Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs
Entrez ID	89845
Gene name	ATP binding cassette subfamily C member 10
Gene symbol	ABCC10
Synonyms (NCBI Gene)	EST182763MRP7SIMRP7
Chromosome	6
Chromosome location	6p21.1
Summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, M

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miRTarBase ID	miRNA	Experiments	Reference
MIRT047155	hsa-miR-183-5p	CLASH	23622248
MIRT758254	hsa-let-7a	CLIP-seq
MIRT758255	hsa-let-7b	CLIP-seq
MIRT758256	hsa-let-7c	CLIP-seq
MIRT758257	hsa-let-7d	CLIP-seq
MIRT758258	hsa-let-7e	CLIP-seq
MIRT758259	hsa-let-7f	CLIP-seq
MIRT758260	hsa-let-7g	CLIP-seq
MIRT758261	hsa-let-7i	CLIP-seq
MIRT758262	hsa-miR-1225-3p	CLIP-seq
MIRT758263	hsa-miR-185	CLIP-seq
MIRT758264	hsa-miR-30a	CLIP-seq
MIRT758265	hsa-miR-30b	CLIP-seq
MIRT758266	hsa-miR-30c	CLIP-seq
MIRT758267	hsa-miR-30d	CLIP-seq
MIRT758268	hsa-miR-30e	CLIP-seq
MIRT758269	hsa-miR-3150b-3p	CLIP-seq
MIRT758270	hsa-miR-3911	CLIP-seq
MIRT758271	hsa-miR-3927	CLIP-seq
MIRT758272	hsa-miR-4306	CLIP-seq
MIRT758273	hsa-miR-4323	CLIP-seq
MIRT758274	hsa-miR-4451	CLIP-seq
MIRT758275	hsa-miR-4458	CLIP-seq
MIRT758276	hsa-miR-4495	CLIP-seq
MIRT758277	hsa-miR-4500	CLIP-seq
MIRT758278	hsa-miR-4644	CLIP-seq
MIRT758279	hsa-miR-4685-5p	CLIP-seq
MIRT758280	hsa-miR-4732-5p	CLIP-seq
MIRT758281	hsa-miR-4765	CLIP-seq
MIRT758282	hsa-miR-4784	CLIP-seq
MIRT758283	hsa-miR-595	CLIP-seq
MIRT758284	hsa-miR-98	CLIP-seq
MIRT758262	hsa-miR-1225-3p	CLIP-seq
MIRT1923634	hsa-miR-1237	CLIP-seq
MIRT1923635	hsa-miR-204	CLIP-seq
MIRT1923636	hsa-miR-211	CLIP-seq
MIRT1923637	hsa-miR-2110	CLIP-seq
MIRT1923638	hsa-miR-4271	CLIP-seq
MIRT1923639	hsa-miR-4314	CLIP-seq
MIRT1923640	hsa-miR-4446-5p	CLIP-seq
MIRT1923641	hsa-miR-4667-5p	CLIP-seq
MIRT1923642	hsa-miR-4700-5p	CLIP-seq
MIRT1923643	hsa-miR-4725-3p	CLIP-seq
MIRT758280	hsa-miR-4732-5p	CLIP-seq
MIRT1923644	hsa-miR-4755-5p	CLIP-seq
MIRT758283	hsa-miR-595	CLIP-seq
MIRT1923645	hsa-miR-623	CLIP-seq
MIRT1923646	hsa-miR-637	CLIP-seq
MIRT1923634	hsa-miR-1237	CLIP-seq
MIRT1923635	hsa-miR-204	CLIP-seq
MIRT1923636	hsa-miR-211	CLIP-seq
MIRT1923637	hsa-miR-2110	CLIP-seq
MIRT2165151	hsa-miR-3664-3p	CLIP-seq
MIRT758270	hsa-miR-3911	CLIP-seq
MIRT1923638	hsa-miR-4271	CLIP-seq
MIRT1923639	hsa-miR-4314	CLIP-seq
MIRT1923640	hsa-miR-4446-5p	CLIP-seq
MIRT1923641	hsa-miR-4667-5p	CLIP-seq
MIRT2165152	hsa-miR-4680-5p	CLIP-seq
MIRT758279	hsa-miR-4685-5p	CLIP-seq
MIRT1923642	hsa-miR-4700-5p	CLIP-seq
MIRT1923643	hsa-miR-4725-3p	CLIP-seq
MIRT1923644	hsa-miR-4755-5p	CLIP-seq
MIRT758281	hsa-miR-4765	CLIP-seq
MIRT758283	hsa-miR-595	CLIP-seq
MIRT1923645	hsa-miR-623	CLIP-seq
MIRT1923646	hsa-miR-637	CLIP-seq
MIRT2165153	hsa-miR-671-5p	CLIP-seq
MIRT2165154	hsa-miR-938	CLIP-seq
MIRT758254	hsa-let-7a	CLIP-seq
MIRT758255	hsa-let-7b	CLIP-seq
MIRT758256	hsa-let-7c	CLIP-seq
MIRT758257	hsa-let-7d	CLIP-seq
MIRT758258	hsa-let-7e	CLIP-seq
MIRT758259	hsa-let-7f	CLIP-seq
MIRT758260	hsa-let-7g	CLIP-seq
MIRT758261	hsa-let-7i	CLIP-seq
MIRT758262	hsa-miR-1225-3p	CLIP-seq
MIRT758269	hsa-miR-3150b-3p	CLIP-seq
MIRT758271	hsa-miR-3927	CLIP-seq
MIRT758273	hsa-miR-4323	CLIP-seq
MIRT758274	hsa-miR-4451	CLIP-seq
MIRT758275	hsa-miR-4458	CLIP-seq
MIRT758277	hsa-miR-4500	CLIP-seq
MIRT758280	hsa-miR-4732-5p	CLIP-seq
MIRT758282	hsa-miR-4784	CLIP-seq
MIRT758284	hsa-miR-98	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	28112518
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006691	Process	Leukotriene metabolic process	IDA	23087055
GO:0006869	Process	Lipid transport	IEA
GO:0008559	Function	ABC-type xenobiotic transporter activity	IBA
GO:0008559	Function	ABC-type xenobiotic transporter activity	IDA	23087055
GO:0008559	Function	ABC-type xenobiotic transporter activity	IEA
GO:0009925	Component	Basal plasma membrane	IDA	35307651
GO:0009925	Component	Basal plasma membrane	IEA
GO:0015431	Function	ABC-type glutathione S-conjugate transporter activity	IDA	23087055
GO:0015431	Function	ABC-type glutathione S-conjugate transporter activity	IEA
GO:0015711	Process	Organic anion transport	IBA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IDA	23087055
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0042908	Process	Xenobiotic transport	IEA
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IEA
GO:0043225	Function	ATPase-coupled inorganic anion transmembrane transporter activity	IEA
GO:0043225	Function	ATPase-coupled inorganic anion transmembrane transporter activity	TAS
GO:0055085	Process	Transmembrane transport	IBA
GO:0055085	Process	Transmembrane transport	IEA
GO:0055085	Process	Transmembrane transport	TAS
GO:0071716	Process	Leukotriene transport	IDA	23087055
GO:0071716	Process	Leukotriene transport	IEA
GO:0098656	Process	Monoatomic anion transmembrane transport	IEA
GO:0140359	Function	ABC-type transporter activity	IDA	23087055
GO:0140359	Function	ABC-type transporter activity	IEA

MIM	HGNC	e!Ensembl
612509	52	ENSG00000124574

Q5T3U5

Protein name

ATP-binding cassette sub-family C member 10 (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 7)

Protein function

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as e

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00664	ABC_membrane	285 → 551	ABC transporter transmembrane region	Family
PF00005	ABC_tran	618 → 754	ABC transporter	Domain
PF00664	ABC_membrane	885 → 1198	ABC transporter transmembrane region	Family
PF00005	ABC_tran	1263 → 1410	ABC transporter	Domain

Tissue specificity

TISSUE SPECIFICITY: In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells, moderately in the adluminal compartment of the seminiferous tubules, and in vascular endothelial cells. {ECO:0000269|PubMed:35307

Sequence

MERLLAQLCGSSAAWPLPLWEGDTTGHCFTQLVLSALPHALLAVLSACYLGTPRSPDYIL
PCSPGWRLRLAASFLLSVFPLLDLLPVALPPGAGPGPIGLEVLAGCVAAVAWISHSLALW
VLAHSPHGHSRGPLALALVALLPAPALVLTVLWHCQRGTLLPPLLPGPMARLCLLILQLA
ALLAYALGWAAPGGPREPWAQEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLARGACGE
LRQPQDICRLPHRLQPTYLARVFQAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGF
SGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVL
NILYCKALQLGPSRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVG
VAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQA
LGARVEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVFTA
LALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDPPAEPSTVLEL
HGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVR
GLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVG
EKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLL
CTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPKAWAENGQESDSATAQSVQNP
EKTKEGLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRN
AADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNG
SSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATP
TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYH
VQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRC
QFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSG
LVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLP
NALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLR
SQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEGGR
SLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRL
NTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGVPASLGGP

Sequence length

1492

Interactions

View interactions

ABCC10 (ATP binding cassette subfamily C member 10)