ACOX1 (acyl-CoA oxidase 1)
| Gene | |
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
51 |
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Acyl-CoA oxidase 1 |
|
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
ACOX1 |
|
Synonyms (NCBI Gene)
Gene synonyms aliases
|
ACOX, AOX, MITCH, PALMCOX, SCOX |
|
Chromosome
Chromosome number
|
17 |
|
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
17q25.1 |
|
Summary
Summary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Def |
|
SNPs
SNP information provided by dbSNP.
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
| Transcription factors | |||||||
|
|||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
|||||||
| Protein | |||||||||||||||||||||
| UniProt ID | Q15067 | ||||||||||||||||||||
| Protein name | Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; | ||||||||||||||||||||
| Protein function | Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids (PubMed:15060085, PubMed:17458872, PubMed:17603022, PubMed:32169171, PubMed:33234382, PubMed:787 | ||||||||||||||||||||
| Family and domains |
Pfam
|
||||||||||||||||||||
| Tissue specificity | TISSUE SPECIFICITY: Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tiss | ||||||||||||||||||||
| Sequence |
|
||||||||||||||||||||
| Sequence length | 660 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
|
Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||