AGTR1 (angiotensin II receptor type 1)

Gene

• Entrez ID: 185
• Gene name: Angiotensin II receptor type 1
• Gene symbol: AGTR1
• Synonyms (NCBI Gene): AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, ATR1, HAT1R
• Chromosome: 3
• Chromosome location: 3q24
• Summary: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene enc

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs5186	A>C	Risk-factor, benign	3 prime UTR variant
rs104893677	C>T	Pathogenic	Missense variant, coding sequence variant
rs387906577	->T	Pathogenic	Coding sequence variant, frameshift variant
rs397514687	C>G,T	Pathogenic	Missense variant, coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay	17668390
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay	17668390
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay	17668390
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay	19177201
MIRT002006	hsa-miR-155-5p	Review	20026422
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR	17588946
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR	17588946
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR	17588946
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR	17588946
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR	17588946
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Real time PCR	17588946
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR, Quantitative proteomic approach, Western blot	20735984
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR, Western blot	16675453
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR, Western blot	16675453
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21310411
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21310411
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21310411
MIRT002006	hsa-miR-155-5p	Western blot	21310411
MIRT002006	hsa-miR-155-5p	Reporter assay	17588946
MIRT002006	hsa-miR-155-5p	Reporter assay	17668390
MIRT002006	hsa-miR-155-5p	Reporter assay	16675453
MIRT023107	hsa-miR-124-3p	Microarray	18668037
MIRT030131	hsa-miR-26b-5p	Microarray	19088304
MIRT002006	hsa-miR-155-5p	Luciferase reporter assay	22664914
MIRT731253	hsa-miR-410-3p	and AsPC-1"	25646808
MIRT731253	hsa-miR-410-3p	and AsPC-1"	25646808
MIRT731253	hsa-miR-410-3p	and AsPC-1"	25646808
MIRT731253	hsa-miR-410-3p	and AsPC-1"	25646808
MIRT733624	hsa-miR-34a-5p	Luciferase reporter assay, qRT-PCR, Western blot	28073349
MIRT733624	hsa-miR-34a-5p	Luciferase reporter assay, qRT-PCR, Western blot	28073349
MIRT733063	hsa-miR-155-3p	Luciferase reporter assay, qRT-PCR, Western blotting	32896760
MIRT733063	hsa-miR-155-3p	Luciferase reporter assay, qRT-PCR, Western blotting	32896760
MIRT733624	hsa-miR-34a-5p	Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR, Western blotting	33650673
MIRT773122	hsa-miR-1	CLIP-seq
MIRT773123	hsa-miR-1321	CLIP-seq
MIRT773124	hsa-miR-206	CLIP-seq
MIRT773125	hsa-miR-2117	CLIP-seq
MIRT773126	hsa-miR-2467-3p	CLIP-seq
MIRT773127	hsa-miR-3125	CLIP-seq
MIRT773128	hsa-miR-3158-5p	CLIP-seq
MIRT773129	hsa-miR-3162-5p	CLIP-seq
MIRT773130	hsa-miR-3678-3p	CLIP-seq
MIRT773131	hsa-miR-3916	CLIP-seq
MIRT773132	hsa-miR-4268	CLIP-seq
MIRT773133	hsa-miR-4273	CLIP-seq
MIRT773134	hsa-miR-4448	CLIP-seq
MIRT773135	hsa-miR-4690-5p	CLIP-seq
MIRT773136	hsa-miR-4739	CLIP-seq
MIRT773137	hsa-miR-4753-3p	CLIP-seq
MIRT773138	hsa-miR-4756-5p	CLIP-seq
MIRT773139	hsa-miR-613	CLIP-seq
MIRT773140	hsa-miR-302a	CLIP-seq
MIRT773141	hsa-miR-302b	CLIP-seq
MIRT773142	hsa-miR-302c	CLIP-seq
MIRT773143	hsa-miR-302d	CLIP-seq
MIRT773144	hsa-miR-302e	CLIP-seq
MIRT773145	hsa-miR-3606	CLIP-seq
MIRT773146	hsa-miR-3616-5p	CLIP-seq
MIRT773147	hsa-miR-3647-5p	CLIP-seq
MIRT773148	hsa-miR-372	CLIP-seq
MIRT773149	hsa-miR-373	CLIP-seq
MIRT773150	hsa-miR-4795-5p	CLIP-seq
MIRT773151	hsa-miR-512-3p	CLIP-seq
MIRT773152	hsa-miR-520a-3p	CLIP-seq
MIRT773153	hsa-miR-520b	CLIP-seq
MIRT773154	hsa-miR-520c-3p	CLIP-seq
MIRT773155	hsa-miR-520d-3p	CLIP-seq
MIRT773156	hsa-miR-520e	CLIP-seq
MIRT773157	hsa-miR-573	CLIP-seq
MIRT773158	hsa-miR-579	CLIP-seq
MIRT773123	hsa-miR-1321	CLIP-seq
MIRT773129	hsa-miR-3162-5p	CLIP-seq
MIRT773135	hsa-miR-4690-5p	CLIP-seq
MIRT773136	hsa-miR-4739	CLIP-seq
MIRT773138	hsa-miR-4756-5p	CLIP-seq
MIRT1928223	hsa-miR-3944-5p	CLIP-seq
MIRT1928224	hsa-miR-431	CLIP-seq
MIRT1928225	hsa-miR-4684-3p	CLIP-seq
MIRT1928226	hsa-miR-511	CLIP-seq
MIRT1928227	hsa-miR-518a-5p	CLIP-seq
MIRT1928228	hsa-miR-527	CLIP-seq
MIRT2471548	hsa-miR-1299	CLIP-seq
MIRT2471549	hsa-miR-1976	CLIP-seq
MIRT2471550	hsa-miR-2116	CLIP-seq
MIRT2471551	hsa-miR-3120-5p	CLIP-seq
MIRT2471552	hsa-miR-3654	CLIP-seq
MIRT1928223	hsa-miR-3944-5p	CLIP-seq
MIRT2471553	hsa-miR-3978	CLIP-seq
MIRT2471554	hsa-miR-4261	CLIP-seq
MIRT773132	hsa-miR-4268	CLIP-seq
MIRT773133	hsa-miR-4273	CLIP-seq
MIRT773134	hsa-miR-4448	CLIP-seq
MIRT2471555	hsa-miR-4520a-3p	CLIP-seq
MIRT2471556	hsa-miR-4638-3p	CLIP-seq
MIRT2471557	hsa-miR-4677-5p	CLIP-seq
MIRT2471558	hsa-miR-4680-5p	CLIP-seq
MIRT2471559	hsa-miR-4738-3p	CLIP-seq
MIRT2471560	hsa-miR-764	CLIP-seq
MIRT2471561	hsa-miR-875-3p	CLIP-seq
MIRT2471562	hsa-miR-938	CLIP-seq
MIRT2471548	hsa-miR-1299	CLIP-seq
MIRT2471549	hsa-miR-1976	CLIP-seq
MIRT2471550	hsa-miR-2116	CLIP-seq
MIRT2674753	hsa-miR-3119	CLIP-seq
MIRT2471551	hsa-miR-3120-5p	CLIP-seq
MIRT2674754	hsa-miR-3140-3p	CLIP-seq
MIRT2471552	hsa-miR-3654	CLIP-seq
MIRT2674755	hsa-miR-375	CLIP-seq
MIRT1928223	hsa-miR-3944-5p	CLIP-seq
MIRT2471553	hsa-miR-3978	CLIP-seq
MIRT2471554	hsa-miR-4261	CLIP-seq
MIRT773132	hsa-miR-4268	CLIP-seq
MIRT773133	hsa-miR-4273	CLIP-seq
MIRT1928224	hsa-miR-431	CLIP-seq
MIRT773134	hsa-miR-4448	CLIP-seq
MIRT2674756	hsa-miR-4474-3p	CLIP-seq
MIRT2471555	hsa-miR-4520a-3p	CLIP-seq
MIRT2471556	hsa-miR-4638-3p	CLIP-seq
MIRT2471557	hsa-miR-4677-5p	CLIP-seq
MIRT2471558	hsa-miR-4680-5p	CLIP-seq
MIRT1928225	hsa-miR-4684-3p	CLIP-seq
MIRT2674757	hsa-miR-4698	CLIP-seq
MIRT2471559	hsa-miR-4738-3p	CLIP-seq
MIRT1928226	hsa-miR-511	CLIP-seq
MIRT1928227	hsa-miR-518a-5p	CLIP-seq
MIRT1928228	hsa-miR-527	CLIP-seq
MIRT2471560	hsa-miR-764	CLIP-seq
MIRT2471561	hsa-miR-875-3p	CLIP-seq
MIRT2674758	hsa-miR-889	CLIP-seq
MIRT2471562	hsa-miR-938	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ETV4	Activation	8206588
HIF1A	Activation	15718424
SND1	Activation	18603592
SP1	Activation	22282354
SP1	Repression	22282354
SP1	Unknown	11072083;15507319
SP3	Unknown	15507319

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001558	Process	Regulation of cell growth	NAS	17159080
GO:0001596	Function	Angiotensin type I receptor activity	IBA
GO:0001596	Function	Angiotensin type I receptor activity	IDA	8987975, 10993080, 15611106, 25913193, 26420482, 30639100, 32079768
GO:0001596	Function	Angiotensin type I receptor activity	IPI	1378723
GO:0001822	Process	Kidney development	IMP	16116425
GO:0002018	Process	Renin-angiotensin regulation of aldosterone production	NAS	17159080
GO:0002034	Process	Maintenance of blood vessel diameter homeostasis by renin-angiotensin	IC	10993080
GO:0002034	Process	Maintenance of blood vessel diameter homeostasis by renin-angiotensin	IDA	25913193, 26420482
GO:0003081	Process	Regulation of systemic arterial blood pressure by renin-angiotensin	IC	1378723
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004945	Function	Angiotensin type II receptor activity	IDA	1567413
GO:0004945	Function	Angiotensin type II receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	1378723, 15611106, 19023134, 21412239, 22935142, 23597562, 26460884, 28298427
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IC	1378723
GO:0005886	Component	Plasma membrane	IDA	19023134, 33713620
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	1378723
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IDA	1567413
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	NAS	17159080
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	TAS	1378723
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IDA	1567413
GO:0007266	Process	Rho protein signal transduction	IDA	15611106
GO:0010744	Process	Positive regulation of macrophage derived foam cell differentiation	IMP	18971559
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	8135787
GO:0019229	Process	Regulation of vasoconstriction	IC	1378723
GO:0019229	Process	Regulation of vasoconstriction	IDA	15117835
GO:0019229	Process	Regulation of vasoconstriction	IEA
GO:0019229	Process	Regulation of vasoconstriction	NAS	17159080
GO:0019722	Process	Calcium-mediated signaling	IDA	1567413
GO:0031711	Function	Bradykinin receptor binding	IPI	10993080
GO:0034374	Process	Low-density lipoprotein particle remodeling	NAS	17069818
GO:0035813	Process	Regulation of renal sodium excretion	NAS	17159080
GO:0038166	Process	Angiotensin-activated signaling pathway	IDA	1567413
GO:0038166	Process	Angiotensin-activated signaling pathway	IMP	18971559
GO:0042127	Process	Regulation of cell population proliferation	NAS	17159080
GO:0046718	Process	Symbiont entry into host cell	IDA	33713620
GO:0046982	Function	Protein heterodimerization activity	IPI	10993080
GO:0050727	Process	Regulation of inflammatory response	IC	1378723
GO:0050729	Process	Positive regulation of inflammatory response	TAS	17159080
GO:0060326	Process	Cell chemotaxis	IDA	15635042
GO:0086097	Process	Phospholipase C-activating angiotensin-activated signaling pathway	IDA	1378723
GO:0090205	Process	Positive regulation of cholesterol metabolic process	IMP	18971559
GO:0097746	Process	Blood vessel diameter maintenance	IC	1378723
GO:1903589	Process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI	25850724
GO:2000379	Process	Positive regulation of reactive oxygen species metabolic process	TAS	17159080

Other IDs

• MIM: 106165
• HGNC: 336
• e!Ensembl: ENSG00000144891

Protein

• UniProt ID: P30556
• Protein name: Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor)
• Protein function: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:15611106, PubMed:1567413, PubMed:25913193, PubMed:26420482, PubMed:30639100, PubMed:32079768, Pub
• PDB: 4YAY, 4ZUD, 6DO1, 6OS0, 6OS1, 6OS2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	45 → 302	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Liver, lung, adrenal and adrenocortical adenomas. {ECO:0000269|PubMed:1378723}.
• Sequence:

  MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
  TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
  CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
  AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
  IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
  FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE

• Sequence length: 359

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Associated diseases

Causal
Disease merge term	Disease name	dbSNP ID	References
Renal Tubular Dysgenesis Of Genetic Origin	Renal tubular dysgenesis	rs387906577, rs104893677, rs398122935, rs397514687	N/A

Unknown
Disease merge term	Disease name	Evidence	References	Source
Hypertension	essential hypertension, genetic	N/A	N/A	GenCC

Associations from Text Mining
Disease Name	Relationship Type	References
Acrocephalosyndactylia	Associate	24167376
Acute Coronary Syndrome	Associate	31195108
Acute Lung Injury	Associate	35726726
Adenocarcinoma	Inhibit	22170435
Agnosia	Associate	38482990
Albuminuria	Associate	24225429, 30630996
Alzheimer Disease	Associate	27884212, 35969296
Aneurysm Ascending Aorta	Associate	26071572
Angina Unstable	Stimulate	28281389
Angina Unstable	Associate	29982608
Anterior Wall Myocardial Infarction	Associate	24167376
Aortic Aneurysm Abdominal	Associate	18239157, 26027897
Aortic Aneurysm Abdominal	Stimulate	26027897
Aortic Aneurysm Familial Abdominal 1	Associate	18239157, 24801553
Aortic Aneurysm Thoracic	Associate	25767191
Aortic Valve Stenosis	Associate	35341274
Arrhythmias Cardiac	Associate	22939041, 37210443
Arterio Arterial Fistula	Associate	27240348
Arteriosclerosis	Associate	33530239
Atherosclerosis	Associate	17298481, 19246543, 22362742, 23259529, 24452940, 34292876
Atrial Fibrillation	Stimulate	20080265
Atrial Fibrillation	Associate	23210602
Atrial Remodeling	Associate	20080265
Bipolar Disorder	Associate	38482990
Bone Marrow Diseases	Stimulate	31042345
Brain Diseases	Associate	24981111, 35091110
Brain Infarction	Associate	17220293
Brain Ischemia	Associate	23343134
Breast Neoplasms	Associate	19286759, 21109584, 22581182, 25077884, 27213551, 31642813
Carcinoma Hepatocellular	Associate	31538912, 38320622
Carcinoma Renal Cell	Associate	21102591, 33916968, 34671200
Carcinoma Squamous Cell	Associate	11337361
Cardiomegaly	Associate	20594303, 9822439
Cardiomyopathy Dilated	Inhibit	9815151
Cardiomyopathy Dilated with Left Ventricular Noncompaction	Associate	20975235
Cardiomyopathy Hypertrophic	Associate	19074594, 20594303, 20975235, 21163866, 9822439
Cardiovascular Diseases	Associate	10937949, 18985387, 20864943, 27342049, 28096461, 29982608, 30920415, 31538912, 34292876, 37270600
Cerebral Hemorrhage	Stimulate	15196067
Cerebral Infarction	Associate	16691016, 16775386, 24167376, 24981111, 32633380, 38025202
Cerebrovascular Disorders	Associate	17220293, 34745325
Cholangiocarcinoma	Associate	31538912
Cognition Disorders	Stimulate	38482990
Cognitive Dysfunction	Associate	19274077, 25124854
Colorectal Neoplasms	Associate	31781593
Congenital Hereditary and Neonatal Diseases and Abnormalities	Associate	39255543
Coronary Artery Disease	Associate	12975417, 24722536, 27021566, 27342049, 37270600
Coronary Disease	Associate	14627489, 15863668, 19327134, 26045830, 31538912
Coronary Disease	Inhibit	16088850
Coronary Restenosis	Associate	26261635, 32093874, 34065198
Coronary Restenosis	Stimulate	34065198
COVID 19	Associate	35091110, 35120165, 35726726
Death	Associate	17519002, 29982608, 35091110
Death Sudden Cardiac	Associate	16105049, 19074594, 19716087, 21658281, 22939041, 24167376, 29982608
Death Sudden Cardiac	Inhibit	19716087
Dementia	Inhibit	35969296
Dental Plaque	Associate	25046588
Depressive Disorder	Associate	22021115, 22703619
Diabetes Mellitus	Associate	19502258, 32306916, 33820928, 34292876, 36577936, 37996337
Diabetes Mellitus	Inhibit	23259529
Diabetes Mellitus Type 2	Associate	30630996, 32306916, 37996337
Diabetic Nephropathies	Associate	24225429, 30630996, 32370637, 37210443, 37996337
Disease	Associate	21109584
Disease Progression	Associate	20478903
Down Syndrome	Associate	17668390
Ductus Arteriosus Patent	Associate	27465141
Eclampsia	Associate	33378010
Endometrial Neoplasms	Associate	22170435
Endometriosis	Associate	22084859, 36524127
Epilepsy	Associate	32633380
Epiretinal Membrane	Associate	28276504
Esophageal Achalasia	Inhibit	24468662
Essential Hypertension	Associate	12358135, 12627871, 14627489, 15492474, 17190732, 17546276, 24992666, 25628312, 26283679, 28157766, 32555714, 35091110, 35126748, 35866766, 36577936
Failed Back Surgery Syndrome	Associate	9815151
Familial Primary Pulmonary Hypertension	Associate	19332265, 25603901
Farber Lipogranulomatosis	Associate	33541272
Fibromatosis Aggressive	Stimulate	33491484
Fibrosis	Associate	15049387, 20478903, 23484035, 24473559
Frailty	Associate	39464190
Glomerulonephritis IGA	Inhibit	15458433
Glomerulonephritis IGA	Associate	38154557
Heart Diseases	Associate	20975235, 21449976
Heart Diseases	Inhibit	9815151
Heart Failure	Associate	10937949, 18279468, 19246543, 22362742, 22939041, 24992619, 26138177, 28096461, 29982608, 35886041
Heart Failure	Inhibit	15569271, 35886041
Hepatitis E	Associate	19308748
Hippocampal Sclerosis	Associate	25124854
HIV Infections	Stimulate	37308552
Hodgkin Disease	Associate	19177201
Hyperaldosteronism	Associate	33796077
Hyperinsulinism	Stimulate	22362742
Hyperkalemia	Associate	33768328
Hyperlipoproteinemia Type II	Associate	23259529
Hypertension	Associate	11153734, 12358135, 12627871, 12631360, 12950120, 14597852, 14627489, 15492474, 15863668, 16691016, 16876684, 17334527, 17668390, 18550936, 18698212, 19246543, 19274051, 19593696, 19730394, 20811292, 20886000, 21298017, 21628354, 21846682, 22362742, 24015270, 24047102, 24981111, 25591555, 25961019, 26240115, 28096461, 30920415, 32306916, 33541272, 35091110, 35126748, 35866766, 37270600, 37525908, 38573093
Hypertension	Inhibit	28381821
Hypertension Malignant	Associate	17984617
Hypertension Pulmonary	Associate	35726726
Hypertensive Nephropathy	Associate	27756246
Hypertrophy	Associate	15049387, 19074594, 9822439
Hypertrophy Left Ventricular	Associate	15049387, 36577936, 9822439
Hypotension	Associate	27940662
Hypotrichosis	Associate	32293282
Idiopathic Pulmonary Fibrosis	Associate	24473559
Idiopathic Pulmonary Fibrosis	Stimulate	32777324
Infarction	Associate	16691016
Infertility	Associate	39255543
Inflammation	Associate	15458433, 19730394, 20478903, 20864943, 30920415, 35726726
Inflammation	Stimulate	35969296
Insulin Resistance	Associate	30920415, 32382544
Intellectual Disability	Associate	38482990
Keratoacanthoma	Associate	11337361
Kidney Diseases	Associate	11339691, 12950120, 15196067, 19327134, 20478903, 24225429, 24241364, 33768328, 34448643, 37525908, 37996337
Kidney Diseases	Inhibit	26084932
Kidney Failure Chronic	Associate	12950120, 16105049, 24977181, 29982608
Kidney Neoplasms	Associate	33768328, 37627246
Leukoencephalopathies	Associate	17220293, 19274051, 22021115
Livedoid Vasculopathy	Associate	15196067
Liver Diseases	Associate	30920415
Long QT Syndrome	Associate	16105049
Lung Injury	Associate	16691016
Marfan Syndrome	Associate	24398790
Melanoma	Associate	29558744
Metabolic Syndrome	Associate	15863668, 19619703, 26910623, 30920415
Mitral Valve Insufficiency	Associate	30581499
Mitral Valve Prolapse	Associate	11999641
Mouth Neoplasms	Associate	26342026
Multiple Myeloma	Associate	31042345
Myocardial Infarction	Associate	11324803, 21163865, 21330421, 22392878, 24167376, 29982608
Neoplasm Metastasis	Associate	30661062
Neoplasms	Associate	16434990, 18059164, 19212105, 21102591, 22581182, 27213551, 28178311, 28304186, 30661062, 31117912, 31642813, 37627246
Neoplasms	Inhibit	34671200
Nephrosis Lipoid	Associate	20478903
Nerve Degeneration	Associate	35513515
Neurocognitive Disorders	Associate	38482990
Non alcoholic Fatty Liver Disease	Associate	23484035, 27342049, 30920415
Obesity	Stimulate	22880127
Obesity	Associate	34292876, 39464190
Ovarian Diseases	Associate	19524223
Ovarian Neoplasms	Associate	16434990
Pancreatic Neoplasms	Associate	11334891
Parkinson Disease	Associate	35513515, 38272954
Paroxysmal ventricular fibrillation	Associate	27759448
Peripheral Arterial Disease	Associate	19782519
Polycystic Kidney Autosomal Dominant	Associate	12950120
Polycythemia Vera	Stimulate	17873518
Post Exercise Hypotension	Associate	27940662
Pre Eclampsia	Associate	19308748, 21436209, 23246097, 36088594, 37308552, 9719367
Pre Eclampsia	Stimulate	26574162
Prehypertension	Associate	20864943
Pressure Ulcer	Associate	20308035
Prostatic Hyperplasia	Associate	20026870
Prostatic Neoplasms	Associate	20026870, 29260398
Prostatic Neoplasms Castration Resistant	Associate	30975734
Pulmonary Arterial Hypertension	Associate	19332265, 25603901
Pulmonary Disease Chronic Obstructive	Associate	34051791
Pulmonary Edema	Associate	27732943
Pulmonary Fibrosis	Associate	35726726
Renal Insufficiency	Associate	37711897
Renal Insufficiency Chronic	Associate	19056482, 19406964, 22147663, 37996337
Retinopathy of Prematurity	Associate	18787502
Rheumatic Diseases	Associate	20080265
Sarcoidosis	Associate	9713444
Scleroderma Systemic	Associate	24473559
Shock	Associate	16691016, 16775386
Squamous Cell Carcinoma of Head and Neck	Associate	25186767, 26342026, 33513805
ST Elevation Myocardial Infarction	Associate	31195108
Stiff Skin Syndrome	Associate	14597852, 24981111, 27936341, 36577936
Stomach Neoplasms	Associate	18059164
Stroke	Stimulate	34745325
Substance Related Disorders	Associate	24452940
Symphalangism C. S. Lewis Type	Associate	16998258
Taste Disorders	Associate	33768328
Thrombosis	Associate	38025202
Thyroid Cancer Papillary	Associate	30661062, 32047817
Tuberculosis Pulmonary	Associate	38380450
Urinary Bladder Neoplasms	Associate	34898568
Vascular Diseases	Associate	22021115, 26261635, 30920415
Vascular System Injuries	Associate	38125704
Ventricular Dysfunction Left	Associate	22237156, 22297600, 26138177