Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	51703
Gene name	Acyl-CoA synthetase long chain family member 5
Gene symbol	ACSL5
Synonyms (NCBI Gene)	ACS2ACS5DIAR13FACL5
Chromosome	10
Chromosome location	10q25.2
Summary	The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty

Show/Hide all (67)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019161	hsa-miR-335-5p	Microarray	18185580
MIRT022047	hsa-miR-128-3p	Microarray	17612493
MIRT023184	hsa-miR-124-3p	Microarray	18668037
MIRT763562	hsa-miR-122	CLIP-seq
MIRT763563	hsa-miR-1229	CLIP-seq
MIRT763564	hsa-miR-1273e	CLIP-seq
MIRT763565	hsa-miR-148a	CLIP-seq
MIRT763566	hsa-miR-148b	CLIP-seq
MIRT763567	hsa-miR-152	CLIP-seq
MIRT763568	hsa-miR-342-3p	CLIP-seq
MIRT763569	hsa-miR-3915	CLIP-seq
MIRT763570	hsa-miR-3928	CLIP-seq
MIRT763571	hsa-miR-3935	CLIP-seq
MIRT763572	hsa-miR-3945	CLIP-seq
MIRT763573	hsa-miR-3978	CLIP-seq
MIRT763574	hsa-miR-4253	CLIP-seq
MIRT763575	hsa-miR-4265	CLIP-seq
MIRT763576	hsa-miR-4296	CLIP-seq
MIRT763577	hsa-miR-4322	CLIP-seq
MIRT763578	hsa-miR-4327	CLIP-seq
MIRT763579	hsa-miR-4417	CLIP-seq
MIRT763580	hsa-miR-4457	CLIP-seq
MIRT763581	hsa-miR-4477a	CLIP-seq
MIRT763582	hsa-miR-4519	CLIP-seq
MIRT763583	hsa-miR-4752	CLIP-seq
MIRT763584	hsa-miR-513b	CLIP-seq
MIRT763585	hsa-miR-570	CLIP-seq
MIRT763586	hsa-miR-204	CLIP-seq
MIRT763587	hsa-miR-211	CLIP-seq
MIRT763588	hsa-miR-4446-5p	CLIP-seq
MIRT763589	hsa-miR-4755-5p	CLIP-seq
MIRT763590	hsa-miR-548u	CLIP-seq
MIRT763591	hsa-miR-623	CLIP-seq
MIRT763569	hsa-miR-3915	CLIP-seq
MIRT763570	hsa-miR-3928	CLIP-seq
MIRT763573	hsa-miR-3978	CLIP-seq
MIRT763581	hsa-miR-4477a	CLIP-seq
MIRT1925055	hsa-miR-1197	CLIP-seq
MIRT763569	hsa-miR-3915	CLIP-seq
MIRT763570	hsa-miR-3928	CLIP-seq
MIRT763573	hsa-miR-3978	CLIP-seq
MIRT1925056	hsa-miR-4476	CLIP-seq
MIRT763581	hsa-miR-4477a	CLIP-seq
MIRT1925057	hsa-miR-4533	CLIP-seq
MIRT1925055	hsa-miR-1197	CLIP-seq
MIRT2166499	hsa-miR-15a	CLIP-seq
MIRT2166500	hsa-miR-15b	CLIP-seq
MIRT2166501	hsa-miR-16	CLIP-seq
MIRT2166502	hsa-miR-195	CLIP-seq
MIRT2166503	hsa-miR-2115	CLIP-seq
MIRT2166504	hsa-miR-214	CLIP-seq
MIRT2166505	hsa-miR-3185	CLIP-seq
MIRT2166506	hsa-miR-3619-5p	CLIP-seq
MIRT763569	hsa-miR-3915	CLIP-seq
MIRT763570	hsa-miR-3928	CLIP-seq
MIRT763573	hsa-miR-3978	CLIP-seq
MIRT2166507	hsa-miR-424	CLIP-seq
MIRT2166508	hsa-miR-4267	CLIP-seq
MIRT2166509	hsa-miR-4291	CLIP-seq
MIRT1925056	hsa-miR-4476	CLIP-seq
MIRT763581	hsa-miR-4477a	CLIP-seq
MIRT1925057	hsa-miR-4533	CLIP-seq
MIRT2166510	hsa-miR-497	CLIP-seq
MIRT2166511	hsa-miR-545	CLIP-seq
MIRT2166512	hsa-miR-548g	CLIP-seq
MIRT2166513	hsa-miR-761	CLIP-seq
MIRT2166514	hsa-miR-922	CLIP-seq

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	17681178, 24269233
GO:0001676	Process	Long-chain fatty acid metabolic process	IEA
GO:0001676	Process	Long-chain fatty acid metabolic process	IMP	22633490
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IDA	17681178, 24269233
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IEA
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IMP	22633490
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	TAS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	17681178, 33191500
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	17681178, 24269233, 33191500
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	IDA	24269233
GO:0005886	Component	Plasma membrane	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0010747	Process	Positive regulation of long-chain fatty acid import across plasma membrane	IBA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	IBA
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0047676	Function	Arachidonate-CoA ligase activity	IBA
GO:0047676	Function	Arachidonate-CoA ligase activity	IEA
GO:0047676	Function	Arachidonate-CoA ligase activity	ISS
GO:0090434	Function	Oleoyl-CoA ligase activity	IDA	33191500
GO:2001236	Process	Regulation of extrinsic apoptotic signaling pathway	IDA	17681178

MIM	HGNC	e!Ensembl
605677	16526	ENSG00000197142

Q9ULC5

Protein name

Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 5) (LACS 5)

Protein function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:22633490, PubMed:24269233, PubMed:33191500). ACSL5 may activate

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00501	AMP-binding	81 → 548	AMP-binding enzyme	Family

Sequence

MLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIEGGARKGVS
QKNNDLTSCCFSDAKTMYEVFQRGLAVSDNGPCLGYRKPNQPYRWLSYKQVSDRAEYLGS
CLLHKGYKSSPDQFVGIFAQNRPEWIISELACYTYSMVAVPLYDTLGPEAIVHIVNKADI
AMVICDTPQKALVLIGNVEKGFTPSLKVIILMDPFDDDLKQRGEKSGIEILSLYDAENLG
KEHFRKPVPPSPEDLSVICFTSGTTGDPKGAMITHQNIVSNAAAFLKCVEHAYEPTPDDV
AISYLPLAHMFERIVQAVVYSCGARVGFFQGDIRLLADDMKTLKPTLFPAVPRLLNRIYD
KVQNEAKTPLKKFLLKLAVSSKFKELQKGIIRHDSFWDKLIFAKIQDSLGGRVRVIVTGA
APMSTSVMTFFRAAMGCQVYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYVKLEDVA
DMNYFTVNNEGEVCIKGTNVFKGYLKDPEKTQEALDSDGWLHTGDIGRWLPNGTLKIIDR
KKNIFKLAQGEYIAPEKIENIYNRSQPVLQIFVHGESLRSSLVGVVVPDTDVLPSFAAKL
GVKGSFEELCQNQVVREAILEDLQKIGKESGLKTFEQVKAIFLHPEPFSIENGLLTPTLK
AKRGELSKYFRTQIDSLYEHIQD

Sequence length

683

Interactions

View interactions

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Diarrhea 13	Pathogenic	rs1336100636	RCV003224825

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs111401860	RCV005939098

Show/Hide Text Mining Associations (24)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	19903339, 34943992
Amyotrophic Lateral Sclerosis	Associate	33523907
Astrocytoma	Associate	31053784
Carcinoma Non Small Cell Lung	Associate	24625834
Colorectal Neoplasms	Associate	25782664
Colorectal Neoplasms	Stimulate	28808653, 32155177
Endometrial Hyperplasia	Associate	34943992
Hereditary Breast and Ovarian Cancer Syndrome	Associate	27171439
Hypertriglyceridemia	Associate	34859867
Lung Neoplasms	Associate	24625834, 38350448
Lupus Erythematosus Systemic	Stimulate	22163040
Melanoma Cutaneous Malignant	Associate	36466837
Metabolic Diseases	Associate	31053784
Migraine Disorders	Associate	27189022
Neoplasms	Associate	21999571, 28122360, 28808653, 31053784
Neoplasms	Inhibit	38350448
Neoplasms Adipose Tissue	Associate	32686444, 34859867
Obesity	Associate	27515448
Overweight	Associate	27515448
Pancreatic Neoplasms	Associate	30712446
Periodontitis	Associate	38167332
Polycystic Ovary Syndrome	Associate	38167332
Stomach Neoplasms	Associate	28122360
Weight Loss	Associate	27515448, 34859867

ACSL5 (acyl-CoA synthetase long chain family member 5)