ASPA (aspartoacylase)

Gene

• Entrez ID: 443
• Gene name: Aspartoacylase
• Gene symbol: ASPA
• Synonyms (NCBI Gene): ACY2, ASP
• Chromosome: 17
• Chromosome location: 17p13.2
• Summary: This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenge

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052301	hsa-let-7b-5p	CLASH	23622248
MIRT711580	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT711578	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT711579	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT711577	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT711576	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT711575	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT447683	hsa-miR-551b-5p	PAR-CLIP	22100165
MIRT447682	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447681	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT447683	hsa-miR-551b-5p	PAR-CLIP	22100165
MIRT447682	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447681	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT711580	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT711578	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT711579	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT711577	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT711576	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT711575	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT447683	hsa-miR-551b-5p	PAR-CLIP	22100165
MIRT447682	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447681	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT447683	hsa-miR-551b-5p	PAR-CLIP	22100165
MIRT447682	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447681	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT803104	hsa-miR-218	CLIP-seq
MIRT803105	hsa-miR-636	CLIP-seq
MIRT1937191	hsa-miR-28-5p	CLIP-seq
MIRT1937192	hsa-miR-3139	CLIP-seq
MIRT1937193	hsa-miR-708	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004046	Function	Aminoacylase activity	TAS	8252036
GO:0005515	Function	Protein binding	IPI	22284616, 25416956, 25910212, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006533	Process	Aspartate catabolic process	TAS	8252036
GO:0008652	Process	Cellular amino acid biosynthetic process	TAS
GO:0016788	Function	Hydrolase activity, acting on ester bonds	IEA
GO:0016811	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IBA	21873635
GO:0019807	Function	Aspartoacylase activity	IEA
GO:0022010	Process	Central nervous system myelination	IEA
GO:0042802	Function	Identical protein binding	IPI	16189514, 17194761
GO:0046872	Function	Metal ion binding	IEA
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	IEA

Other IDs

• MIM: 608034
• HGNC: 756
• e!Ensembl: ENSG00000108381

Protein

• UniProt ID: P45381
• Protein name: Aspartoacylase (EC 3.5.1.15) (Aminoacylase-2) (ACY-2)
• Protein function: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues
• PDB: 2I3C, 2O4H, 2O53, 2Q51, 4MRI, 4MXU, 4NFR, 4TNU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04952	AstE_AspA	10 → 301	Succinylglutamate desuccinylase / Aspartoacylase family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Brain white matter, skeletal muscle, kidney, adrenal glands, lung and liver. {ECO:0000269|PubMed:8252036}.
• Sequence:

  MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
  CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS
  NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG
  PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA
  AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK
  LTLNAKSIRCCLH

• Sequence length: 313