YES1 (YES proto-oncogene 1, Src family tyrosine kinase)

Gene

• Entrez ID: 7525
• Gene name: YES proto-oncogene 1, Src family tyrosine kinase
• Gene symbol: YES1
• Synonyms: HsT441, P61-YES, Yes, c-yes
• Chromosome: 18
• Chromosome location: 18p11.32
• Summary: This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000263	hsa-miR-17-5p	Luciferase reporter assay	19734348
MIRT000263	hsa-miR-17-5p	qRT-PCR, Luciferase reporter assay, Western blot	25561420
MIRT000627	hsa-miR-145-5p	qRT-PCR, Luciferase reporter assay, Western blot, Microarray	20098684
MIRT000627	hsa-miR-145-5p	Reporter assay;Microarray	21351259
MIRT005569	hsa-miR-519a-3p	Immunoblot, Luciferase reporter assay, qRT-PCR	21274007
MIRT021096	hsa-miR-186-5p	Sequencing, PAR-CLIP	20371350
MIRT021096	hsa-miR-186-5p	PAR-CLIP	23446348
MIRT021309	hsa-miR-125a-5p	Sequencing	20371350
MIRT021309	hsa-miR-125a-5p	CLASH	23622248
MIRT021620	hsa-miR-142-3p	Microarray	17612493
MIRT024970	hsa-miR-205-5p	Reporter assay	21330408
MIRT024970	hsa-miR-205-5p	PAR-CLIP	22012620
MIRT025605	hsa-miR-10a-5p	Sequencing	20371350
MIRT044267	hsa-miR-106b-5p	CLASH	23622248
MIRT199312	hsa-miR-4528	PAR-CLIP	22012620
MIRT199338	hsa-miR-4778-3p	PAR-CLIP	23446348
MIRT199338	hsa-miR-4778-3p	PAR-CLIP	20371350
MIRT508281	hsa-miR-4659b-3p	PAR-CLIP	23446348
MIRT508281	hsa-miR-4659b-3p	PAR-CLIP	20371350
MIRT508282	hsa-miR-4659a-3p	PAR-CLIP	23446348
MIRT508282	hsa-miR-4659a-3p	PAR-CLIP	20371350
MIRT508283	hsa-miR-6875-3p	PAR-CLIP	23446348
MIRT508283	hsa-miR-6875-3p	PAR-CLIP	20371350
MIRT508284	hsa-miR-3678-3p	PAR-CLIP	23446348
MIRT508284	hsa-miR-3678-3p	PAR-CLIP	20371350
MIRT508285	hsa-miR-2467-3p	PAR-CLIP	23446348
MIRT508285	hsa-miR-2467-3p	PAR-CLIP	20371350
MIRT508286	hsa-miR-4699-5p	PAR-CLIP	23446348
MIRT508286	hsa-miR-4699-5p	PAR-CLIP	20371350
MIRT508287	hsa-miR-3133	PAR-CLIP	23446348
MIRT508287	hsa-miR-3133	PAR-CLIP	20371350
MIRT508288	hsa-miR-548x-3p	PAR-CLIP	23446348
MIRT508288	hsa-miR-548x-3p	PAR-CLIP	20371350
MIRT508289	hsa-miR-548j-3p	PAR-CLIP	23446348
MIRT508289	hsa-miR-548j-3p	PAR-CLIP	20371350
MIRT508290	hsa-miR-548aq-3p	PAR-CLIP	23446348
MIRT508290	hsa-miR-548aq-3p	PAR-CLIP	20371350
MIRT508291	hsa-miR-548am-3p	PAR-CLIP	23446348
MIRT508291	hsa-miR-548am-3p	PAR-CLIP	20371350
MIRT508292	hsa-miR-548aj-3p	PAR-CLIP	23446348
MIRT508292	hsa-miR-548aj-3p	PAR-CLIP	20371350
MIRT508293	hsa-miR-548ah-3p	PAR-CLIP	23446348
MIRT508293	hsa-miR-548ah-3p	PAR-CLIP	20371350
MIRT508294	hsa-miR-548ae-3p	PAR-CLIP	23446348
MIRT508294	hsa-miR-548ae-3p	PAR-CLIP	20371350
MIRT508295	hsa-miR-548z	PAR-CLIP	23446348
MIRT508295	hsa-miR-548z	PAR-CLIP	20371350
MIRT508296	hsa-miR-548h-3p	PAR-CLIP	23446348
MIRT508296	hsa-miR-548h-3p	PAR-CLIP	20371350
MIRT508297	hsa-miR-548d-3p	PAR-CLIP	23446348
MIRT508297	hsa-miR-548d-3p	PAR-CLIP	20371350
MIRT508298	hsa-miR-548bb-3p	PAR-CLIP	23446348
MIRT508298	hsa-miR-548bb-3p	PAR-CLIP	20371350
MIRT508299	hsa-miR-548ac	PAR-CLIP	23446348
MIRT508299	hsa-miR-548ac	PAR-CLIP	20371350
MIRT533123	hsa-miR-129-5p	PAR-CLIP	22012620
MIRT533123	hsa-miR-129-5p	PAR-CLIP	27292025
MIRT533124	hsa-miR-4776-3p	PAR-CLIP	22012620
MIRT533124	hsa-miR-4776-3p	PAR-CLIP	27292025
MIRT533125	hsa-miR-192-3p	PAR-CLIP	22012620
MIRT533125	hsa-miR-192-3p	PAR-CLIP	27292025
MIRT533126	hsa-miR-4687-3p	PAR-CLIP	22012620
MIRT533126	hsa-miR-4687-3p	PAR-CLIP	27292025
MIRT533127	hsa-miR-4263	PAR-CLIP	22012620
MIRT533128	hsa-miR-5189-3p	PAR-CLIP	22012620
MIRT533128	hsa-miR-5189-3p	PAR-CLIP	27292025
MIRT533129	hsa-miR-4724-3p	PAR-CLIP	22012620
MIRT533130	hsa-miR-224-5p	PAR-CLIP	22012620
MIRT665338	hsa-miR-4508	HITS-CLIP	23824327
MIRT665339	hsa-miR-7977	HITS-CLIP	23824327
MIRT665340	hsa-miR-6806-5p	HITS-CLIP	23824327
MIRT665341	hsa-miR-3178	HITS-CLIP	23824327
MIRT665342	hsa-miR-5787	HITS-CLIP	23824327
MIRT665343	hsa-miR-4505	HITS-CLIP	23824327
MIRT665344	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT665345	hsa-miR-4284	HITS-CLIP	23824327
MIRT665346	hsa-miR-4486	HITS-CLIP	23824327
MIRT665347	hsa-miR-4478	HITS-CLIP	23824327
MIRT665348	hsa-miR-4419b	HITS-CLIP	23824327
MIRT665349	hsa-miR-3929	HITS-CLIP	23824327
MIRT669783	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT761682	hsa-miR-125b-2-3p	PAR-CLIP	27292025
MIRT762099	hsa-miR-1273h-5p	PAR-CLIP	27292025
MIRT762271	hsa-miR-1288-5p	PAR-CLIP	27292025
MIRT762846	hsa-miR-149-3p	PAR-CLIP	27292025
MIRT764637	hsa-miR-30b-3p	PAR-CLIP	27292025
MIRT764685	hsa-miR-30c-1-3p	PAR-CLIP	27292025
MIRT764730	hsa-miR-30c-2-3p	PAR-CLIP	27292025
MIRT764824	hsa-miR-3122	PAR-CLIP	27292025
MIRT766865	hsa-miR-3689a-3p	PAR-CLIP	27292025
MIRT766953	hsa-miR-3689b-3p	PAR-CLIP	27292025
MIRT767041	hsa-miR-3689c	PAR-CLIP	27292025
MIRT767628	hsa-miR-3913-5p	PAR-CLIP	27292025
MIRT767899	hsa-miR-3974	PAR-CLIP	27292025
MIRT769057	hsa-miR-4433a-3p	PAR-CLIP	27292025
MIRT769215	hsa-miR-4457	PAR-CLIP	27292025
MIRT769378	hsa-miR-4459	PAR-CLIP	27292025
MIRT769864	hsa-miR-450a-1-3p	PAR-CLIP	27292025
MIRT770964	hsa-miR-4683	PAR-CLIP	27292025
MIRT771762	hsa-miR-4728-5p	PAR-CLIP	27292025
MIRT772162	hsa-miR-4768-3p	PAR-CLIP	27292025
MIRT773405	hsa-miR-513b-5p	PAR-CLIP	27292025
MIRT775716	hsa-miR-6087	PAR-CLIP	27292025
MIRT775753	hsa-miR-6089	PAR-CLIP	27292025
MIRT776100	hsa-miR-624-3p	PAR-CLIP	27292025
MIRT777014	hsa-miR-6513-5p	PAR-CLIP	27292025
MIRT778943	hsa-miR-6779-5p	PAR-CLIP	27292025
MIRT779033	hsa-miR-6780a-5p	PAR-CLIP	27292025
MIRT779172	hsa-miR-6785-5p	PAR-CLIP	27292025
MIRT779262	hsa-miR-6788-5p	PAR-CLIP	27292025
MIRT779472	hsa-miR-6799-5p	PAR-CLIP	27292025
MIRT780968	hsa-miR-6883-5p	PAR-CLIP	27292025
MIRT781115	hsa-miR-6888-5p	PAR-CLIP	27292025
MIRT781403	hsa-miR-7106-5p	PAR-CLIP	27292025
MIRT781459	hsa-miR-7112-5p	PAR-CLIP	27292025
MIRT782580	hsa-miR-887-5p	PAR-CLIP	27292025

Transcription factors

Transcription factor	Regulation	Reference
NANOG	Activation	22378194

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001784	Function	Phosphotyrosine residue binding	IPI	20624904
GO:0004713	Function	Protein tyrosine kinase activity	EXP	1381360, 9799234, 11448999, 12923167, 18697750
GO:0004713	Function	Protein tyrosine kinase activity	IBA	21873635
GO:0004713	Function	Protein tyrosine kinase activity	TAS
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IBA	21873635
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	TAS	19267251
GO:0005102	Function	Signaling receptor binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	15657067, 16964398, 21233420, 21713032, 21725358, 22939624, 23866081, 24728074, 24860872, 25036101, 25036637, 25416956, 25731159, 25814554, 28514442, 31515488, 31980649, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005794	Component	Golgi apparatus	IDA	20605918
GO:0005815	Component	Microtubule organizing center	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	20605918
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006464	Process	Cellular protein modification process	TAS	2436037
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	IBA	21873635
GO:0019899	Function	Enzyme binding	IPI	20605918
GO:0030154	Process	Cell differentiation	IBA	21873635
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IBA	21873635
GO:0031295	Process	T cell costimulation	TAS
GO:0038096	Process	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
GO:0043114	Process	Regulation of vascular permeability	TAS	19267251
GO:0044325	Function	Ion channel binding	IPI	12538589
GO:0045087	Process	Innate immune response	IBA	21873635
GO:0048013	Process	Ephrin receptor signaling pathway	TAS
GO:0050900	Process	Leukocyte migration	TAS
GO:0070062	Component	Extracellular exosome	HDA	19199708

Other IDs

• MIM: 164880
• HGNC: 12841
• e!Ensembl: ENSG00000176105

Protein

• UniProt ID: P07947
• Protein name: Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
• Protein function: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
• PDB: 2HDA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00018	SH3_1	97 → 144	SH3 domain	Domain
  PF00017	SH2	158 → 240	SH2 domain	Domain
  PF07714	PK_Tyr_Ser-Thr	277 → 526	Protein tyrosine and serine/threonine kinase	Domain

• Sequence:

  MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
  PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
  INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
  IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
  TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
  KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
  KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
  IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
  VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
  ENL

• Sequence length: 543