Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23205
Gene name Gene Name - the full gene name approved by the HGNC.	Acyl-CoA synthetase bubblegum family member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ACSBG1
Synonyms (NCBI Gene) Gene synonyms aliases	BG, BG1, BGM, GR-LACS, LPD
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q25.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. [provided by RefSeq, Jul 2008]

Show/Hide all(108)

miRTarBase ID	miRNA	Experiments	Reference
MIRT724566	hsa-miR-4457	HITS-CLIP	19536157
MIRT724565	hsa-miR-125b-2-3p	HITS-CLIP	19536157
MIRT616864	hsa-miR-1290	HITS-CLIP	19536157
MIRT724564	hsa-miR-4450	HITS-CLIP	19536157
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	19536157
MIRT724563	hsa-miR-513b-5p	HITS-CLIP	19536157
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	19536157
MIRT669654	hsa-miR-3183	HITS-CLIP	23824327
MIRT669653	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT669652	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT669651	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT669650	hsa-miR-4421	HITS-CLIP	23824327
MIRT669649	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT669648	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT669647	hsa-miR-4469	HITS-CLIP	23824327
MIRT669646	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT669645	hsa-miR-623	HITS-CLIP	23824327
MIRT669644	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT669643	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT669642	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT669641	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT669640	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT669639	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT669638	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT669637	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616868	hsa-miR-3942-5p	HITS-CLIP	23824327
MIRT616867	hsa-miR-4703-5p	HITS-CLIP	23824327
MIRT616866	hsa-miR-3908	HITS-CLIP	23824327
MIRT616865	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT616864	hsa-miR-1290	HITS-CLIP	23824327
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	23824327
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT461448	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT461447	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT461446	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT461444	hsa-miR-4257	PAR-CLIP	23592263
MIRT461445	hsa-miR-4459	PAR-CLIP	23592263
MIRT461443	hsa-miR-665	PAR-CLIP	23592263
MIRT461442	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461441	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT461440	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT461439	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT461438	hsa-miR-558	PAR-CLIP	23592263
MIRT461437	hsa-miR-4487	PAR-CLIP	23592263
MIRT461436	hsa-miR-1827	PAR-CLIP	23592263
MIRT461435	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT461434	hsa-miR-6086	PAR-CLIP	23592263
MIRT461433	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT461432	hsa-miR-3612	PAR-CLIP	23592263
MIRT461431	hsa-miR-650	PAR-CLIP	23592263
MIRT461430	hsa-miR-4792	PAR-CLIP	23592263
MIRT461429	hsa-miR-4710	PAR-CLIP	23592263
MIRT461428	hsa-miR-7855-5p	PAR-CLIP	23592263
MIRT461427	hsa-miR-1273e	PAR-CLIP	23592263
MIRT724566	hsa-miR-4457	HITS-CLIP	19536157
MIRT724565	hsa-miR-125b-2-3p	HITS-CLIP	19536157
MIRT616864	hsa-miR-1290	HITS-CLIP	19536157
MIRT724564	hsa-miR-4450	HITS-CLIP	19536157
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	19536157
MIRT724563	hsa-miR-513b-5p	HITS-CLIP	19536157
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	19536157
MIRT669654	hsa-miR-3183	HITS-CLIP	23824327
MIRT669653	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT669652	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT669651	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT669650	hsa-miR-4421	HITS-CLIP	23824327
MIRT669649	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT669648	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT669647	hsa-miR-4469	HITS-CLIP	23824327
MIRT669646	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT669645	hsa-miR-623	HITS-CLIP	23824327
MIRT669644	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT669643	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT669642	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT669641	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT669640	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT669639	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT669638	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT669637	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616868	hsa-miR-3942-5p	HITS-CLIP	23824327
MIRT616867	hsa-miR-4703-5p	HITS-CLIP	23824327
MIRT616866	hsa-miR-3908	HITS-CLIP	23824327
MIRT616865	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT616864	hsa-miR-1290	HITS-CLIP	23824327
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	23824327
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT461448	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT461447	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT461446	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT461444	hsa-miR-4257	PAR-CLIP	23592263
MIRT461445	hsa-miR-4459	PAR-CLIP	23592263
MIRT461443	hsa-miR-665	PAR-CLIP	23592263
MIRT461442	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461441	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT461440	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT461439	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT461438	hsa-miR-558	PAR-CLIP	23592263
MIRT461437	hsa-miR-4487	PAR-CLIP	23592263
MIRT461436	hsa-miR-1827	PAR-CLIP	23592263
MIRT461435	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT461434	hsa-miR-6086	PAR-CLIP	23592263
MIRT461433	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT461432	hsa-miR-3612	PAR-CLIP	23592263
MIRT461431	hsa-miR-650	PAR-CLIP	23592263
MIRT461430	hsa-miR-4792	PAR-CLIP	23592263
MIRT461429	hsa-miR-4710	PAR-CLIP	23592263
MIRT461428	hsa-miR-7855-5p	PAR-CLIP	23592263
MIRT461427	hsa-miR-1273e	PAR-CLIP	23592263

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000038	Process	Very long-chain fatty acid metabolic process	IDA	10954726
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	10954726, 24269233
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IBA	21873635
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IDA	10954726, 24269233
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	10954726
GO:0005783	Component	Endoplasmic reticulum	IDA	24269233
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	24269233
GO:0016405	Function	CoA-ligase activity	IBA	21873635
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031957	Function	Very long-chain fatty acid-CoA ligase activity	IDA	10954726
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0042552	Process	Myelination	NAS	10954726
GO:0042759	Process	Long-chain fatty acid biosynthetic process	IBA	21873635
GO:0051384	Process	Response to glucocorticoid	IEA

MIM	HGNC	e!Ensembl
614362	29567	ENSG00000103740

Protein

UniProt ID

Q96GR2

Protein name

Long-chain-fatty-acid--CoA ligase ACSBG1 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 1) (hBG1) (hsBG) (hsBGM) (Lipidosin)

Protein function

Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:10954726, PubMed:12975357, PubMed:2426923

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00501	AMP-binding	109 → 573	AMP-binding enzyme	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all regions of brain except pituitary. {ECO:0000269|PubMed:10954726, ECO:0000269|PubMed:12975357, ECO:0000269|PubMed:24269233}.

Sequence

MPRNSGAGYGCPHGDPSMLDSRETPQESRQDMIVRTTQEKLKTSSLTDRQPLSKESLNHA
LELSVPEKVNNAQWDAPEEALWTTRADGRVRLRIDPSCPQLPYTVHRMFYEALDKYGDLI
ALGFKRQDKWEHISYSQYYLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFFSAVGTVFA
GGIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLEKILKIWKQLPHLKAVVIYKEPPP
NKMANVYTMEEFMELGNEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNIT
WTARYGSQAGDIRPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALKGSL
VNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPGSDL
KPFTTRLADYLVLAKVRQALGFAKCQKNFYGAAPMMAETQHFFLGLNIRLYAGYGLSETS
GPHFMSSPYNYRLYSSGKLVPGCRVKLVNQDAEGIGEICLWGRTIFMGYLNMEDKTCEAI
DEEGWLHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLI
GDQRKFLSMLLTLKCTLDPDTSDQTDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQA
IEEGIRRVNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFYQ
EQKM

Sequence length

724

Interactions

View interactions

ACSBG1 (acyl-CoA synthetase bubblegum family member 1)