ACSL6 (acyl-CoA synthetase long chain family member 6)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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23305 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Acyl-CoA synthetase long chain family member 6 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ACSL6 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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ACS2, FACL6, LACS 6, LACS2, LACS5 |
Chromosome
Chromosome number
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5 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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5q31.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | ||||||||||||||||
UniProt ID | Q9UKU0 | |||||||||||||||
Protein name | Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 6) (LACS 6) | |||||||||||||||
Protein function | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in br | |||||||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain. {ECO:0000269|PubMed:10548543}. | |||||||||||||||
Sequence |
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Sequence length | 697 | |||||||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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