Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5825
Gene name Gene Name - the full gene name approved by the HGNC.	ATP binding cassette subfamily D member 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ABCD3
Synonyms (NCBI Gene) Gene synonyms aliases	ABC43, CBAS5, PMP70, PXMP1, ZWS2
Disease Acronyms (UniProt) Disease acronyms from UniProt database	CBAS5
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p21.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, M

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miRTarBase ID	miRNA	Experiments	Reference
MIRT030935	hsa-miR-21-5p	Microarray	18591254
MIRT758783	hsa-miR-323b-3p	CLIP-seq
MIRT758784	hsa-miR-3926	CLIP-seq
MIRT758785	hsa-miR-4438	CLIP-seq
MIRT758786	hsa-miR-5095	CLIP-seq
MIRT758787	hsa-miR-548s	CLIP-seq
MIRT758788	hsa-miR-1272	CLIP-seq
MIRT758789	hsa-miR-1297	CLIP-seq
MIRT758790	hsa-miR-1305	CLIP-seq
MIRT758791	hsa-miR-219-5p	CLIP-seq
MIRT758792	hsa-miR-26a	CLIP-seq
MIRT758793	hsa-miR-26b	CLIP-seq
MIRT758794	hsa-miR-296-3p	CLIP-seq
MIRT758795	hsa-miR-3121-3p	CLIP-seq
MIRT758796	hsa-miR-3130-5p	CLIP-seq
MIRT758797	hsa-miR-365	CLIP-seq
MIRT758798	hsa-miR-3682-5p	CLIP-seq
MIRT758799	hsa-miR-4307	CLIP-seq
MIRT758800	hsa-miR-4328	CLIP-seq
MIRT758801	hsa-miR-4445	CLIP-seq
MIRT758802	hsa-miR-4465	CLIP-seq
MIRT758803	hsa-miR-4482	CLIP-seq
MIRT758804	hsa-miR-4676-5p	CLIP-seq
MIRT758805	hsa-miR-4698	CLIP-seq
MIRT758806	hsa-miR-4749-3p	CLIP-seq
MIRT758807	hsa-miR-4762-3p	CLIP-seq
MIRT758808	hsa-miR-4782-3p	CLIP-seq
MIRT758809	hsa-miR-4798-5p	CLIP-seq
MIRT758810	hsa-miR-498	CLIP-seq
MIRT758811	hsa-miR-499-3p	CLIP-seq
MIRT758812	hsa-miR-499a-3p	CLIP-seq
MIRT758813	hsa-miR-508-3p	CLIP-seq
MIRT758814	hsa-miR-575	CLIP-seq
MIRT1923721	hsa-miR-135a	CLIP-seq
MIRT1923722	hsa-miR-135b	CLIP-seq
MIRT1923723	hsa-miR-1915	CLIP-seq
MIRT758799	hsa-miR-4307	CLIP-seq
MIRT1923724	hsa-miR-4726-3p	CLIP-seq
MIRT2467143	hsa-miR-105	CLIP-seq
MIRT2467144	hsa-miR-1252	CLIP-seq
MIRT2467145	hsa-miR-1273d	CLIP-seq
MIRT2467146	hsa-miR-1289	CLIP-seq
MIRT2467147	hsa-miR-1343	CLIP-seq
MIRT1923721	hsa-miR-135a	CLIP-seq
MIRT1923722	hsa-miR-135b	CLIP-seq
MIRT2467148	hsa-miR-140-3p	CLIP-seq
MIRT1923723	hsa-miR-1915	CLIP-seq
MIRT2467149	hsa-miR-2682	CLIP-seq
MIRT2467150	hsa-miR-27a	CLIP-seq
MIRT2467151	hsa-miR-27b	CLIP-seq
MIRT758794	hsa-miR-296-3p	CLIP-seq
MIRT2467152	hsa-miR-299-5p	CLIP-seq
MIRT2467153	hsa-miR-3074-5p	CLIP-seq
MIRT2467154	hsa-miR-3119	CLIP-seq
MIRT758795	hsa-miR-3121-3p	CLIP-seq
MIRT758796	hsa-miR-3130-5p	CLIP-seq
MIRT2467155	hsa-miR-3163	CLIP-seq
MIRT2467156	hsa-miR-3198	CLIP-seq
MIRT2467157	hsa-miR-323-3p	CLIP-seq
MIRT2467158	hsa-miR-337-3p	CLIP-seq
MIRT2467159	hsa-miR-3622b-5p	CLIP-seq
MIRT2467160	hsa-miR-3646	CLIP-seq
MIRT2467161	hsa-miR-3662	CLIP-seq
MIRT2467162	hsa-miR-3667-5p	CLIP-seq
MIRT2467163	hsa-miR-3689a-5p	CLIP-seq
MIRT2467164	hsa-miR-3689b	CLIP-seq
MIRT2467165	hsa-miR-3689e	CLIP-seq
MIRT2467166	hsa-miR-3689f	CLIP-seq
MIRT2467167	hsa-miR-3690	CLIP-seq
MIRT2467168	hsa-miR-369-3p	CLIP-seq
MIRT2467169	hsa-miR-374a	CLIP-seq
MIRT2467170	hsa-miR-374b	CLIP-seq
MIRT2467171	hsa-miR-374c	CLIP-seq
MIRT2467172	hsa-miR-3908	CLIP-seq
MIRT2467173	hsa-miR-3913-3p	CLIP-seq
MIRT2467174	hsa-miR-3942-5p	CLIP-seq
MIRT2467175	hsa-miR-410	CLIP-seq
MIRT2467176	hsa-miR-412	CLIP-seq
MIRT2467177	hsa-miR-4252	CLIP-seq
MIRT2467178	hsa-miR-4254	CLIP-seq
MIRT2467179	hsa-miR-4261	CLIP-seq
MIRT2467180	hsa-miR-4272	CLIP-seq
MIRT2467181	hsa-miR-4294	CLIP-seq
MIRT2467182	hsa-miR-4309	CLIP-seq
MIRT758800	hsa-miR-4328	CLIP-seq
MIRT2467183	hsa-miR-4420	CLIP-seq
MIRT2467184	hsa-miR-4423-3p	CLIP-seq
MIRT2467185	hsa-miR-4436a	CLIP-seq
MIRT2467186	hsa-miR-4477a	CLIP-seq
MIRT2467187	hsa-miR-4477b	CLIP-seq
MIRT758803	hsa-miR-4482	CLIP-seq
MIRT2467188	hsa-miR-449c	CLIP-seq
MIRT2467189	hsa-miR-451b	CLIP-seq
MIRT2467190	hsa-miR-4662a-3p	CLIP-seq
MIRT2467191	hsa-miR-4667-3p	CLIP-seq
MIRT2467192	hsa-miR-4680-5p	CLIP-seq
MIRT2467193	hsa-miR-4696	CLIP-seq
MIRT758805	hsa-miR-4698	CLIP-seq
MIRT2467194	hsa-miR-4699-5p	CLIP-seq
MIRT2467195	hsa-miR-4700-3p	CLIP-seq
MIRT2467196	hsa-miR-4703-5p	CLIP-seq
MIRT2467197	hsa-miR-4719	CLIP-seq
MIRT2467198	hsa-miR-4720-5p	CLIP-seq
MIRT1923724	hsa-miR-4726-3p	CLIP-seq
MIRT2467199	hsa-miR-4729	CLIP-seq
MIRT2467200	hsa-miR-4731-3p	CLIP-seq
MIRT2467201	hsa-miR-4733-5p	CLIP-seq
MIRT2467202	hsa-miR-4735-5p	CLIP-seq
MIRT2467203	hsa-miR-4736	CLIP-seq
MIRT2467204	hsa-miR-4738-3p	CLIP-seq
MIRT2467205	hsa-miR-4747-5p	CLIP-seq
MIRT2467206	hsa-miR-4753-3p	CLIP-seq
MIRT2467207	hsa-miR-4756-3p	CLIP-seq
MIRT2467208	hsa-miR-4760-3p	CLIP-seq
MIRT2467209	hsa-miR-4766-3p	CLIP-seq
MIRT2467210	hsa-miR-4773	CLIP-seq
MIRT2467211	hsa-miR-4775	CLIP-seq
MIRT2467212	hsa-miR-4786-3p	CLIP-seq
MIRT2467213	hsa-miR-4789-5p	CLIP-seq
MIRT2467214	hsa-miR-4790-3p	CLIP-seq
MIRT2467215	hsa-miR-4795-3p	CLIP-seq
MIRT2467216	hsa-miR-4799-3p	CLIP-seq
MIRT2467217	hsa-miR-4801	CLIP-seq
MIRT2467218	hsa-miR-4802-3p	CLIP-seq
MIRT2467219	hsa-miR-4803	CLIP-seq
MIRT2467220	hsa-miR-489	CLIP-seq
MIRT2467221	hsa-miR-491-3p	CLIP-seq
MIRT2467222	hsa-miR-494	CLIP-seq
MIRT2467223	hsa-miR-513a-5p	CLIP-seq
MIRT2467224	hsa-miR-515-3p	CLIP-seq
MIRT2467225	hsa-miR-519e	CLIP-seq
MIRT2467226	hsa-miR-548aa	CLIP-seq
MIRT2467227	hsa-miR-548c-3p	CLIP-seq
MIRT2467228	hsa-miR-548n	CLIP-seq
MIRT2467229	hsa-miR-548t	CLIP-seq
MIRT2467230	hsa-miR-568	CLIP-seq
MIRT2467231	hsa-miR-577	CLIP-seq
MIRT2467232	hsa-miR-590-3p	CLIP-seq
MIRT2467233	hsa-miR-599	CLIP-seq
MIRT2467234	hsa-miR-617	CLIP-seq
MIRT2467235	hsa-miR-655	CLIP-seq
MIRT2467236	hsa-miR-656	CLIP-seq
MIRT2467237	hsa-miR-657	CLIP-seq
MIRT2467238	hsa-miR-889	CLIP-seq
MIRT2467239	hsa-miR-940	CLIP-seq
MIRT2467143	hsa-miR-105	CLIP-seq
MIRT2467144	hsa-miR-1252	CLIP-seq
MIRT2467145	hsa-miR-1273d	CLIP-seq
MIRT2467146	hsa-miR-1289	CLIP-seq
MIRT2467147	hsa-miR-1343	CLIP-seq
MIRT1923721	hsa-miR-135a	CLIP-seq
MIRT1923722	hsa-miR-135b	CLIP-seq
MIRT2467148	hsa-miR-140-3p	CLIP-seq
MIRT2467149	hsa-miR-2682	CLIP-seq
MIRT2467150	hsa-miR-27a	CLIP-seq
MIRT2467151	hsa-miR-27b	CLIP-seq
MIRT758794	hsa-miR-296-3p	CLIP-seq
MIRT2467152	hsa-miR-299-5p	CLIP-seq
MIRT2467153	hsa-miR-3074-5p	CLIP-seq
MIRT2467154	hsa-miR-3119	CLIP-seq
MIRT758795	hsa-miR-3121-3p	CLIP-seq
MIRT758796	hsa-miR-3130-5p	CLIP-seq
MIRT2467155	hsa-miR-3163	CLIP-seq
MIRT2467156	hsa-miR-3198	CLIP-seq
MIRT2467157	hsa-miR-323-3p	CLIP-seq
MIRT2467159	hsa-miR-3622b-5p	CLIP-seq
MIRT2467160	hsa-miR-3646	CLIP-seq
MIRT2467161	hsa-miR-3662	CLIP-seq
MIRT2467162	hsa-miR-3667-5p	CLIP-seq
MIRT2467163	hsa-miR-3689a-5p	CLIP-seq
MIRT2467164	hsa-miR-3689b	CLIP-seq
MIRT2467165	hsa-miR-3689e	CLIP-seq
MIRT2467166	hsa-miR-3689f	CLIP-seq
MIRT2467167	hsa-miR-3690	CLIP-seq
MIRT2467168	hsa-miR-369-3p	CLIP-seq
MIRT2467169	hsa-miR-374a	CLIP-seq
MIRT2467170	hsa-miR-374b	CLIP-seq
MIRT2467171	hsa-miR-374c	CLIP-seq
MIRT2467172	hsa-miR-3908	CLIP-seq
MIRT2467173	hsa-miR-3913-3p	CLIP-seq
MIRT2467174	hsa-miR-3942-5p	CLIP-seq
MIRT2467175	hsa-miR-410	CLIP-seq
MIRT2467176	hsa-miR-412	CLIP-seq
MIRT2467177	hsa-miR-4252	CLIP-seq
MIRT2467178	hsa-miR-4254	CLIP-seq
MIRT2467179	hsa-miR-4261	CLIP-seq
MIRT2467180	hsa-miR-4272	CLIP-seq
MIRT2467181	hsa-miR-4294	CLIP-seq
MIRT2467182	hsa-miR-4309	CLIP-seq
MIRT758800	hsa-miR-4328	CLIP-seq
MIRT2467183	hsa-miR-4420	CLIP-seq
MIRT2467184	hsa-miR-4423-3p	CLIP-seq
MIRT2467185	hsa-miR-4436a	CLIP-seq
MIRT2467186	hsa-miR-4477a	CLIP-seq
MIRT2467187	hsa-miR-4477b	CLIP-seq
MIRT758803	hsa-miR-4482	CLIP-seq
MIRT2467188	hsa-miR-449c	CLIP-seq
MIRT2467189	hsa-miR-451b	CLIP-seq
MIRT2467190	hsa-miR-4662a-3p	CLIP-seq
MIRT2467191	hsa-miR-4667-3p	CLIP-seq
MIRT2467192	hsa-miR-4680-5p	CLIP-seq
MIRT2467193	hsa-miR-4696	CLIP-seq
MIRT758805	hsa-miR-4698	CLIP-seq
MIRT2467194	hsa-miR-4699-5p	CLIP-seq
MIRT2467195	hsa-miR-4700-3p	CLIP-seq
MIRT2467196	hsa-miR-4703-5p	CLIP-seq
MIRT2467197	hsa-miR-4719	CLIP-seq
MIRT2467198	hsa-miR-4720-5p	CLIP-seq
MIRT2467199	hsa-miR-4729	CLIP-seq
MIRT2467200	hsa-miR-4731-3p	CLIP-seq
MIRT2467201	hsa-miR-4733-5p	CLIP-seq
MIRT2467202	hsa-miR-4735-5p	CLIP-seq
MIRT2467203	hsa-miR-4736	CLIP-seq
MIRT2467204	hsa-miR-4738-3p	CLIP-seq
MIRT2467205	hsa-miR-4747-5p	CLIP-seq
MIRT2467206	hsa-miR-4753-3p	CLIP-seq
MIRT2467207	hsa-miR-4756-3p	CLIP-seq
MIRT2467208	hsa-miR-4760-3p	CLIP-seq
MIRT2467209	hsa-miR-4766-3p	CLIP-seq
MIRT2467210	hsa-miR-4773	CLIP-seq
MIRT2467211	hsa-miR-4775	CLIP-seq
MIRT2467212	hsa-miR-4786-3p	CLIP-seq
MIRT2467213	hsa-miR-4789-5p	CLIP-seq
MIRT2467214	hsa-miR-4790-3p	CLIP-seq
MIRT2467215	hsa-miR-4795-3p	CLIP-seq
MIRT2467216	hsa-miR-4799-3p	CLIP-seq
MIRT2467217	hsa-miR-4801	CLIP-seq
MIRT2467218	hsa-miR-4802-3p	CLIP-seq
MIRT2467219	hsa-miR-4803	CLIP-seq
MIRT2467220	hsa-miR-489	CLIP-seq
MIRT2467221	hsa-miR-491-3p	CLIP-seq
MIRT2467222	hsa-miR-494	CLIP-seq
MIRT2467223	hsa-miR-513a-5p	CLIP-seq
MIRT2467224	hsa-miR-515-3p	CLIP-seq
MIRT2467225	hsa-miR-519e	CLIP-seq
MIRT2467226	hsa-miR-548aa	CLIP-seq
MIRT2467227	hsa-miR-548c-3p	CLIP-seq
MIRT2467228	hsa-miR-548n	CLIP-seq
MIRT2467229	hsa-miR-548t	CLIP-seq
MIRT2467230	hsa-miR-568	CLIP-seq
MIRT2467231	hsa-miR-577	CLIP-seq
MIRT2467232	hsa-miR-590-3p	CLIP-seq
MIRT2467233	hsa-miR-599	CLIP-seq
MIRT2467234	hsa-miR-617	CLIP-seq
MIRT2467235	hsa-miR-655	CLIP-seq
MIRT2467236	hsa-miR-656	CLIP-seq
MIRT2467237	hsa-miR-657	CLIP-seq
MIRT2467238	hsa-miR-889	CLIP-seq
MIRT2467239	hsa-miR-940	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005324	Function	Long-chain fatty acid transporter activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10551832, 10704444, 10777694, 11453642, 11590176, 11883941, 14709540, 16344115, 17609205, 21102411
GO:0005524	Function	ATP binding	IBA	21873635
GO:0005524	Function	ATP binding	IDA	11248239
GO:0005739	Component	Mitochondrion	IEA
GO:0005777	Component	Peroxisome	IDA	9425230, 9922452, 10704444, 11453642, 16344115, 17542813, 19479899, 20007743
GO:0005778	Component	Peroxisomal membrane	IBA	21873635
GO:0005778	Component	Peroxisomal membrane	IDA	17609205
GO:0005778	Component	Peroxisomal membrane	TAS
GO:0005782	Component	Peroxisomal matrix	IDA	9765053
GO:0005829	Component	Cytosol	TAS
GO:0006633	Process	Fatty acid biosynthetic process	IMP	25168382
GO:0006635	Process	Fatty acid beta-oxidation	IBA	21873635
GO:0006635	Process	Fatty acid beta-oxidation	IGI	9425230
GO:0007031	Process	Peroxisome organization	IBA	21873635
GO:0007031	Process	Peroxisome organization	IDA	9425230
GO:0007031	Process	Peroxisome organization	IMP	9765053
GO:0014070	Process	Response to organic cyclic compound	IEA
GO:0015910	Process	Long-chain fatty acid import into peroxisome	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA
GO:0016887	Function	ATPase activity	IBA	21873635
GO:0016887	Function	ATPase activity	IDA	11248239
GO:0042493	Process	Response to drug	IEA
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IBA	21873635
GO:0042760	Process	Very long-chain fatty acid catabolic process	IBA	21873635
GO:0042760	Process	Very long-chain fatty acid catabolic process	IGI	9425230
GO:0042803	Function	Protein homodimerization activity	IDA	17609205
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043621	Function	Protein self-association	IEA
GO:0055085	Process	Transmembrane transport	TAS

MIM	HGNC	e!Ensembl
170995	67	ENSG00000117528

Protein

UniProt ID

P28288

Protein name

ATP-binding cassette sub-family D member 3 (EC 3.1.2.-) (EC 7.6.2.-) (70 kDa peroxisomal membrane protein) (PMP70)

Protein function

Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the

PDB

8Z0F , 8Z9X

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06472	ABC_membrane_2	70 → 338	ABC transporter transmembrane region 2	Family
PF00005	ABC_tran	456 → 599	ABC transporter	Domain

Sequence

MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVD
KVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRK
DFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN
RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVS
GLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLV
EHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQS
GRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEG
VQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKS
SLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDL
VLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSA
VSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS

Sequence length

659

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Congenital Bile Acid Synthesis Defect	congenital bile acid synthesis defect 5			GenCC

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining
Adrenoleukodystrophy	Associate	20661612, 23671276, 30544401, 7717396, 7876858
Carcinoma Hepatocellular	Associate	34651050
Carcinoma Non Small Cell Lung	Associate	23369236
Genetic Diseases Inborn	Associate	8621506, 8876235
Glioma	Associate	20378009, 35959373
Lymphoma	Associate	28731463
Neoplasms	Associate	20378009
Neoplasms	Stimulate	25802834
Prostatic Neoplasms	Associate	25802834
Prostatitis	Associate	25802834
Sveinsson Chorioretinal Atrophy	Stimulate	25802834
Zellweger Syndrome	Associate	29773809

ABCD3 (ATP binding cassette subfamily D member 3)