Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	23205
Gene name	Acyl-CoA synthetase bubblegum family member 1
Gene symbol	ACSBG1
Synonyms (NCBI Gene)	BGBG1BGMGR-LACSLPD
Chromosome	15
Chromosome location	15q25.1
Summary	The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. [provided by RefSeq, Jul 2008]

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Show/Hide all (108)

miRTarBase ID	miRNA	Experiments	Reference
MIRT724566	hsa-miR-4457	HITS-CLIP	19536157
MIRT724565	hsa-miR-125b-2-3p	HITS-CLIP	19536157
MIRT616864	hsa-miR-1290	HITS-CLIP	19536157
MIRT724564	hsa-miR-4450	HITS-CLIP	19536157
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	19536157
MIRT724563	hsa-miR-513b-5p	HITS-CLIP	19536157
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	19536157
MIRT669654	hsa-miR-3183	HITS-CLIP	23824327
MIRT669653	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT669652	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT669651	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT669650	hsa-miR-4421	HITS-CLIP	23824327
MIRT669649	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT669648	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT669647	hsa-miR-4469	HITS-CLIP	23824327
MIRT669646	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT669645	hsa-miR-623	HITS-CLIP	23824327
MIRT669644	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT669643	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT669642	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT669641	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT669640	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT669639	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT669638	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT669637	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616868	hsa-miR-3942-5p	HITS-CLIP	23824327
MIRT616867	hsa-miR-4703-5p	HITS-CLIP	23824327
MIRT616866	hsa-miR-3908	HITS-CLIP	23824327
MIRT616865	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT616864	hsa-miR-1290	HITS-CLIP	23824327
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	23824327
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT461448	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT461447	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT461446	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT461444	hsa-miR-4257	PAR-CLIP	23592263
MIRT461445	hsa-miR-4459	PAR-CLIP	23592263
MIRT461443	hsa-miR-665	PAR-CLIP	23592263
MIRT461442	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461441	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT461440	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT461439	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT461438	hsa-miR-558	PAR-CLIP	23592263
MIRT461437	hsa-miR-4487	PAR-CLIP	23592263
MIRT461436	hsa-miR-1827	PAR-CLIP	23592263
MIRT461435	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT461434	hsa-miR-6086	PAR-CLIP	23592263
MIRT461433	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT461432	hsa-miR-3612	PAR-CLIP	23592263
MIRT461431	hsa-miR-650	PAR-CLIP	23592263
MIRT461430	hsa-miR-4792	PAR-CLIP	23592263
MIRT461429	hsa-miR-4710	PAR-CLIP	23592263
MIRT461428	hsa-miR-7855-5p	PAR-CLIP	23592263
MIRT461427	hsa-miR-1273e	PAR-CLIP	23592263
MIRT724566	hsa-miR-4457	HITS-CLIP	19536157
MIRT724565	hsa-miR-125b-2-3p	HITS-CLIP	19536157
MIRT616864	hsa-miR-1290	HITS-CLIP	19536157
MIRT724564	hsa-miR-4450	HITS-CLIP	19536157
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	19536157
MIRT724563	hsa-miR-513b-5p	HITS-CLIP	19536157
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	19536157
MIRT669654	hsa-miR-3183	HITS-CLIP	23824327
MIRT669653	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT669652	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT669651	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT669650	hsa-miR-4421	HITS-CLIP	23824327
MIRT669649	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT669648	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT669647	hsa-miR-4469	HITS-CLIP	23824327
MIRT669646	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT669645	hsa-miR-623	HITS-CLIP	23824327
MIRT669644	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT669643	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT669642	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT669641	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT669640	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT669639	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT669638	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT669637	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616868	hsa-miR-3942-5p	HITS-CLIP	23824327
MIRT616867	hsa-miR-4703-5p	HITS-CLIP	23824327
MIRT616866	hsa-miR-3908	HITS-CLIP	23824327
MIRT616865	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT616864	hsa-miR-1290	HITS-CLIP	23824327
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	23824327
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT461448	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT461447	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT461446	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT461444	hsa-miR-4257	PAR-CLIP	23592263
MIRT461445	hsa-miR-4459	PAR-CLIP	23592263
MIRT461443	hsa-miR-665	PAR-CLIP	23592263
MIRT461442	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461441	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT461440	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT461439	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT461438	hsa-miR-558	PAR-CLIP	23592263
MIRT461437	hsa-miR-4487	PAR-CLIP	23592263
MIRT461436	hsa-miR-1827	PAR-CLIP	23592263
MIRT461435	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT461434	hsa-miR-6086	PAR-CLIP	23592263
MIRT461433	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT461432	hsa-miR-3612	PAR-CLIP	23592263
MIRT461431	hsa-miR-650	PAR-CLIP	23592263
MIRT461430	hsa-miR-4792	PAR-CLIP	23592263
MIRT461429	hsa-miR-4710	PAR-CLIP	23592263
MIRT461428	hsa-miR-7855-5p	PAR-CLIP	23592263
MIRT461427	hsa-miR-1273e	PAR-CLIP	23592263

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000038	Process	Very long-chain fatty acid metabolic process	IDA	10954726
GO:0000166	Function	Nucleotide binding	IEA
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	10954726, 24269233
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IBA
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IDA	10954726, 24269233
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10954726
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	24269233
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	24269233
GO:0005886	Component	Plasma membrane	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031957	Function	Very long-chain fatty acid-CoA ligase activity	IDA	10954726
GO:0031957	Function	Very long-chain fatty acid-CoA ligase activity	TAS
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0042552	Process	Myelination	NAS	10954726
GO:0042759	Process	Long-chain fatty acid biosynthetic process	IBA
GO:0051384	Process	Response to glucocorticoid	IEA

MIM	HGNC	e!Ensembl
614362	29567	ENSG00000103740

Q96GR2

Protein name

Long-chain-fatty-acid--CoA ligase ACSBG1 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 1) (hBG1) (hsBG) (hsBGM) (Lipidosin)

Protein function

Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:10954726, PubMed:12975357, PubMed:2426923

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00501	AMP-binding	109 → 573	AMP-binding enzyme	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all regions of brain except pituitary. {ECO:0000269|PubMed:10954726, ECO:0000269|PubMed:12975357, ECO:0000269|PubMed:24269233}.

Sequence

MPRNSGAGYGCPHGDPSMLDSRETPQESRQDMIVRTTQEKLKTSSLTDRQPLSKESLNHA
LELSVPEKVNNAQWDAPEEALWTTRADGRVRLRIDPSCPQLPYTVHRMFYEALDKYGDLI
ALGFKRQDKWEHISYSQYYLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFFSAVGTVFA
GGIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLEKILKIWKQLPHLKAVVIYKEPPP
NKMANVYTMEEFMELGNEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNIT
WTARYGSQAGDIRPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALKGSL
VNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPGSDL
KPFTTRLADYLVLAKVRQALGFAKCQKNFYGAAPMMAETQHFFLGLNIRLYAGYGLSETS
GPHFMSSPYNYRLYSSGKLVPGCRVKLVNQDAEGIGEICLWGRTIFMGYLNMEDKTCEAI
DEEGWLHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLI
GDQRKFLSMLLTLKCTLDPDTSDQTDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQA
IEEGIRRVNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFYQ
EQKM

Sequence length

724

Interactions

View interactions

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign	rs74894991	RCV005906018
Ovarian serous cystadenocarcinoma	Benign	rs74894991	RCV005906020
Sarcoma	Benign	rs74894991	RCV005906019
Uterine corpus endometrial carcinoma	Benign	rs74894991	RCV005906021

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	27857161
Diabetic Retinopathy	Associate	10688808
Gallstones	Associate	24083370
Hyperimmunoglobulin G1(A1) Syndrome	Associate	1702266
Leukemia Lymphocytic Chronic B Cell	Associate	7437515
Lung Neoplasms	Associate	34970420
Mucopolysaccharidosis VII	Associate	1702266
Multiple Myeloma	Associate	7437515
Neoplasm Metastasis	Associate	27986920
Neoplasms	Associate	27986920
Ovarian Neoplasms	Associate	25321415
Pulmonary Disease Chronic Obstructive	Associate	36924977

ACSBG1 (acyl-CoA synthetase bubblegum family member 1)