Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
208
Gene name Gene Name - the full gene name approved by the HGNC.
AKT serine/threonine kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
AKT2
Synonyms (NCBI Gene) Gene synonyms aliases
HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA
Disease Acronyms (UniProt) Disease acronyms from UniProt database
HIHGHH
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of can
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs121434593 C>T Pathogenic Coding sequence variant, missense variant
rs387906659 C>A,T Pathogenic Stop gained, coding sequence variant, missense variant, 5 prime UTR variant
rs778561687 C>A,T Likely-pathogenic Missense variant, coding sequence variant
rs1057519754 T>C Likely-pathogenic Coding sequence variant, intron variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000425 hsa-miR-184 qRT-PCR, Luciferase reporter assay, Western blot 20409325
MIRT006104 hsa-miR-203a-3p Northern blot, qRT-PCR, Western blot 21354697
MIRT006104 hsa-miR-203a-3p Northern blot, qRT-PCR, Western blot 21354697
MIRT006473 hsa-miR-708-5p PC3 22552290
MIRT006473 hsa-miR-708-5p PC3 22552290
Transcription factors
Transcription factor Regulation Reference
NFKB1 Repression 20514445
PROX1 Repression 22982861
RELA Repression 20514445
TWIST1 Activation 21876555;22982861
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001934 Process Positive regulation of protein phosphorylation ISS
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 10983986, 16540465
GO:0004674 Function Protein serine/threonine kinase activity TAS 21432781
GO:0005515 Function Protein binding IPI 10490823, 10983986, 12434148, 16417406, 16792529, 17030088, 19713527, 20059950, 20856200, 21291857, 21737686, 22939624, 23823123, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
164731 392 ENSG00000105221
Protein
UniProt ID P31751
Protein name RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta)
Protein function Serine/threonine kinase closely related to AKT1 and AKT3. All 3 enzymes, AKT1, AKT2 and AKT3, are collectively known as AKT kinase. AKT regulates many processes including metabolism, proliferation, cell survival, growth and angiogenesis, through
PDB 1GZK , 1GZN , 1GZO , 1MRV , 1MRY , 1O6K , 1O6L , 1P6S , 2JDO , 2JDR , 2UW9 , 2X39 , 2XH5 , 3D0E , 3E87 , 3E88 , 3E8D , 8Q61 , 9C1W
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00169 PH 6 108 PH domain Domain
PF00069 Pkinase 152 409 Protein kinase domain Domain
PF00433 Pkinase_C 430 475 Protein kinase C terminal domain Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Expressed in myoblasts (PubMed:17565718). {ECO:0000269|PubMed:17565718}.
Sequence
Sequence length 481
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Diabetes Mellitus diabetes mellitus, noninsulin-dependent, type 2 diabetes mellitus GenCC
Hypoinsulinemic Hypoglycemia And Hemihypertrophy hypoinsulinemic hypoglycemia and body hemihypertrophy GenCC
Associations from Text Mining
Disease Name Relationship Type References
Acanthosis Nigricans Associate 34673243
Acute Disease Associate 21590431
Acute Pain Stimulate 21590431
Adenocarcinoma of Lung Associate 29200198, 30942957, 32211805
Arthritis Rheumatoid Associate 20419126
Breast Neoplasms Associate 14680486, 19933843, 20471940, 21297943, 22809628, 23305873, 23929892, 24838891, 27097161, 27223437, 28478612, 29667444, 31781306, 32558176, 33378961
View all (2 more)
Calcinosis Cutis Associate 27067543
Carcinogenesis Associate 23449277
Carcinoma Basal Cell Associate 22082146, 23435205
Carcinoma Hepatocellular Associate 22580126, 25424347, 26254095