Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
7525 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
YES proto-oncogene 1, Src family tyrosine kinase |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
YES1 |
SynonymsGene synonyms aliases
|
HsT441, P61-YES, Yes, c-yes |
ChromosomeChromosome number
|
18 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
18p11.32 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a c |
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
NANOG |
Activation |
22378194 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001784 |
Function |
Phosphotyrosine residue binding |
IPI |
20624904 |
GO:0004713 |
Function |
Protein tyrosine kinase activity |
EXP |
1381360, 9799234, 11448999, 12923167, 18697750 |
GO:0004713 |
Function |
Protein tyrosine kinase activity |
IBA |
21873635 |
GO:0004713 |
Function |
Protein tyrosine kinase activity |
TAS |
|
GO:0004715 |
Function |
Non-membrane spanning protein tyrosine kinase activity |
IBA |
21873635 |
GO:0004715 |
Function |
Non-membrane spanning protein tyrosine kinase activity |
TAS |
19267251 |
GO:0005102 |
Function |
Signaling receptor binding |
IBA |
21873635 |
GO:0005515 |
Function |
Protein binding |
IPI |
15657067, 16964398, 21233420, 21713032, 21725358, 22939624, 23866081, 24728074, 24860872, 25036101, 25036637, 25416956, 25731159, 25814554, 28514442, 31515488, 31980649, 32296183 |
GO:0005524 |
Function |
ATP binding |
IEA |
|
GO:0005794 |
Component |
Golgi apparatus |
IDA |
20605918 |
GO:0005815 |
Component |
Microtubule organizing center |
IEA |
|
GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005886 |
Component |
Plasma membrane |
IDA |
20605918 |
GO:0005925 |
Component |
Focal adhesion |
HDA |
21423176 |
GO:0006464 |
Process |
Cellular protein modification process |
TAS |
2436037 |
GO:0007169 |
Process |
Transmembrane receptor protein tyrosine kinase signaling pathway |
IBA |
21873635 |
GO:0019899 |
Function |
Enzyme binding |
IPI |
20605918 |
GO:0030154 |
Process |
Cell differentiation |
IBA |
21873635 |
GO:0031234 |
Component |
Extrinsic component of cytoplasmic side of plasma membrane |
IBA |
21873635 |
GO:0031295 |
Process |
T cell costimulation |
TAS |
|
GO:0038096 |
Process |
Fc-gamma receptor signaling pathway involved in phagocytosis |
TAS |
|
GO:0043114 |
Process |
Regulation of vascular permeability |
TAS |
19267251 |
GO:0044325 |
Function |
Ion channel binding |
IPI |
12538589 |
GO:0045087 |
Process |
Innate immune response |
IBA |
21873635 |
GO:0048013 |
Process |
Ephrin receptor signaling pathway |
TAS |
|
GO:0050900 |
Process |
Leukocyte migration |
TAS |
|
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19199708 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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|
Protein
|
UniProt ID |
P07947 |
Protein name |
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) |
Protein function |
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDG |
PDB |
2HDA
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00018 |
SH3_1 |
97 → 144 |
SH3 domain |
Domain |
PF00017 |
SH2 |
158 → 240 |
SH2 domain |
Domain |
PF07714 |
PK_Tyr_Ser-Thr |
277 → 526 |
Protein tyrosine and serine/threonine kinase |
Domain |
|
Sequence |
|
Sequence length |
543 |
Interactions |
View interactions |