Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23457
Gene name Gene Name - the full gene name approved by the HGNC.	ATP binding cassette subfamily B member 9
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ABCB9
Synonyms (NCBI Gene) Gene synonyms aliases	EST122234, TAPL
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q24.31
Summary Summary of gene provided in NCBI Entrez Gene.	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct

Show/Hide all(24)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003169	hsa-miR-210-3p	immunoprecipitaion, Microarray, qRT-PCR	19826008
MIRT018865	hsa-miR-335-5p	Microarray	18185580
MIRT050137	hsa-miR-26a-5p	CLASH	23622248
MIRT437432	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	24099915
MIRT437432	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	24099915
MIRT758243	hsa-miR-1324	CLIP-seq
MIRT758244	hsa-miR-1470	CLIP-seq
MIRT758245	hsa-miR-203	CLIP-seq
MIRT758246	hsa-miR-4287	CLIP-seq
MIRT758247	hsa-miR-4469	CLIP-seq
MIRT758248	hsa-miR-4497	CLIP-seq
MIRT758249	hsa-miR-4667-3p	CLIP-seq
MIRT758250	hsa-miR-4685-3p	CLIP-seq
MIRT758251	hsa-miR-4757-5p	CLIP-seq
MIRT758252	hsa-miR-671-5p	CLIP-seq
MIRT758253	hsa-miR-922	CLIP-seq
MIRT2165143	hsa-miR-1321	CLIP-seq
MIRT2165144	hsa-miR-24	CLIP-seq
MIRT2165145	hsa-miR-3194-5p	CLIP-seq
MIRT2165146	hsa-miR-4435	CLIP-seq
MIRT2165147	hsa-miR-4739	CLIP-seq
MIRT2165148	hsa-miR-4749-3p	CLIP-seq
MIRT2165149	hsa-miR-4756-5p	CLIP-seq
MIRT2165150	hsa-miR-483-3p	CLIP-seq

Show/Hide all(34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002474	Process	Antigen processing and presentation of peptide antigen via MHC class I	IDA	17977821
GO:0005515	Function	Protein binding	IPI	21194361, 22641697, 30877195
GO:0005524	Function	ATP binding	IDA	15863492
GO:0005524	Function	ATP binding	IEA
GO:0005764	Component	Lysosome	IDA	22641697, 30877195
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005765	Component	Lysosomal membrane	IDA	10748049, 17977821, 18952056, 21194361, 21212514
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005769	Component	Early endosome	IDA	17977821
GO:0005783	Component	Endoplasmic reticulum	IDA	17977821
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	1101155, 11011155, 15577206
GO:0006518	Process	Peptide metabolic process	IDA	25646430, 31417173
GO:0015031	Process	Protein transport	IEA
GO:0015421	Function	ABC-type oligopeptide transporter activity	IDA	15863492, 25646430, 30877195, 31417173
GO:0015421	Function	ABC-type oligopeptide transporter activity	IEA
GO:0015440	Function	ABC-type peptide transporter activity	IBA
GO:0015440	Function	ABC-type peptide transporter activity	IDA	17977821, 18434309, 22641697
GO:0015440	Function	ABC-type peptide transporter activity	IEA
GO:0015833	Process	Peptide transport	IDA	15863492, 17977821, 18434309, 22641697, 25646430, 31417173
GO:0015833	Process	Peptide transport	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	18434309
GO:0016020	Component	Membrane	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0022857	Function	Transmembrane transporter activity	IDA	18434309
GO:0035672	Process	Oligopeptide transmembrane transport	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	18434309
GO:0042803	Function	Protein homodimerization activity	IPI	18952056
GO:0055085	Process	Transmembrane transport	IBA
GO:0055085	Process	Transmembrane transport	IEA
GO:0140359	Function	ABC-type transporter activity	IEA

MIM	HGNC	e!Ensembl
605453	50	ENSG00000150967

Protein

UniProt ID

Q9NP78

Protein name

ABC-type oligopeptide transporter ABCB9 (EC 7.4.2.6) (ATP-binding cassette sub-family B member 9) (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (hABCB9) (TAP-like protein) (TAPL)

Protein function

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation (PubMed:15863492, PubMed:17977821, PubMed:18434309, PubMed:22641697, PubMed:25646430, PubMed:3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00664	ABC_membrane	188 → 457	ABC transporter transmembrane region	Family
PF00005	ABC_tran	522 → 671	ABC transporter	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages. {ECO:0000269|PubMed:107480

Sequence

MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL
LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF
VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY
TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS
FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV
SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA
LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL
LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF
EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP
SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI
SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN
PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ
QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA

Sequence length

766

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Chorioamnionitis	Stimulate	29402780
Diabetes Mellitus Type 2	Associate	25799151, 27115357
Neoplasms	Associate	31083274
Ovarian Neoplasms	Inhibit	31083274
Parkinson Disease	Associate	28851441
Schizophrenia	Associate	28552197

ABCB9 (ATP binding cassette subfamily B member 9)