ADRB1 (adrenoceptor beta 1)

Gene
Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
153
Gene name Gene Name - the full gene name approved by the HGNC.
Adrenoceptor beta 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADRB1
Synonyms (NCBI Gene) Gene synonyms aliases
ADRB1R, B1AR, BETA1AR, FNSS2, RHR
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q25.3
Summary Summary of gene provided in NCBI Entrez Gene.
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter
SNPs SNP information provided by dbSNP.
Gene SNPs Other IDs Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs1801253 G>A,C Drug-response Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs Other IDs Associated diseases
Show/Hide all(860)
miRTarBase ID miRNA Experiments Reference
MIRT717492 hsa-miR-188-5p HITS-CLIP 19536157
MIRT717491 hsa-miR-6866-3p HITS-CLIP 19536157
MIRT717490 hsa-miR-186-3p HITS-CLIP 19536157
MIRT717489 hsa-miR-3124-3p HITS-CLIP 19536157
MIRT717488 hsa-miR-2113 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Other IDs Associated diseases
Show/Hide all(44)
GO ID Ontology Definition Evidence Reference
GO:0001996 Process Positive regulation of heart rate by epinephrine-norepinephrine IEA
GO:0001997 Process Positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA
GO:0002024 Process Diet induced thermogenesis IEA
GO:0002025 Process Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
GO:0002025 Process Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Other IDs Associated diseases
MIM HGNC e!Ensembl
109630 285 ENSG00000043591
Protein
Gene SNPs Other IDs Associated diseases
UniProt ID P08588
Protein name Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor)
Protein function Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G
PDB 2LSQ , 7BTS , 7BU6 , 7BU7 , 7BVQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 75 → 377 7 transmembrane receptor (rhodopsin family) Family
Sequence
Sequence length 477
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs Other IDs Associated diseases
Show/Hide Unknown Diseases (6)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Chronic Obstructive Pulmonary Disease Pulmonary disease, chronic obstructive, susceptibility to N/A N/A ClinVar
Colorectal Cancer Familial colorectal cancer N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Hypertension Hypertension (confirmatory factor analysis Factor 12), Hypertension (PheCode 401), Essential hypertension (PheCode 401.1), High blood pressure / hypertension, Hypertension N/A N/A GWAS
Show/Hide Text Mining Associations (94)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 37952358
Arrhythmias Cardiac Associate 21617318, 22664639, 37102236, 38138160
Atherosclerosis Associate 24371822
Atrial Fibrillation Associate 20625396, 22192668, 22499333, 24159564, 24332148, 24982877, 34270905
Bipolar Disorder Associate 29230810
Body Weight Associate 29587766
Breast Neoplasms Associate 33234738, 34930307, 35113855
Cachexia Stimulate 20426789
Carcinoma Pancreatic Ductal Associate 22797009
Cardiomyopathies Associate 21617318, 37102236