Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2182
Gene name Gene Name - the full gene name approved by the HGNC.	Acyl-CoA synthetase long chain family member 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ACSL4
Synonyms (NCBI Gene) Gene synonyms aliases	ACS4, FACL4, LACS4, MRX63, MRX68, XLID63
Disease Acronyms (UniProt) Disease acronyms from UniProt database	XLID63
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xq23
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty

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SNP ID	Visualize variation	Clinical significance	Consequence
rs122458138	G>T	Pathogenic	Coding sequence variant, missense variant
rs122458139	G>A	Pathogenic	Coding sequence variant, missense variant
rs183171123	T>C	Conflicting-interpretations-of-pathogenicity, benign	Intron variant
rs200451158	T>C	Conflicting-interpretations-of-pathogenicity, likely-benign	Missense variant, coding sequence variant
rs886042180	AT>-	Pathogenic	Frameshift variant, coding sequence variant
rs1569423317	T>C	Pathogenic	Splice acceptor variant
rs1603401125	A>C	Likely-pathogenic	Coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020060	hsa-miR-375	Microarray	20215506
MIRT025215	hsa-miR-34a-5p	Proteomics	21566225
MIRT025215	hsa-miR-34a-5p	Proteomics	21566225
MIRT025215	hsa-miR-34a-5p	Proteomics	21566225
MIRT025215	hsa-miR-34a-5p	Reporter assay;Proteomics	21566225
MIRT028658	hsa-miR-30a-5p	Proteomics	18668040
MIRT043925	hsa-miR-378a-3p	CLASH	23622248
MIRT054569	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	24576478
MIRT054569	hsa-miR-205-5p	Luciferase reporter assay, qRT-PCR, Western blot	24576478
MIRT549467	hsa-miR-144-3p	HITS-CLIP	21572407
MIRT549466	hsa-miR-19a-3p	HITS-CLIP	21572407
MIRT549465	hsa-miR-19b-3p	HITS-CLIP	21572407
MIRT549464	hsa-miR-3666	HITS-CLIP	21572407
MIRT549463	hsa-miR-454-3p	HITS-CLIP	21572407
MIRT549462	hsa-miR-301a-3p	HITS-CLIP	21572407
MIRT549461	hsa-miR-4295	HITS-CLIP	21572407
MIRT549460	hsa-miR-130a-3p	HITS-CLIP	21572407
MIRT549459	hsa-miR-130b-3p	HITS-CLIP	21572407
MIRT549458	hsa-miR-301b-3p	HITS-CLIP	21572407
MIRT175384	hsa-miR-106b-5p	HITS-CLIP	21572407
MIRT175396	hsa-miR-20b-5p	HITS-CLIP	21572407
MIRT175406	hsa-miR-519d-3p	HITS-CLIP	21572407
MIRT175402	hsa-miR-526b-3p	HITS-CLIP	21572407
MIRT175380	hsa-miR-93-5p	HITS-CLIP	21572407
MIRT175378	hsa-miR-17-5p	HITS-CLIP	21572407
MIRT175379	hsa-miR-20a-5p	HITS-CLIP	21572407
MIRT175381	hsa-miR-106a-5p	HITS-CLIP	21572407
MIRT175442	hsa-miR-548az-5p	HITS-CLIP	21572407
MIRT175420	hsa-miR-548t-5p	HITS-CLIP	21572407
MIRT549457	hsa-miR-3662	HITS-CLIP	21572407
MIRT549455	hsa-miR-132-3p	HITS-CLIP	21572407
MIRT549454	hsa-miR-212-3p	HITS-CLIP	21572407
MIRT549453	hsa-miR-6507-5p	HITS-CLIP	21572407
MIRT175408	hsa-miR-519a-3p	HITS-CLIP	21572407
MIRT175403	hsa-miR-519b-3p	HITS-CLIP	21572407
MIRT175400	hsa-miR-519c-3p	HITS-CLIP	21572407
MIRT549452	hsa-miR-580-5p	HITS-CLIP	21572407
MIRT549451	hsa-miR-8485	HITS-CLIP	21572407
MIRT175300	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT549450	hsa-miR-3163	HITS-CLIP	21572407
MIRT549449	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT124873	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT549448	hsa-miR-586	HITS-CLIP	21572407
MIRT549447	hsa-miR-16-1-3p	HITS-CLIP	21572407
MIRT549446	hsa-miR-3653-3p	HITS-CLIP	21572407
MIRT124869	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT175430	hsa-miR-4477a	HITS-CLIP	21572407
MIRT549445	hsa-miR-518a-5p	HITS-CLIP	21572407
MIRT549444	hsa-miR-527	HITS-CLIP	21572407
MIRT175328	hsa-miR-448	HITS-CLIP	21572407
MIRT549443	hsa-miR-33a-5p	HITS-CLIP	21572407
MIRT549442	hsa-miR-33b-5p	HITS-CLIP	21572407
MIRT549441	hsa-miR-3658	HITS-CLIP	21572407
MIRT175287	hsa-miR-450b-5p	HITS-CLIP	21572407
MIRT108449	hsa-miR-507	HITS-CLIP	21572407
MIRT108450	hsa-miR-557	HITS-CLIP	21572407
MIRT549440	hsa-miR-3680-3p	HITS-CLIP	21572407
MIRT108438	hsa-miR-129-5p	HITS-CLIP	21572407
MIRT549451	hsa-miR-8485	HITS-CLIP	23824327
MIRT175300	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT124873	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT549448	hsa-miR-586	HITS-CLIP	23824327
MIRT124869	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT175328	hsa-miR-448	HITS-CLIP	23824327
MIRT549467	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT549466	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT549465	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT549464	hsa-miR-3666	PAR-CLIP	21572407
MIRT549463	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT549462	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT549461	hsa-miR-4295	PAR-CLIP	21572407
MIRT549460	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT549459	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT549458	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT175384	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT175396	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT175406	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT175402	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT175380	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT175378	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT175379	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT175381	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT175442	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT175420	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT549457	hsa-miR-3662	PAR-CLIP	21572407
MIRT549456	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT549455	hsa-miR-132-3p	PAR-CLIP	21572407
MIRT549454	hsa-miR-212-3p	PAR-CLIP	21572407
MIRT549453	hsa-miR-6507-5p	PAR-CLIP	21572407
MIRT175408	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT175403	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT175400	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT549452	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT549451	hsa-miR-8485	PAR-CLIP	21572407
MIRT175300	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT549450	hsa-miR-3163	PAR-CLIP	21572407
MIRT549449	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT124873	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT549448	hsa-miR-586	PAR-CLIP	21572407
MIRT549447	hsa-miR-16-1-3p	PAR-CLIP	21572407
MIRT549446	hsa-miR-3653-3p	PAR-CLIP	21572407
MIRT124869	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT175430	hsa-miR-4477a	PAR-CLIP	21572407
MIRT549445	hsa-miR-518a-5p	PAR-CLIP	21572407
MIRT549444	hsa-miR-527	PAR-CLIP	21572407
MIRT175328	hsa-miR-448	PAR-CLIP	21572407
MIRT549443	hsa-miR-33a-5p	PAR-CLIP	21572407
MIRT549442	hsa-miR-33b-5p	PAR-CLIP	21572407
MIRT549441	hsa-miR-3658	PAR-CLIP	21572407
MIRT175287	hsa-miR-450b-5p	PAR-CLIP	21572407
MIRT108449	hsa-miR-507	PAR-CLIP	21572407
MIRT108450	hsa-miR-557	PAR-CLIP	21572407
MIRT549440	hsa-miR-3680-3p	PAR-CLIP	21572407
MIRT108438	hsa-miR-129-5p	PAR-CLIP	21572407
MIRT175377	hsa-miR-8084	PAR-CLIP	22100165
MIRT108446	hsa-miR-200b-3p	PAR-CLIP	22100165
MIRT108447	hsa-miR-200c-3p	PAR-CLIP	22100165
MIRT108448	hsa-miR-429	PAR-CLIP	22100165
MIRT444495	hsa-miR-369-3p	PAR-CLIP	22100165
MIRT444494	hsa-miR-5692b	PAR-CLIP	22100165
MIRT444493	hsa-miR-5692c	PAR-CLIP	22100165
MIRT444492	hsa-miR-374a-5p	PAR-CLIP	22100165
MIRT444491	hsa-miR-374b-5p	PAR-CLIP	22100165
MIRT444489	hsa-miR-578	PAR-CLIP	22100165
MIRT175377	hsa-miR-8084	PAR-CLIP	22100165
MIRT108446	hsa-miR-200b-3p	PAR-CLIP	22100165
MIRT108447	hsa-miR-200c-3p	PAR-CLIP	22100165
MIRT108448	hsa-miR-429	PAR-CLIP	22100165
MIRT444495	hsa-miR-369-3p	PAR-CLIP	22100165
MIRT444494	hsa-miR-5692b	PAR-CLIP	22100165
MIRT444493	hsa-miR-5692c	PAR-CLIP	22100165
MIRT444492	hsa-miR-374a-5p	PAR-CLIP	22100165
MIRT444491	hsa-miR-374b-5p	PAR-CLIP	22100165
MIRT444490	hsa-miR-1298-5p	PAR-CLIP	22100165
MIRT444489	hsa-miR-578	PAR-CLIP	22100165
MIRT441286	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT441285	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT441286	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT441285	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT549466	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT549465	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT737243	hsa-miR-211-5p	Luciferase reporter assay, Western blotting, RNA-seq, qRT-PCR	32859232
MIRT549467	hsa-miR-144-3p	HITS-CLIP	21572407
MIRT549466	hsa-miR-19a-3p	HITS-CLIP	21572407
MIRT549465	hsa-miR-19b-3p	HITS-CLIP	21572407
MIRT549464	hsa-miR-3666	HITS-CLIP	21572407
MIRT549463	hsa-miR-454-3p	HITS-CLIP	21572407
MIRT549462	hsa-miR-301a-3p	HITS-CLIP	21572407
MIRT549461	hsa-miR-4295	HITS-CLIP	21572407
MIRT549460	hsa-miR-130a-3p	HITS-CLIP	21572407
MIRT549459	hsa-miR-130b-3p	HITS-CLIP	21572407
MIRT549458	hsa-miR-301b-3p	HITS-CLIP	21572407
MIRT175384	hsa-miR-106b-5p	HITS-CLIP	21572407
MIRT175396	hsa-miR-20b-5p	HITS-CLIP	21572407
MIRT175406	hsa-miR-519d-3p	HITS-CLIP	21572407
MIRT175402	hsa-miR-526b-3p	HITS-CLIP	21572407
MIRT175380	hsa-miR-93-5p	HITS-CLIP	21572407
MIRT175378	hsa-miR-17-5p	HITS-CLIP	21572407
MIRT175379	hsa-miR-20a-5p	HITS-CLIP	21572407
MIRT175381	hsa-miR-106a-5p	HITS-CLIP	21572407
MIRT175442	hsa-miR-548az-5p	HITS-CLIP	21572407
MIRT175420	hsa-miR-548t-5p	HITS-CLIP	21572407
MIRT549457	hsa-miR-3662	HITS-CLIP	21572407
MIRT549455	hsa-miR-132-3p	HITS-CLIP	21572407
MIRT549454	hsa-miR-212-3p	HITS-CLIP	21572407
MIRT549453	hsa-miR-6507-5p	HITS-CLIP	21572407
MIRT175408	hsa-miR-519a-3p	HITS-CLIP	21572407
MIRT175403	hsa-miR-519b-3p	HITS-CLIP	21572407
MIRT175400	hsa-miR-519c-3p	HITS-CLIP	21572407
MIRT549452	hsa-miR-580-5p	HITS-CLIP	21572407
MIRT549451	hsa-miR-8485	HITS-CLIP	21572407
MIRT175300	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT549450	hsa-miR-3163	HITS-CLIP	21572407
MIRT549449	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT124873	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT549448	hsa-miR-586	HITS-CLIP	21572407
MIRT549447	hsa-miR-16-1-3p	HITS-CLIP	21572407
MIRT549446	hsa-miR-3653-3p	HITS-CLIP	21572407
MIRT124869	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT175430	hsa-miR-4477a	HITS-CLIP	21572407
MIRT549445	hsa-miR-518a-5p	HITS-CLIP	21572407
MIRT549444	hsa-miR-527	HITS-CLIP	21572407
MIRT175328	hsa-miR-448	HITS-CLIP	21572407
MIRT549443	hsa-miR-33a-5p	HITS-CLIP	21572407
MIRT549442	hsa-miR-33b-5p	HITS-CLIP	21572407
MIRT549441	hsa-miR-3658	HITS-CLIP	21572407
MIRT175287	hsa-miR-450b-5p	HITS-CLIP	21572407
MIRT108449	hsa-miR-507	HITS-CLIP	21572407
MIRT108450	hsa-miR-557	HITS-CLIP	21572407
MIRT549440	hsa-miR-3680-3p	HITS-CLIP	21572407
MIRT108438	hsa-miR-129-5p	HITS-CLIP	21572407
MIRT549451	hsa-miR-8485	HITS-CLIP	23824327
MIRT175300	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT124873	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT549448	hsa-miR-586	HITS-CLIP	23824327
MIRT124869	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT175328	hsa-miR-448	HITS-CLIP	23824327
MIRT549467	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT549466	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT549465	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT549464	hsa-miR-3666	PAR-CLIP	21572407
MIRT549463	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT549462	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT549461	hsa-miR-4295	PAR-CLIP	21572407
MIRT549460	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT549459	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT549458	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT175384	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT175396	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT175406	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT175402	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT175380	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT175378	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT175379	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT175381	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT175442	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT175420	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT549457	hsa-miR-3662	PAR-CLIP	21572407
MIRT549456	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT549455	hsa-miR-132-3p	PAR-CLIP	21572407
MIRT549454	hsa-miR-212-3p	PAR-CLIP	21572407
MIRT549453	hsa-miR-6507-5p	PAR-CLIP	21572407
MIRT175408	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT175403	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT175400	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT549452	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT549451	hsa-miR-8485	PAR-CLIP	21572407
MIRT175300	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT549450	hsa-miR-3163	PAR-CLIP	21572407
MIRT549449	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT124873	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT549448	hsa-miR-586	PAR-CLIP	21572407
MIRT549447	hsa-miR-16-1-3p	PAR-CLIP	21572407
MIRT549446	hsa-miR-3653-3p	PAR-CLIP	21572407
MIRT124869	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT175430	hsa-miR-4477a	PAR-CLIP	21572407
MIRT549445	hsa-miR-518a-5p	PAR-CLIP	21572407
MIRT549444	hsa-miR-527	PAR-CLIP	21572407
MIRT175328	hsa-miR-448	PAR-CLIP	21572407
MIRT549443	hsa-miR-33a-5p	PAR-CLIP	21572407
MIRT549442	hsa-miR-33b-5p	PAR-CLIP	21572407
MIRT549441	hsa-miR-3658	PAR-CLIP	21572407
MIRT175287	hsa-miR-450b-5p	PAR-CLIP	21572407
MIRT108449	hsa-miR-507	PAR-CLIP	21572407
MIRT108450	hsa-miR-557	PAR-CLIP	21572407
MIRT549440	hsa-miR-3680-3p	PAR-CLIP	21572407
MIRT108438	hsa-miR-129-5p	PAR-CLIP	21572407
MIRT175377	hsa-miR-8084	PAR-CLIP	22100165
MIRT108446	hsa-miR-200b-3p	PAR-CLIP	22100165
MIRT108447	hsa-miR-200c-3p	PAR-CLIP	22100165
MIRT108448	hsa-miR-429	PAR-CLIP	22100165
MIRT444495	hsa-miR-369-3p	PAR-CLIP	22100165
MIRT444494	hsa-miR-5692b	PAR-CLIP	22100165
MIRT444493	hsa-miR-5692c	PAR-CLIP	22100165
MIRT444492	hsa-miR-374a-5p	PAR-CLIP	22100165
MIRT444491	hsa-miR-374b-5p	PAR-CLIP	22100165
MIRT444489	hsa-miR-578	PAR-CLIP	22100165
MIRT175377	hsa-miR-8084	PAR-CLIP	22100165
MIRT108446	hsa-miR-200b-3p	PAR-CLIP	22100165
MIRT108447	hsa-miR-200c-3p	PAR-CLIP	22100165
MIRT108448	hsa-miR-429	PAR-CLIP	22100165
MIRT444495	hsa-miR-369-3p	PAR-CLIP	22100165
MIRT444494	hsa-miR-5692b	PAR-CLIP	22100165
MIRT444493	hsa-miR-5692c	PAR-CLIP	22100165
MIRT444492	hsa-miR-374a-5p	PAR-CLIP	22100165
MIRT444491	hsa-miR-374b-5p	PAR-CLIP	22100165
MIRT444490	hsa-miR-1298-5p	PAR-CLIP	22100165
MIRT444489	hsa-miR-578	PAR-CLIP	22100165
MIRT054569	hsa-miR-205-5p	Microarray, qRT-PCR	35816043
MIRT763532	hsa-miR-1915	CLIP-seq
MIRT763533	hsa-miR-374a	CLIP-seq
MIRT763534	hsa-miR-374b	CLIP-seq
MIRT763535	hsa-miR-4291	CLIP-seq
MIRT763536	hsa-miR-4310	CLIP-seq
MIRT763537	hsa-miR-4726-3p	CLIP-seq
MIRT763538	hsa-miR-548an	CLIP-seq
MIRT763539	hsa-miR-1207-3p	CLIP-seq
MIRT763540	hsa-miR-1323	CLIP-seq
MIRT763541	hsa-miR-1537	CLIP-seq
MIRT763542	hsa-miR-3687	CLIP-seq
MIRT763543	hsa-miR-410	CLIP-seq
MIRT763544	hsa-miR-4442	CLIP-seq
MIRT763545	hsa-miR-4793-3p	CLIP-seq
MIRT763546	hsa-miR-548a-5p	CLIP-seq
MIRT763547	hsa-miR-548ab	CLIP-seq
MIRT763548	hsa-miR-548ak	CLIP-seq
MIRT763549	hsa-miR-548b-5p	CLIP-seq
MIRT763550	hsa-miR-548c-5p	CLIP-seq
MIRT763551	hsa-miR-548d-5p	CLIP-seq
MIRT763552	hsa-miR-548h	CLIP-seq
MIRT763553	hsa-miR-548i	CLIP-seq
MIRT763554	hsa-miR-548j	CLIP-seq
MIRT763555	hsa-miR-548k	CLIP-seq
MIRT763556	hsa-miR-548l	CLIP-seq
MIRT763557	hsa-miR-548o	CLIP-seq
MIRT763558	hsa-miR-548w	CLIP-seq
MIRT763559	hsa-miR-548y	CLIP-seq
MIRT763560	hsa-miR-559	CLIP-seq
MIRT763561	hsa-miR-590-3p	CLIP-seq
MIRT1922545	hsa-miR-1275	CLIP-seq
MIRT1922546	hsa-miR-19a	CLIP-seq
MIRT1922547	hsa-miR-19b	CLIP-seq
MIRT1922548	hsa-miR-3200-5p	CLIP-seq
MIRT1922549	hsa-miR-342-3p	CLIP-seq
MIRT1922550	hsa-miR-342-5p	CLIP-seq
MIRT1922551	hsa-miR-377	CLIP-seq
MIRT1922552	hsa-miR-4251	CLIP-seq
MIRT1922553	hsa-miR-4329	CLIP-seq
MIRT1922554	hsa-miR-4662a-3p	CLIP-seq
MIRT1922555	hsa-miR-4664-5p	CLIP-seq
MIRT1922556	hsa-miR-4665-5p	CLIP-seq
MIRT1925035	hsa-miR-101	CLIP-seq
MIRT1925036	hsa-miR-1257	CLIP-seq
MIRT1925037	hsa-miR-1297	CLIP-seq
MIRT1925038	hsa-miR-144	CLIP-seq
MIRT1925039	hsa-miR-204	CLIP-seq
MIRT1925040	hsa-miR-211	CLIP-seq
MIRT1925041	hsa-miR-26a	CLIP-seq
MIRT1925042	hsa-miR-26b	CLIP-seq
MIRT1925043	hsa-miR-33a	CLIP-seq
MIRT1925044	hsa-miR-33b	CLIP-seq
MIRT1925045	hsa-miR-4436b-3p	CLIP-seq
MIRT1925046	hsa-miR-4446-5p	CLIP-seq
MIRT1925047	hsa-miR-4465	CLIP-seq
MIRT1925048	hsa-miR-4660	CLIP-seq
MIRT1925049	hsa-miR-4755-5p	CLIP-seq
MIRT1925050	hsa-miR-582-5p	CLIP-seq
MIRT1925051	hsa-miR-584	CLIP-seq
MIRT1925052	hsa-miR-595	CLIP-seq
MIRT1925053	hsa-miR-623	CLIP-seq
MIRT1925054	hsa-miR-646	CLIP-seq
MIRT1922546	hsa-miR-19a	CLIP-seq
MIRT1922547	hsa-miR-19b	CLIP-seq
MIRT2166498	hsa-miR-205	CLIP-seq
MIRT2383830	hsa-miR-132	CLIP-seq
MIRT2383831	hsa-miR-212	CLIP-seq
MIRT2383832	hsa-miR-380	CLIP-seq
MIRT2383833	hsa-miR-4328	CLIP-seq
MIRT2435177	hsa-miR-576-5p	CLIP-seq
MIRT2443084	hsa-miR-3127-5p	CLIP-seq
MIRT2443085	hsa-miR-4270	CLIP-seq
MIRT2443086	hsa-miR-4441	CLIP-seq
MIRT2443087	hsa-miR-4668-5p	CLIP-seq
MIRT2443088	hsa-miR-4774-3p	CLIP-seq
MIRT2468948	hsa-miR-1236	CLIP-seq
MIRT2468949	hsa-miR-1279	CLIP-seq
MIRT1925037	hsa-miR-1297	CLIP-seq
MIRT2383830	hsa-miR-132	CLIP-seq
MIRT763540	hsa-miR-1323	CLIP-seq
MIRT2468950	hsa-miR-134	CLIP-seq
MIRT2468951	hsa-miR-145	CLIP-seq
MIRT2468952	hsa-miR-150	CLIP-seq
MIRT2468953	hsa-miR-1910	CLIP-seq
MIRT2468954	hsa-miR-1913	CLIP-seq
MIRT2468955	hsa-miR-199a-3p	CLIP-seq
MIRT2468956	hsa-miR-199b-3p	CLIP-seq
MIRT1925039	hsa-miR-204	CLIP-seq
MIRT1925040	hsa-miR-211	CLIP-seq
MIRT2468957	hsa-miR-2113	CLIP-seq
MIRT2468958	hsa-miR-2114	CLIP-seq
MIRT2383831	hsa-miR-212	CLIP-seq
MIRT2468959	hsa-miR-214	CLIP-seq
MIRT1925041	hsa-miR-26a	CLIP-seq
MIRT1925042	hsa-miR-26b	CLIP-seq
MIRT2468960	hsa-miR-3118	CLIP-seq
MIRT2468961	hsa-miR-3129-5p	CLIP-seq
MIRT2468962	hsa-miR-3148	CLIP-seq
MIRT2468963	hsa-miR-3153	CLIP-seq
MIRT2468964	hsa-miR-3161	CLIP-seq
MIRT2468965	hsa-miR-3164	CLIP-seq
MIRT2468966	hsa-miR-3180-5p	CLIP-seq
MIRT2468967	hsa-miR-320a	CLIP-seq
MIRT2468968	hsa-miR-320b	CLIP-seq
MIRT2468969	hsa-miR-320c	CLIP-seq
MIRT2468970	hsa-miR-320d	CLIP-seq
MIRT2468971	hsa-miR-324-3p	CLIP-seq
MIRT2468972	hsa-miR-325	CLIP-seq
MIRT2468973	hsa-miR-3619-5p	CLIP-seq
MIRT763533	hsa-miR-374a	CLIP-seq
MIRT763534	hsa-miR-374b	CLIP-seq
MIRT2468974	hsa-miR-374c	CLIP-seq
MIRT1922551	hsa-miR-377	CLIP-seq
MIRT2468975	hsa-miR-3978	CLIP-seq
MIRT2468976	hsa-miR-4263	CLIP-seq
MIRT2468977	hsa-miR-4429	CLIP-seq
MIRT1925045	hsa-miR-4436b-3p	CLIP-seq
MIRT1925047	hsa-miR-4465	CLIP-seq
MIRT2468978	hsa-miR-4475	CLIP-seq
MIRT2468979	hsa-miR-4521	CLIP-seq
MIRT2468980	hsa-miR-4522	CLIP-seq
MIRT2468981	hsa-miR-455-3p	CLIP-seq
MIRT2468982	hsa-miR-4639-3p	CLIP-seq
MIRT2468983	hsa-miR-4659a-3p	CLIP-seq
MIRT2468984	hsa-miR-4659b-3p	CLIP-seq
MIRT2468985	hsa-miR-4668-3p	CLIP-seq
MIRT2443087	hsa-miR-4668-5p	CLIP-seq
MIRT2468986	hsa-miR-4678	CLIP-seq
MIRT2468987	hsa-miR-4694-3p	CLIP-seq
MIRT2468988	hsa-miR-4713-5p	CLIP-seq
MIRT2468989	hsa-miR-4724-3p	CLIP-seq
MIRT2468990	hsa-miR-4729	CLIP-seq
MIRT2468991	hsa-miR-4742-3p	CLIP-seq
MIRT1925049	hsa-miR-4755-5p	CLIP-seq
MIRT2468992	hsa-miR-4762-3p	CLIP-seq
MIRT2468993	hsa-miR-4762-5p	CLIP-seq
MIRT2468994	hsa-miR-4766-5p	CLIP-seq
MIRT2468995	hsa-miR-4795-3p	CLIP-seq
MIRT2468996	hsa-miR-4799-5p	CLIP-seq
MIRT2468997	hsa-miR-522	CLIP-seq
MIRT2468998	hsa-miR-532-3p	CLIP-seq
MIRT2468999	hsa-miR-548ag	CLIP-seq
MIRT2469000	hsa-miR-548ai	CLIP-seq
MIRT2469001	hsa-miR-548c-3p	CLIP-seq
MIRT763557	hsa-miR-548o	CLIP-seq
MIRT2435177	hsa-miR-576-5p	CLIP-seq
MIRT2469002	hsa-miR-599	CLIP-seq
MIRT2469003	hsa-miR-618	CLIP-seq
MIRT1925053	hsa-miR-623	CLIP-seq
MIRT2469004	hsa-miR-628-3p	CLIP-seq
MIRT2469005	hsa-miR-655	CLIP-seq
MIRT2469006	hsa-miR-656	CLIP-seq
MIRT2469007	hsa-miR-761	CLIP-seq
MIRT2469008	hsa-miR-934	CLIP-seq
MIRT2469009	hsa-miR-938	CLIP-seq
MIRT2468948	hsa-miR-1236	CLIP-seq
MIRT2468949	hsa-miR-1279	CLIP-seq
MIRT1925037	hsa-miR-1297	CLIP-seq
MIRT2674316	hsa-miR-1298	CLIP-seq
MIRT2383830	hsa-miR-132	CLIP-seq
MIRT763540	hsa-miR-1323	CLIP-seq
MIRT2468950	hsa-miR-134	CLIP-seq
MIRT2468951	hsa-miR-145	CLIP-seq
MIRT2468952	hsa-miR-150	CLIP-seq
MIRT2468953	hsa-miR-1910	CLIP-seq
MIRT2468954	hsa-miR-1913	CLIP-seq
MIRT2468955	hsa-miR-199a-3p	CLIP-seq
MIRT2468956	hsa-miR-199b-3p	CLIP-seq
MIRT2674317	hsa-miR-200b	CLIP-seq
MIRT2674318	hsa-miR-200c	CLIP-seq
MIRT1925039	hsa-miR-204	CLIP-seq
MIRT2166498	hsa-miR-205	CLIP-seq
MIRT1925040	hsa-miR-211	CLIP-seq
MIRT2468957	hsa-miR-2113	CLIP-seq
MIRT2468958	hsa-miR-2114	CLIP-seq
MIRT2383831	hsa-miR-212	CLIP-seq
MIRT2468959	hsa-miR-214	CLIP-seq
MIRT1925041	hsa-miR-26a	CLIP-seq
MIRT1925042	hsa-miR-26b	CLIP-seq
MIRT2468960	hsa-miR-3118	CLIP-seq
MIRT2443084	hsa-miR-3127-5p	CLIP-seq
MIRT2468961	hsa-miR-3129-5p	CLIP-seq
MIRT2468962	hsa-miR-3148	CLIP-seq
MIRT2468963	hsa-miR-3153	CLIP-seq
MIRT2468964	hsa-miR-3161	CLIP-seq
MIRT2468965	hsa-miR-3164	CLIP-seq
MIRT2468966	hsa-miR-3180-5p	CLIP-seq
MIRT2468967	hsa-miR-320a	CLIP-seq
MIRT2468968	hsa-miR-320b	CLIP-seq
MIRT2468969	hsa-miR-320c	CLIP-seq
MIRT2468970	hsa-miR-320d	CLIP-seq
MIRT2468971	hsa-miR-324-3p	CLIP-seq
MIRT2468972	hsa-miR-325	CLIP-seq
MIRT2468973	hsa-miR-3619-5p	CLIP-seq
MIRT2674319	hsa-miR-3691-3p	CLIP-seq
MIRT763533	hsa-miR-374a	CLIP-seq
MIRT763534	hsa-miR-374b	CLIP-seq
MIRT2468974	hsa-miR-374c	CLIP-seq
MIRT1922551	hsa-miR-377	CLIP-seq
MIRT2468975	hsa-miR-3978	CLIP-seq
MIRT2468976	hsa-miR-4263	CLIP-seq
MIRT2443085	hsa-miR-4270	CLIP-seq
MIRT2674320	hsa-miR-4282	CLIP-seq
MIRT2468977	hsa-miR-4429	CLIP-seq
MIRT1925045	hsa-miR-4436b-3p	CLIP-seq
MIRT2443086	hsa-miR-4441	CLIP-seq
MIRT1925046	hsa-miR-4446-5p	CLIP-seq
MIRT1925047	hsa-miR-4465	CLIP-seq
MIRT2468978	hsa-miR-4475	CLIP-seq
MIRT2468979	hsa-miR-4521	CLIP-seq
MIRT2468980	hsa-miR-4522	CLIP-seq
MIRT2468981	hsa-miR-455-3p	CLIP-seq
MIRT2468983	hsa-miR-4659a-3p	CLIP-seq
MIRT2468984	hsa-miR-4659b-3p	CLIP-seq
MIRT2468985	hsa-miR-4668-3p	CLIP-seq
MIRT2443087	hsa-miR-4668-5p	CLIP-seq
MIRT2468986	hsa-miR-4678	CLIP-seq
MIRT2468987	hsa-miR-4694-3p	CLIP-seq
MIRT2468988	hsa-miR-4713-5p	CLIP-seq
MIRT2468989	hsa-miR-4724-3p	CLIP-seq
MIRT2468990	hsa-miR-4729	CLIP-seq
MIRT2468991	hsa-miR-4742-3p	CLIP-seq
MIRT1925049	hsa-miR-4755-5p	CLIP-seq
MIRT2468992	hsa-miR-4762-3p	CLIP-seq
MIRT2468993	hsa-miR-4762-5p	CLIP-seq
MIRT2468994	hsa-miR-4766-5p	CLIP-seq
MIRT2443088	hsa-miR-4774-3p	CLIP-seq
MIRT2468995	hsa-miR-4795-3p	CLIP-seq
MIRT2468996	hsa-miR-4799-5p	CLIP-seq
MIRT2674321	hsa-miR-520d-5p	CLIP-seq
MIRT2468997	hsa-miR-522	CLIP-seq
MIRT2674322	hsa-miR-524-5p	CLIP-seq
MIRT2468998	hsa-miR-532-3p	CLIP-seq
MIRT2674323	hsa-miR-548ac	CLIP-seq
MIRT2468999	hsa-miR-548ag	CLIP-seq
MIRT2469000	hsa-miR-548ai	CLIP-seq
MIRT2469001	hsa-miR-548c-3p	CLIP-seq
MIRT2674324	hsa-miR-548d-3p	CLIP-seq
MIRT763557	hsa-miR-548o	CLIP-seq
MIRT2674325	hsa-miR-548z	CLIP-seq
MIRT2435177	hsa-miR-576-5p	CLIP-seq
MIRT763561	hsa-miR-590-3p	CLIP-seq
MIRT2469002	hsa-miR-599	CLIP-seq
MIRT2469003	hsa-miR-618	CLIP-seq
MIRT1925053	hsa-miR-623	CLIP-seq
MIRT2469004	hsa-miR-628-3p	CLIP-seq
MIRT2469005	hsa-miR-655	CLIP-seq
MIRT2469006	hsa-miR-656	CLIP-seq
MIRT2469007	hsa-miR-761	CLIP-seq
MIRT2469008	hsa-miR-934	CLIP-seq
MIRT2469009	hsa-miR-938	CLIP-seq

Show/Hide all(35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001676	Process	Long-chain fatty acid metabolic process	IBA	21873635
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	24269233
GO:0001676	Process	Long-chain fatty acid metabolic process	IMP	22633490
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IBA	21873635
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IDA	10669417, 24269233
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IMP	22633490
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	11889465
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005778	Component	Peroxisomal membrane	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005811	Component	Lipid droplet	IBA	21873635
GO:0005811	Component	Lipid droplet	IDA	14741744
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0006629	Process	Lipid metabolic process	IDA	9598324
GO:0007584	Process	Response to nutrient	IEA
GO:0015908	Process	Fatty acid transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0019432	Process	Triglyceride biosynthetic process	IEA
GO:0030182	Process	Neuron differentiation	IBA	21873635
GO:0031957	Function	Very long-chain fatty acid-CoA ligase activity	IMP	11889465
GO:0032024	Process	Positive regulation of insulin secretion	ISS
GO:0035336	Process	Long-chain fatty-acyl-CoA metabolic process	IBA	21873635
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0043025	Component	Neuronal cell body	IEA
GO:0044233	Component	Mitochondria-associated endoplasmic reticulum membrane	IDA	23455425
GO:0047676	Function	Arachidonate-CoA ligase activity	IBA	21873635
GO:0047676	Function	Arachidonate-CoA ligase activity	IDA	9598324
GO:0060136	Process	Embryonic process involved in female pregnancy	IEA
GO:0060996	Process	Dendritic spine development	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337
GO:0070672	Process	Response to interleukin-15	IEA

MIM	HGNC	e!Ensembl
300157	3571	ENSG00000068366

Protein

UniProt ID

O60488

Protein name

Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4)

Protein function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially activates arachidonate

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00501	AMP-binding	103 → 578	AMP-binding enzyme	Family

Sequence

MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYR
SVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLIL
GNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTL
YATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPE
GFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMT
GQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSK
GDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLC
NLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEV
TDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAED
YSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDN
ICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAM
KLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK

Sequence length

711

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental retardation	non-syndromic X-linked intellectual disability, intellectual disability, X-linked 63			GenCC

Show/Hide Text Mining Associations (68)

Disease Name	Relationship Type	References
Associations from Text Mining
Acute Kidney Injury	Associate	35569444
Adrenocortical Carcinoma	Associate	35500219
Arthritis Rheumatoid	Associate	26147000
Atherosclerosis	Associate	39742023
Brain Injuries	Associate	29638160
Breast Neoplasms	Associate	21085606, 27171439, 29450800, 31311992, 34482070, 38078907, 39862136, 40612672
Carcinogenesis	Associate	15849811, 32357142
Carcinoma Hepatocellular	Associate	12824919, 15849811, 28887439, 30138348, 32357142, 32859232, 35603967, 40500772
Carcinoma Non Small Cell Lung	Associate	33730930, 36482742
Carcinoma Non Small Cell Lung	Inhibit	36060648
Carcinoma Pancreatic Ductal	Inhibit	35000852
Carcinoma Pancreatic Ductal	Stimulate	40349055
Cerebral Infarction	Associate	35197442
Cholangiocarcinoma	Associate	36111744
Cholangiocarcinoma	Stimulate	37193981
Chromosome Disorders	Associate	12525535
Cognition Disorders	Associate	12525535
Colonic Neoplasms	Associate	21085606
Colorectal Neoplasms	Associate	15849811, 27171439, 28894242, 33611811, 35855531, 37059712, 37428466
Corneal Endothelial Cell Loss	Associate	39742023
Depressive Disorder	Associate	19346733
Diabetes Mellitus	Associate	38354757
Diabetic Nephropathies	Associate	33565572
Diabetic Retinopathy	Associate	36092160
Elliptocytosis 1	Associate	9480748
Esophageal Squamous Cell Carcinoma	Associate	37203411
Fatty Liver	Associate	30270343
Fibrosarcoma	Associate	29450800
Glioblastoma	Associate	32452511, 37158834
Glioma	Inhibit	31789401
Glioma	Associate	35697672
Glomerulonephritis IGA	Associate	36147466
Heart Defects Congenital	Associate	35035663
Heart Diseases	Stimulate	34288826
Heat Stroke	Stimulate	35853732
Hypoxia	Stimulate	39323909
Hypoxia	Associate	40682199
Idiopathic Pulmonary Fibrosis	Inhibit	38117249
Infarction Middle Cerebral Artery	Associate	35197442
Intellectual Disability	Associate	12525535, 9480748
Kidney Calculi	Associate	36907445
Leiomyosarcoma	Associate	29450800
Liver Diseases	Associate	30138348
Liver Neoplasms	Associate	18059177
Melanoma Cutaneous Malignant	Associate	33663112
Mental Retardation X Linked	Associate	12525535
Mental Retardation X Linked 1	Associate	12525535
Mental Retardation X Linked Syndromic Turner Type	Associate	12525535
Metabolic Syndrome	Associate	19346733
Myocardial Infarction	Associate	35231061
Neoplasm Metastasis	Associate	36060648, 36482742, 38078907
Neoplasms	Associate	18059177, 28887439, 29450800, 36060648, 37183818, 37193981
Nephritis Hereditary	Associate	9480748
Nerve Degeneration	Associate	35197442
Non alcoholic Fatty Liver Disease	Associate	30270343
Osteoarthritis	Associate	38062071
Osteoglophonic dwarfism	Stimulate	38287843
Pancreatic Intraductal Neoplasms	Associate	40349055
Pancreatic Neoplasms	Stimulate	40349055
Personality Disorders	Associate	31311992
Polycystic Ovary Syndrome	Associate	36884209
Precancerous Conditions	Associate	40349055
Reperfusion Injury	Associate	36819784
Rhabdomyosarcoma	Associate	29450800
Sarcoma	Associate	29450800
Squamous Cell Carcinoma of Head and Neck	Associate	37993428, 38186303
Triple Negative Breast Neoplasms	Associate	31311992
Vascular Diseases	Associate	36092160

ACSL4 (acyl-CoA synthetase long chain family member 4)