Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	225
Gene name Gene Name - the full gene name approved by the HGNC.	ATP binding cassette subfamily D member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ABCD2
Synonyms (NCBI Gene) Gene synonyms aliases	ABC39, ALDL1, ALDR, ALDRP, hALDR
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q12
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, M

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miRTarBase ID	miRNA	Experiments	Reference
MIRT711021	hsa-miR-5003-3p	HITS-CLIP	19536157
MIRT711020	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT711019	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT711018	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT711017	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT711016	hsa-miR-3074-5p	HITS-CLIP	19536157
MIRT711015	hsa-miR-4263	HITS-CLIP	19536157
MIRT711014	hsa-miR-576-5p	HITS-CLIP	19536157
MIRT711013	hsa-miR-605-5p	HITS-CLIP	19536157
MIRT711012	hsa-miR-5586-5p	HITS-CLIP	19536157
MIRT711011	hsa-miR-4267	HITS-CLIP	19536157
MIRT484114	hsa-miR-4759	PAR-CLIP	20371350
MIRT484113	hsa-miR-3169	PAR-CLIP	20371350
MIRT484112	hsa-miR-8083	PAR-CLIP	20371350
MIRT573082	hsa-miR-130a-3p	PAR-CLIP	20371350
MIRT573081	hsa-miR-130b-3p	PAR-CLIP	20371350
MIRT573079	hsa-miR-301a-3p	PAR-CLIP	20371350
MIRT573080	hsa-miR-301b-3p	PAR-CLIP	20371350
MIRT573078	hsa-miR-3666	PAR-CLIP	20371350
MIRT573077	hsa-miR-4295	PAR-CLIP	20371350
MIRT573076	hsa-miR-454-3p	PAR-CLIP	20371350
MIRT484111	hsa-miR-1208	PAR-CLIP	20371350
MIRT484110	hsa-miR-3607-3p	PAR-CLIP	20371350
MIRT484109	hsa-miR-3117-3p	PAR-CLIP	20371350
MIRT484108	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT573075	hsa-miR-4671-3p	PAR-CLIP	20371350
MIRT539544	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT539543	hsa-miR-5094	PAR-CLIP	22012620
MIRT539542	hsa-miR-4699-3p	PAR-CLIP	22012620
MIRT539541	hsa-miR-5190	PAR-CLIP	22012620
MIRT539540	hsa-miR-5187-3p	PAR-CLIP	22012620
MIRT539539	hsa-miR-15b-3p	PAR-CLIP	22012620
MIRT539538	hsa-miR-1257	PAR-CLIP	22012620
MIRT539537	hsa-miR-4276	PAR-CLIP	22012620
MIRT484114	hsa-miR-4759	PAR-CLIP	23592263
MIRT484113	hsa-miR-3169	PAR-CLIP	23592263
MIRT484112	hsa-miR-8083	PAR-CLIP	23592263
MIRT484111	hsa-miR-1208	PAR-CLIP	23592263
MIRT484110	hsa-miR-3607-3p	PAR-CLIP	23592263
MIRT484109	hsa-miR-3117-3p	PAR-CLIP	23592263
MIRT484108	hsa-miR-411-5p	PAR-CLIP	23592263
MIRT484114	hsa-miR-4759	PAR-CLIP	23592263
MIRT484113	hsa-miR-3169	PAR-CLIP	23592263
MIRT484112	hsa-miR-8083	PAR-CLIP	23592263
MIRT484111	hsa-miR-1208	PAR-CLIP	23592263
MIRT484110	hsa-miR-3607-3p	PAR-CLIP	23592263
MIRT484109	hsa-miR-3117-3p	PAR-CLIP	23592263
MIRT484108	hsa-miR-411-5p	PAR-CLIP	23592263
MIRT711021	hsa-miR-5003-3p	HITS-CLIP	19536157
MIRT711020	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT711019	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT711018	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT711017	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT711016	hsa-miR-3074-5p	HITS-CLIP	19536157
MIRT711015	hsa-miR-4263	HITS-CLIP	19536157
MIRT711014	hsa-miR-576-5p	HITS-CLIP	19536157
MIRT711013	hsa-miR-605-5p	HITS-CLIP	19536157
MIRT711012	hsa-miR-5586-5p	HITS-CLIP	19536157
MIRT711011	hsa-miR-4267	HITS-CLIP	19536157
MIRT484114	hsa-miR-4759	PAR-CLIP	20371350
MIRT484113	hsa-miR-3169	PAR-CLIP	20371350
MIRT484112	hsa-miR-8083	PAR-CLIP	20371350
MIRT573082	hsa-miR-130a-3p	PAR-CLIP	20371350
MIRT573081	hsa-miR-130b-3p	PAR-CLIP	20371350
MIRT573079	hsa-miR-301a-3p	PAR-CLIP	20371350
MIRT573080	hsa-miR-301b-3p	PAR-CLIP	20371350
MIRT573078	hsa-miR-3666	PAR-CLIP	20371350
MIRT573077	hsa-miR-4295	PAR-CLIP	20371350
MIRT573076	hsa-miR-454-3p	PAR-CLIP	20371350
MIRT484111	hsa-miR-1208	PAR-CLIP	20371350
MIRT484110	hsa-miR-3607-3p	PAR-CLIP	20371350
MIRT484109	hsa-miR-3117-3p	PAR-CLIP	20371350
MIRT484108	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT573075	hsa-miR-4671-3p	PAR-CLIP	20371350
MIRT539544	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT539543	hsa-miR-5094	PAR-CLIP	22012620
MIRT539542	hsa-miR-4699-3p	PAR-CLIP	22012620
MIRT539541	hsa-miR-5190	PAR-CLIP	22012620
MIRT539540	hsa-miR-5187-3p	PAR-CLIP	22012620
MIRT539539	hsa-miR-15b-3p	PAR-CLIP	22012620
MIRT539538	hsa-miR-1257	PAR-CLIP	22012620
MIRT539537	hsa-miR-4276	PAR-CLIP	22012620
MIRT484114	hsa-miR-4759	PAR-CLIP	23592263
MIRT484113	hsa-miR-3169	PAR-CLIP	23592263
MIRT484112	hsa-miR-8083	PAR-CLIP	23592263
MIRT484111	hsa-miR-1208	PAR-CLIP	23592263
MIRT484110	hsa-miR-3607-3p	PAR-CLIP	23592263
MIRT484109	hsa-miR-3117-3p	PAR-CLIP	23592263
MIRT484108	hsa-miR-411-5p	PAR-CLIP	23592263
MIRT484114	hsa-miR-4759	PAR-CLIP	23592263
MIRT484113	hsa-miR-3169	PAR-CLIP	23592263
MIRT484112	hsa-miR-8083	PAR-CLIP	23592263
MIRT484111	hsa-miR-1208	PAR-CLIP	23592263
MIRT484110	hsa-miR-3607-3p	PAR-CLIP	23592263
MIRT484109	hsa-miR-3117-3p	PAR-CLIP	23592263
MIRT484108	hsa-miR-411-5p	PAR-CLIP	23592263
MIRT758764	hsa-miR-1185	CLIP-seq
MIRT758765	hsa-miR-1290	CLIP-seq
MIRT758766	hsa-miR-155	CLIP-seq
MIRT758767	hsa-miR-3163	CLIP-seq
MIRT758768	hsa-miR-340	CLIP-seq
MIRT758769	hsa-miR-3605-5p	CLIP-seq
MIRT758770	hsa-miR-361-5p	CLIP-seq
MIRT758771	hsa-miR-3658	CLIP-seq
MIRT758772	hsa-miR-3679-5p	CLIP-seq
MIRT758773	hsa-miR-4282	CLIP-seq
MIRT758774	hsa-miR-4330	CLIP-seq
MIRT758775	hsa-miR-4659a-3p	CLIP-seq
MIRT758776	hsa-miR-4659b-3p	CLIP-seq
MIRT758777	hsa-miR-4668-3p	CLIP-seq
MIRT758778	hsa-miR-4778-3p	CLIP-seq
MIRT758779	hsa-miR-556-3p	CLIP-seq
MIRT758780	hsa-miR-578	CLIP-seq
MIRT758781	hsa-miR-579	CLIP-seq
MIRT758782	hsa-miR-643	CLIP-seq
MIRT758770	hsa-miR-361-5p	CLIP-seq
MIRT758773	hsa-miR-4282	CLIP-seq
MIRT758775	hsa-miR-4659a-3p	CLIP-seq
MIRT758776	hsa-miR-4659b-3p	CLIP-seq
MIRT758770	hsa-miR-361-5p	CLIP-seq
MIRT758773	hsa-miR-4282	CLIP-seq
MIRT2165252	hsa-miR-548aa	CLIP-seq
MIRT2165253	hsa-miR-555	CLIP-seq
MIRT2165254	hsa-miR-944	CLIP-seq
MIRT758765	hsa-miR-1290	CLIP-seq
MIRT758770	hsa-miR-361-5p	CLIP-seq
MIRT758773	hsa-miR-4282	CLIP-seq
MIRT758775	hsa-miR-4659a-3p	CLIP-seq
MIRT758776	hsa-miR-4659b-3p	CLIP-seq
MIRT758778	hsa-miR-4778-3p	CLIP-seq
MIRT2165253	hsa-miR-555	CLIP-seq
MIRT758780	hsa-miR-578	CLIP-seq
MIRT758781	hsa-miR-579	CLIP-seq
MIRT758782	hsa-miR-643	CLIP-seq
MIRT758775	hsa-miR-4659a-3p	CLIP-seq
MIRT758776	hsa-miR-4659b-3p	CLIP-seq
MIRT2467142	hsa-miR-586	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000038	Process	Very long-chain fatty acid metabolic process	IDA	10196381
GO:0005324	Function	Long-chain fatty acid transporter activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10704444, 10777694, 11883941
GO:0005524	Function	ATP binding	IBA	21873635
GO:0005777	Component	Peroxisome	IDA	10196381, 10329405, 21145416
GO:0005778	Component	Peroxisomal membrane	IBA	21873635
GO:0005778	Component	Peroxisomal membrane	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006635	Process	Fatty acid beta-oxidation	IBA	21873635
GO:0006635	Process	Fatty acid beta-oxidation	IGI	21145416
GO:0007031	Process	Peroxisome organization	IBA	21873635
GO:0015910	Process	Long-chain fatty acid import into peroxisome	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0016887	Function	ATPase activity	IBA	21873635
GO:0032000	Process	Positive regulation of fatty acid beta-oxidation	IDA	10196381
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IBA	21873635
GO:0042760	Process	Very long-chain fatty acid catabolic process	IBA	21873635
GO:0042760	Process	Very long-chain fatty acid catabolic process	IGI	21145416
GO:0042760	Process	Very long-chain fatty acid catabolic process	ISS
GO:0042803	Function	Protein homodimerization activity	IDA	21145416
GO:0043217	Process	Myelin maintenance	ISS
GO:0055085	Process	Transmembrane transport	TAS
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	ISS
GO:1903427	Process	Negative regulation of reactive oxygen species biosynthetic process	ISS
GO:1990535	Process	Neuron projection maintenance	ISS
GO:2001280	Process	Positive regulation of unsaturated fatty acid biosynthetic process	ISS

MIM	HGNC	e!Ensembl
601081	66	ENSG00000173208

Protein

UniProt ID

Q9UBJ2

Protein name

ATP-binding cassette sub-family D member 2 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy-like 1) (Adrenoleukodystrophy-related protein) (hALDR)

Protein function

ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:21145416, PubMed:29397936). Like ABCD1 seems to have fatty ac

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06472	ABC_membrane_2	91 → 365	ABC transporter transmembrane region 2	Family
PF00005	ABC_tran	494 → 637	ABC transporter	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in brain and heart. {ECO:0000269|PubMed:9345306}.

Sequence

MTHMLNAAADRVKWTRSSAAKRAACLVAAAYALKTLYPIIGKRLKQSGHGKKKAAAYPAA
ENTEILHCTETICEKPSPGVNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFL
SIYVAGLDGKIVKSIVEKKPRTFIIKLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLV
DHAYETYFTNQTYYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSY
TLIQTATSRGASPIGPTLLAGLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHSRII
ANVEEIAFYRGHKVEMKQLQKSYKALADQMNLILSKRLWYIMIEQFLMKYVWSSSGLIMV
AIPIITATGFADGEDGQKQVMVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYT
ARVYNMFWVFDEVKRGIYKRTAVIQESESHSKNGAKVELPLSDTLAIKGKVIDVDHGIIC
ENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPP
QHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWD
AVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLS
ITHRPSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNEL
CKILGEDSVLKTIKNEDETS

Sequence length

740

Interactions

View interactions

ABCD2 (ATP binding cassette subfamily D member 2)