ACACA (acetyl-CoA carboxylase alpha)

Gene

• Entrez ID: 31
• Gene name: Acetyl-CoA carboxylase alpha
• Gene symbol: ACACA
• Synonyms (NCBI Gene): ACAC, ACACAD, ACACalpha, ACC, ACC1, ACCA, ACCalpha, Acac1, hACC1
• Chromosome: 17
• Chromosome location: 17q12
• Summary: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and b

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017082	hsa-miR-335-5p	Microarray	18185580
MIRT030449	hsa-miR-24-3p	Microarray	19748357
MIRT032204	hsa-let-7b-5p	Proteomics	18668040
MIRT032204	hsa-let-7b-5p	CLASH	23622248
MIRT049478	hsa-miR-92a-3p	CLASH	23622248
MIRT046646	hsa-miR-222-3p	CLASH	23622248
MIRT042815	hsa-miR-324-3p	CLASH	23622248
MIRT042815	hsa-miR-324-3p	CLASH	23622248
MIRT042761	hsa-miR-339-5p	CLASH	23622248
MIRT042761	hsa-miR-339-5p	CLASH	23622248
MIRT041233	hsa-miR-193b-3p	CLASH	23622248
MIRT693748	hsa-miR-1255b-2-3p	HITS-CLIP	23313552
MIRT693747	hsa-miR-1250-3p	HITS-CLIP	23313552
MIRT693746	hsa-miR-361-3p	HITS-CLIP	23313552
MIRT693745	hsa-miR-3690	HITS-CLIP	23313552
MIRT693744	hsa-miR-4254	HITS-CLIP	23313552
MIRT693743	hsa-miR-4251	HITS-CLIP	23313552
MIRT693742	hsa-miR-378a-3p	HITS-CLIP	23313552
MIRT693741	hsa-miR-378b	HITS-CLIP	23313552
MIRT693740	hsa-miR-378c	HITS-CLIP	23313552
MIRT693739	hsa-miR-378d	HITS-CLIP	23313552
MIRT693738	hsa-miR-378e	HITS-CLIP	23313552
MIRT693737	hsa-miR-378f	HITS-CLIP	23313552
MIRT693736	hsa-miR-378h	HITS-CLIP	23313552
MIRT693735	hsa-miR-378i	HITS-CLIP	23313552
MIRT693734	hsa-miR-422a	HITS-CLIP	23313552
MIRT693733	hsa-miR-219a-2-3p	HITS-CLIP	23313552
MIRT693732	hsa-miR-6857-3p	HITS-CLIP	23313552
MIRT693731	hsa-miR-4740-5p	HITS-CLIP	23313552
MIRT693730	hsa-miR-1288-3p	HITS-CLIP	23313552
MIRT693729	hsa-miR-4515	HITS-CLIP	23313552
MIRT693728	hsa-miR-1343-3p	HITS-CLIP	23313552
MIRT693727	hsa-miR-6783-3p	HITS-CLIP	23313552
MIRT693726	hsa-miR-580-3p	HITS-CLIP	23313552
MIRT693725	hsa-miR-1269a	HITS-CLIP	23313552
MIRT693724	hsa-miR-1269b	HITS-CLIP	23313552
MIRT693723	hsa-miR-4433b-5p	HITS-CLIP	23313552
MIRT693722	hsa-miR-491-3p	HITS-CLIP	23313552
MIRT693721	hsa-miR-3074-5p	HITS-CLIP	23313552
MIRT693720	hsa-miR-7152-5p	HITS-CLIP	23313552
MIRT693719	hsa-miR-4646-3p	HITS-CLIP	23313552
MIRT441299	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT441300	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441299	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT441300	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT693748	hsa-miR-1255b-2-3p	HITS-CLIP	23313552
MIRT693747	hsa-miR-1250-3p	HITS-CLIP	23313552
MIRT693746	hsa-miR-361-3p	HITS-CLIP	23313552
MIRT693745	hsa-miR-3690	HITS-CLIP	23313552
MIRT693744	hsa-miR-4254	HITS-CLIP	23313552
MIRT693743	hsa-miR-4251	HITS-CLIP	23313552
MIRT693742	hsa-miR-378a-3p	HITS-CLIP	23313552
MIRT693741	hsa-miR-378b	HITS-CLIP	23313552
MIRT693740	hsa-miR-378c	HITS-CLIP	23313552
MIRT693739	hsa-miR-378d	HITS-CLIP	23313552
MIRT693738	hsa-miR-378e	HITS-CLIP	23313552
MIRT693737	hsa-miR-378f	HITS-CLIP	23313552
MIRT693736	hsa-miR-378h	HITS-CLIP	23313552
MIRT693735	hsa-miR-378i	HITS-CLIP	23313552
MIRT693734	hsa-miR-422a	HITS-CLIP	23313552
MIRT693733	hsa-miR-219a-2-3p	HITS-CLIP	23313552
MIRT693732	hsa-miR-6857-3p	HITS-CLIP	23313552
MIRT693731	hsa-miR-4740-5p	HITS-CLIP	23313552
MIRT693730	hsa-miR-1288-3p	HITS-CLIP	23313552
MIRT693729	hsa-miR-4515	HITS-CLIP	23313552
MIRT693728	hsa-miR-1343-3p	HITS-CLIP	23313552
MIRT693727	hsa-miR-6783-3p	HITS-CLIP	23313552
MIRT693726	hsa-miR-580-3p	HITS-CLIP	23313552
MIRT693725	hsa-miR-1269a	HITS-CLIP	23313552
MIRT693724	hsa-miR-1269b	HITS-CLIP	23313552
MIRT693723	hsa-miR-4433b-5p	HITS-CLIP	23313552
MIRT693722	hsa-miR-491-3p	HITS-CLIP	23313552
MIRT693721	hsa-miR-3074-5p	HITS-CLIP	23313552
MIRT693720	hsa-miR-7152-5p	HITS-CLIP	23313552
MIRT693719	hsa-miR-4646-3p	HITS-CLIP	23313552
MIRT761221	hsa-miR-1224-3p	CLIP-seq
MIRT761222	hsa-miR-1343	CLIP-seq
MIRT761223	hsa-miR-1825	CLIP-seq
MIRT761224	hsa-miR-1912	CLIP-seq
MIRT761225	hsa-miR-1914	CLIP-seq
MIRT761226	hsa-miR-193a-5p	CLIP-seq
MIRT761227	hsa-miR-1976	CLIP-seq
MIRT761228	hsa-miR-199a-5p	CLIP-seq
MIRT761229	hsa-miR-199b-5p	CLIP-seq
MIRT761230	hsa-miR-219-1-3p	CLIP-seq
MIRT761231	hsa-miR-24	CLIP-seq
MIRT761232	hsa-miR-3130-5p	CLIP-seq
MIRT761233	hsa-miR-3607-5p	CLIP-seq
MIRT761234	hsa-miR-3662	CLIP-seq
MIRT761235	hsa-miR-371b-3p	CLIP-seq
MIRT761236	hsa-miR-3925-3p	CLIP-seq
MIRT761237	hsa-miR-3974	CLIP-seq
MIRT761238	hsa-miR-4297	CLIP-seq
MIRT761239	hsa-miR-4482	CLIP-seq
MIRT761240	hsa-miR-4488	CLIP-seq
MIRT761241	hsa-miR-4491	CLIP-seq
MIRT761242	hsa-miR-4657	CLIP-seq
MIRT761243	hsa-miR-4675	CLIP-seq
MIRT761244	hsa-miR-4697-5p	CLIP-seq
MIRT761245	hsa-miR-4731-5p	CLIP-seq
MIRT761246	hsa-miR-4741	CLIP-seq
MIRT761247	hsa-miR-508-5p	CLIP-seq
MIRT761248	hsa-miR-512-3p	CLIP-seq
MIRT761249	hsa-miR-550a	CLIP-seq
MIRT761250	hsa-miR-571	CLIP-seq
MIRT761251	hsa-miR-572	CLIP-seq
MIRT761252	hsa-miR-582-3p	CLIP-seq
MIRT761253	hsa-miR-582-5p	CLIP-seq
MIRT761254	hsa-miR-637	CLIP-seq
MIRT761255	hsa-miR-105	CLIP-seq
MIRT761256	hsa-miR-1238	CLIP-seq
MIRT761257	hsa-miR-3189-3p	CLIP-seq
MIRT761258	hsa-miR-3914	CLIP-seq
MIRT761259	hsa-miR-4252	CLIP-seq
MIRT761260	hsa-miR-4276	CLIP-seq
MIRT761238	hsa-miR-4297	CLIP-seq
MIRT761261	hsa-miR-4317	CLIP-seq
MIRT761262	hsa-miR-4504	CLIP-seq
MIRT761263	hsa-miR-4691-5p	CLIP-seq
MIRT761264	hsa-miR-651	CLIP-seq
MIRT761265	hsa-miR-1245b-5p	CLIP-seq
MIRT761266	hsa-miR-1273c	CLIP-seq
MIRT761267	hsa-miR-127-5p	CLIP-seq
MIRT761268	hsa-miR-128	CLIP-seq
MIRT761269	hsa-miR-134	CLIP-seq
MIRT761270	hsa-miR-144	CLIP-seq
MIRT761271	hsa-miR-1827	CLIP-seq
MIRT761272	hsa-miR-18a	CLIP-seq
MIRT761273	hsa-miR-18b	CLIP-seq
MIRT761274	hsa-miR-1909	CLIP-seq
MIRT761225	hsa-miR-1914	CLIP-seq
MIRT761275	hsa-miR-1972	CLIP-seq
MIRT761227	hsa-miR-1976	CLIP-seq
MIRT761276	hsa-miR-200b	CLIP-seq
MIRT761277	hsa-miR-200c	CLIP-seq
MIRT761278	hsa-miR-27a	CLIP-seq
MIRT761279	hsa-miR-27b	CLIP-seq
MIRT761280	hsa-miR-3118	CLIP-seq
MIRT761281	hsa-miR-3142	CLIP-seq
MIRT761282	hsa-miR-3164	CLIP-seq
MIRT761283	hsa-miR-338-3p	CLIP-seq
MIRT761284	hsa-miR-3657	CLIP-seq
MIRT761285	hsa-miR-3683	CLIP-seq
MIRT761286	hsa-miR-370	CLIP-seq
MIRT761287	hsa-miR-3944-5p	CLIP-seq
MIRT761288	hsa-miR-4270	CLIP-seq
MIRT761289	hsa-miR-429	CLIP-seq
MIRT761290	hsa-miR-4435	CLIP-seq
MIRT761291	hsa-miR-4441	CLIP-seq
MIRT761292	hsa-miR-4519	CLIP-seq
MIRT761293	hsa-miR-4530	CLIP-seq
MIRT761294	hsa-miR-4633-5p	CLIP-seq
MIRT761295	hsa-miR-4669	CLIP-seq
MIRT761296	hsa-miR-4685-5p	CLIP-seq
MIRT761297	hsa-miR-4724-3p	CLIP-seq
MIRT761298	hsa-miR-4724-5p	CLIP-seq
MIRT761299	hsa-miR-4733-3p	CLIP-seq
MIRT761300	hsa-miR-4735-3p	CLIP-seq
MIRT761301	hsa-miR-4759	CLIP-seq
MIRT761302	hsa-miR-4762-3p	CLIP-seq
MIRT761303	hsa-miR-4790-3p	CLIP-seq
MIRT761304	hsa-miR-486-5p	CLIP-seq
MIRT761305	hsa-miR-493	CLIP-seq
MIRT761306	hsa-miR-554	CLIP-seq
MIRT761307	hsa-miR-765	CLIP-seq
MIRT761308	hsa-miR-767-3p	CLIP-seq
MIRT761309	hsa-miR-938	CLIP-seq
MIRT761310	hsa-miR-940	CLIP-seq
MIRT761268	hsa-miR-128	CLIP-seq
MIRT761222	hsa-miR-1343	CLIP-seq
MIRT761231	hsa-miR-24	CLIP-seq
MIRT761278	hsa-miR-27a	CLIP-seq
MIRT761279	hsa-miR-27b	CLIP-seq
MIRT1924487	hsa-miR-4284	CLIP-seq
MIRT1924488	hsa-miR-4469	CLIP-seq
MIRT1924489	hsa-miR-4768-5p	CLIP-seq
MIRT1924490	hsa-miR-671-5p	CLIP-seq
MIRT761223	hsa-miR-1825	CLIP-seq
MIRT761228	hsa-miR-199a-5p	CLIP-seq
MIRT761229	hsa-miR-199b-5p	CLIP-seq
MIRT761238	hsa-miR-4297	CLIP-seq
MIRT761263	hsa-miR-4691-5p	CLIP-seq
MIRT2165703	hsa-miR-1226	CLIP-seq
MIRT761265	hsa-miR-1245b-5p	CLIP-seq
MIRT761266	hsa-miR-1273c	CLIP-seq
MIRT761269	hsa-miR-134	CLIP-seq
MIRT761270	hsa-miR-144	CLIP-seq
MIRT2165704	hsa-miR-1587	CLIP-seq
MIRT761223	hsa-miR-1825	CLIP-seq
MIRT761271	hsa-miR-1827	CLIP-seq
MIRT2165705	hsa-miR-193a-3p	CLIP-seq
MIRT2165706	hsa-miR-193b	CLIP-seq
MIRT761275	hsa-miR-1972	CLIP-seq
MIRT761227	hsa-miR-1976	CLIP-seq
MIRT761228	hsa-miR-199a-5p	CLIP-seq
MIRT761229	hsa-miR-199b-5p	CLIP-seq
MIRT761276	hsa-miR-200b	CLIP-seq
MIRT761277	hsa-miR-200c	CLIP-seq
MIRT761280	hsa-miR-3118	CLIP-seq
MIRT2165707	hsa-miR-3135b	CLIP-seq
MIRT761281	hsa-miR-3142	CLIP-seq
MIRT761282	hsa-miR-3164	CLIP-seq
MIRT2165708	hsa-miR-3176	CLIP-seq
MIRT2165709	hsa-miR-3184	CLIP-seq
MIRT2165710	hsa-miR-3605-3p	CLIP-seq
MIRT2165711	hsa-miR-3614-3p	CLIP-seq
MIRT2165712	hsa-miR-3652	CLIP-seq
MIRT761285	hsa-miR-3683	CLIP-seq
MIRT2165713	hsa-miR-378g	CLIP-seq
MIRT2165714	hsa-miR-3922-3p	CLIP-seq
MIRT761236	hsa-miR-3925-3p	CLIP-seq
MIRT2165715	hsa-miR-3942-3p	CLIP-seq
MIRT2165716	hsa-miR-423-5p	CLIP-seq
MIRT761289	hsa-miR-429	CLIP-seq
MIRT2165717	hsa-miR-4320	CLIP-seq
MIRT2165718	hsa-miR-4417	CLIP-seq
MIRT2165719	hsa-miR-4430	CLIP-seq
MIRT761290	hsa-miR-4435	CLIP-seq
MIRT2165720	hsa-miR-4450	CLIP-seq
MIRT2165721	hsa-miR-4456	CLIP-seq
MIRT2165722	hsa-miR-4492	CLIP-seq
MIRT2165723	hsa-miR-4493	CLIP-seq
MIRT2165724	hsa-miR-4498	CLIP-seq
MIRT761292	hsa-miR-4519	CLIP-seq
MIRT2165725	hsa-miR-4525	CLIP-seq
MIRT761293	hsa-miR-4530	CLIP-seq
MIRT2165726	hsa-miR-4656	CLIP-seq
MIRT2165727	hsa-miR-4660	CLIP-seq
MIRT761243	hsa-miR-4675	CLIP-seq
MIRT2165728	hsa-miR-4677-3p	CLIP-seq
MIRT2165729	hsa-miR-4679	CLIP-seq
MIRT761296	hsa-miR-4685-5p	CLIP-seq
MIRT2165730	hsa-miR-4716-3p	CLIP-seq
MIRT761298	hsa-miR-4724-5p	CLIP-seq
MIRT761245	hsa-miR-4731-5p	CLIP-seq
MIRT761299	hsa-miR-4733-3p	CLIP-seq
MIRT761246	hsa-miR-4741	CLIP-seq
MIRT761301	hsa-miR-4759	CLIP-seq
MIRT2165731	hsa-miR-4778-5p	CLIP-seq
MIRT2165732	hsa-miR-4785	CLIP-seq
MIRT761303	hsa-miR-4790-3p	CLIP-seq
MIRT2165733	hsa-miR-541	CLIP-seq
MIRT2165734	hsa-miR-652	CLIP-seq
MIRT2165735	hsa-miR-762	CLIP-seq
MIRT761307	hsa-miR-765	CLIP-seq
MIRT2165736	hsa-miR-766	CLIP-seq
MIRT2165737	hsa-miR-767-5p	CLIP-seq
MIRT761310	hsa-miR-940	CLIP-seq
MIRT761223	hsa-miR-1825	CLIP-seq
MIRT761228	hsa-miR-199a-5p	CLIP-seq
MIRT761229	hsa-miR-199b-5p	CLIP-seq
MIRT2165738	hsa-miR-3617	CLIP-seq
MIRT761238	hsa-miR-4297	CLIP-seq
MIRT2165723	hsa-miR-4493	CLIP-seq
MIRT2165727	hsa-miR-4660	CLIP-seq
MIRT761263	hsa-miR-4691-5p	CLIP-seq
MIRT2165739	hsa-miR-641	CLIP-seq
MIRT761223	hsa-miR-1825	CLIP-seq
MIRT761221	hsa-miR-1224-3p	CLIP-seq
MIRT2165703	hsa-miR-1226	CLIP-seq
MIRT761268	hsa-miR-128	CLIP-seq
MIRT761222	hsa-miR-1343	CLIP-seq
MIRT2468211	hsa-miR-140-5p	CLIP-seq
MIRT761223	hsa-miR-1825	CLIP-seq
MIRT761224	hsa-miR-1912	CLIP-seq
MIRT761225	hsa-miR-1914	CLIP-seq
MIRT761226	hsa-miR-193a-5p	CLIP-seq
MIRT761227	hsa-miR-1976	CLIP-seq
MIRT761228	hsa-miR-199a-5p	CLIP-seq
MIRT761229	hsa-miR-199b-5p	CLIP-seq
MIRT2468212	hsa-miR-2052	CLIP-seq
MIRT2468213	hsa-miR-2113	CLIP-seq
MIRT761231	hsa-miR-24	CLIP-seq
MIRT761278	hsa-miR-27a	CLIP-seq
MIRT761279	hsa-miR-27b	CLIP-seq
MIRT761232	hsa-miR-3130-5p	CLIP-seq
MIRT2468214	hsa-miR-3140-5p	CLIP-seq
MIRT2468215	hsa-miR-3150a-3p	CLIP-seq
MIRT2468216	hsa-miR-3151	CLIP-seq
MIRT2468217	hsa-miR-3154	CLIP-seq
MIRT2468218	hsa-miR-3157-3p	CLIP-seq
MIRT2468219	hsa-miR-3175	CLIP-seq
MIRT2468220	hsa-miR-3185	CLIP-seq
MIRT2468221	hsa-miR-337-3p	CLIP-seq
MIRT2165710	hsa-miR-3605-3p	CLIP-seq
MIRT2468222	hsa-miR-3611	CLIP-seq
MIRT761234	hsa-miR-3662	CLIP-seq
MIRT761286	hsa-miR-370	CLIP-seq
MIRT761235	hsa-miR-371b-3p	CLIP-seq
MIRT761236	hsa-miR-3925-3p	CLIP-seq
MIRT2468223	hsa-miR-3925-5p	CLIP-seq
MIRT2165715	hsa-miR-3942-3p	CLIP-seq
MIRT2468224	hsa-miR-409-5p	CLIP-seq
MIRT1924487	hsa-miR-4284	CLIP-seq
MIRT2468225	hsa-miR-4290	CLIP-seq
MIRT761238	hsa-miR-4297	CLIP-seq
MIRT2468226	hsa-miR-4328	CLIP-seq
MIRT2468227	hsa-miR-4447	CLIP-seq
MIRT2468228	hsa-miR-4472	CLIP-seq
MIRT761239	hsa-miR-4482	CLIP-seq
MIRT761240	hsa-miR-4488	CLIP-seq
MIRT2165723	hsa-miR-4493	CLIP-seq
MIRT2468229	hsa-miR-4517	CLIP-seq
MIRT2468230	hsa-miR-4633-3p	CLIP-seq
MIRT761243	hsa-miR-4675	CLIP-seq
MIRT2468231	hsa-miR-4687-3p	CLIP-seq
MIRT761263	hsa-miR-4691-5p	CLIP-seq
MIRT761244	hsa-miR-4697-5p	CLIP-seq
MIRT761245	hsa-miR-4731-5p	CLIP-seq
MIRT761299	hsa-miR-4733-3p	CLIP-seq
MIRT761246	hsa-miR-4741	CLIP-seq
MIRT1924489	hsa-miR-4768-5p	CLIP-seq
MIRT2468232	hsa-miR-4772-3p	CLIP-seq
MIRT2468233	hsa-miR-4773	CLIP-seq
MIRT2468234	hsa-miR-4802-5p	CLIP-seq
MIRT2468235	hsa-miR-491-5p	CLIP-seq
MIRT761247	hsa-miR-508-5p	CLIP-seq
MIRT761248	hsa-miR-512-3p	CLIP-seq
MIRT2468236	hsa-miR-548an	CLIP-seq
MIRT761249	hsa-miR-550a	CLIP-seq
MIRT761251	hsa-miR-572	CLIP-seq
MIRT761252	hsa-miR-582-3p	CLIP-seq
MIRT761253	hsa-miR-582-5p	CLIP-seq
MIRT761254	hsa-miR-637	CLIP-seq
MIRT2165734	hsa-miR-652	CLIP-seq
MIRT2468237	hsa-miR-758	CLIP-seq
MIRT2468238	hsa-miR-769-5p	CLIP-seq
MIRT2468239	hsa-miR-874	CLIP-seq
MIRT2468240	hsa-miR-939	CLIP-seq
MIRT761221	hsa-miR-1224-3p	CLIP-seq
MIRT2674181	hsa-miR-1236	CLIP-seq
MIRT761222	hsa-miR-1343	CLIP-seq
MIRT2468211	hsa-miR-140-5p	CLIP-seq
MIRT2674182	hsa-miR-148a	CLIP-seq
MIRT2674183	hsa-miR-148b	CLIP-seq
MIRT2674184	hsa-miR-149	CLIP-seq
MIRT2674185	hsa-miR-152	CLIP-seq
MIRT761223	hsa-miR-1825	CLIP-seq
MIRT761224	hsa-miR-1912	CLIP-seq
MIRT761225	hsa-miR-1914	CLIP-seq
MIRT761226	hsa-miR-193a-5p	CLIP-seq
MIRT761227	hsa-miR-1976	CLIP-seq
MIRT761228	hsa-miR-199a-5p	CLIP-seq
MIRT761229	hsa-miR-199b-5p	CLIP-seq
MIRT2674186	hsa-miR-2117	CLIP-seq
MIRT2674187	hsa-miR-298	CLIP-seq
MIRT2674188	hsa-miR-3064-5p	CLIP-seq
MIRT761232	hsa-miR-3130-5p	CLIP-seq
MIRT2674189	hsa-miR-3182	CLIP-seq
MIRT761234	hsa-miR-3662	CLIP-seq
MIRT2674190	hsa-miR-3692	CLIP-seq
MIRT761235	hsa-miR-371b-3p	CLIP-seq
MIRT761236	hsa-miR-3925-3p	CLIP-seq
MIRT2674191	hsa-miR-4268	CLIP-seq
MIRT2674192	hsa-miR-4277	CLIP-seq
MIRT761238	hsa-miR-4297	CLIP-seq
MIRT761239	hsa-miR-4482	CLIP-seq
MIRT761240	hsa-miR-4488	CLIP-seq
MIRT761243	hsa-miR-4675	CLIP-seq
MIRT761244	hsa-miR-4697-5p	CLIP-seq
MIRT2674193	hsa-miR-4717-3p	CLIP-seq
MIRT2674194	hsa-miR-4727-5p	CLIP-seq
MIRT761245	hsa-miR-4731-5p	CLIP-seq
MIRT761246	hsa-miR-4741	CLIP-seq
MIRT2674195	hsa-miR-4753-3p	CLIP-seq
MIRT2674196	hsa-miR-4769-3p	CLIP-seq
MIRT2468232	hsa-miR-4772-3p	CLIP-seq
MIRT2674197	hsa-miR-4794	CLIP-seq
MIRT761247	hsa-miR-508-5p	CLIP-seq
MIRT761248	hsa-miR-512-3p	CLIP-seq
MIRT761249	hsa-miR-550a	CLIP-seq
MIRT761251	hsa-miR-572	CLIP-seq
MIRT761253	hsa-miR-582-5p	CLIP-seq
MIRT761254	hsa-miR-637	CLIP-seq
MIRT2674198	hsa-miR-760	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CREB1	Activation	19842072

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001650	Component	Fibrillar center	IDA
GO:0001894	Process	Tissue homeostasis	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0003989	Function	Acetyl-CoA carboxylase activity	IBA
GO:0003989	Function	Acetyl-CoA carboxylase activity	IDA	20457939, 26976583, 29899443
GO:0003989	Function	Acetyl-CoA carboxylase activity	IEA
GO:0003989	Function	Acetyl-CoA carboxylase activity	ISS	20952656
GO:0003989	Function	Acetyl-CoA carboxylase activity	TAS	7905825
GO:0005515	Function	Protein binding	IPI	16326698, 16794074, 18056116, 19343720, 20457939, 20952656, 29899443, 32296183, 38892011
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006084	Process	Acetyl-CoA metabolic process	IEA
GO:0006084	Process	Acetyl-CoA metabolic process	ISS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006633	Process	Fatty acid biosynthetic process	IBA
GO:0006633	Process	Fatty acid biosynthetic process	IC
GO:0006633	Process	Fatty acid biosynthetic process	IEA
GO:0006633	Process	Fatty acid biosynthetic process	ISS
GO:0006637	Process	Acyl-CoA metabolic process	IEA
GO:0008610	Process	Lipid biosynthetic process	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016874	Function	Ligase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	20457939
GO:0046872	Function	Metal ion binding	IEA
GO:0046949	Process	Fatty-acyl-CoA biosynthetic process	TAS
GO:0051289	Process	Protein homotetramerization	IEA
GO:0051289	Process	Protein homotetramerization	ISS	20952656
GO:0055088	Process	Lipid homeostasis	IEA
GO:0071380	Process	Cellular response to prostaglandin E stimulus	IEA
GO:2001295	Process	Malonyl-CoA biosynthetic process	IEA

Other IDs

• MIM: 200350
• HGNC: 84
• e!Ensembl: ENSG00000278540

Protein

• UniProt ID: Q13085
• Protein name: Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha)
• Protein function: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the
• PDB: 2YL2, 3COJ, 4ASI, 6G2D, 6G2H, 6G2I, 8XKZ, 8XL0, 8XL1, 8XL2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00289	Biotin_carb_N	117 → 237	Biotin carboxylase, N-terminal domain	Domain
  PF02786	CPSase_L_D2	272 → 473	Carbamoyl-phosphate synthase L chain, ATP binding domain	Domain
  PF02785	Biotin_carb_C	507 → 615	Biotin carboxylase C-terminal domain	Domain
  PF00364	Biotin_lipoyl	752 → 818	Biotin-requiring enzyme	Domain
  PF08326	ACC_central	819 → 1569	Acetyl-CoA carboxylase, central region	Family
  PF01039	Carboxyl_trans	1669 → 2223	Carboxyl transferase domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain, placenta, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
• Sequence:

  MDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLS
  DLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEK
  VLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPG
  GPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWAL
  GDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQA
  AEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEV
  QILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSA
  GTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMY
  GVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGY
  FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLET
  ESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSVSNFLHSLERGQV
  LPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDG
  SSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYA
  EIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQ
  STALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQ
  DIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREV
  FFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSD
  MNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALR
  ARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYH
  SNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRM
  SFSSNLNHYGMTHVASVSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSP
  PQSPTFPEAGHTSLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLV
  DHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQ
  LELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFE
  YLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYG
  SRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQA
  YGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQA
  FLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVI
  GNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGARIGLAEEIRHMFHVAWVD
  PEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGS
  GMIAGESSLAYNEIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGR
  EVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPID
  RIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGG
  IPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPL
  MVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVIDSSI
  NPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAE
  RKELENKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLR
  RLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLAEWLEKQLTE
  EDGVHSVIEENIKCISRDYVLKQIRSLVQANPEVAMDSIIHMTQHISPTQRAEVIRILST
  MDSPST

• Sequence length: 2346

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acetyl-CoA: carboxylase deficiency	Likely pathogenic; Pathogenic	rs2544608353, rs749657231	RCV002323523 RCV003485860

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
ACACA-related disorder	Conflicting classifications of pathogenicity; Benign; Likely benign; Uncertain significance	rs140628687, rs148586245, rs17848759, rs139772228, rs751920161, rs6607364, rs372559158, rs145228147, rs147833219, rs199873625, rs770428631, rs192767080, rs199767518, rs766878038, rs149049072, rs61743749, rs551534773, rs771495558, rs867660985, rs146088438, rs149182938, rs777992403, rs367784761, rs781599443, rs201442473, rs542037525, rs141608509, rs55811414, rs192888791, rs148549486, rs147020148, rs2229416, rs184995115, rs111441513, rs200301970	RCV003918875 RCV003958754 RCV003911164 RCV003926284 RCV004758232 RCV004758233 RCV003961079 RCV003973485 RCV003916536 RCV004731295 RCV003916539 RCV003929359 RCV003949032 RCV003949072 RCV003981182 RCV003909211 RCV003973862 RCV003927207 RCV003941731 RCV003949558 RCV003924514 RCV003949428 RCV003969321 RCV003936805 RCV003936872 RCV003934637 RCV003918117 RCV003918118 RCV003980304 RCV003918119 RCV003938031 RCV003928164 RCV003983165 RCV003938032 RCV003938033 RCV003936264
Acute myeloid leukemia	Benign	rs6607364	RCV005901556
Cervical cancer	Benign	rs6607364	RCV005901558
Hereditary breast ovarian cancer syndrome	Uncertain significance	rs2146590612	RCV001374522
Lung cancer	Benign	rs6607364	RCV005901561
Malignant tumor of esophagus	Benign	rs6607364	RCV005901557
Ovarian serous cystadenocarcinoma	Benign	rs6607364	RCV005901559
Uterine carcinosarcoma	Benign	rs6607364	RCV005901560
Uterine corpus endometrial carcinoma	Benign	rs6607364	RCV005901562

Associations from Text Mining
Disease Name	Relationship Type	References
46 Xy Gonadal Dysgenesis Partial With Minifascicular Neuropathy	Stimulate	28125642
Alzheimer Disease	Associate	22982105
Breast Neoplasms	Associate	17157792, 17631500, 18056116, 26632252, 27506935
Carcinogenesis	Associate	35449157
Carcinoma Adenoid Cystic	Associate	35032368
Carcinoma Hepatocellular	Associate	25735330, 25826294, 30841449, 34311471, 34981667, 35449157, 36456877, 40389832
Carcinoma Pancreatic Ductal	Associate	23159620
Carcinoma Renal Cell	Associate	28984208
Cataract	Associate	37511188
Central Nervous System Diseases	Associate	35633176
Cholangiocarcinoma	Associate	36972768
Colorectal Neoplasms	Associate	30809968, 35067161, 36328987
Death	Associate	25826294
Diabetes Gestational	Associate	28125642
Diabetes Mellitus Type 2	Associate	19390150, 21172433
Diabetes Mellitus Type 2	Inhibit	19543203
Diabetic Nephropathies	Associate	31573977
Ectodermal Dysplasia	Associate	32070410
Fatty Liver	Associate	24603540, 25474087, 36251517, 37002924
Fibrosis	Associate	36251517
Gerstmann Syndrome	Associate	25227797, 25735330, 25826294, 35162967
Glioma	Associate	34573317
Head and Neck Neoplasms	Associate	33274210
Hypercholesterolemia	Associate	19846279
Hypertriglyceridemia	Associate	19846279
Hypoxia	Associate	26452058
Inflammation	Inhibit	26718495
Insulin Resistance	Associate	19390150
Leukemia Myeloid Acute	Associate	36355448
Leukopenia	Associate	31692082
Lung Neoplasms	Associate	38066059, 38069382
Mitochondrial Diseases	Associate	36410440
Neoplasm Metastasis	Associate	26632252
Neoplasms	Associate	21184748, 25246709, 26452058, 28546520, 30372889, 35247885, 36355448
Neurodegenerative Diseases	Associate	35633176
Non alcoholic Fatty Liver Disease	Associate	36771140, 37002924
Obesity	Inhibit	19543203, 26694359, 36371454
Obesity	Associate	21184748
Prostatic Neoplasms	Associate	32258129, 36410440, 37845385, 38049827
Prostatic Neoplasms Castration Resistant	Associate	36410440
Renal Insufficiency Chronic	Associate	31257514, 31692082
Squamous Cell Carcinoma of Head and Neck	Associate	24769813
Stomach Neoplasms	Inhibit	26520441
Thalassemia	Associate	36861191
Thrombocytopenia	Associate	31692082
Tuberculosis	Associate	31692082
Urinary Bladder Neoplasms	Associate	34418989