ACSBG2 (acyl-CoA synthetase bubblegum family member 2)

Gene

• Entrez ID: 81616
• Gene name: Acyl-CoA synthetase bubblegum family member 2
• Gene symbol: ACSBG2
• Synonyms (NCBI Gene): BGR, BRGL, PRTD-NY3, PRTDNY3
• Chromosome: 19
• Chromosome location: 19p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT763336	hsa-miR-2682	CLIP-seq
MIRT763337	hsa-miR-3074-5p	CLIP-seq
MIRT763338	hsa-miR-370	CLIP-seq
MIRT763339	hsa-miR-3910	CLIP-seq
MIRT763340	hsa-miR-4269	CLIP-seq
MIRT763341	hsa-miR-4328	CLIP-seq
MIRT763342	hsa-miR-4493	CLIP-seq
MIRT763343	hsa-miR-449c	CLIP-seq
MIRT763344	hsa-miR-4514	CLIP-seq
MIRT763345	hsa-miR-4692	CLIP-seq
MIRT763346	hsa-miR-4711-5p	CLIP-seq
MIRT763347	hsa-miR-4742-5p	CLIP-seq
MIRT763348	hsa-miR-578	CLIP-seq
MIRT763349	hsa-miR-643	CLIP-seq
MIRT1924980	hsa-miR-145	CLIP-seq
MIRT1924981	hsa-miR-3671	CLIP-seq
MIRT1924982	hsa-miR-4277	CLIP-seq
MIRT1924983	hsa-miR-4677-3p	CLIP-seq
MIRT1924984	hsa-miR-4679	CLIP-seq
MIRT1924985	hsa-miR-4762-5p	CLIP-seq
MIRT1924986	hsa-miR-607	CLIP-seq
MIRT1924987	hsa-miR-615-5p	CLIP-seq
MIRT763344	hsa-miR-4514	CLIP-seq
MIRT2166321	hsa-miR-4645-5p	CLIP-seq
MIRT2166322	hsa-miR-4673	CLIP-seq
MIRT763345	hsa-miR-4692	CLIP-seq
MIRT2166323	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IBA
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IDA	16371355, 16762313
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	16371355
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA	16762313
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IDA	16371355, 16762313
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0016020	Component	Membrane	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0031957	Function	Very long-chain fatty acid-CoA ligase activity	TAS
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0042759	Process	Long-chain fatty acid biosynthetic process	IBA
GO:0047617	Function	Fatty acyl-CoA hydrolase activity	IDA	16762313
GO:0047676	Function	Arachidonate-CoA ligase activity	IDA	16762313
GO:0047676	Function	Arachidonate-CoA ligase activity	IEA

Other IDs

• MIM: 614363
• HGNC: 24174
• e!Ensembl: ENSG00000130377

Protein

• UniProt ID: Q5FVE4
• Protein name: Long-chain-fatty-acid--CoA ligase ACSBG2 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 2) (Arachidonate--CoA ligase ACSBG2) (EC 6.2.1.15) (Bubblegum-related protein) (PRTD-NY3)
• Protein function: Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated an
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00501	AMP-binding	57 → 519	AMP-binding enzyme	Family

• Tissue specificity: TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:15685348, ECO:0000269|PubMed:16371355, ECO:0000269|PubMed:16762313}.
• Sequence:

  MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRES
  VNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFI
  TAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKA
  IIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGV
  MLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADA
  LKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKK
  MLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELY
  GLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESET
  ETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPII
  SNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQD
  PLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQ
  IDHMYH

• Sequence length: 666