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WASL (WASP like actin nucleation promoting factor)
Gene
Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8976
Gene nameGene Name - the full gene name approved by the HGNC.
WASP like actin nucleation promoting factor
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
WASL
SynonymsGene synonyms aliases
N-WASP, NWASP, WASPB
ChromosomeChromosome number
7
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q31.32
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT051960 hsa-let-7b-5p CLASH 23622248
MIRT051048 hsa-miR-17-5p CLASH 23622248
MIRT049810 hsa-miR-92a-3p CLASH 23622248
MIRT437604 hsa-miR-142-3p Microarray, qRT-PCR 22815788
MIRT520215 hsa-miR-548c-3p HITS-CLIP 21572407
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Other IDs
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 11231575, 11331876, 12732638, 14732713, 15296718, 15527496, 16253999, 16293614, 16483316, 16531231, 16582881, 16595635, 16767080, 17015620, 17474147, 18388313, 18650809, 18662323, 20936779, 21516116, 21706016, 22921828, 23414517, 24332715, 25416956, 26496610, 26871637, 27107012, 285
GO:0005634 Component Nucleus IDA 16767080
GO:0005829 Component Cytosol IDA 18388313
GO:0005829 Component Cytosol TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Other IDs
UniProt ID O00401
Protein name Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)
Protein function Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Involved in various processes, such as mitos
PDB 2FF3 , 2LNH , 2VCP , 4CC2 , 4CC7 , 9DLX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00568 WH1
31 → 138
WH1 domain
 Domain
PF00786 PBD
202 → 261
P21-Rho-binding domain
 Domain
PF02205 WH2
403 → 428
WH2 motif
 Family
PF02205 WH2
430 → 455
WH2 motif
 Family
Sequence 
MSSVQQQPPPPRRVTNVGSLLLTPQENESLFTFLGKKCVTMSSAVVQLYAADRNCMWSKK
CSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALN
FANEEEAKKFRKAVTDLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVN
NISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCG
ISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPP
PPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPP
PPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLK
KVEQNSRPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSK
AIHSSDEDEDEDDEEDFEDDDEWED
Sequence length 505
Interactions View interactions

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