Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID	1244
Gene name	ATP binding cassette subfamily C member 2
Gene symbol	ABCC2
Synonyms (NCBI Gene)	ABC30CMOATDJSMRP2cMRP
Chromosome	10
Chromosome location	10q24.2
Summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, M

Show/Hide all (58)

SNP ID	Visualize variation	Clinical significance	Consequence
rs17222547	C>A	Pathogenic	Coding sequence variant, non coding transcript variant, genic downstream transcript variant, stop gained, 3 prime UTR variant
rs17222674	A>G	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant, non coding transcript variant
rs17222716	G>C	Conflicting-interpretations-of-pathogenicity	Intron variant, genic downstream transcript variant
rs34937870	G>A,T	Pathogenic	Splice donor variant, genic downstream transcript variant, intron variant
rs56131651	G>A	Conflicting-interpretations-of-pathogenicity, likely-benign	Missense variant, coding sequence variant, non coding transcript variant
rs56199535	C>A,G,T	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant, synonymous variant
rs72558199	C>T	Pathogenic, likely-pathogenic	Coding sequence variant, non coding transcript variant, genic downstream transcript variant, downstream transcript variant, stop gained
rs72558200	G>A	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant, genic downstream transcript variant
rs72558201	A>G,T	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant, genic downstream transcript variant
rs72558202	A>G	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant, genic downstream transcript variant
rs139082536	G>A,C	Conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, 3 prime UTR variant, synonymous variant, non coding transcript variant, coding sequence variant
rs139800035	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant
rs144192700	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Genic downstream transcript variant, synonymous variant, non coding transcript variant, coding sequence variant
rs146405172	G>A	Likely-pathogenic	Splice donor variant
rs146575217	C>G	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Coding sequence variant, genic downstream transcript variant, non coding transcript variant, synonymous variant
rs183923599	C>T	Pathogenic	Coding sequence variant, genic downstream transcript variant, non coding transcript variant, stop gained
rs371866713	C>A,G	Pathogenic	Coding sequence variant, stop gained, non coding transcript variant
rs387906395	T>A,G	Pathogenic	Splice donor variant
rs387906396	T>C	Pathogenic	Splice donor variant
rs559137047	C>T	Pathogenic	Non coding transcript variant, genic downstream transcript variant, stop gained, coding sequence variant
rs559908064	C>A,G	Conflicting-interpretations-of-pathogenicity	Genic upstream transcript variant, non coding transcript variant, synonymous variant, coding sequence variant
rs577353173	G>A,T	Pathogenic	Coding sequence variant, genic downstream transcript variant, stop gained, non coding transcript variant, missense variant
rs756707816	G>A,C	Pathogenic	Splice acceptor variant
rs761406918	C>T	Pathogenic	Non coding transcript variant, coding sequence variant, genic downstream transcript variant, stop gained
rs762243203	G>A	Pathogenic	Downstream transcript variant, splice donor variant, genic downstream transcript variant
rs762291612	CC>-	Pathogenic	Non coding transcript variant, coding sequence variant, genic downstream transcript variant, frameshift variant
rs762346634	->TC	Pathogenic	Non coding transcript variant, coding sequence variant, downstream transcript variant, genic downstream transcript variant, frameshift variant
rs762914474	TT>-	Pathogenic	Non coding transcript variant, coding sequence variant, genic downstream transcript variant, frameshift variant
rs764958537	T>C	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs765580991	T>-	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs769798659	A>-	Pathogenic	Coding sequence variant, genic upstream transcript variant, non coding transcript variant, frameshift variant
rs771652807	->T	Pathogenic	Downstream transcript variant, stop gained, coding sequence variant, genic downstream transcript variant, non coding transcript variant
rs772673105	CT>-	Uncertain-significance, pathogenic	Coding sequence variant, frameshift variant, non coding transcript variant
rs773850184	C>T	Pathogenic	Coding sequence variant, stop gained, non coding transcript variant
rs774778158	AT>-	Pathogenic	Coding sequence variant, frameshift variant, genic downstream transcript variant, non coding transcript variant
rs775771081	C>-	Pathogenic	Coding sequence variant, frameshift variant, genic downstream transcript variant, non coding transcript variant
rs776087856	G>A	Uncertain-significance, pathogenic	Coding sequence variant, stop gained, non coding transcript variant
rs777325157	ACAACAC>-	Pathogenic	Coding sequence variant, downstream transcript variant, frameshift variant, genic downstream transcript variant, non coding transcript variant
rs777902199	C>G,T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs864309675	TG>-	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs919078015	A>-	Pathogenic	Frameshift variant, coding sequence variant, non coding transcript variant, genic downstream transcript variant
rs1158274146	CT>-	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant
rs1161530285	G>A	Pathogenic	Genic upstream transcript variant, splice donor variant
rs1208873596	C>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs1257076487	C>A	Pathogenic	Non coding transcript variant, stop gained, coding sequence variant
rs1314486961	->A	Pathogenic	Coding sequence variant, initiator codon variant, frameshift variant, non coding transcript variant
rs1333544687	->T	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant, genic downstream transcript variant
rs1554845888	T>A	Pathogenic	Non coding transcript variant, stop gained, coding sequence variant, genic upstream transcript variant
rs1554849397	C>T	Pathogenic	Non coding transcript variant, stop gained, coding sequence variant
rs1554850241	C>T	Conflicting-interpretations-of-pathogenicity	Non coding transcript variant, synonymous variant, coding sequence variant
rs1554851699	->T	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant
rs1554853026	TTAA>-	Pathogenic	Downstream transcript variant, intron variant, frameshift variant, non coding transcript variant, coding sequence variant, genic downstream transcript variant
rs1554854612	->TC	Pathogenic	Downstream transcript variant, coding sequence variant, non coding transcript variant, frameshift variant, genic downstream transcript variant
rs1564674618	GAGT>-	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant
rs1564687941	A>-	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant
rs1564688595	C>-	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant
rs1564702358	A>T	Pathogenic	Downstream transcript variant, non coding transcript variant, stop gained, coding sequence variant, genic downstream transcript variant
rs1590192032	G>A	Pathogenic	Genic downstream transcript variant, coding sequence variant, non coding transcript variant, stop gained

Show/Hide all (34)

miRTarBase ID	miRNA	Experiments	Reference
MIRT731994	hsa-miR-490-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	28386339
MIRT731994	hsa-miR-490-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	28386339
MIRT732840	hsa-miR-379-3p	Luciferase reporter assayRNA-seqqRT-PCR	31757862
MIRT734920	hsa-miR-424-3p	Luciferase reporter assayWestern blottingqRT-PCR	33273826
MIRT758343	hsa-let-7a	CLIP-seq
MIRT758344	hsa-let-7b	CLIP-seq
MIRT758345	hsa-let-7c	CLIP-seq
MIRT758346	hsa-let-7d	CLIP-seq
MIRT758347	hsa-let-7e	CLIP-seq
MIRT758348	hsa-let-7f	CLIP-seq
MIRT758349	hsa-let-7g	CLIP-seq
MIRT758350	hsa-let-7i	CLIP-seq
MIRT758351	hsa-miR-1273d	CLIP-seq
MIRT758352	hsa-miR-1297	CLIP-seq
MIRT758353	hsa-miR-26a	CLIP-seq
MIRT758354	hsa-miR-26b	CLIP-seq
MIRT758355	hsa-miR-3132	CLIP-seq
MIRT758356	hsa-miR-3529	CLIP-seq
MIRT758357	hsa-miR-379	CLIP-seq
MIRT758358	hsa-miR-3927	CLIP-seq
MIRT758359	hsa-miR-4263	CLIP-seq
MIRT758360	hsa-miR-4299	CLIP-seq
MIRT758361	hsa-miR-4458	CLIP-seq
MIRT758362	hsa-miR-4465	CLIP-seq
MIRT758363	hsa-miR-4500	CLIP-seq
MIRT758364	hsa-miR-451b	CLIP-seq
MIRT758365	hsa-miR-4540	CLIP-seq
MIRT758366	hsa-miR-4729	CLIP-seq
MIRT758367	hsa-miR-513c	CLIP-seq
MIRT758368	hsa-miR-514b-5p	CLIP-seq
MIRT758369	hsa-miR-576-5p	CLIP-seq
MIRT758370	hsa-miR-619	CLIP-seq
MIRT758371	hsa-miR-98	CLIP-seq
MIRT758355	hsa-miR-3132	CLIP-seq

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Transcription factor	Regulation	Reference
IRF3	Activation	15185298

Show/Hide all (50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005515	Function	Protein binding	IPI	17825285, 21988832
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7559771
GO:0006805	Process	Xenobiotic metabolic process	IEA
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0006855	Process	Xenobiotic transmembrane transport	IMP	18245269
GO:0006869	Process	Lipid transport	IEA
GO:0008514	Function	Organic anion transmembrane transporter activity	TAS	7559771
GO:0008559	Function	ABC-type xenobiotic transporter activity	IBA
GO:0008559	Function	ABC-type xenobiotic transporter activity	IEA
GO:0008559	Function	ABC-type xenobiotic transporter activity	IMP	10220572, 18245269
GO:0008559	Function	ABC-type xenobiotic transporter activity	TAS
GO:0009986	Component	Cell surface	HDA	19581412
GO:0009986	Component	Cell surface	IDA	17825285
GO:0010629	Process	Negative regulation of gene expression	ISS
GO:0015127	Function	Bilirubin transmembrane transporter activity	IMP	10421658
GO:0015127	Function	Bilirubin transmembrane transporter activity	TAS
GO:0015431	Function	ABC-type glutathione S-conjugate transporter activity	IEA
GO:0015431	Function	ABC-type glutathione S-conjugate transporter activity	IMP	10220572
GO:0015721	Process	Bile acid and bile salt transport	IMP	16332456
GO:0015723	Process	Bilirubin transport	IMP	10421658
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IBA
GO:0016324	Component	Apical plasma membrane	IDA	10220572, 11093739, 17825285, 28408210
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0042167	Process	Heme catabolic process	TAS
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IDA	11500505
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	TAS	7559771
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IDA	11500505
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IEA
GO:0043225	Function	ATPase-coupled inorganic anion transmembrane transporter activity	IEA
GO:0043225	Function	ATPase-coupled inorganic anion transmembrane transporter activity	TAS
GO:0046581	Component	Intercellular canaliculus	IEA
GO:0046618	Process	Xenobiotic export from cell	IMP	18245269
GO:0046942	Process	Carboxylic acid transport	IEA
GO:0055085	Process	Transmembrane transport	IBA
GO:0055085	Process	Transmembrane transport	IEA
GO:0055085	Process	Transmembrane transport	TAS
GO:0070633	Process	Transepithelial transport	ISS
GO:0071716	Process	Leukotriene transport	IMP	10220572
GO:0098656	Process	Monoatomic anion transmembrane transport	IEA
GO:0140359	Function	ABC-type transporter activity	IEA
GO:0140359	Function	ABC-type transporter activity	TAS
GO:0150104	Process	Transport across blood-brain barrier	NAS	26590417, 30280653
GO:1990962	Process	Xenobiotic transport across blood-brain barrier	ISS

MIM	HGNC	e!Ensembl
601107	53	ENSG00000023839

Q92887

Protein name

ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2)

Protein function

ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide va

PDB

8IZQ , 8IZR , 8JX7 , 8JXQ , 8JXU , 8JY4 , 8JY5 , 9BR2 , 9BUK , 9C12 , 9C2I

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00664	ABC_membrane	322 → 593	ABC transporter transmembrane region	Family
PF00005	ABC_tran	654 → 789	ABC transporter	Domain
PF00664	ABC_membrane	979 → 1251	ABC transporter transmembrane region	Family
PF00005	ABC_tran	1317 → 1465	ABC transporter	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver. Expressed in small intestine (PubMed:28408210). {ECO:0000269|PubMed:28408210}.

Sequence

MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGYLWLLAPWQLLHVYKSRTKRSS
TTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLVLLIQYS
RQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILI
FSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVS
KFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSG
TKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIG
YLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGET
VNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAIL
STKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFS
QLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMI
SSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLD
IMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNIL
FGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLD
IYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIV
EKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAAS
ITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETG
KVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQR
DMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRI
VNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMF
YVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSW
ITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTS
EIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGI
TCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTII
PQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIG
QRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD
SDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF

Sequence length

1545

Interactions

View interactions

425

Show/Hide Causal Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
ABCC2-related disorder	Likely pathogenic; Pathogenic	rs376398719, rs781481868, rs146405172, rs17222547, rs780765144, rs34937870, rs56199535, rs72558202, rs72558200, rs371866713, rs777438560, rs754267460, rs554976086, rs66898362, rs753329079 View all (14 more)	RCV004746452 RCV003399193 RCV003965261 RCV003416080 RCV004747093 RCV003895238 RCV004745150 RCV003407306 RCV003421913 RCV003409423 RCV003402735 RCV003412139 RCV004747320 RCV003909038 RCV003966639 RCV003893457 RCV004723508 RCV003894002 RCV003982281 RCV003911524 RCV003415739 RCV004745492 RCV004745495 RCV003953002 RCV003396303 RCV004745568 RCV004745575 RCV004745581 RCV004745582 RCV003405317
Autosomal recessive inherited pseudoxanthoma elasticum	Likely pathogenic; Pathogenic	rs146405172	RCV000991170
Colon adenocarcinoma	Likely pathogenic	rs781481868	RCV005912590
Dubin-Johnson syndrome	Likely pathogenic; Pathogenic	rs903690171, rs376398719, rs775410341, rs2038788369, rs1351419381, rs2132976682, rs766573679, rs2133124899, rs34937870, rs2492860078, rs864309675, rs56199535, rs387906395, rs200606989, rs72558202 View all (28 more)	RCV005038586 RCV001781687 RCV001781703 RCV001785189 RCV001807897 RCV002052178 RCV002052262 RCV002272767 RCV000190561 RCV005034436 RCV000203293 RCV000008923 RCV000008925 RCV000008926 RCV000008927 RCV000008928 RCV000008929 RCV000008930 RCV000853302 RCV005033854 RCV003338150 RCV005036790 RCV004796817 RCV004796825 RCV004796826 RCV004801369 RCV004796849 RCV005356551 RCV003842937 RCV004759327 RCV000342000 RCV000024307 RCV003129872 RCV001809690 RCV004760639 RCV005240299 RCV001784362 RCV005357971 RCV005633658 RCV004720281 RCV001809792 RCV000853304 RCV004702575 RCV005036409
Thyroid cancer, nonmedullary, 1	Likely pathogenic	rs781481868	RCV005912591

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign; Conflicting classifications of pathogenicity	rs60190212, rs139800035	RCV005914660 RCV005895889
Familial cancer of breast	Conflicting classifications of pathogenicity	rs139800035, rs144192700	RCV005895888 RCV005891752
Hepatocellular carcinoma	Benign; Likely benign; Conflicting classifications of pathogenicity	rs138988852, rs144192700	RCV005891751 RCV005891753
Lung cancer	Benign	rs60190212	RCV005914661
Melanoma	Conflicting classifications of pathogenicity	rs139800035, rs144192700	RCV005895890 RCV005891754

Show/Hide Text Mining Associations (106)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute Kidney Injury	Associate	28640195
Adenocarcinoma	Associate	16107775
Adenocarcinoma of Lung	Associate	33879658, 37589509, 38594917
Adenoma	Stimulate	25793771
Anemia	Associate	24404132, 25881102
Arthritis Rheumatoid	Associate	23897011
Asthma	Associate	30655622
Beta ketothiolase deficiency	Associate	28583112
Bone Diseases	Associate	28583112
Brain Injuries Traumatic	Associate	23896815
Breast Neoplasms	Associate	15517899, 20102361, 20124171, 21986666, 30458661, 34092579, 35461219
Carcinogenesis	Associate	25793771, 27709738
Carcinoma Hepatocellular	Stimulate	12428063
Carcinoma Hepatocellular	Associate	29138286, 29464551, 33208122, 35363194, 36274106, 36985726, 37369012, 37733713
Carcinoma Non Small Cell Lung	Associate	17534875, 17606722, 19568750, 27590272, 27988838, 28442702, 35740931
Carcinoma Ovarian Epithelial	Associate	19603017
Carcinoma Renal Cell	Inhibit	16080518
Cholangiocarcinoma	Associate	15884115, 23480753, 29464551
Cholestasis	Associate	12524417, 18176959, 18395921, 26212029, 31316180
Chorioamnionitis	Stimulate	29402780
Colonic Neoplasms	Associate	16107775
Colorectal Neoplasms	Associate	18981587, 22201120, 25793771, 26295158, 28968471, 30360603, 31278324, 31395900, 34599518
Cyclic neutropenia	Associate	24404132
Death	Stimulate	17606722
Diarrhea	Associate	17534875, 25611302, 40282412
Diarrhea	Inhibit	25611302
Disease Progression	Associate	30360603
Disease Resistance	Associate	22630058
Drug Related Side Effects and Adverse Reactions	Stimulate	21887680
Drug Related Side Effects and Adverse Reactions	Associate	21887680, 24404132, 25881102, 27566582, 31288073, 32748396, 33390536
Drug Resistant Epilepsy	Associate	19603017, 20922799, 22630058, 27886333
Epilepsy	Stimulate	11879359
Epilepsy	Associate	22630058, 23717663, 27886333, 36253887
Esophageal Neoplasms	Associate	21206495
Esophageal Squamous Cell Carcinoma	Associate	20193114, 20331629, 21206495
Fallopian Tube Neoplasms	Associate	23135210
Fanconi Syndrome	Associate	25485598
Fatty Liver Alcoholic	Associate	28097795
Gallbladder Neoplasms	Associate	23841074
Gastrointestinal Diseases	Associate	24404132
Gilbert Disease	Associate	36274106
Glioma	Associate	15751272
Glycosuria Renal	Associate	39713147
Heart Failure	Associate	23927520
Hematologic Neoplasms	Associate	21918980
Hepatitis C Chronic	Associate	22166890
Hepatolenticular Degeneration	Associate	33208122, 34117631
Hippocampal Sclerosis	Associate	15101825
Hyperbilirubinemia	Associate	29453415, 32183854, 36555809
Hyperbilirubinemia Conjugated Type III	Associate	12388192, 26264947
Hypocalcemia	Associate	40282412
Infant Newborn Diseases	Associate	32758197
Inflammation	Associate	17095618, 23401306, 34092579
Intrahepatic Cholestasis of Pregnancy	Associate	18176959, 18395921, 24366234, 28924228, 33546617, 34638773
Jaundice	Associate	26212029
Jaundice Chronic Idiopathic	Associate	10053008, 12087194, 12388192, 19881259, 21541183, 23429660, 26264947, 26350512, 28923092, 29032691, 32183854, 32758197, 36274106, 36555809, 38277553
Kidney Diseases	Associate	26807589
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	11552983
Leukemia Myeloid Acute	Associate	10828037
Leukopenia	Associate	18294295
Liver Cirrhosis	Associate	27543206, 29138286
Liver Diseases	Associate	23429660
Liver Failure	Associate	23401306, 26212029
Liver Neoplasms	Associate	10081488
Lymphoma	Associate	21918980
Melanoma	Stimulate	12839578
Melanoma	Associate	28293855, 39213172
Mesothelioma Malignant	Associate	11697834
Microvillus inclusion disease	Associate	29218485
Multiple Myeloma	Associate	30079960
Nausea	Associate	33794950
Neoplasms	Associate	11500505, 16831027, 17534875, 18981587, 21986666, 23841074, 25793771, 27342070, 29176691, 33879658, 40641097
Neoplastic Syndromes Hereditary	Associate	26350512, 36274106
Neuroblastoma	Associate	10081488, 32295184
Neurologic Manifestations	Associate	31395900
Neurotoxicity Syndromes	Associate	22868256, 25881102
Neutropenia	Associate	17534875, 18294295, 25611302, 32778670
Neutropenia	Inhibit	25611302
Non alcoholic Fatty Liver Disease	Associate	21878559, 29341352, 32897538
Ototoxicity	Associate	22630058, 23401306, 27886333
Ovarian Neoplasms	Associate	15771954, 24124770, 25881102
Pain	Associate	22454423
Pancreatic Neoplasms	Associate	20922799, 31874997
Polycystic Kidney Autosomal Dominant	Inhibit	32748396
Polyposis Syndrome Hereditary Mixed 1	Associate	25793771
Pseudoxanthoma Elasticum	Stimulate	18936737
Pulmonary Disease Chronic Obstructive	Associate	30655622
Recurrence	Stimulate	23841074
Renal Insufficiency Chronic	Associate	39713147
Retinal Dysplasia	Associate	25793771
Retinitis Pigmentosa Concentric	Associate	36253887
Seizures	Associate	23717663
SeSAME syndrome	Associate	26535588
Sexual Dysfunction Physiological	Associate	30360603
Small Cell Lung Carcinoma	Associate	18214043, 20439344
Spinal Dysraphism	Associate	29681089
Squamous Cell Carcinoma of Head and Neck	Associate	25275603
Stomach Neoplasms	Associate	27487151, 31852133
Stomatitis	Associate	24404132
Thrombocytopenia	Associate	24404132
Thyroid cancer medullary	Associate	16831027
Tn Syndrome	Associate	35628426
Triple Negative Breast Neoplasms	Associate	27527855
Tuberculosis Multidrug Resistant	Associate	16672223, 19881259, 24637737, 27988838
Tuberculosis Multidrug Resistant	Inhibit	26799285
Weight Loss	Associate	27988838

ABCC2 (ATP binding cassette subfamily C member 2)