Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs Transcription factors Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11194
Gene name Gene Name - the full gene name approved by the HGNC.	ATP binding cassette subfamily B member 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ABCB8
Synonyms (NCBI Gene) Gene synonyms aliases	EST328128, M-ABC1, MABC1, MITOSUR
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q36.1
Summary Summary of gene provided in NCBI Entrez Gene.	This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss

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miRTarBase ID	miRNA	Experiments	Reference
MIRT051898	hsa-let-7b-5p	CLASH	23622248
MIRT051898	hsa-let-7b-5p	CLASH	23622248
MIRT758214	hsa-miR-1245b-5p	CLIP-seq
MIRT758215	hsa-miR-1258	CLIP-seq
MIRT758216	hsa-miR-1291	CLIP-seq
MIRT758217	hsa-miR-1295	CLIP-seq
MIRT758218	hsa-miR-146b-3p	CLIP-seq
MIRT758219	hsa-miR-2861	CLIP-seq
MIRT758220	hsa-miR-296-5p	CLIP-seq
MIRT758221	hsa-miR-299-3p	CLIP-seq
MIRT758222	hsa-miR-3142	CLIP-seq
MIRT758223	hsa-miR-3147	CLIP-seq
MIRT758224	hsa-miR-3165	CLIP-seq
MIRT758225	hsa-miR-329	CLIP-seq
MIRT758226	hsa-miR-362-3p	CLIP-seq
MIRT758227	hsa-miR-3657	CLIP-seq
MIRT758228	hsa-miR-3691-5p	CLIP-seq
MIRT758229	hsa-miR-370	CLIP-seq
MIRT758230	hsa-miR-4265	CLIP-seq
MIRT758231	hsa-miR-4296	CLIP-seq
MIRT758232	hsa-miR-4322	CLIP-seq
MIRT758233	hsa-miR-4417	CLIP-seq
MIRT758234	hsa-miR-4425	CLIP-seq
MIRT758235	hsa-miR-4669	CLIP-seq
MIRT758236	hsa-miR-4731-5p	CLIP-seq
MIRT758237	hsa-miR-4762-5p	CLIP-seq
MIRT758238	hsa-miR-4764-5p	CLIP-seq
MIRT758239	hsa-miR-4772-3p	CLIP-seq
MIRT758240	hsa-miR-486-3p	CLIP-seq
MIRT758241	hsa-miR-661	CLIP-seq
MIRT758242	hsa-miR-891b	CLIP-seq
MIRT1923596	hsa-miR-103a	CLIP-seq
MIRT1923597	hsa-miR-107	CLIP-seq
MIRT1923598	hsa-miR-1184	CLIP-seq
MIRT1923599	hsa-miR-1202	CLIP-seq
MIRT1923600	hsa-miR-1205	CLIP-seq
MIRT1923601	hsa-miR-1265	CLIP-seq
MIRT1923602	hsa-miR-148a	CLIP-seq
MIRT1923603	hsa-miR-148b	CLIP-seq
MIRT1923604	hsa-miR-152	CLIP-seq
MIRT1923605	hsa-miR-198	CLIP-seq
MIRT1923606	hsa-miR-3124-3p	CLIP-seq
MIRT1923607	hsa-miR-3150a-3p	CLIP-seq
MIRT1923608	hsa-miR-3158-5p	CLIP-seq
MIRT1923609	hsa-miR-3169	CLIP-seq
MIRT1923610	hsa-miR-3175	CLIP-seq
MIRT1923611	hsa-miR-3194-5p	CLIP-seq
MIRT1923612	hsa-miR-331-3p	CLIP-seq
MIRT1923613	hsa-miR-3664-3p	CLIP-seq
MIRT1923614	hsa-miR-3689d	CLIP-seq
MIRT1923615	hsa-miR-3972	CLIP-seq
MIRT1923616	hsa-miR-423-3p	CLIP-seq
MIRT1923617	hsa-miR-4419a	CLIP-seq
MIRT1923618	hsa-miR-4436a	CLIP-seq
MIRT1923619	hsa-miR-4446-3p	CLIP-seq
MIRT1923620	hsa-miR-4468	CLIP-seq
MIRT1923621	hsa-miR-4510	CLIP-seq
MIRT1923622	hsa-miR-4519	CLIP-seq
MIRT1923623	hsa-miR-4656	CLIP-seq
MIRT1923624	hsa-miR-4707-5p	CLIP-seq
MIRT1923625	hsa-miR-4721	CLIP-seq
MIRT1923626	hsa-miR-4722-3p	CLIP-seq
MIRT1923627	hsa-miR-4728-5p	CLIP-seq
MIRT1923628	hsa-miR-4757-5p	CLIP-seq
MIRT758240	hsa-miR-486-3p	CLIP-seq
MIRT1923629	hsa-miR-510	CLIP-seq
MIRT1923630	hsa-miR-587	CLIP-seq
MIRT1923631	hsa-miR-654-3p	CLIP-seq
MIRT1923632	hsa-miR-885-5p	CLIP-seq
MIRT1923633	hsa-miR-939	CLIP-seq
MIRT2165072	hsa-miR-1193	CLIP-seq
MIRT2165073	hsa-miR-1262	CLIP-seq
MIRT2165074	hsa-miR-128	CLIP-seq
MIRT2165075	hsa-miR-1285	CLIP-seq
MIRT2165076	hsa-miR-1293	CLIP-seq
MIRT2165077	hsa-miR-135a	CLIP-seq
MIRT2165078	hsa-miR-135b	CLIP-seq
MIRT2165079	hsa-miR-1909	CLIP-seq
MIRT2165080	hsa-miR-1911	CLIP-seq
MIRT2165081	hsa-miR-1915	CLIP-seq
MIRT2165082	hsa-miR-2355-5p	CLIP-seq
MIRT2165083	hsa-miR-2467-5p	CLIP-seq
MIRT758219	hsa-miR-2861	CLIP-seq
MIRT2165084	hsa-miR-29a	CLIP-seq
MIRT2165085	hsa-miR-29b	CLIP-seq
MIRT2165086	hsa-miR-29c	CLIP-seq
MIRT2165087	hsa-miR-3120-3p	CLIP-seq
MIRT2165088	hsa-miR-3120-5p	CLIP-seq
MIRT2165089	hsa-miR-3136-5p	CLIP-seq
MIRT1923607	hsa-miR-3150a-3p	CLIP-seq
MIRT2165090	hsa-miR-3168	CLIP-seq
MIRT1923609	hsa-miR-3169	CLIP-seq
MIRT2165091	hsa-miR-3170	CLIP-seq
MIRT1923610	hsa-miR-3175	CLIP-seq
MIRT2165092	hsa-miR-3176	CLIP-seq
MIRT2165093	hsa-miR-3187-5p	CLIP-seq
MIRT2165094	hsa-miR-3188	CLIP-seq
MIRT2165095	hsa-miR-3202	CLIP-seq
MIRT2165096	hsa-miR-330-3p	CLIP-seq
MIRT2165097	hsa-miR-3612	CLIP-seq
MIRT2165098	hsa-miR-378g	CLIP-seq
MIRT2165099	hsa-miR-3914	CLIP-seq
MIRT2165100	hsa-miR-3922-3p	CLIP-seq
MIRT2165101	hsa-miR-3929	CLIP-seq
MIRT2165102	hsa-miR-3975	CLIP-seq
MIRT2165103	hsa-miR-409-5p	CLIP-seq
MIRT758230	hsa-miR-4265	CLIP-seq
MIRT2165104	hsa-miR-4267	CLIP-seq
MIRT758231	hsa-miR-4296	CLIP-seq
MIRT758232	hsa-miR-4322	CLIP-seq
MIRT758233	hsa-miR-4417	CLIP-seq
MIRT2165105	hsa-miR-4419b	CLIP-seq
MIRT2165106	hsa-miR-4439	CLIP-seq
MIRT2165107	hsa-miR-4478	CLIP-seq
MIRT2165108	hsa-miR-4481	CLIP-seq
MIRT2165109	hsa-miR-4483	CLIP-seq
MIRT2165110	hsa-miR-4486	CLIP-seq
MIRT2165111	hsa-miR-4502	CLIP-seq
MIRT2165112	hsa-miR-4513	CLIP-seq
MIRT2165113	hsa-miR-4533	CLIP-seq
MIRT2165114	hsa-miR-4640-5p	CLIP-seq
MIRT2165115	hsa-miR-4645-5p	CLIP-seq
MIRT2165116	hsa-miR-4646-3p	CLIP-seq
MIRT2165117	hsa-miR-4649-3p	CLIP-seq
MIRT2165118	hsa-miR-4673	CLIP-seq
MIRT2165119	hsa-miR-4680-5p	CLIP-seq
MIRT2165120	hsa-miR-4690-3p	CLIP-seq
MIRT2165121	hsa-miR-4701-3p	CLIP-seq
MIRT2165122	hsa-miR-4711-5p	CLIP-seq
MIRT2165123	hsa-miR-4726-3p	CLIP-seq
MIRT2165124	hsa-miR-4726-5p	CLIP-seq
MIRT1923627	hsa-miR-4728-5p	CLIP-seq
MIRT758236	hsa-miR-4731-5p	CLIP-seq
MIRT2165125	hsa-miR-4740-5p	CLIP-seq
MIRT2165126	hsa-miR-4745-5p	CLIP-seq
MIRT2165127	hsa-miR-4749-3p	CLIP-seq
MIRT1923628	hsa-miR-4757-5p	CLIP-seq
MIRT2165128	hsa-miR-4758-5p	CLIP-seq
MIRT2165129	hsa-miR-4780	CLIP-seq
MIRT2165130	hsa-miR-4802-5p	CLIP-seq
MIRT2165131	hsa-miR-485-5p	CLIP-seq
MIRT2165132	hsa-miR-491-5p	CLIP-seq
MIRT2165133	hsa-miR-541	CLIP-seq
MIRT2165134	hsa-miR-544b	CLIP-seq
MIRT2165135	hsa-miR-576-3p	CLIP-seq
MIRT2165136	hsa-miR-612	CLIP-seq
MIRT2165137	hsa-miR-623	CLIP-seq
MIRT2165138	hsa-miR-634	CLIP-seq
MIRT2165139	hsa-miR-650	CLIP-seq
MIRT2165140	hsa-miR-654-5p	CLIP-seq
MIRT758241	hsa-miR-661	CLIP-seq
MIRT2165141	hsa-miR-767-5p	CLIP-seq
MIRT2165142	hsa-miR-873	CLIP-seq
MIRT1923633	hsa-miR-939	CLIP-seq
MIRT2165092	hsa-miR-3176	CLIP-seq
MIRT2165100	hsa-miR-3922-3p	CLIP-seq
MIRT1923599	hsa-miR-1202	CLIP-seq
MIRT2442911	hsa-miR-3138	CLIP-seq
MIRT2442912	hsa-miR-3157-5p	CLIP-seq
MIRT2442913	hsa-miR-3158-3p	CLIP-seq
MIRT1923611	hsa-miR-3194-5p	CLIP-seq
MIRT1923615	hsa-miR-3972	CLIP-seq
MIRT2442914	hsa-miR-4691-3p	CLIP-seq
MIRT2442915	hsa-miR-4752	CLIP-seq
MIRT2442916	hsa-miR-4800-5p	CLIP-seq
MIRT758240	hsa-miR-486-3p	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
SP1	Activation	21046154

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25063848, 31435016
GO:0005524	Function	ATP binding	IDA	31435016
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005739	Component	Mitochondrion	IDA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0016021	Component	Integral component of membrane	IBA	21873635
GO:0016887	Function	ATPase activity	IEA
GO:0031966	Component	Mitochondrial membrane	IDA	9878413
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IBA	21873635
GO:0043190	Component	ATP-binding cassette (ABC) transporter complex	TAS	9878413
GO:0055085	Process	Transmembrane transport	IBA	21873635
GO:0062157	Component	Mitochondrial ATP-gated potassium channel complex	IDA	31435016
GO:0071805	Process	Potassium ion transmembrane transport	IDA	31435016

MIM	HGNC	e!Ensembl
605464	49	ENSG00000197150

Protein

UniProt ID

Q9NUT2

Protein name

Mitochondrial potassium channel ATP-binding subunit (ATP-binding cassette sub-family B member 8, mitochondrial) (ABCB8) (Mitochondrial ATP-binding cassette 1) (M-ABC1) (Mitochondrial sulfonylurea-receptor) (MITOSUR)

Protein function

ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)) (PubMed:31435016). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial in

PDB

5OCH , 7EHL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00664	ABC_membrane	148 → 425	ABC transporter transmembrane region	Family
PF00005	ABC_tran	490 → 640	ABC transporter	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MLVHLFRVGIRGGPFPGRLLPPLRFQTFSAVRNTWRNGKTGQLHKAEGEYSDGYRSSSLL
RAVAHLRSQLWAHLPRAPLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPP
ASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYT
RDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDI
TFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMV
ATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAE
LEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQT
VQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFS
YPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT
LDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEG
YNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAG
RTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALDAPRTAAP
PPKKPEGPRSHQHKS

Sequence length

735

Interactions

View interactions

ABCB8 (ATP binding cassette subfamily B member 8)