ADRB1 (adrenoceptor beta 1)

Gene Gene information from NCBI Gene database.
Gene SNPs Other IDs Associated diseases
Entrez ID 153
Gene name Adrenoceptor beta 1
Gene symbol ADRB1
Synonyms (NCBI Gene)
ADRB1RB1ARBETA1ARFNSS2RHR
Chromosome 10
Chromosome location 10q25.3
Summary The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter
SNPs SNP information provided by dbSNP.
1
Gene SNPs Other IDs Associated diseases
Show/Hide all (1)
SNP ID Visualize variation Clinical significance Consequence
rs1801253 G>A,C Drug-response Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
860
Gene SNPs Other IDs Associated diseases
Show/Hide all (860)
miRTarBase ID miRNA Experiments Reference
MIRT717492 hsa-miR-188-5p HITS-CLIP 19536157
MIRT717491 hsa-miR-6866-3p HITS-CLIP 19536157
MIRT717490 hsa-miR-186-3p HITS-CLIP 19536157
MIRT717489 hsa-miR-3124-3p HITS-CLIP 19536157
MIRT717488 hsa-miR-2113 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
44
Gene SNPs Other IDs Associated diseases
Show/Hide all (44)
GO ID Ontology Definition Evidence Reference
GO:0001996 Process Positive regulation of heart rate by epinephrine-norepinephrine IEA
GO:0001997 Process Positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA
GO:0002024 Process Diet induced thermogenesis IEA
GO:0002025 Process Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
GO:0002025 Process Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Other IDs Associated diseases
MIM HGNC e!Ensembl
109630 285 ENSG00000043591
Protein Protein information from UniProt database.
Gene SNPs Other IDs Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P08588
Protein name Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor)
Protein function Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G
PDB 2LSQ , 7BTS , 7BU6 , 7BU7 , 7BVQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 75 → 377 7 transmembrane receptor (rhodopsin family) Family
Sequence
Sequence length 477
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
8
Gene SNPs Other IDs Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
SHORT SLEEP, FAMILIAL NATURAL, 2 Pathogenic rs776439595 RCV000851538
Show/Hide Unknown Diseases (3)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
ADRB1-related disorder Likely benign; association; Benign rs545652970, rs1801253, rs1801252 RCV003941858
RCV003974844
RCV003974845
Pulmonary disease, chronic obstructive, susceptibility to association; Benign rs1801253 RCV002508776
Resting heart rate Likely benign rs1801252 RCV000019323
Show/Hide Text Mining Associations (94)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 37952358
Arrhythmias Cardiac Associate 21617318, 22664639, 37102236, 38138160
Atherosclerosis Associate 24371822
Atrial Fibrillation Associate 20625396, 22192668, 22499333, 24159564, 24332148, 24982877, 34270905
Bipolar Disorder Associate 29230810
Body Weight Associate 29587766
Breast Neoplasms Associate 33234738, 34930307, 35113855
Cachexia Stimulate 20426789
Carcinoma Pancreatic Ductal Associate 22797009
Cardiomyopathies Associate 21617318, 37102236