Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	52
Gene name	Acid phosphatase 1
Gene symbol	ACP1
Synonyms (NCBI Gene)	HAAPLMW-PTPLMWPTP
Chromosome	2
Chromosome location	2p25.3
Summary	The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This e

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Show/Hide all (254)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050258	hsa-miR-25-3p	CLASH	23622248
MIRT043619	hsa-miR-151a-3p	CLASH	23622248
MIRT043619	hsa-miR-151a-3p	CLASH	23622248
MIRT302322	hsa-miR-595	PAR-CLIP	21572407
MIRT551907	hsa-miR-6882-5p	PAR-CLIP	21572407
MIRT302329	hsa-miR-5680	PAR-CLIP	21572407
MIRT302323	hsa-miR-648	PAR-CLIP	21572407
MIRT551906	hsa-miR-300	PAR-CLIP	21572407
MIRT551905	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT551904	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT302330	hsa-miR-6513-3p	PAR-CLIP	21572407
MIRT551903	hsa-miR-6772-5p	PAR-CLIP	21572407
MIRT302327	hsa-miR-4455	PAR-CLIP	21572407
MIRT551902	hsa-miR-609	PAR-CLIP	21572407
MIRT302326	hsa-miR-3650	PAR-CLIP	21572407
MIRT551901	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT551900	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT551899	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT551898	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT302325	hsa-miR-3115	PAR-CLIP	21572407
MIRT531610	hsa-miR-205-5p	PAR-CLIP	22012620
MIRT531609	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT531608	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT302322	hsa-miR-595	PAR-CLIP	21572407
MIRT551907	hsa-miR-6882-5p	PAR-CLIP	21572407
MIRT302329	hsa-miR-5680	PAR-CLIP	21572407
MIRT302323	hsa-miR-648	PAR-CLIP	21572407
MIRT551906	hsa-miR-300	PAR-CLIP	21572407
MIRT551905	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT551904	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT302330	hsa-miR-6513-3p	PAR-CLIP	21572407
MIRT551903	hsa-miR-6772-5p	PAR-CLIP	21572407
MIRT302327	hsa-miR-4455	PAR-CLIP	21572407
MIRT551902	hsa-miR-609	PAR-CLIP	21572407
MIRT302326	hsa-miR-3650	PAR-CLIP	21572407
MIRT551901	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT551900	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT551899	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT551898	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT302325	hsa-miR-3115	PAR-CLIP	21572407
MIRT531610	hsa-miR-205-5p	PAR-CLIP	22012620
MIRT531609	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT531608	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT763155	hsa-miR-1236	CLIP-seq
MIRT763156	hsa-miR-1305	CLIP-seq
MIRT763157	hsa-miR-151-3p	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT763159	hsa-miR-4305	CLIP-seq
MIRT763160	hsa-miR-4463	CLIP-seq
MIRT763161	hsa-miR-4499	CLIP-seq
MIRT763162	hsa-miR-4652-5p	CLIP-seq
MIRT763163	hsa-miR-4677-3p	CLIP-seq
MIRT763164	hsa-miR-4768-5p	CLIP-seq
MIRT763165	hsa-miR-576-5p	CLIP-seq
MIRT763166	hsa-miR-587	CLIP-seq
MIRT763155	hsa-miR-1236	CLIP-seq
MIRT763167	hsa-miR-1264	CLIP-seq
MIRT763168	hsa-miR-1266	CLIP-seq
MIRT763169	hsa-miR-1286	CLIP-seq
MIRT763170	hsa-miR-1294	CLIP-seq
MIRT763171	hsa-miR-1297	CLIP-seq
MIRT763156	hsa-miR-1305	CLIP-seq
MIRT763157	hsa-miR-151-3p	CLIP-seq
MIRT763172	hsa-miR-192	CLIP-seq
MIRT763173	hsa-miR-214	CLIP-seq
MIRT763174	hsa-miR-215	CLIP-seq
MIRT763175	hsa-miR-26a	CLIP-seq
MIRT763176	hsa-miR-26b	CLIP-seq
MIRT763177	hsa-miR-2861	CLIP-seq
MIRT763178	hsa-miR-3155	CLIP-seq
MIRT763179	hsa-miR-3155b	CLIP-seq
MIRT763180	hsa-miR-3619-5p	CLIP-seq
MIRT763181	hsa-miR-3661	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT763182	hsa-miR-381	CLIP-seq
MIRT763183	hsa-miR-421	CLIP-seq
MIRT763184	hsa-miR-4251	CLIP-seq
MIRT763159	hsa-miR-4305	CLIP-seq
MIRT763185	hsa-miR-4438	CLIP-seq
MIRT763160	hsa-miR-4463	CLIP-seq
MIRT763186	hsa-miR-4465	CLIP-seq
MIRT763161	hsa-miR-4499	CLIP-seq
MIRT763187	hsa-miR-4518	CLIP-seq
MIRT763188	hsa-miR-4666-3p	CLIP-seq
MIRT763163	hsa-miR-4677-3p	CLIP-seq
MIRT763189	hsa-miR-4709-5p	CLIP-seq
MIRT763190	hsa-miR-4722-5p	CLIP-seq
MIRT763164	hsa-miR-4768-5p	CLIP-seq
MIRT763191	hsa-miR-484	CLIP-seq
MIRT763192	hsa-miR-539	CLIP-seq
MIRT763193	hsa-miR-554	CLIP-seq
MIRT763194	hsa-miR-576-3p	CLIP-seq
MIRT763165	hsa-miR-576-5p	CLIP-seq
MIRT763166	hsa-miR-587	CLIP-seq
MIRT763195	hsa-miR-601	CLIP-seq
MIRT763196	hsa-miR-615-5p	CLIP-seq
MIRT763197	hsa-miR-631	CLIP-seq
MIRT763198	hsa-miR-761	CLIP-seq
MIRT2166186	hsa-miR-1237	CLIP-seq
MIRT2166187	hsa-miR-1248	CLIP-seq
MIRT763168	hsa-miR-1266	CLIP-seq
MIRT2166188	hsa-miR-1283	CLIP-seq
MIRT763169	hsa-miR-1286	CLIP-seq
MIRT2166189	hsa-miR-1299	CLIP-seq
MIRT763157	hsa-miR-151-3p	CLIP-seq
MIRT2166190	hsa-miR-1976	CLIP-seq
MIRT763173	hsa-miR-214	CLIP-seq
MIRT763178	hsa-miR-3155	CLIP-seq
MIRT763179	hsa-miR-3155b	CLIP-seq
MIRT763180	hsa-miR-3619-5p	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT2166191	hsa-miR-380	CLIP-seq
MIRT763182	hsa-miR-381	CLIP-seq
MIRT2166192	hsa-miR-4279	CLIP-seq
MIRT763159	hsa-miR-4305	CLIP-seq
MIRT763160	hsa-miR-4463	CLIP-seq
MIRT763161	hsa-miR-4499	CLIP-seq
MIRT763187	hsa-miR-4518	CLIP-seq
MIRT763162	hsa-miR-4652-5p	CLIP-seq
MIRT763163	hsa-miR-4677-3p	CLIP-seq
MIRT2166193	hsa-miR-4722-3p	CLIP-seq
MIRT763190	hsa-miR-4722-5p	CLIP-seq
MIRT2166194	hsa-miR-4764-5p	CLIP-seq
MIRT2166195	hsa-miR-4782-5p	CLIP-seq
MIRT763191	hsa-miR-484	CLIP-seq
MIRT2166196	hsa-miR-516b	CLIP-seq
MIRT763192	hsa-miR-539	CLIP-seq
MIRT763193	hsa-miR-554	CLIP-seq
MIRT763165	hsa-miR-576-5p	CLIP-seq
MIRT763166	hsa-miR-587	CLIP-seq
MIRT2166197	hsa-miR-591	CLIP-seq
MIRT763195	hsa-miR-601	CLIP-seq
MIRT763196	hsa-miR-615-5p	CLIP-seq
MIRT763198	hsa-miR-761	CLIP-seq
MIRT763157	hsa-miR-151-3p	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT763159	hsa-miR-4305	CLIP-seq
MIRT763160	hsa-miR-4463	CLIP-seq
MIRT763161	hsa-miR-4499	CLIP-seq
MIRT763163	hsa-miR-4677-3p	CLIP-seq
MIRT2425899	hsa-let-7a	CLIP-seq
MIRT2425900	hsa-let-7b	CLIP-seq
MIRT2425901	hsa-let-7c	CLIP-seq
MIRT2425902	hsa-let-7d	CLIP-seq
MIRT2425903	hsa-let-7e	CLIP-seq
MIRT2425904	hsa-let-7f	CLIP-seq
MIRT2425905	hsa-let-7g	CLIP-seq
MIRT2425906	hsa-let-7i	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT2425907	hsa-miR-4458	CLIP-seq
MIRT2425908	hsa-miR-4500	CLIP-seq
MIRT763162	hsa-miR-4652-5p	CLIP-seq
MIRT2425909	hsa-miR-98	CLIP-seq
MIRT2425899	hsa-let-7a	CLIP-seq
MIRT2425900	hsa-let-7b	CLIP-seq
MIRT2425901	hsa-let-7c	CLIP-seq
MIRT2425902	hsa-let-7d	CLIP-seq
MIRT2425903	hsa-let-7e	CLIP-seq
MIRT2425904	hsa-let-7f	CLIP-seq
MIRT2425905	hsa-let-7g	CLIP-seq
MIRT2425906	hsa-let-7i	CLIP-seq
MIRT763155	hsa-miR-1236	CLIP-seq
MIRT2166186	hsa-miR-1237	CLIP-seq
MIRT2166187	hsa-miR-1248	CLIP-seq
MIRT763168	hsa-miR-1266	CLIP-seq
MIRT763169	hsa-miR-1286	CLIP-seq
MIRT763170	hsa-miR-1294	CLIP-seq
MIRT763171	hsa-miR-1297	CLIP-seq
MIRT2166189	hsa-miR-1299	CLIP-seq
MIRT763156	hsa-miR-1305	CLIP-seq
MIRT763157	hsa-miR-151-3p	CLIP-seq
MIRT763172	hsa-miR-192	CLIP-seq
MIRT763173	hsa-miR-214	CLIP-seq
MIRT763174	hsa-miR-215	CLIP-seq
MIRT2468778	hsa-miR-2467-3p	CLIP-seq
MIRT763175	hsa-miR-26a	CLIP-seq
MIRT763176	hsa-miR-26b	CLIP-seq
MIRT763177	hsa-miR-2861	CLIP-seq
MIRT763178	hsa-miR-3155	CLIP-seq
MIRT763179	hsa-miR-3155b	CLIP-seq
MIRT2468779	hsa-miR-3529	CLIP-seq
MIRT2468780	hsa-miR-3616-3p	CLIP-seq
MIRT763180	hsa-miR-3619-5p	CLIP-seq
MIRT763181	hsa-miR-3661	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT2468781	hsa-miR-379	CLIP-seq
MIRT2166191	hsa-miR-380	CLIP-seq
MIRT763182	hsa-miR-381	CLIP-seq
MIRT2468782	hsa-miR-3927	CLIP-seq
MIRT2468783	hsa-miR-3942-3p	CLIP-seq
MIRT2468784	hsa-miR-4257	CLIP-seq
MIRT2468785	hsa-miR-4290	CLIP-seq
MIRT763159	hsa-miR-4305	CLIP-seq
MIRT2425907	hsa-miR-4458	CLIP-seq
MIRT763160	hsa-miR-4463	CLIP-seq
MIRT763186	hsa-miR-4465	CLIP-seq
MIRT2468786	hsa-miR-4468	CLIP-seq
MIRT763161	hsa-miR-4499	CLIP-seq
MIRT2425908	hsa-miR-4500	CLIP-seq
MIRT763187	hsa-miR-4518	CLIP-seq
MIRT2468787	hsa-miR-4645-5p	CLIP-seq
MIRT763162	hsa-miR-4652-5p	CLIP-seq
MIRT763188	hsa-miR-4666-3p	CLIP-seq
MIRT2468788	hsa-miR-4673	CLIP-seq
MIRT763163	hsa-miR-4677-3p	CLIP-seq
MIRT2468789	hsa-miR-4709-3p	CLIP-seq
MIRT763190	hsa-miR-4722-5p	CLIP-seq
MIRT2468790	hsa-miR-4724-5p	CLIP-seq
MIRT2166194	hsa-miR-4764-5p	CLIP-seq
MIRT763164	hsa-miR-4768-5p	CLIP-seq
MIRT2166195	hsa-miR-4782-5p	CLIP-seq
MIRT763191	hsa-miR-484	CLIP-seq
MIRT2166196	hsa-miR-516b	CLIP-seq
MIRT2468791	hsa-miR-520g	CLIP-seq
MIRT2468792	hsa-miR-520h	CLIP-seq
MIRT763192	hsa-miR-539	CLIP-seq
MIRT763193	hsa-miR-554	CLIP-seq
MIRT763165	hsa-miR-576-5p	CLIP-seq
MIRT763166	hsa-miR-587	CLIP-seq
MIRT2166197	hsa-miR-591	CLIP-seq
MIRT763195	hsa-miR-601	CLIP-seq
MIRT763196	hsa-miR-615-5p	CLIP-seq
MIRT763197	hsa-miR-631	CLIP-seq
MIRT763198	hsa-miR-761	CLIP-seq
MIRT2425909	hsa-miR-98	CLIP-seq
MIRT763155	hsa-miR-1236	CLIP-seq
MIRT763168	hsa-miR-1266	CLIP-seq
MIRT763169	hsa-miR-1286	CLIP-seq
MIRT763156	hsa-miR-1305	CLIP-seq
MIRT763157	hsa-miR-151-3p	CLIP-seq
MIRT763173	hsa-miR-214	CLIP-seq
MIRT763178	hsa-miR-3155	CLIP-seq
MIRT763179	hsa-miR-3155b	CLIP-seq
MIRT763180	hsa-miR-3619-5p	CLIP-seq
MIRT763158	hsa-miR-3670	CLIP-seq
MIRT763182	hsa-miR-381	CLIP-seq
MIRT763159	hsa-miR-4305	CLIP-seq
MIRT763160	hsa-miR-4463	CLIP-seq
MIRT763161	hsa-miR-4499	CLIP-seq
MIRT763187	hsa-miR-4518	CLIP-seq
MIRT763162	hsa-miR-4652-5p	CLIP-seq
MIRT763188	hsa-miR-4666-3p	CLIP-seq
MIRT763163	hsa-miR-4677-3p	CLIP-seq
MIRT763190	hsa-miR-4722-5p	CLIP-seq
MIRT763164	hsa-miR-4768-5p	CLIP-seq
MIRT763191	hsa-miR-484	CLIP-seq
MIRT763192	hsa-miR-539	CLIP-seq
MIRT763193	hsa-miR-554	CLIP-seq
MIRT763165	hsa-miR-576-5p	CLIP-seq
MIRT763166	hsa-miR-587	CLIP-seq
MIRT2166197	hsa-miR-591	CLIP-seq
MIRT763195	hsa-miR-601	CLIP-seq
MIRT763196	hsa-miR-615-5p	CLIP-seq
MIRT763198	hsa-miR-761	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003993	Function	Acid phosphatase activity	IDA	10336608
GO:0003993	Function	Acid phosphatase activity	IDA	9038134, 9705307, 10336608
GO:0003993	Function	Acid phosphatase activity	IEA
GO:0003993	Function	Acid phosphatase activity	TAS	1587862
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	9705307
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0004726	Function	Non-membrane spanning protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	9499402, 15846844, 25556234, 32814053
GO:0005737	Component	Cytoplasm	IDA	10940933
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	10940933
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0017124	Function	SH3 domain binding	IEA
GO:0042383	Component	Sarcolemma	IEA
GO:0045202	Component	Synapse	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

MIM	HGNC	e!Ensembl
171500	122	ENSG00000143727

P24666

Protein name

Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1)

Protein function

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2. ; FUN

PDB

1XWW , 3N8I , 4Z99 , 4Z9A , 4Z9B , 5JNR , 5JNS , 5JNT , 5KQG , 5KQL , 5KQM , 5KQP , 5PNT , 6Y2V , 6Y2W , 7KH8 , 7UW6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01451	LMWPc	9 → 154	Low molecular weight phosphotyrosine protein phosphatase	Domain

Tissue specificity

TISSUE SPECIFICITY: [Isoform 2]: Expressed in T-lymphocytes. {ECO:0000269|PubMed:9038134}.

Sequence

MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRG
QSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSY
DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH

Sequence length

158

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
ACP1 A/B POLYMORPHISM	Benign	rs79716074	RCV000014681

Show/Hide Text Mining Associations (26)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	38017020
Bipolar Disorder	Associate	21423239
Breast Neoplasms	Associate	24086724, 26861043
Carcinogenesis	Associate	24086724
Carcinoma Hepatocellular	Associate	20926737
Cardiovascular Diseases	Associate	21767392
Colorectal Neoplasms	Stimulate	25811796, 34610471
Coronary Artery Disease	Associate	23197232
Drug Hypersensitivity	Associate	18490013
Endometriosis	Associate	18490013
Favism	Associate	21644204
Gastrointestinal Neoplasms	Stimulate	34610471
Glucosephosphate Dehydrogenase Deficiency	Associate	21644204
Hemolysis	Associate	21644204
Immune System Diseases	Associate	18490013
Leiomyoma	Associate	30122580
Leukemia Lymphocytic Chronic B Cell	Associate	22035742
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	22957062
Lung Neoplasms	Associate	21742797
Melanoma	Associate	29573568
Neoplasms	Associate	21742797, 22957062, 24086724, 25811796, 29573568, 34610471
Obesity	Associate	19217450, 24129437
Osteonecrosis	Associate	21148812, 31686588
Prostatic Neoplasms	Associate	34610471
Retinal Dysplasia	Stimulate	25811796
Tuberculosis Multidrug Resistant	Associate	22957062

ACP1 (acid phosphatase 1)