Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2181
Gene name Gene Name - the full gene name approved by the HGNC.
Acyl-CoA synthetase long chain family member 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ACSL3
Synonyms (NCBI Gene) Gene synonyms aliases
ACS3, FACL3, LACS 3, LACS3, PRO2194
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q36.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017614 hsa-miR-335-5p Microarray 18185580
MIRT019639 hsa-miR-340-5p Sequencing 20371350
MIRT019874 hsa-miR-375 Microarray 20215506
MIRT024182 hsa-miR-221-3p Sequencing 20371350
MIRT048455 hsa-miR-100-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001676 Process Long-chain fatty acid metabolic process IBA 21873635
GO:0001676 Process Long-chain fatty acid metabolic process IMP 22633490
GO:0001676 Process Long-chain fatty acid metabolic process ISS
GO:0004467 Function Long-chain fatty acid-CoA ligase activity IBA 21873635
GO:0004467 Function Long-chain fatty acid-CoA ligase activity IMP 20219900, 22633490
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602371 3570 ENSG00000123983
Protein
UniProt ID O95573
Protein name Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2)
Protein function Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholi
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00501 AMP-binding 113 587 AMP-binding enzyme Family
Sequence
Sequence length 720
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Metabolic Syndrome Metabolic Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37072786, 39323079
Asthma Associate 19221603
Breast Neoplasms Associate 29450800
Carcinoma Hepatocellular Associate 37248280, 37957550, 39179766
Carcinoma Non Small Cell Lung Associate 33030783
Carcinoma Renal Cell Associate 36081434
Colorectal Neoplasms Associate 36129915
Death Sudden Cardiac Associate 22661490
Fibrosarcoma Associate 29450800
Hepatitis C Associate 18003621