Gene Gene information from NCBI Gene database.
Entrez ID 2181
Gene name Acyl-CoA synthetase long chain family member 3
Gene symbol ACSL3
Synonyms (NCBI Gene)
ACS3FACL3LACS 3LACS3PRO2194
Chromosome 2
Chromosome location 2q36.1
Summary The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty
miRNA miRNA information provided by mirtarbase database.
497
miRTarBase ID miRNA Experiments Reference
MIRT017614 hsa-miR-335-5p Microarray 18185580
MIRT019639 hsa-miR-340-5p Sequencing 20371350
MIRT019874 hsa-miR-375 Microarray 20215506
MIRT024182 hsa-miR-221-3p Sequencing 20371350
MIRT048455 hsa-miR-100-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
47
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001676 Process Long-chain fatty acid metabolic process IBA
GO:0001676 Process Long-chain fatty acid metabolic process IMP 22633490
GO:0001676 Process Long-chain fatty acid metabolic process ISS
GO:0004467 Function Long-chain fatty acid-CoA ligase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602371 3570 ENSG00000123983
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95573
Protein name Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2)
Protein function Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholi
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00501 AMP-binding 113 587 AMP-binding enzyme Family
Sequence
Sequence length 720
Interactions View interactions