ARHGAP29 (Rho GTPase activating protein 29)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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9411 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Rho GTPase activating protein 29 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ARHGAP29 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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PARG1 |
Chromosome
Chromosome number
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1 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1p22.1-p21.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for R |
SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | ||||||||||||||||
UniProt ID | Q52LW3 | |||||||||||||||
Protein name | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | |||||||||||||||
Protein function | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RAS | |||||||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney. {ECO:0000269|PubMed:9305890}. | |||||||||||||||
Sequence |
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Sequence length | 1261 | |||||||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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