ADCY4 (adenylate cyclase 4)

Gene

• Entrez ID: 196883
• Gene name: Adenylate cyclase 4
• Gene symbol: ADCY4
• Synonyms (NCBI Gene): AC4
• Chromosome: 14
• Chromosome location: 14q12
• Summary: This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with ade

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004016	Function	Adenylate cyclase activity	IBA
GO:0004016	Function	Adenylate cyclase activity	IEA
GO:0004016	Function	Adenylate cyclase activity	ISS
GO:0005080	Function	Protein kinase C binding	IDA	17081159
GO:0005515	Function	Protein binding	IPI	17081159, 25416956, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	11549699
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006171	Process	CAMP biosynthetic process	IBA
GO:0006171	Process	CAMP biosynthetic process	IEA
GO:0006171	Process	CAMP biosynthetic process	ISS
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISS
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0009190	Process	Cyclic nucleotide biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016829	Function	Lyase activity	IEA
GO:0016849	Function	Phosphorus-oxygen lyase activity	IEA
GO:0030425	Component	Dendrite	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 600292
• HGNC: 235
• e!Ensembl: ENSG00000129467

Protein

• UniProt ID: Q8NFM4
• Protein name: Adenylate cyclase type 4 (EC 4.6.1.1) (ATP pyrophosphate-lyase 4) (Adenylate cyclase type IV) (Adenylyl cyclase 4)
• Protein function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16214	AC_N	4 → 249	Adenylyl cyclase N-terminal extracellular and transmembrane region	Family
  PF00211	Guanylate_cyc	264 → 436	Adenylate and Guanylate cyclase catalytic domain	Domain
  PF06327	DUF1053	479 → 584	Domain of Unknown Function (DUF1053)	Family
  PF00211	Guanylate_cyc	864 → 1064	Adenylate and Guanylate cyclase catalytic domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level). {ECO:0000269|PubMed:11549699}.
• Sequence:

  MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPS
  FLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQV
  SYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVL
  FLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK
  AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE
  LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG
  VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG
  AYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTR
  YLESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAK
  FFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFI
  IQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRP
  GLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPY
  SMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDS
  RPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRL
  LLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLR
  LLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMV
  EFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMEST
  GVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGPPSATLG

• Sequence length: 1077

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cervical cancer	Likely benign	rs78654006	RCV005933137
Cholangiocarcinoma	Likely benign	rs78654006	RCV005929293
Clear cell carcinoma of kidney	Likely benign	rs78654006	RCV005933138
Colon adenocarcinoma	Likely benign	rs78654006	RCV005933133
Familial cancer of breast	Likely benign	rs78654006	RCV005933132
Gastric cancer	Likely benign	rs78654006	RCV005933140
Lung cancer	Likely benign	rs78654006	RCV005929294
Malignant tumor of esophagus	Likely benign	rs78654006	RCV005933136
Malignant tumor of urinary bladder	Likely benign	rs78654006	RCV005933135
Melanoma	Likely benign	rs78654006	RCV005929292
Ovarian serous cystadenocarcinoma	Likely benign	rs78654006	RCV005933141
Papillary renal cell carcinoma type 1	Likely benign	rs78654006	RCV005933134
Thymoma	Likely benign	rs78654006	RCV005933142
Thyroid cancer, nonmedullary, 1	Likely benign	rs78654006	RCV005929291
Uveal melanoma	Likely benign	rs78654006	RCV005933139

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma	Inhibit	33120770
Adenocarcinoma of Lung	Associate	32384511, 33120770, 36032660
Breast Neoplasms	Associate	33499882
Hemangioblastoma	Associate	33446752
Leukemia Lymphoma Adult T Cell	Associate	37832654