-5p	CLIP-seq
MIRT1938444	hsa-miR-4768-5p	CLIP-seq
MIRT1938445	hsa-miR-489	CLIP-seq
MIRT807446	hsa-miR-491-5p	CLIP-seq
MIRT1938446	hsa-miR-501-5p	CLIP-seq
MIRT1938447	hsa-miR-581	CLIP-seq
MIRT1938448	hsa-miR-592	CLIP-seq
MIRT1938449	hsa-miR-599	CLIP-seq
MIRT1938450	hsa-miR-625	CLIP-seq
MIRT1938451	hsa-miR-627	CLIP-seq
MIRT807481	hsa-miR-761	CLIP-seq
MIRT1938452	hsa-miR-762	CLIP-seq
MIRT1938453	hsa-miR-921	CLIP-seq
MIRT1938454	hsa-miR-924	CLIP-seq
MIRT807451	hsa-miR-129-5p	CLIP-seq
MIRT1938407	hsa-miR-1976	CLIP-seq
MIRT807454	hsa-miR-214	CLIP-seq
MIRT807455	hsa-miR-3130-3p	CLIP-seq
MIRT807456	hsa-miR-3163	CLIP-seq
MIRT2177797	hsa-miR-3189-3p	CLIP-seq
MIRT2177798	hsa-miR-361-3p	CLIP-seq
MIRT2177799	hsa-miR-3617	CLIP-seq
MIRT807463	hsa-miR-3619-5p	CLIP-seq
MIRT2177800	hsa-miR-362-5p	CLIP-seq
MIRT807464	hsa-miR-3665	CLIP-seq
MIRT2177801	hsa-miR-3667-5p	CLIP-seq
MIRT2177802	hsa-miR-3677-5p	CLIP-seq
MIRT2177803	hsa-miR-370	CLIP-seq
MIRT2177804	hsa-miR-3918	CLIP-seq
MIRT2177805	hsa-miR-3926	CLIP-seq
MIRT2177806	hsa-miR-4286	CLIP-seq
MIRT2177807	hsa-miR-4639-5p	CLIP-seq
MIRT807470	hsa-miR-4668-3p	CLIP-seq
MIRT1938444	hsa-miR-4768-5p	CLIP-seq
MIRT807475	hsa-miR-4776-3p	CLIP-seq
MIRT807444	hsa-miR-4793-3p	CLIP-seq
MIRT2177808	hsa-miR-500a	CLIP-seq
MIRT2177809	hsa-miR-500b	CLIP-seq
MIRT807476	hsa-miR-544	CLIP-seq
MIRT2177810	hsa-miR-548s	CLIP-seq
MIRT807479	hsa-miR-622	CLIP-seq
MIRT2177811	hsa-miR-641	CLIP-seq
MIRT807480	hsa-miR-657	CLIP-seq
MIRT807481	hsa-miR-761	CLIP-seq
MIRT2444376	hsa-miR-1237	CLIP-seq
MIRT807427	hsa-miR-1915	CLIP-seq
MIRT2444377	hsa-miR-3127-3p	CLIP-seq
MIRT2177798	hsa-miR-361-3p	CLIP-seq
MIRT2444378	hsa-miR-4685-5p	CLIP-seq
MIRT2444379	hsa-miR-4762-3p	CLIP-seq
MIRT807454	hsa-miR-214	CLIP-seq
MIRT807463	hsa-miR-3619-5p	CLIP-seq
MIRT807481	hsa-miR-761	CLIP-seq
MIRT807454	hsa-miR-214	CLIP-seq
MIRT807463	hsa-miR-3619-5p	CLIP-seq
MIRT807481	hsa-miR-761	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
SP1	Activation	22851172

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005388	Function	Calcium transmembrane transporter activity, phosphorylative mechanism	IBA	21873635
GO:0005388	Function	Calcium transmembrane transporter activity, phosphorylative mechanism	IDA	9843705
GO:0005524	Function	ATP binding	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	8809064
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006816	Process	Calcium ion transport	TAS	8809064
GO:0006874	Process	Cellular calcium ion homeostasis	IBA	21873635
GO:0006874	Process	Cellular calcium ion homeostasis	IMP	18068335
GO:0006919	Process	Activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	16725111
GO:0008553	Function	Proton-exporting ATPase activity, phosphorylative mechanism	IBA	21873635
GO:0008656	Function	Cysteine-type endopeptidase activator activity involved in apoptotic process	IDA	16725111
GO:0015085	Function	Calcium ion transmembrane transporter activity	IDA	11956212, 15028735
GO:0016021	Component	Integral component of membrane	IEA
GO:0016529	Component	Sarcoplasmic reticulum	IDA	8809064
GO:0016887	Function	ATPase activity	IBA	21873635
GO:0030899	Function	Calcium-dependent ATPase activity	IDA	9843705
GO:0031090	Component	Organelle membrane	IDA	15028735
GO:0031095	Component	Platelet dense tubular network membrane	TAS
GO:0031965	Component	Nuclear membrane	IEA
GO:0033017	Component	Sarcoplasmic reticulum membrane	IBA	21873635
GO:0034220	Process	Ion transmembrane transport	TAS
GO:0044325	Function	Ion channel binding	IPI	18068335
GO:0046872	Function	Metal ion binding	IEA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA	16725111
GO:0070588	Process	Calcium ion transmembrane transport	IBA	21873635
GO:0070588	Process	Calcium ion transmembrane transport	IDA	9843705, 11956212
GO:0150104	Process	Transport across blood-brain barrier	NAS	30280653
GO:1900121	Process	Negative regulation of receptor binding	IMP	18068335
GO:1902600	Process	Proton transmembrane transport	IEA
GO:1903515	Process	Calcium ion transport from cytosol to endoplasmic reticulum	IDA	15028735
GO:1903779	Process	Regulation of cardiac conduction	TAS

MIM	HGNC	e!Ensembl
601929	813	ENSG00000074370

Protein

UniProt ID

Q93084

Protein name

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3)

Protein function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in m

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00690	Cation_ATPase_N	4 → 72	Cation transporter/ATPase, N-terminus	Domain
PF00122	E1-E2_ATPase	121 → 329		Family
PF13246	Cation_ATPase	418 → 528		Family
PF00689	Cation_ATPase_C	784 → 987	Cation transporting ATPase, C-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelia

Sequence

MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDL
LVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALK
EYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSIL
TGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMA
AVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFVVAEADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALC
NDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMR
KEFTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPT
SREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGML
DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDD
LSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAM
GSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAI
LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAI
GVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMA
LSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVT
PLSGRQWVVVLQISLPVILLDEALKYLSRNHMHEEMSQK

Sequence length

999

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Diabetes	Diabetes	GWAS
Atrial Fibrillation	Atrial Fibrillation	GWAS

Show/Hide Text Mining Associations (45)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	23157274
Adenoma	Inhibit	15972967
Adenomatous Polyposis Coli	Associate	15972967
Airway Remodeling	Associate	19541629
Alzheimer Disease	Inhibit	21285369, 30822648
Alzheimer Disease	Associate	28800327
Asthma	Associate	19541629
Barrett Esophagus	Associate	21829465
Breast Neoplasms	Associate	34684111, 35133336
Burkitt Lymphoma	Associate	19650915
Carcinogenesis	Inhibit	15972967
Carcinogenesis	Associate	22948776
Clear cell metastatic renal cell carcinoma	Inhibit	22948776
Colonic Diseases	Inhibit	15972967
Colonic Neoplasms	Associate	36532007, 37626132
COVID 19	Inhibit	35239653
Diabetes Mellitus	Associate	17883705, 26584293
Diabetes Mellitus Type 1	Associate	17883705
Ductus Arteriosus Patent	Associate	33837257
Gastroesophageal Reflux	Associate	21829465
Gastrointestinal Stromal Tumors	Associate	38184384
Heart Failure	Associate	28393439, 36834924
Infections	Inhibit	19650915
Leukemia	Associate	28651627
Lung Neoplasms	Associate	23157274
Lymphatic Metastasis	Associate	22948776
Metabolic Diseases	Associate	35364719
Myocardial Infarction	Associate	36073642
Neoplasm Metastasis	Associate	22948776
Neoplasms	Stimulate	22948776
Neoplasms	Inhibit	25820259
Neoplasms	Associate	35133336
Periodontitis	Associate	36894919
Peripheral Arterial Disease	Associate	26584293
Polyps	Associate	15972967
Pre Eclampsia	Associate	30415221
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	28651627
Prostatic Neoplasms	Associate	35133336
Pulmonary Disease Chronic Obstructive	Associate	15718407
Status Asthmaticus	Inhibit	19541629
Stomach Neoplasms	Associate	22948776
Stomach Ulcer	Associate	35133336
Tetralogy of Fallot	Associate	39969158
Thrombocytopenia	Associate	17883705
von Willebrand Disease Type 2	Associate	17883705

ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3)