ACOX3 (acyl-CoA oxidase 3, pristanoyl)

Gene

• Entrez ID: 8310
• Gene name: Acyl-CoA oxidase 3, pristanoyl
• Gene symbol: ACOX3
• Synonyms (NCBI Gene): -
• Chromosome: 4
• Chromosome location: 4p16.1
• Summary: Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT763147	hsa-miR-15a	CLIP-seq
MIRT763148	hsa-miR-15b	CLIP-seq
MIRT763149	hsa-miR-16	CLIP-seq
MIRT763150	hsa-miR-195	CLIP-seq
MIRT763151	hsa-miR-24	CLIP-seq
MIRT763152	hsa-miR-424	CLIP-seq
MIRT763153	hsa-miR-4437	CLIP-seq
MIRT763154	hsa-miR-497	CLIP-seq
MIRT2166138	hsa-miR-1245b-3p	CLIP-seq
MIRT2166139	hsa-miR-1247	CLIP-seq
MIRT2166140	hsa-miR-1285	CLIP-seq
MIRT2166141	hsa-miR-1299	CLIP-seq
MIRT2166142	hsa-miR-1304	CLIP-seq
MIRT2166143	hsa-miR-1470	CLIP-seq
MIRT2166144	hsa-miR-154	CLIP-seq
MIRT763147	hsa-miR-15a	CLIP-seq
MIRT763148	hsa-miR-15b	CLIP-seq
MIRT763149	hsa-miR-16	CLIP-seq
MIRT2166145	hsa-miR-181a	CLIP-seq
MIRT2166146	hsa-miR-181b	CLIP-seq
MIRT2166147	hsa-miR-181c	CLIP-seq
MIRT2166148	hsa-miR-181d	CLIP-seq
MIRT763150	hsa-miR-195	CLIP-seq
MIRT2166149	hsa-miR-19a	CLIP-seq
MIRT2166150	hsa-miR-19b	CLIP-seq
MIRT2166151	hsa-miR-204	CLIP-seq
MIRT2166152	hsa-miR-211	CLIP-seq
MIRT2166153	hsa-miR-214	CLIP-seq
MIRT763151	hsa-miR-24	CLIP-seq
MIRT2166154	hsa-miR-3187-5p	CLIP-seq
MIRT2166155	hsa-miR-3529	CLIP-seq
MIRT2166156	hsa-miR-3619-5p	CLIP-seq
MIRT2166157	hsa-miR-379	CLIP-seq
MIRT2166158	hsa-miR-3920	CLIP-seq
MIRT2166159	hsa-miR-3927	CLIP-seq
MIRT2166160	hsa-miR-3942-3p	CLIP-seq
MIRT763152	hsa-miR-424	CLIP-seq
MIRT2166161	hsa-miR-425	CLIP-seq
MIRT2166162	hsa-miR-4262	CLIP-seq
MIRT2166163	hsa-miR-4291	CLIP-seq
MIRT763153	hsa-miR-4437	CLIP-seq
MIRT2166164	hsa-miR-4466	CLIP-seq
MIRT2166165	hsa-miR-4469	CLIP-seq
MIRT2166166	hsa-miR-455-5p	CLIP-seq
MIRT2166167	hsa-miR-4667-3p	CLIP-seq
MIRT2166168	hsa-miR-4711-5p	CLIP-seq
MIRT2166169	hsa-miR-4755-5p	CLIP-seq
MIRT2166170	hsa-miR-4767	CLIP-seq
MIRT2166171	hsa-miR-4782-5p	CLIP-seq
MIRT763154	hsa-miR-497	CLIP-seq
MIRT2166172	hsa-miR-516b	CLIP-seq
MIRT2166173	hsa-miR-552	CLIP-seq
MIRT2166174	hsa-miR-612	CLIP-seq
MIRT2166175	hsa-miR-623	CLIP-seq
MIRT2166176	hsa-miR-661	CLIP-seq
MIRT2166177	hsa-miR-675	CLIP-seq
MIRT2166178	hsa-miR-761	CLIP-seq
MIRT2166179	hsa-miR-764	CLIP-seq
MIRT2166180	hsa-miR-875-3p	CLIP-seq
MIRT2166181	hsa-miR-922	CLIP-seq
MIRT2166144	hsa-miR-154	CLIP-seq
MIRT2166161	hsa-miR-425	CLIP-seq
MIRT2468759	hsa-miR-1303	CLIP-seq
MIRT2468760	hsa-miR-1587	CLIP-seq
MIRT2468761	hsa-miR-28-5p	CLIP-seq
MIRT2468762	hsa-miR-3123	CLIP-seq
MIRT2468763	hsa-miR-3139	CLIP-seq
MIRT2468764	hsa-miR-3160-3p	CLIP-seq
MIRT2468765	hsa-miR-3925-5p	CLIP-seq
MIRT2468766	hsa-miR-4492	CLIP-seq
MIRT2468767	hsa-miR-4498	CLIP-seq
MIRT2468768	hsa-miR-4656	CLIP-seq
MIRT2468769	hsa-miR-4675	CLIP-seq
MIRT2468770	hsa-miR-4687-3p	CLIP-seq
MIRT2468771	hsa-miR-4741	CLIP-seq
MIRT2468772	hsa-miR-548a-3p	CLIP-seq
MIRT2468773	hsa-miR-548e	CLIP-seq
MIRT2468774	hsa-miR-548f	CLIP-seq
MIRT2468775	hsa-miR-570	CLIP-seq
MIRT2468776	hsa-miR-708	CLIP-seq
MIRT2468777	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003997	Function	Acyl-CoA oxidase activity	IBA	21873635
GO:0005504	Function	Fatty acid binding	IBA	21873635
GO:0005777	Component	Peroxisome	IBA	21873635
GO:0005777	Component	Peroxisome	IDA	8993592
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006625	Process	Protein targeting to peroxisome	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016402	Function	Pristanoyl-CoA oxidase activity	IBA	21873635
GO:0033540	Process	Fatty acid beta-oxidation using acyl-CoA oxidase	IBA	21873635
GO:0033540	Process	Fatty acid beta-oxidation using acyl-CoA oxidase	IEA
GO:0033540	Process	Fatty acid beta-oxidation using acyl-CoA oxidase	TAS
GO:0050660	Function	Flavin adenine dinucleotide binding	IBA	21873635
GO:0055088	Process	Lipid homeostasis	IBA	21873635
GO:0071949	Function	FAD binding	IEA

Other IDs

• MIM: 603402
• HGNC: 121
• e!Ensembl: ENSG00000087008

Protein

• UniProt ID: O15254
• Protein name: Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase)
• Protein function: Oxidizes the CoA-esters of 2-methyl-branched fatty acids.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02770	Acyl-CoA_dh_M	155 → 266	Acyl-CoA dehydrogenase, middle domain	Domain
  PF01756	ACOX	510 → 693	Acyl-CoA oxidase	Family

• Sequence:

  MASTVEGGDTALLPEFPRGPLDAYRARASFSWKELALFTEGEGMLRFKKTIFSALENDPL
  FARSPGADLSLEKYRELNFLRCKRIFEYDFLSVEDMFKSPLKVPALIQCLGMYDSSLAAK
  YLLHSLVFGSAVYSSGSERHLTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPAT
  EEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMP
  GVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGAS
  LGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPTEEEEIPVLEYPMQQWRLLPYL
  AAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALASASKPLASWTTQQGIQ
  ECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFR
  SPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSG
  SSDFEARNKCQVSHGRPLALAFVELTVVQRFHEHVHQPSVPPSLRAVLGRLSALYALWSL
  SRHAALLYRGGYFSGEQAGEVLESAVLALCSQLKDDAVALVDVIAPPDFVLDSPIGRADG
  ELYKNLWGAVLQESKVLERASWWPEFSVNKPVIGSLKSKL

• Sequence length: 700

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Carpal Tunnel Syndrome	Carpal Tunnel Syndrome			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Inhibit	35335125
Lung Neoplasms	Associate	34970420