Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10057
Gene name Gene Name - the full gene name approved by the HGNC.
ATP binding cassette subfamily C member 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ABCC5
Synonyms (NCBI Gene) Gene synonyms aliases
ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q27.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, M
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027512 hsa-miR-98-5p Microarray 19088304
MIRT044899 hsa-miR-188-5p CLASH 23622248
MIRT038057 hsa-miR-423-5p CLASH 23622248
MIRT036666 hsa-miR-935 CLASH 23622248
MIRT036328 hsa-miR-1229-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005524 Function ATP binding IEA
GO:0005796 Component Golgi lumen IEA
GO:0005886 Component Plasma membrane IDA 18619525, 28112518
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane TAS 9827529
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605251 56 ENSG00000114770
Protein
UniProt ID O15440
Protein name ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11)
Protein function ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lac
PDB 8KCI , 8WI2 , 8WI3 , 8WI4 , 8WI5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00664 ABC_membrane 179 447 ABC transporter transmembrane region Family
PF00005 ABC_tran 578 713 ABC transporter Domain
PF00664 ABC_membrane 859 1143 ABC transporter transmembrane region Family
PF00005 ABC_tran 1210 1358 ABC transporter Domain
Tissue specificity TISSUE SPECIFICITY: [Isoform 3]: Predominant isoform in retinal pigment epithelium, bladder, and stomach. {ECO:0000269|PubMed:17521428}.; TISSUE SPECIFICITY: Ubiquitously expressed, but levels in brain and muscle are especially high (PubMed:10438534, PubM
Sequence
MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLS
LDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLAR
VAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLI
LSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTW
ALNYRTGVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGG
PVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNE
VLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSV
HMTLGFDLTAAQAFTVVTVFNSMTFAL
KVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIK
NKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQA
VLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSG
KTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNS
CCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLS
ALDAHVG
NHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATI
FNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGS
VPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETS
VSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPM
KFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGP
LVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQEL
LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT
GLF
QFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM
RYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISD
IGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLE
SEVMENGDNFSVGERQLLCIARALLRHCKILILDEATA
AMDTETDLLIQETIREAFADCT
MLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG
Sequence length 1437
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 33879658
Arthritis Rheumatoid Associate 23897011
Axenfeld Rieger syndrome Associate 32906129
Brain Ischemia Associate 14507663
Bronchopulmonary Dysplasia Associate 37478211
Calcinosis Cutis Associate 20597995
Carcinoma Hepatocellular Associate 33051247, 33988674, 34494510, 34768109, 35363194
Carcinoma Non Small Cell Lung Associate 15882455, 32965722, 33390536
Cardiomyopathies Associate 14507663
Chemical and Drug Induced Liver Injury Associate 34464454