GediPNet logo

XRCC6 (X-ray repair cross complementing 6)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2547
Gene nameGene Name - the full gene name approved by the HGNC.
X-ray repair cross complementing 6
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
XRCC6
SynonymsGene synonyms aliases
CTC75, CTCBF, G22P1, KU70, ML8, TLAA
ChromosomeChromosome number
22
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q13.2
SummarySummary of gene provided in NCBI Entrez Gene.
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of non
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT048583 hsa-miR-100-5p CLASH 23622248
MIRT047271 hsa-miR-181b-5p CLASH 23622248
MIRT046859 hsa-miR-221-3p CLASH 23622248
MIRT045877 hsa-miR-128-3p CLASH 23622248
MIRT043624 hsa-miR-326 CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000723 Process Telomere maintenance IBA 21873635
GO:0000723 Process Telomere maintenance TAS 15824061, 18710952, 24095731
GO:0000781 Component Chromosome, telomeric region HDA 19135898
GO:0000783 Component Nuclear telomere cap complex TAS 15100233
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 18809223
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P12956
Protein name X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC b
Protein function Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, P
PDB 1JEQ , 1JEY , 1JJR , 3RZX , 5Y3R , 6ERF , 6ERG , 6ERH , 6ZHA , 6ZHE , 7AXZ , 7K0Y , 7K1J , 7K1K , 7K1N , 7LSY , 7LT3 , 7NFC , 7NFE , 7SGL , 7SU3 , 7Z6O , 7Z87 , 7Z88 , 7ZT6 , 7ZVT , 7ZWA , 7ZYG , 8AG4 , 8AG5 , 8ASC , 8BH3 , 8BHV , 8BHY , 8BOT , 8EZA , 8EZB , 8RD4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03731 Ku_N
37 256
Ku70/Ku80 N-terminal alpha/beta domain
Domain
PF02735 Ku
263 468
Ku70/Ku80 beta-barrel domain
Domain
PF03730 Ku_C
472 557
Ku70/Ku80 C-terminal arm
Family
PF02037 SAP
573 607
SAP domain
Family
Sequence
Sequence length 609
Interactions View interactions

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412