ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide)

Gene
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
128
Gene name Gene Name - the full gene name approved by the HGNC.
Alcohol dehydrogenase 5 (class III), chi polypeptide
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADH5
Synonyms (NCBI Gene) Gene synonyms aliases
ADH-3, ADHX, AMEDS, BMFS7, FALDH, FDH, GSH-FDH, GSNOR, HEL-S-60p
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q23
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein for
miRNA miRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(717)
miRTarBase ID miRNA Experiments Reference
MIRT020534 hsa-miR-155-5p Proteomics 18668040
MIRT044260 hsa-miR-106b-5p CLASH 23622248
MIRT695423 hsa-miR-3927-3p HITS-CLIP 23313552
MIRT695422 hsa-miR-6831-5p HITS-CLIP 23313552
MIRT695421 hsa-miR-1247-3p HITS-CLIP 23313552
Transcription factors
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
RARB Unknown 1996113
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all(34)
GO ID Ontology Definition Evidence Reference
GO:0001523 Process Retinoid metabolic process IEA
GO:0003016 Process Respiratory system process IEA
GO:0004022 Function Alcohol dehydrogenase (NAD+) activity IBA
GO:0004022 Function Alcohol dehydrogenase (NAD+) activity IEA
GO:0005504 Function Fatty acid binding IDA 8460164
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
103710 253 ENSG00000197894
Protein
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID P11766
Protein name Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutat
Protein function Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarac
PDB 1M6H , 1M6W , 1MA0 , 1MC5 , 1MP0 , 1TEH , 2FZE , 2FZW , 3QJ5 , 8GV3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08240 ADH_N 32 → 160 Alcohol dehydrogenase GroES-like domain Domain
PF00107 ADH_zinc_N 202 → 334 Zinc-binding dehydrogenase Family
Sequence
Sequence length 374
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Gout Gout N/A N/A GWAS
Show/Hide Text Mining Associations (14)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 29808834
Asthma Associate 17543375, 20335826
Asthma Stimulate 19395503, 25359343
Breast Neoplasms Associate 26854735
Carcinoma Non Small Cell Lung Associate 29808834
Colorectal Neoplasms Associate 31878280
Congenital Bone Marrow Failure Syndromes Associate 33512438
Fanconi Anemia Associate 33512438
Flushing Associate 33512438
Folate Malabsorption Hereditary Associate 28228507