Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	8310
Gene name	Acyl-CoA oxidase 3, pristanoyl
Gene symbol	ACOX3
Synonyms (NCBI Gene)	-
Chromosome	4
Chromosome location	4p16.1
Summary	Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was

Show/Hide all (81)

miRTarBase ID	miRNA	Experiments
MIRT763147	hsa-miR-15a	CLIP-seq
MIRT763148	hsa-miR-15b	CLIP-seq
MIRT763149	hsa-miR-16	CLIP-seq
MIRT763150	hsa-miR-195	CLIP-seq
MIRT763151	hsa-miR-24	CLIP-seq
MIRT763152	hsa-miR-424	CLIP-seq
MIRT763153	hsa-miR-4437	CLIP-seq
MIRT763154	hsa-miR-497	CLIP-seq
MIRT2166138	hsa-miR-1245b-3p	CLIP-seq
MIRT2166139	hsa-miR-1247	CLIP-seq
MIRT2166140	hsa-miR-1285	CLIP-seq
MIRT2166141	hsa-miR-1299	CLIP-seq
MIRT2166142	hsa-miR-1304	CLIP-seq
MIRT2166143	hsa-miR-1470	CLIP-seq
MIRT2166144	hsa-miR-154	CLIP-seq
MIRT763147	hsa-miR-15a	CLIP-seq
MIRT763148	hsa-miR-15b	CLIP-seq
MIRT763149	hsa-miR-16	CLIP-seq
MIRT2166145	hsa-miR-181a	CLIP-seq
MIRT2166146	hsa-miR-181b	CLIP-seq
MIRT2166147	hsa-miR-181c	CLIP-seq
MIRT2166148	hsa-miR-181d	CLIP-seq
MIRT763150	hsa-miR-195	CLIP-seq
MIRT2166149	hsa-miR-19a	CLIP-seq
MIRT2166150	hsa-miR-19b	CLIP-seq
MIRT2166151	hsa-miR-204	CLIP-seq
MIRT2166152	hsa-miR-211	CLIP-seq
MIRT2166153	hsa-miR-214	CLIP-seq
MIRT763151	hsa-miR-24	CLIP-seq
MIRT2166154	hsa-miR-3187-5p	CLIP-seq
MIRT2166155	hsa-miR-3529	CLIP-seq
MIRT2166156	hsa-miR-3619-5p	CLIP-seq
MIRT2166157	hsa-miR-379	CLIP-seq
MIRT2166158	hsa-miR-3920	CLIP-seq
MIRT2166159	hsa-miR-3927	CLIP-seq
MIRT2166160	hsa-miR-3942-3p	CLIP-seq
MIRT763152	hsa-miR-424	CLIP-seq
MIRT2166161	hsa-miR-425	CLIP-seq
MIRT2166162	hsa-miR-4262	CLIP-seq
MIRT2166163	hsa-miR-4291	CLIP-seq
MIRT763153	hsa-miR-4437	CLIP-seq
MIRT2166164	hsa-miR-4466	CLIP-seq
MIRT2166165	hsa-miR-4469	CLIP-seq
MIRT2166166	hsa-miR-455-5p	CLIP-seq
MIRT2166167	hsa-miR-4667-3p	CLIP-seq
MIRT2166168	hsa-miR-4711-5p	CLIP-seq
MIRT2166169	hsa-miR-4755-5p	CLIP-seq
MIRT2166170	hsa-miR-4767	CLIP-seq
MIRT2166171	hsa-miR-4782-5p	CLIP-seq
MIRT763154	hsa-miR-497	CLIP-seq
MIRT2166172	hsa-miR-516b	CLIP-seq
MIRT2166173	hsa-miR-552	CLIP-seq
MIRT2166174	hsa-miR-612	CLIP-seq
MIRT2166175	hsa-miR-623	CLIP-seq
MIRT2166176	hsa-miR-661	CLIP-seq
MIRT2166177	hsa-miR-675	CLIP-seq
MIRT2166178	hsa-miR-761	CLIP-seq
MIRT2166179	hsa-miR-764	CLIP-seq
MIRT2166180	hsa-miR-875-3p	CLIP-seq
MIRT2166181	hsa-miR-922	CLIP-seq
MIRT2166144	hsa-miR-154	CLIP-seq
MIRT2166161	hsa-miR-425	CLIP-seq
MIRT2468759	hsa-miR-1303	CLIP-seq
MIRT2468760	hsa-miR-1587	CLIP-seq
MIRT2468761	hsa-miR-28-5p	CLIP-seq
MIRT2468762	hsa-miR-3123	CLIP-seq
MIRT2468763	hsa-miR-3139	CLIP-seq
MIRT2468764	hsa-miR-3160-3p	CLIP-seq
MIRT2468765	hsa-miR-3925-5p	CLIP-seq
MIRT2468766	hsa-miR-4492	CLIP-seq
MIRT2468767	hsa-miR-4498	CLIP-seq
MIRT2468768	hsa-miR-4656	CLIP-seq
MIRT2468769	hsa-miR-4675	CLIP-seq
MIRT2468770	hsa-miR-4687-3p	CLIP-seq
MIRT2468771	hsa-miR-4741	CLIP-seq
MIRT2468772	hsa-miR-548a-3p	CLIP-seq
MIRT2468773	hsa-miR-548e	CLIP-seq
MIRT2468774	hsa-miR-548f	CLIP-seq
MIRT2468775	hsa-miR-570	CLIP-seq
MIRT2468776	hsa-miR-708	CLIP-seq
MIRT2468777	hsa-miR-762	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003997	Function	Acyl-CoA oxidase activity	IEA
GO:0005504	Function	Fatty acid binding	IBA
GO:0005504	Function	Fatty acid binding	IEA
GO:0005777	Component	Peroxisome	IBA
GO:0005777	Component	Peroxisome	IDA	8993592
GO:0005777	Component	Peroxisome	IEA
GO:0005782	Component	Peroxisomal matrix	IEA
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006635	Process	Fatty acid beta-oxidation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016402	Function	Pristanoyl-CoA oxidase activity	IBA
GO:0016402	Function	Pristanoyl-CoA oxidase activity	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016627	Function	Oxidoreductase activity, acting on the CH-CH group of donors	IEA
GO:0033540	Process	Fatty acid beta-oxidation using acyl-CoA oxidase	IBA
GO:0033540	Process	Fatty acid beta-oxidation using acyl-CoA oxidase	IEA
GO:0050660	Function	Flavin adenine dinucleotide binding	IBA
GO:0071949	Function	FAD binding	IEA

MIM	HGNC	e!Ensembl
603402	121	ENSG00000087008

O15254

Protein name

Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase)

Protein function

Oxidizes the CoA-esters of 2-methyl-branched fatty acids.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02770	Acyl-CoA_dh_M	155 → 266	Acyl-CoA dehydrogenase, middle domain	Domain
PF01756	ACOX	510 → 693	Acyl-CoA oxidase	Family

Sequence

MASTVEGGDTALLPEFPRGPLDAYRARASFSWKELALFTEGEGMLRFKKTIFSALENDPL
FARSPGADLSLEKYRELNFLRCKRIFEYDFLSVEDMFKSPLKVPALIQCLGMYDSSLAAK
YLLHSLVFGSAVYSSGSERHLTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPAT
EEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMP
GVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGAS
LGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPTEEEEIPVLEYPMQQWRLLPYL
AAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALASASKPLASWTTQQGIQ
ECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFR
SPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSG
SSDFEARNKCQVSHGRPLALAFVELTVVQRFHEHVHQPSVPPSLRAVLGRLSALYALWSL
SRHAALLYRGGYFSGEQAGEVLESAVLALCSQLKDDAVALVDVIAPPDFVLDSPIGRADG
ELYKNLWGAVLQESKVLERASWWPEFSVNKPVIGSLKSKL

Sequence length

700

Interactions

View interactions

Show/Hide Unknown Diseases (16)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs62286003	RCV005901527
Adrenocortical carcinoma, hereditary	Benign	rs62286003	RCV005901530
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	rs62286003	RCV005901541
Clear cell carcinoma of kidney	Benign	rs62286003	RCV005901532
Colon adenocarcinoma	Benign	rs62286003	RCV005901526
Colorectal cancer	Benign	rs62286003	RCV005901535
Familial pancreatic carcinoma	Benign	rs62286003	RCV005901534
Gastric cancer	Benign	rs62286003	RCV005901537
Malignant tumor of esophagus	Benign	rs62286003	RCV005901528
Nonpapillary renal cell carcinoma	Benign	rs62286003	RCV005901529
Ovarian cancer	Benign	rs62286003	RCV005901531
Ovarian serous cystadenocarcinoma	Benign	rs62286003	RCV005901538
Sarcoma	Benign	rs62286003	RCV005901536
Uterine carcinosarcoma	Benign	rs62286003	RCV005901539
Uterine corpus endometrial carcinoma	Benign	rs62286003	RCV005901540
Uveal melanoma	Benign	rs62286003	RCV005901533

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Inhibit	35335125
Lung Neoplasms	Associate	34970420

ACOX3 (acyl-CoA oxidase 3, pristanoyl)