Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Transcription factors Other IDs
Entrez ID	48
Gene name	Aconitase 1
Gene symbol	ACO1
Synonyms (NCBI Gene)	ACONSHEL60IREB1IREBPIREBP1IRP1
Chromosome	9
Chromosome location	9p21.1
Summary	The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4F

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miRTarBase ID	miRNA	Experiments	Reference
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624820	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT624818	hsa-miR-4503	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT639007	hsa-miR-556-5p	HITS-CLIP	23824327
MIRT639006	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT636743	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT639005	hsa-miR-8055	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT639007	hsa-miR-556-5p	HITS-CLIP	23824327
MIRT639006	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT636743	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT639005	hsa-miR-8055	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT636743	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624820	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT624818	hsa-miR-4503	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624820	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT624818	hsa-miR-4503	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624820	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT624818	hsa-miR-4503	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT639007	hsa-miR-556-5p	HITS-CLIP	23824327
MIRT639006	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT636743	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT639005	hsa-miR-8055	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT639007	hsa-miR-556-5p	HITS-CLIP	23824327
MIRT639006	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT636743	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT639005	hsa-miR-8055	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT636743	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624820	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT624818	hsa-miR-4503	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT624830	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT624829	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT624828	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT624827	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT624826	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT624825	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT624824	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT624823	hsa-miR-1976	HITS-CLIP	23824327
MIRT624822	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT624821	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT624820	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT624819	hsa-miR-4279	HITS-CLIP	23824327
MIRT624818	hsa-miR-4503	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT615856	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT615855	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT615854	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT762807	hsa-miR-1207-3p	CLIP-seq
MIRT762808	hsa-miR-1252	CLIP-seq
MIRT762809	hsa-miR-1253	CLIP-seq
MIRT762810	hsa-miR-1255a	CLIP-seq
MIRT762811	hsa-miR-1255b	CLIP-seq
MIRT762812	hsa-miR-1273e	CLIP-seq
MIRT762813	hsa-miR-1299	CLIP-seq
MIRT762814	hsa-miR-141	CLIP-seq
MIRT762815	hsa-miR-185	CLIP-seq
MIRT762816	hsa-miR-19a	CLIP-seq
MIRT762817	hsa-miR-19b	CLIP-seq
MIRT762818	hsa-miR-200a	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT762820	hsa-miR-2116	CLIP-seq
MIRT762821	hsa-miR-3123	CLIP-seq
MIRT762822	hsa-miR-3148	CLIP-seq
MIRT762823	hsa-miR-3150b-3p	CLIP-seq
MIRT762824	hsa-miR-3175	CLIP-seq
MIRT762825	hsa-miR-34b	CLIP-seq
MIRT762826	hsa-miR-3616-5p	CLIP-seq
MIRT762827	hsa-miR-3647-5p	CLIP-seq
MIRT762828	hsa-miR-4261	CLIP-seq
MIRT762829	hsa-miR-4294	CLIP-seq
MIRT762830	hsa-miR-4306	CLIP-seq
MIRT762831	hsa-miR-4311	CLIP-seq
MIRT762832	hsa-miR-4496	CLIP-seq
MIRT762833	hsa-miR-4639-3p	CLIP-seq
MIRT762834	hsa-miR-4644	CLIP-seq
MIRT762835	hsa-miR-4689	CLIP-seq
MIRT762836	hsa-miR-4699-5p	CLIP-seq
MIRT762837	hsa-miR-4714-5p	CLIP-seq
MIRT762838	hsa-miR-4782-5p	CLIP-seq
MIRT762839	hsa-miR-4784	CLIP-seq
MIRT762840	hsa-miR-4795-5p	CLIP-seq
MIRT762841	hsa-miR-516b	CLIP-seq
MIRT762842	hsa-miR-518a-5p	CLIP-seq
MIRT762843	hsa-miR-527	CLIP-seq
MIRT762844	hsa-miR-573	CLIP-seq
MIRT762845	hsa-miR-581	CLIP-seq
MIRT762846	hsa-miR-595	CLIP-seq
MIRT762847	hsa-miR-633	CLIP-seq
MIRT762848	hsa-miR-648	CLIP-seq
MIRT762849	hsa-miR-668	CLIP-seq
MIRT762850	hsa-miR-875-3p	CLIP-seq
MIRT1924866	hsa-miR-1178	CLIP-seq
MIRT1924867	hsa-miR-1224-3p	CLIP-seq
MIRT1924868	hsa-miR-1260	CLIP-seq
MIRT1924869	hsa-miR-1260b	CLIP-seq
MIRT1924870	hsa-miR-1280	CLIP-seq
MIRT1924871	hsa-miR-1283	CLIP-seq
MIRT762813	hsa-miR-1299	CLIP-seq
MIRT762814	hsa-miR-141	CLIP-seq
MIRT1924872	hsa-miR-148a	CLIP-seq
MIRT1924873	hsa-miR-148b	CLIP-seq
MIRT1924874	hsa-miR-152	CLIP-seq
MIRT1924875	hsa-miR-188-3p	CLIP-seq
MIRT762818	hsa-miR-200a	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT762822	hsa-miR-3148	CLIP-seq
MIRT1924876	hsa-miR-3156-3p	CLIP-seq
MIRT1924877	hsa-miR-3614-5p	CLIP-seq
MIRT762838	hsa-miR-4782-5p	CLIP-seq
MIRT762841	hsa-miR-516b	CLIP-seq
MIRT762849	hsa-miR-668	CLIP-seq
MIRT762850	hsa-miR-875-3p	CLIP-seq
MIRT762814	hsa-miR-141	CLIP-seq
MIRT762818	hsa-miR-200a	CLIP-seq
MIRT2166075	hsa-miR-374c	CLIP-seq
MIRT2166076	hsa-miR-4774-5p	CLIP-seq
MIRT2166077	hsa-miR-655	CLIP-seq
MIRT762849	hsa-miR-668	CLIP-seq
MIRT1924867	hsa-miR-1224-3p	CLIP-seq
MIRT1924868	hsa-miR-1260	CLIP-seq
MIRT1924869	hsa-miR-1260b	CLIP-seq
MIRT1924870	hsa-miR-1280	CLIP-seq
MIRT762813	hsa-miR-1299	CLIP-seq
MIRT1924875	hsa-miR-188-3p	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT762822	hsa-miR-3148	CLIP-seq
MIRT1924876	hsa-miR-3156-3p	CLIP-seq
MIRT762838	hsa-miR-4782-5p	CLIP-seq
MIRT762841	hsa-miR-516b	CLIP-seq
MIRT762850	hsa-miR-875-3p	CLIP-seq
MIRT1924866	hsa-miR-1178	CLIP-seq
MIRT1924867	hsa-miR-1224-3p	CLIP-seq
MIRT1924868	hsa-miR-1260	CLIP-seq
MIRT1924869	hsa-miR-1260b	CLIP-seq
MIRT1924870	hsa-miR-1280	CLIP-seq
MIRT1924872	hsa-miR-148a	CLIP-seq
MIRT1924873	hsa-miR-148b	CLIP-seq
MIRT1924874	hsa-miR-152	CLIP-seq
MIRT1924875	hsa-miR-188-3p	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT1924876	hsa-miR-3156-3p	CLIP-seq
MIRT1924877	hsa-miR-3614-5p	CLIP-seq
MIRT1924867	hsa-miR-1224-3p	CLIP-seq
MIRT762809	hsa-miR-1253	CLIP-seq
MIRT1924868	hsa-miR-1260	CLIP-seq
MIRT1924869	hsa-miR-1260b	CLIP-seq
MIRT1924870	hsa-miR-1280	CLIP-seq
MIRT762813	hsa-miR-1299	CLIP-seq
MIRT1924875	hsa-miR-188-3p	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT2464821	hsa-miR-3121-3p	CLIP-seq
MIRT762822	hsa-miR-3148	CLIP-seq
MIRT1924876	hsa-miR-3156-3p	CLIP-seq
MIRT762831	hsa-miR-4311	CLIP-seq
MIRT762838	hsa-miR-4782-5p	CLIP-seq
MIRT762841	hsa-miR-516b	CLIP-seq
MIRT762850	hsa-miR-875-3p	CLIP-seq
MIRT1924866	hsa-miR-1178	CLIP-seq
MIRT1924867	hsa-miR-1224-3p	CLIP-seq
MIRT762809	hsa-miR-1253	CLIP-seq
MIRT1924868	hsa-miR-1260	CLIP-seq
MIRT1924869	hsa-miR-1260b	CLIP-seq
MIRT2468613	hsa-miR-1271	CLIP-seq
MIRT1924870	hsa-miR-1280	CLIP-seq
MIRT1924871	hsa-miR-1283	CLIP-seq
MIRT762813	hsa-miR-1299	CLIP-seq
MIRT1924872	hsa-miR-148a	CLIP-seq
MIRT1924873	hsa-miR-148b	CLIP-seq
MIRT1924874	hsa-miR-152	CLIP-seq
MIRT1924875	hsa-miR-188-3p	CLIP-seq
MIRT2468614	hsa-miR-2113	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT2464821	hsa-miR-3121-3p	CLIP-seq
MIRT762821	hsa-miR-3123	CLIP-seq
MIRT762822	hsa-miR-3148	CLIP-seq
MIRT1924876	hsa-miR-3156-3p	CLIP-seq
MIRT1924877	hsa-miR-3614-5p	CLIP-seq
MIRT2468615	hsa-miR-3668	CLIP-seq
MIRT2468616	hsa-miR-3714	CLIP-seq
MIRT2468617	hsa-miR-3925-5p	CLIP-seq
MIRT2468618	hsa-miR-3976	CLIP-seq
MIRT762831	hsa-miR-4311	CLIP-seq
MIRT2468619	hsa-miR-4700-3p	CLIP-seq
MIRT762838	hsa-miR-4782-5p	CLIP-seq
MIRT2468620	hsa-miR-495	CLIP-seq
MIRT762841	hsa-miR-516b	CLIP-seq
MIRT2468621	hsa-miR-550a	CLIP-seq
MIRT2468622	hsa-miR-624	CLIP-seq
MIRT762850	hsa-miR-875-3p	CLIP-seq
MIRT2468623	hsa-miR-96	CLIP-seq
MIRT1924866	hsa-miR-1178	CLIP-seq
MIRT1924867	hsa-miR-1224-3p	CLIP-seq
MIRT762809	hsa-miR-1253	CLIP-seq
MIRT1924868	hsa-miR-1260	CLIP-seq
MIRT1924869	hsa-miR-1260b	CLIP-seq
MIRT2468613	hsa-miR-1271	CLIP-seq
MIRT1924870	hsa-miR-1280	CLIP-seq
MIRT1924871	hsa-miR-1283	CLIP-seq
MIRT762813	hsa-miR-1299	CLIP-seq
MIRT1924872	hsa-miR-148a	CLIP-seq
MIRT1924873	hsa-miR-148b	CLIP-seq
MIRT1924874	hsa-miR-152	CLIP-seq
MIRT1924875	hsa-miR-188-3p	CLIP-seq
MIRT2468614	hsa-miR-2113	CLIP-seq
MIRT762819	hsa-miR-2115	CLIP-seq
MIRT2674260	hsa-miR-3065-3p	CLIP-seq
MIRT2464821	hsa-miR-3121-3p	CLIP-seq
MIRT762821	hsa-miR-3123	CLIP-seq
MIRT2674261	hsa-miR-3125	CLIP-seq
MIRT762822	hsa-miR-3148	CLIP-seq
MIRT1924876	hsa-miR-3156-3p	CLIP-seq
MIRT2674262	hsa-miR-335	CLIP-seq
MIRT1924877	hsa-miR-3614-5p	CLIP-seq
MIRT2468615	hsa-miR-3668	CLIP-seq
MIRT2468616	hsa-miR-3714	CLIP-seq
MIRT2674263	hsa-miR-3916	CLIP-seq
MIRT2468617	hsa-miR-3925-5p	CLIP-seq
MIRT2468618	hsa-miR-3976	CLIP-seq
MIRT762831	hsa-miR-4311	CLIP-seq
MIRT2674264	hsa-miR-4468	CLIP-seq
MIRT2674265	hsa-miR-4476	CLIP-seq
MIRT2468619	hsa-miR-4700-3p	CLIP-seq
MIRT2674266	hsa-miR-4725-5p	CLIP-seq
MIRT762838	hsa-miR-4782-5p	CLIP-seq
MIRT2468620	hsa-miR-495	CLIP-seq
MIRT2674267	hsa-miR-504	CLIP-seq
MIRT762841	hsa-miR-516b	CLIP-seq
MIRT2468621	hsa-miR-550a	CLIP-seq
MIRT2468622	hsa-miR-624	CLIP-seq
MIRT762850	hsa-miR-875-3p	CLIP-seq
MIRT2468623	hsa-miR-96	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
MTF1	Unknown	16886906
SP1	Unknown	16886906

Show/Hide all (50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000900	Function	MRNA regulatory element binding translation repressor activity	EXP	1946430, 7983023, 8041788
GO:0000900	Function	MRNA regulatory element binding translation repressor activity	IEA
GO:0003723	Function	RNA binding	IDA	1946430
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	NAS	1903202
GO:0003994	Function	Aconitate hydratase activity	IBA
GO:0003994	Function	Aconitate hydratase activity	IDA	1946430, 8041788
GO:0003994	Function	Aconitate hydratase activity	IEA
GO:0003994	Function	Aconitate hydratase activity	IMP	1281544
GO:0005515	Function	Protein binding	IPI	19762596, 19762597, 35512704
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	IMP	1281544
GO:0005737	Component	Cytoplasm	NAS	1738601
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005783	Component	Endoplasmic reticulum	IDA	16144863
GO:0005794	Component	Golgi apparatus	IDA	16144863
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	1281544, 16527810
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006099	Process	Tricarboxylic acid cycle	IEA
GO:0006101	Process	Citrate metabolic process	IBA
GO:0006101	Process	Citrate metabolic process	IDA	8041788, 16527810
GO:0006101	Process	Citrate metabolic process	IMP	1281544
GO:0006417	Process	Regulation of translation	IEA
GO:0006740	Process	NADPH regeneration	IEA
GO:0006879	Process	Intracellular iron ion homeostasis	IBA
GO:0006879	Process	Intracellular iron ion homeostasis	IEA
GO:0006879	Process	Intracellular iron ion homeostasis	TAS
GO:0009791	Process	Post-embryonic development	IEA
GO:0010040	Process	Response to iron(II) ion	IDA	8041788
GO:0010468	Process	Regulation of gene expression	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0017148	Process	Negative regulation of translation	IEA
GO:0030350	Function	Iron-responsive element binding	IBA
GO:0030350	Function	Iron-responsive element binding	IDA	8041788
GO:0030350	Function	Iron-responsive element binding	IEA
GO:0030350	Function	Iron-responsive element binding	IMP	1281544, 23891004
GO:0046872	Function	Metal ion binding	IEA
GO:0050892	Process	Intestinal absorption	IEA
GO:0051536	Function	Iron-sulfur cluster binding	EXP	16407072
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051538	Function	3 iron, 4 sulfur cluster binding	IBA
GO:0051538	Function	3 iron, 4 sulfur cluster binding	IMP	1281544
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IBA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IDA	16407072
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IEA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IMP	1281544
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

MIM	HGNC	e!Ensembl
100880	117	ENSG00000122729

P21399

Protein name

Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)

Protein function

Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1281544, PubMed:1946430, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes

PDB

2B3X , 2B3Y

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00330	Aconitase	59 → 564	Aconitase family (aconitate hydratase)	Family
PF00694	Aconitase_C	692 → 821	Aconitase C-terminal domain	Domain

Sequence

MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI
ENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPA
DLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQV
NLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLP
QVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMC
PEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVE
LDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNT
EFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTY
YLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEG
RVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVE
RQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPK
SIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMA
RGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSR
DWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIP
ENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK

Sequence length

889

Interactions

View interactions

ACO1 (aconitase 1)